Abstract:
:Acinetobacter pittii is an important pathogen causing nosocomial infection worldwide. In this study, a multidrug-resistant A. pittii ABC38 was used as host bacterium to isolate the lytic phage vB_ApiP_XC38. The biological characteristics of vB_ApiP_XC38 were studied and the genome was sequenced and analyzed. vB_ApiP_XC38 belonged to Podoviridae family. The phage had double-stranded genome, which comprised 79,328 bp with 39.58% G+C content displaying very low similarity (< 1% identity) with published genomes of other phages and bacteria. A total of 97 open reading frames (ORFs) were predicted and contained nucleotide metabolism and replication module, structural components module, and lysis module. The ANI, AAI, and phylogenetic analysis indicated that all phages were found distant from vB_ApiP_XC38. Altogether, morphological, genomics, and phylogenetic analysis suggest that vB_ApiP_XC38 is more likely a novel phage of A. pittii.
journal_name
Virus Genesjournal_title
Virus genesauthors
Cheng M,Luo M,Xi H,Zhao Y,Le S,Chen LK,Tan D,Guan Y,Wang T,Han W,Wu N,Zhu T,Gu Jdoi
10.1007/s11262-020-01766-0subject
Has Abstractpub_date
2020-08-01 00:00:00pages
498-507issue
4eissn
0920-8569issn
1572-994Xpii
10.1007/s11262-020-01766-0journal_volume
56pub_type
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