Sera of Peruvians with fever of unknown origins include viral nucleic acids from non-vertebrate hosts.

Abstract:

:Serum samples collected from 88 Peruvians with unexplained fever were analyzed for viral sequences using metagenomics. Nucleic acids of anelloviruses, pegivirus A (GBV-C), HIV, Dengue virus, and Oropouche virus were detected. We also characterized from two sera the RNA genomes of new species of partitivirus and dicistrovirus belonging to viral families known to infect fungi or arthropod, respectively. Genomic DNA of a putative fungal cellular host could be PCR amplified from the partitivirus-containing serum sample. The detection in human serum of nucleic acids from viral families not known to infect vertebrates may indicate contamination during sample collection and aliquoting or human infection by their presumed cellular host, here a fungus. The role, if any, of the non-vertebrate infecting viruses detected in serum in inducing fever is unknown.

journal_name

Virus Genes

journal_title

Virus genes

authors

Phan TG,Del Valle Mendoza J,Sadeghi M,Altan E,Deng X,Delwart E

doi

10.1007/s11262-017-1514-3

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

33-40

issue

1

eissn

0920-8569

issn

1572-994X

pii

10.1007/s11262-017-1514-3

journal_volume

54

pub_type

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