Molecular characterization of the env gene from Brazilian field isolates of Bovine leukemia virus.

Abstract:

:Molecular characterization of Bovine leukemia virus (BLV) isolates from Brazil using the env gene sequences revealed a high conservation of this gene. In most cases the substitutions corresponded to silent transitions. In addition, cystein residues, potential glycosylation sites, neutralization domains and other critical residues involved with the envelope structural domains and viral infectivity were conserved. Most of the substitutions found in the aminoacid sequences of the gp51 protein were localized in the G and H epitopes. Using the SIFT software, it was predicted that they should not alter the protein functions. Phylogenetic analyses showed that partial or complete env gene sequences grouped in three or four phylogenetic clusters, respectively. The sequences from the Brazilian isolates had similar mutation rates as compared to samples from other countries, and belonged to at least two phylogenetic clusters.

journal_name

Virus Genes

journal_title

Virus genes

authors

Camargos MF,Pereda A,Stancek D,Rocha MA,dos Reis JK,Greiser-Wilke I,Leite RC

doi

10.1007/s11262-006-0011-x

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

343-50

issue

3

eissn

0920-8569

issn

1572-994X

journal_volume

34

pub_type

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