Abstract:
:Recent studies indicate that alphaherpesviruses express latency associated transcripts (LATs) from the antisense strand of immediate early (IE) genes of the viral genome. It has been discussed that LATs containing extended open reading frames (ORFs) might be translated into protein products. We found that a salient feature of some herpesvirus DNAs is a high GC preference at the third codon positions. As a consequence, the probability of a stop codon arising at two of the six frames of the DNA strand is very low. The regions missing stop codons frequently start with ATG, resulting in extended ORFs. Therefore, the presence of a gene-long ORF does not necessarily mean that it is relevant to real translation.
journal_name
Virus Genesjournal_title
Virus genesauthors
Boldogköi Z,Murvai Jdoi
10.1007/BF01703434subject
Has Abstractpub_date
1994-09-01 00:00:00pages
47-51issue
1eissn
0920-8569issn
1572-994Xjournal_volume
9pub_type
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