Barriers to systemic application of virus-based vectors in gene therapy: lessons from adenovirus type 5.

abstract：:Duck hepatitis A virus type 1, (DHAV-1) 2A2pro, is one of the most highly conserved viral proteins within the DHAV serotypes. However, its effect on host cells is unclear. We predicted that DHAV-1 2A2pro was a GTPase-like protein based on the results of multiple sequence alignment and homologous modeling analysis. Upo...

journal_title：Virus genes

authors： Cao J,Ou X,Zhu D,Ma G,Cheng A,Wang M,Chen S,Jia R,Liu M,Sun K,Yang Q,Wu Y,Chen X

更新日期：2016-12-01 00:00:00

abstract：:Parvoviridae, which are classified into two subfamilies Parvovirinae and Densovirinae, can infect both vertebrate and insects and are related to a wide range of diseases in insects, animals, and humans. In this report, several new parvoviruses were identified in swine sera collected in southeastern China. The sequence...

journal_title：Virus genes

authors： Wang F,Wei Y,Zhu C,Huang X,Xu Y,Yu L,Yu X

更新日期：2010-10-01 00:00:00

abstract：:Watermelon mosaic virus (WMV) is one of the most important viruses that causes different symptoms in Cucurbitaceae. WMV is a potyvirus with a worldwide distribution, but occurs most commonly in temperate and Mediterranean regions. Cucurbit species grown in Yazd, Esfahan, West Azerbaijan, Hormozgan, and Kerman province...

journal_title：Virus genes

authors： Sharifi M,Massumi H,Heydarnejad J,Hosseini Pour A,Shaabanian M,Rahimian H

更新日期：2008-12-01 00:00:00

abstract：:Pseudorabies virus (PRV) belongs to the Alphaherpesvirinae subfamily of Herpesviridae. PRV-induced pseudorabies is a highly contagious disease that has caused huge economic losses to the global swine industry. The PRV gE/gI gene deletion vaccine strain (Fa ΔgE/gI strain) constructed from the PRV Fa wild-type strain wa...

journal_title：Virus genes

authors： Liu X,Zhou Y,Luo Y,Chen Y

更新日期：2020-08-01 00:00:00

abstract：:We report here the complete genome sequence of a bipartite virus, herein denoted WLPRV/human/BRA/TO-34/201, from a sample collected in 2015 from a two-year-old child in Brazil presenting acute gastroenteritis. The virus has 98-99% identity (segments 2 and 1, respectively) with the Wuhan large pig roundworm virus (uncl...

journal_title：Virus genes

authors： Luchs A,Leal E,Komninakis SV,de Pádua Milagres FA,Brustulin R,da Aparecida Rodrigues Teles M,Gill DE,Deng X,Delwart E,Sabino EC,da Costa AC

更新日期：2018-06-01 00:00:00

abstract：:Hantaan (HTN) virus, the etiologic agent of clinically severe hemorrhagic fever with renal syndrome (HFRS), was first isolated in 1976 from lung tissues of striped field mice (Apodemus agrarius) captured in Songnae-ri, Kyungki-do, Korea. To clarify the genetic diversity and phylogenetic relationship among Korean strai...

journal_title：Virus genes

authors： Song JW,Baek LJ,Kim SH,Kho EY,Kim JH,Yanagihara R,Song KJ

更新日期：2000-10-01 00:00:00

abstract：:Pandemic H1N1 2009 (pH1N1), influenza virus containing triple reassortant internal genes (TRIG) from avian, human, and swine influenza viruses emerged in 2009 as a highly infectious virus that was able to be transmitted from humans to pigs. During June 2010-May 2012, influenza virus surveillance was conducted in Thai ...

journal_title：Virus genes

authors： Charoenvisal N,Keawcharoen J,Sreta D,Chaiyawong S,Nonthabenjawan N,Tantawet S,Jittimanee S,Arunorat J,Amonsin A,Thanawongnuwech R

更新日期：2013-08-01 00:00:00

abstract：:The nucleotide sequence of the genome segment (S6) encoding the nonstructural protein NS1 of an Australian isolate of bluetongue virus serotype 20 (BTV 20) has been determined from a series of overlapping cDNA clones synthesized using two terminal 15-mer oligonucleotides as primers. The gene consists of 1769 nucleotid...

journal_title：Virus genes

authors： Cowley JA

更新日期：1992-11-01 00:00:00

abstract：:An evolutionary analysis was conducted of 354 hemagglutinin (HA) and 208 neuraminidase (NA) genes, including newly generated sequences of 5 HA and 30 NA, of Egyptian H5N1 clade 2.2.1 viruses isolated from poultry and humans. Five distinct phylogenetically distinguishable clusters arose from a monophyletic origin since...

journal_title：Virus genes

authors： Abdelwhab EM,Arafa AS,Stech J,Grund C,Stech O,Graeber-Gerberding M,Beer M,Hassan MK,Aly MM,Harder TC,Hafez HM

