Abstract:
:The complete nucleotide sequence of mumps virus isolated in Korea, Dg1062/Korea/98 (Dg1062), was determined. As other mumps viruses, its genome was to be 15,384 nucleotides (nts) in length and encoded seven proteins. The both 5' and 3' ends were confirmed to be 55 and 24 nts by RACE method, respectively. The full-length nucleotide sequence of Dg1062 isolate differed from other strains by 2.9-6.8% in the nucleotide sequence level, resulting in 206 nucleotide and 54 amino acid substitutions which were observed in only Dg1062 isolate relative to the consensus sequences of other strains. Despite the variations of amino acids over the full genome including HN gene, it might be considered that this isolate have no significant variations in the antigenic sites. This result is the first report of full-length genome of genotype I strain and provides an overview on the diversity of genetic characteristics of circulating mumps virus.
journal_name
Virus Genesjournal_title
Virus genesauthors
Lee JY,Na BK,Lee HD,Chang SW,Kim KA,Kim JH,Cho HW,Kim J,Kang Cdoi
10.1023/B:VIRU.0000016859.04203.88subject
Has Abstractpub_date
2004-03-01 00:00:00pages
201-5issue
2eissn
0920-8569issn
1572-994Xpii
5264805journal_volume
28pub_type
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