Abstract:
:Although it is known that Cambodia is one of the high endemic area of hepatitis B virus (HBV) infection, molecular characterization of HBV circulating in this country has not been reported. In this study, pre-S gene of HBV from 12 Cambodian patients was sequenced. Phylogenetic analysis based on the pre-S gene sequence revealed that 8 out of 12 isolates (66.7%) belonged to HBV/C1 and remaining four (33.3%) were HBV/B4. Furthermore, complete genomic sequences were also determined for three Cambodian HBV isolates. They all comprised of 3,215 bp long and two of them belonged to subgenotype B4, which had recombination event with genotype C in the precore/core gene confirmed by SimPlot and BootScanning analyses. Our results showed that both HBV strains belonged to subgenotypes B4 and C1, which are circulating in this country. This is the first report on molecular characterization of the HBV prevalent in Cambodia.
journal_name
Virus Genesjournal_title
Virus genesauthors
Huy TT,Sall AA,Reynes JM,Abe Kdoi
10.1007/s11262-008-0205-5subject
Has Abstractpub_date
2008-04-01 00:00:00pages
299-305issue
2eissn
0920-8569issn
1572-994Xjournal_volume
36pub_type
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