更新日期：2012-08-01 00:00:00

abstract：:Fourteen infectious bronchitis viruses (IBVs) were isolated in Korea between 2001 and 2003 from chickens suspected to be infected with IBVs. The nucleocapsid (N) protein genes of the various IBVs were amplified by reverse transcriptase-polymerase chain reaction (RT-PCR) and were cloned and sequenced, and the nucleotid...

journal_title：Virus genes

authors： Park JY,Pak SI,Sung HW,Kim JH,Song CS,Lee CW,Kwon HM

更新日期：2005-10-01 00:00:00

abstract：:During October 2014, unfamiliar mild mosaic and mottling symptoms were identified on leaves of pepper (Capsicum chinense cv. Habanero) seedlings grown in the Arava valley in Israel 2-3 weeks post planting. Symptomatic plants were tested positive by ELISA using laboratory-produced antisera for tobamovirus species. Typi...

journal_title：Virus genes

authors： Luria N,Smith E,Sela N,Lachman O,Bekelman I,Koren A,Dombrovsky A

更新日期：2018-04-01 00:00:00

abstract：:Ramu stunt disease of sugarcane was first reported in Papua New Guinea in the mid 1980s. The disease can reduce sugarcane yields significantly and causes severe stunting and mortality in highly susceptible cultivars. The causal agent of Ramu stunt has been investigated but its characterization has not been completed. ...

journal_title：Virus genes

authors： Mollov D,Maroon-Lango C,Kuniata L

更新日期：2016-02-01 00:00:00

abstract：:Yellow oat-grass plants (Trisetum flavescens L.) with mild mosaic and pronounced dwarfing symptoms were observed at different locations in the Czech Republic. Electron microscope observations of symptomatic plants revealed the presence of filamentous particles and inclusion bodies characteristic of the family Potyviri...

journal_title：Virus genes

authors： Hassan M,Sirlova L,Jokes M,Vacke J

更新日期：2009-08-01 00:00:00

abstract：:Emerging pseudorabies virus (PRV) variant has led to frequent outbreaks of PRV infection among Bartha-K61-vaccinated swine population in Chinese swine farms and caused high mortality in pigs of all age since late 2011. Here, we generated a gE/gI-deleted PRV (rPRVXJ-delgI/gE-EGFP) based on PRV variant strain (PRV-XJ) t...

journal_title：Virus genes

authors： Yin Y,Xu Z,Liu X,Li P,Yang F,Zhao J,Fan Y,Sun X,Zhu L

更新日期：2017-08-01 00:00:00

abstract：:The original version of this article unfortunately contained errors in the "Results" section. ...

journal_title：Virus genes

authors： Guadie D,Tesfaye K,Knierim D,Winter S,Abraham A

更新日期：2019-06-01 00:00:00

abstract：:We have extended our studies using the mouse lymphoid cell system to determine if polyomavirus (Py) cell type specificity is a consequence of the simple presence of either the A and B enhancers, or if specificity results from specific combinations or arrangements of the individual enhancer elements. Mouse fibroblasts ...

journal_title：Virus genes

authors： Campbell BA,Villarreal LP

更新日期：1987-11-01 00:00:00

abstract：:Mal de Río Cuarto virus (MRCV) is a newly described species of the genus Fijivirus, family Reoviridae. Compared with other plant-infecting genus of the family, the function and localization of MRCV and other Fijivirus proteins are poorly understood. Through analysis of viral particle purifications, we positively ident...

journal_title：Virus genes

authors： Distéfano AJ,Maldonado S,Hopp HE,del Vas M

更新日期：2009-06-01 00:00:00

abstract：:The presence of Gooseberry vein banding associated virus (GVBaV), a badnavirus in the family Caulimoviridae, is strongly correlated with gooseberry vein banding disease in Ribes spp. In this study, full-length genomic sequences of four GVBaV isolates from different hosts and geographic regions were determined to be 76...

journal_title：Virus genes

authors： Xu D,Mock R,Kinard G,Li R

更新日期：2011-08-01 00:00:00

abstract：:The Jumonji C-domain containing protein 6 (JMJD6) has had a convoluted history, and recent reports indicating a multifactorial role in foot-and-mouth disease virus (FMDV) infection have further complicated the functionality of this protein. It was first identified as the phosphatidylserine receptor on the cell surface...

journal_title：Virus genes

authors： Lawrence P,Rieder E

更新日期：2017-06-01 00:00:00

abstract：:By using a phage vector (lambda ZAP II) and the mRNA extracted from IMR-32 cells infected with the RC.HL strain of rabies virus, we constructed a cDNA library from which four nucleoprotein (N)-specific cDNA clones were obtained by Southern blot hybridization. These clones contained a cDNA insert of about 1.4 kb, in wh...

