Abstract:
:For millions of years viruses have adapted strategies to interfere with the immune defense of the host, which in turn has to deal with this challenge. In general the antiviral defense remains one step behind the pathogen. To achieve this strategic advantage large DNA-containing Viruses encode cellular homologues that mimic or counteract key molecules of the host immune system. Understanding how these cellular homologues enable the viruses to evade the antiviral defense and persist in the host for the lifetime will ultimatively lead also to a better understanding of the principle functions of the immune system. In this review we focused on cellular homologues encoded by human herpesviruses and discuss the functional consequences of their expression.
journal_name
Virus Genesjournal_title
Virus genesauthors
Raftery M,Müller A,Schönrich Gsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
65-75issue
1-2eissn
0920-8569issn
1572-994Xjournal_volume
21pub_type
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