Abstract:
:Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary adenocarcinoma (OPA), a contagious lung cancer in sheep. Previous studies have shown that the JSRV envelope protein (Env) functions as an oncogene, in that it can morphologically transform rodent fibroblast and epithelial cell lines. To obtain a small animal model for JSRV-induced OPA, we generated a transgene expressing an epitope-tagged JSRV Env under control of the lung-specific Surfactant Protein A (SPA) promoter. Transgenic mice containing the SPA-Env-HA transgene showed low efficiency but specific expression in the lung. F1 male progeny from one transgenic founder developed subdermal lipomas that expressed the transgene. These results indicate that the JSRV Env protein is capable of inducing tumors in transgenic mice, and in other cell types besides lung epithelial cells.
journal_name
Virus Genesjournal_title
Virus genesauthors
Dakessian RM,Inoshima Y,Fan Hdoi
10.1007/s11262-006-0031-6subject
Has Abstractpub_date
2007-08-01 00:00:00pages
73-80issue
1eissn
0920-8569issn
1572-994Xjournal_volume
35pub_type
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