Abstract:
:Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer associated with the Merkel cell polyomavirus (MCPyV). The MCPyV genome, which is clonally integrated in the majority of MCCs, encodes the regulatory small T (sT) antigen. Previously, reports have established MCPyV sT antigen as a potent oncogene capable of inducing cell transformation. In the current study, we demonstrate a distinct role for c-Jun hyperactivation in MCPyV sT antigen pathogenesis. As MCPyV sT antigen's association with aggressive cancer growth has been previously established, this finding may represent a potential therapeutic target for the treatment of MCCs.
journal_name
Virus Genesjournal_title
Virus genesauthors
Wu JH,Simonette RA,Nguyen HP,Rady PL,Tyring SKdoi
10.1007/s11262-016-1304-3subject
Has Abstractpub_date
2016-06-01 00:00:00pages
397-9issue
3eissn
0920-8569issn
1572-994Xpii
10.1007/s11262-016-1304-3journal_volume
52pub_type
杂志文章相关文献
VIRUS GENES文献大全abstract::White spot syndrome virus (WSSV) is one of the most virulent pathogens causing high mortality in shrimp. The viral early genes play a key role in DNA replication and virus proliferation. In this study, a WSSV gene (wsv477) encoding 208 amino acid peptides was characterized as an early gene. The temporal analysis showe...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-006-0053-0
更新日期:2007-04-01 00:00:00
abstract::Bovine viral diarrhea virus (BVDV) belongs to the Pestivirus genus of the Flaviviridae family and has worldwide distribution, being one of the main causes of economic losses in cattle raising. The genome of pestiviruses is a single strand of positive-sense RNA with a length of 12.3 kb, which encodes one open reading f...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-020-01756-2
更新日期:2020-08-01 00:00:00
abstract::Seed-transmitted viruses have caused significant damage to watermelon crops in Korea in recent years, with cucumber green mottle mosaic virus (CGMMV) infection widespread as a result of infected seed lots. To determine the likely origin of CGMMV infection, we collected CGMMV isolates from watermelon and melon fields a...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-016-1415-x
更新日期:2017-04-01 00:00:00
abstract::The genomic diversity of Argentine Tospoviruses from different geographical areas, and from several distinct crops was analysed here. For each isolate, RT-PCR, cloning and sequencing of a 450 nt fragment of the N gene were performed. Comparisons of RNA and predicted amino acid sequence identity and similarity were mad...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/BF00366986
更新日期:1996-01-01 00:00:00
abstract::We evaluated the predicted biochemical properties of Gag proteins from a diverse group of feline immunodeficiency viruses (FIV) to determine how different evolutionary histories of virus and host have changed or constrained these important structural proteins. Our data are based on FIV sequences derived from domestic ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-006-0058-8
更新日期:2007-10-01 00:00:00
abstract::Comparison of the genomic organization of variola and vaccinia viruses has been carried out. Molecular factors of virulence of these viruses is the focus of this review. Possible roles of the genes of soluble cytokine receptors, complement control proteins, factors of virus replication, and dissemination in vivo for v...
