Complete nucleotide sequence of a mumps virus genotype I strain isolated in Korea.

Abstract:

:The complete nucleotide sequence of mumps virus isolated in Korea, Dg1062/Korea/98 (Dg1062), was determined. As other mumps viruses, its genome was to be 15,384 nucleotides (nts) in length and encoded seven proteins. The both 5' and 3' ends were confirmed to be 55 and 24 nts by RACE method, respectively. The full-length nucleotide sequence of Dg1062 isolate differed from other strains by 2.9-6.8% in the nucleotide sequence level, resulting in 206 nucleotide and 54 amino acid substitutions which were observed in only Dg1062 isolate relative to the consensus sequences of other strains. Despite the variations of amino acids over the full genome including HN gene, it might be considered that this isolate have no significant variations in the antigenic sites. This result is the first report of full-length genome of genotype I strain and provides an overview on the diversity of genetic characteristics of circulating mumps virus.

journal_name

Virus Genes

journal_title

Virus genes

authors

Lee JY,Na BK,Lee HD,Chang SW,Kim KA,Kim JH,Cho HW,Kim J,Kang C

doi

10.1023/B:VIRU.0000016859.04203.88

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

201-5

issue

2

eissn

0920-8569

issn

1572-994X

pii

5264805

journal_volume

28

pub_type

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