journal_title：Virus genes

authors： Goto H,Minamoto N,Ito H,Sugiyama M,Kinjo T,Mannen K,Mifune K,Kawai A

更新日期：1994-03-01 00:00:00

abstract：:The complete genome sequence of Nootka lupine vein-clearing virus (NLVCV) was determined to be 4,172 nucleotides in length containing four open reading frames (ORFs) with a similar genetic organization of virus species in the genus Carmovirus, family Tombusviridae. The order and gene product size, starting from the 5'...

journal_title：Virus genes

authors： Robertson NL,Côté F,Paré C,Leblanc E,Bergeron MG,Leclerc D

更新日期：2007-12-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome (PRRS) is considered to be one of the most important infectious diseases affecting livestock. This study used gene sequence analysis of ORF5 and Nsp2 to determine the molecular epidemiology of PRRSV in different parts of the Guangxi province of China. These genes were sele...

journal_title：Virus genes

authors： Zhang HY,Liang JJ,Meng XM,Li H,Yang J,Su LJ,Zhang HP,Xie LJ,He XX,Li YS,Yin S,Li XQ,Li XN,Luo TR

更新日期：2013-02-01 00:00:00

abstract：:Satsuma dwarf virus (SDV) and two closely related viruses, Citrus mosaic (CiMV), and Naval orange infectious mottling (NIMV), seriously affect citrus varieties grown in Japan and East Asia. All three viruses have icosahedral particles built of two proteins encapsidating two single-stranded genomic RNAs. The natural mo...

journal_title：Virus genes

authors： Karasev AV,Han SS,Iwanami T

更新日期：2001-01-01 00:00:00

abstract：:Cap-independent translations of viral RNAs of enteroviruses and rhinoviruses, cardioviruses and aphthoviruses, hepatitis A and C viruses (HAV and HCV), and pestivirus are initiated by the direct binding of 40S ribosomal subunits to a cis-acting genetic element termed the internal ribosome entry site (IRES) or ribosome...

journal_title：Virus genes

authors： Le SY,Siddiqui A,Maizel JV Jr

更新日期：1996-01-01 00:00:00

abstract：:Spodoptera litura multicapsid nucleopolyhedrovirus (SpltMNPV) odv-e25 is 684 bp long, potentially encoding 227 amino acids with a predicted molecular weight of 24.9 kDa. Homology analysis indicated that SpltMNPV ODV-E25 has 35-65% amino acid identity with that of other known baculoviruses. RT-PCR results revealed that...

journal_title：Virus genes

authors： Li Z,Pan L,Yu H,Li S,Zhang G,Pang Y

更新日期：2006-02-01 00:00:00

abstract：:The 5' non-coding region (5'-NCR) of 27 classical swine fever virus (CSFV) isolates from Lao People's Democratic Republic (Lao PDR) during 1997 and 1999 were amplified by RT-PCR. A 150-bp region of the 5'-NCR amplicons was analysed and compared with reference CSFV of European and Asian origin and a phylogenetic dendro...

journal_title：Virus genes

authors： Blacksell SD,Khounsy S,Boyle DB,Gleeson LJ,Westbury HA,Mackenzie JS

更新日期：2005-12-01 00:00:00

abstract：:Hepatitis E virus (HEV) has emerged as an important cause of epidemic and sporadic acute viral hepatitis worldwide, which is a major public health challenge. A better understanding of the interaction between the virus and the host cell would be very helpful for its therapy. Swine HEV (SHEV) open reading frame 3 (ORF3)...

journal_title：Virus genes

authors： Cheng Y,Du L,Shi Q,Jiao H,Zhang X,Hao Y,Rong H,Zhang J,Jia X,Guo S,Kuang W,Zhang H,Chen C,Wang F

更新日期：2013-08-01 00:00:00

abstract：:Base usage and dinucleotide frequency have been extensively studied in many eukaryotic organisms and bacteria, but not for viruses. In this paper, a comprehensive analysis of these aspects for infectious bursal disease virus (IBDV) was presented. The analysis of base usage indicated that all of the IBDV genes possess ...

journal_title：Virus genes

authors： Tan DY,Hair Bejo M,Aini I,Omar AR,Goh YM

更新日期：2004-01-01 00:00:00

abstract：:Boid inclusion body disease (BIBD) is a viral disease of boids caused by reptarenavirus. In this study, tissue from naturally infected boid snakes were homogenized and propagated in African Monkey kidney (Vero) and rat embryonic fibroblast (REF) cells. Virus replication was determined by the presence of cytopathic eff...

journal_title：Virus genes

authors： Abba Y,Hassim H,Hamzah H,Ibrahim OE,Ilyasu Y,Bande F,Mohd Lila MA,Noordin MM

更新日期：2016-10-01 00:00:00

abstract：:Infectious full-length cDNA clones from the genomic RNAs of a subgroup II cucumber mosaic cucumovirus strain (Trk7) were obtained. Sequence analysis of the whole genome revealed strong homology (99%) to the genome of Q-CMV, the only subgroup II strain whose entire genomic nucleotide sequence had been available in the ...

journal_title：Virus genes

authors： Szilassy D,Salánki K,Balázs E

更新日期：1999-01-01 00:00:00