journal_title:Virus genes
pub_type: 杂志文章,评审
doi:10.1007/BF01724297
更新日期:1995-01-01 00:00:00
abstract::H1 influenza A viruses that were distinct from the classical swine H1 lineage were identified in pigs in Canada in 2003–2004; antigenic and genetic characterization identified the hemagglutinin (HA) as human H1 lineage. The viruses identified in Canadian pigs were human lineage in entirety or double (human–swine) reas...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0386-6
更新日期:2009-10-01 00:00:00
abstract::We have extended our studies using the mouse lymphoid cell system to determine if polyomavirus (Py) cell type specificity is a consequence of the simple presence of either the A and B enhancers, or if specificity results from specific combinations or arrangements of the individual enhancer elements. Mouse fibroblasts ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/BF00125683
更新日期:1987-11-01 00:00:00
abstract::One of the consequences of equine herpesvirus 1 (EHV-1) infection in the natural host is a neurological disease that can lead to paralysis. The pathology associated with EHV-1-induced neurological disease includes vasculitis of the small blood vessels within the central nervous system and subsequent damage to the surr...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/B:VIRU.0000032785.19420.14
更新日期:2004-08-01 00:00:00
abstract::A unique feature of ascovirus infection is cleavage of host cells into virus containing vesicles. It has been suggested that the virus induces apoptosis, either by expression of a caspase or other means, which is then diverted toward vesicle formation. There is little known about the mechanism of vesicle formation. Re...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0407-5
更新日期:2009-12-01 00:00:00
abstract::Coxsackieviruses are important human pathogens that induce myocarditis and pancreatitis. However, there are no vaccines or therapeutic reagents for their clinical treatment. Although RNA interference (RNAi)-based approaches to the prevention of viral production have been developed recently, limitations to the in vivo ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-007-0192-y
更新日期:2008-02-01 00:00:00
abstract::The Agrotis ipsilon multiple nucleopolyhedrovirus (AgipMNPV) is a group II nucleopolyhedrovirus (NPV) from the black cutworm, A. ipsilon, with potential as a biopesticide to control infestations of cutworm larvae. The genome of the Illinois strain of AgipMNPV was completely sequenced. The AgipMNPV genome was 155,122 n...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0297-y
更新日期:2009-02-01 00:00:00
abstract::During October 2014, unfamiliar mild mosaic and mottling symptoms were identified on leaves of pepper (Capsicum chinense cv. Habanero) seedlings grown in the Arava valley in Israel 2-3 weeks post planting. Symptomatic plants were tested positive by ELISA using laboratory-produced antisera for tobamovirus species. Typi...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-018-1539-2
更新日期:2018-04-01 00:00:00
abstract::Spodoptera litura multicapsid nucleopolyhedrovirus (SpltMNPV) ORF39 (designated as the bjdp gene) is the only J domain gene recorded in baculovirus genomes to date. Computer-assisted analysis revealed that its deduced amino acid sequences possessed a coiled-coil region and a RNA recognition motif (RRM). In vivo the bd...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1020980109450
更新日期:2002-12-01 00:00:00
abstract::DNA viruses as their host cells require a DNA-dependent DNA polymerase (Pol) to faithfully replicate their genomic information. Large eukaryotic DNA viruses as well as bacterial viruses encode a specific Pol equipped with a proofreading 3'-5'-exonuclease, and other replication proteins. All known viral Pol belong to f...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1007997609122
更新日期:1998-01-01 00:00:00
abstract::Porcine reproductive and respiratory syndrome (PRRS) is considered to be one of the most important infectious diseases affecting livestock. This study used gene sequence analysis of ORF5 and Nsp2 to determine the molecular epidemiology of PRRSV in different parts of the Guangxi province of China. These genes were sele...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-012-0824-8
更新日期:2013-02-01 00:00:00
abstract::Glycosylation on the globular head of the hemagglutinin (HA) protein of influenza virus acts as an important target for recognition and destruction of virus by innate immune proteins of the collectin family. In the current study, we have characterized the dynamic amino acid changes at N-linked glycosylation sites of f...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-013-0993-0
更新日期:2014-02-01 00:00:00
abstract::Boid inclusion body disease (BIBD) is a viral disease of boids caused by reptarenavirus. In this study, tissue from naturally infected boid snakes were homogenized and propagated in African Monkey kidney (Vero) and rat embryonic fibroblast (REF) cells. Virus replication was determined by the presence of cytopathic eff...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-016-1345-7
