Merkel cell polyomavirus in Merkel cell carcinogenesis: small T antigen-mediates c-Jun phosphorylation.

Abstract:

:Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer associated with the Merkel cell polyomavirus (MCPyV). The MCPyV genome, which is clonally integrated in the majority of MCCs, encodes the regulatory small T (sT) antigen. Previously, reports have established MCPyV sT antigen as a potent oncogene capable of inducing cell transformation. In the current study, we demonstrate a distinct role for c-Jun hyperactivation in MCPyV sT antigen pathogenesis. As MCPyV sT antigen's association with aggressive cancer growth has been previously established, this finding may represent a potential therapeutic target for the treatment of MCCs.

journal_name

Virus Genes

journal_title

Virus genes

authors

Wu JH,Simonette RA,Nguyen HP,Rady PL,Tyring SK

doi

10.1007/s11262-016-1304-3

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

397-9

issue

3

eissn

0920-8569

issn

1572-994X

pii

10.1007/s11262-016-1304-3

journal_volume

52

pub_type

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