Abstract:
:Molecular characterization of Bovine leukemia virus (BLV) isolates from Brazil using the env gene sequences revealed a high conservation of this gene. In most cases the substitutions corresponded to silent transitions. In addition, cystein residues, potential glycosylation sites, neutralization domains and other critical residues involved with the envelope structural domains and viral infectivity were conserved. Most of the substitutions found in the aminoacid sequences of the gp51 protein were localized in the G and H epitopes. Using the SIFT software, it was predicted that they should not alter the protein functions. Phylogenetic analyses showed that partial or complete env gene sequences grouped in three or four phylogenetic clusters, respectively. The sequences from the Brazilian isolates had similar mutation rates as compared to samples from other countries, and belonged to at least two phylogenetic clusters.
journal_name
Virus Genesjournal_title
Virus genesauthors
Camargos MF,Pereda A,Stancek D,Rocha MA,dos Reis JK,Greiser-Wilke I,Leite RCdoi
10.1007/s11262-006-0011-xsubject
Has Abstractpub_date
2007-06-01 00:00:00pages
343-50issue
3eissn
0920-8569issn
1572-994Xjournal_volume
34pub_type
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