更新日期:2016-10-01 00:00:00
abstract::Herpes simplex virus type 1 (HSV-1) reactivates from a small fraction of latently infected neurons in vivo and neuronally differentiated (ND), quiescently infected (QIF)-PC12 cells in vitro. This may be the result of reactivation initiating in only a few cells, or reactivation followed by premature termination of the ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-005-0052-6
更新日期:2006-10-01 00:00:00
abstract::We have determined the 5' and 3' non-coding regions (NCR) of four dengue-2 viruses isolated from dengue patients with different clinical severities in Nakhon Phanom, Northeastern Thailand in 1993. The results were compared to prototype dengue-2 strains and were found to have highest homology with the New Guinea C stra...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1007914520454
更新日期:1997-01-01 00:00:00
abstract::The establishment of viral pathogens in new host environments following spillover events probably requires adaptive changes within both the new host and pathogen. After many generations, signals for ancient cross-species transmission may become lost and a strictly host-adapted phylogeny may mimic true co-divergence wh...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-019-01702-x
更新日期:2019-12-01 00:00:00
abstract::This study brings the analysis of amino acid sequences of hemagglutinin (HA) from the influenza virus A that can infect a wide variety of birds and mammals. 191 sequences belonging to all known 15 HA subtypes were compared. The emphasis was given on functional sites (receptor-binding cavity with its right and left edg...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1014038120979
更新日期:2002-01-01 00:00:00
abstract::Novel duck reovirus (NDRV), the prototype strain of the species Avian orthoreovirus (ARV), is associated with high mortality in Pekin ducklings. σC is an outer capsid protein encoded by the S1 genome segment of NDRV which mediates attachment to host cells. Our previous studies using immunoprecipitation and mass spectr...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-020-01750-8
更新日期:2020-06-01 00:00:00
abstract::The near-complete (99.7 %) genome sequence of a novel Russian Plum pox virus (PPV) isolate Pk, belonging to the strain Winona (W), has been determined by 454 pyrosequencing with the exception of the thirty-one 5'-terminal nucleotides. This region was amplified using 5'RACE kit and sequenced by the Sanger method. Genom...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-013-0946-7
更新日期:2013-10-01 00:00:00
abstract::The NS3 protein of rice stripe virus (RSV), encoded by the virion strand of RNA3, is a viral suppressor of RNA silencing (VSR). Rice expressing NS3 had a normal phenotype, was initially sensitive to RSV but recovered at the later stages of infection. RSV accumulated slightly more in transgenic than in wild-type plants...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-014-1051-2
更新日期:2014-06-01 00:00:00
abstract::Endogenous retrovirus-like sequences that are homologous to the multigenic murine and Syrian hamster intracisternal type A particle (IAP) genes can be detected in very few copies in the Chinese hamster (CH) genome. They were cloned from a CHO gene library and two recombinants, harboring the major IAP-like DNA genes ch...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/BF00570029
更新日期:1990-12-01 00:00:00
abstract::Two double-stranded RNA (dsRNA) segments of a virus with a bipartite genome identified in fig (Ficus carica L.) and denoted Fig cryptic virus (FCV) were cloned and sequenced. Viral dsRNAs are 1696 bp (RNA-1) and 1415 bp (RNA-2) in size. RNA-1 contains a single ORF (1419 nt) potentially encoding a 54 kDa protein and co...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-011-0581-0
更新日期:2011-06-01 00:00:00
abstract::Enterovirus 96 (EV-96) is a recently described member of the species Enterovirus C and is associated with paralysis and myelitis. In this study, using metagenomic sequencing, we identified a new enterovirus 96 strain (EV-96-SZ/GD/CHN/2014) as the sole pathogen causing hand, foot, and mouth disease (HFMD). A genomic co...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-017-1431-5
更新日期:2017-06-01 00:00:00
abstract::We describe the isolation and characterization of an insect-specific flavivirus (ISF) from Ochlerotatus caspius (Pallas, 1771) mosquitoes collected in southern Portugal. The RNA genome of this virus, tentatively designated OCFVPT, for O. caspius flavivirus from Portugal, encodes a polyprotein showing all the features ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-013-0960-9
更新日期:2013-12-01 00:00:00
abstract::Amino acid and phylogenetic analysis showed that PB1-F2 of H7N7 and H3N8 equine influenza virus (EIV) evolved into two and nine clades, respectively. The PB1-F2 gene of H7N7 EIV strains isolated after 1973 was identified as being replaced by that of H3N8 EIV circulating simultaneously. All H7N7 EIV strains before 1973...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-013-0935-x
更新日期:2013-10-01 00:00:00