Gene A32 product of vaccinia virus may be an ATPase involved in viral DNA packaging as indicated by sequence comparisons with other putative viral ATPases.

Abstract:

:Statistically significant sequence similarity was revealed between the gene A32 product of vaccinia virus (VV), gene I products (gpI) of filamentous single-stranded DNA bacteriophages, and IVa2 gene products of adenoviruses. Four conserved sequence motifs were delineated, the two N-proximal of which correspond to the A and B motifs of the purine NTP-binding pattern. Based on the role of gpI and IVa2 proteins in virion morphogenesis, and on the conservation of the NTP-binding pattern in these proteins, we hypothesize that the A32 gene product might be involved in an ATP-consuming function in VV virion formation, e.g., packaging of the DNA in the virus particle.

journal_name

Virus Genes

journal_title

Virus genes

authors

Koonin EV,Senkevich TG,Chernos VI

doi

10.1007/BF01702351

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

89-94

issue

1

eissn

0920-8569

issn

1572-994X

journal_volume

7

pub_type

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