Characterization of a newly emerged genetic cluster of H1N1 and H1N2 swine influenza virus in the United States.

Abstract:

:H1 influenza A viruses that were distinct from the classical swine H1 lineage were identified in pigs in Canada in 2003–2004; antigenic and genetic characterization identified the hemagglutinin (HA) as human H1 lineage. The viruses identified in Canadian pigs were human lineage in entirety or double (human–swine) reassortants. Here, we report the whole genome sequence analysis of four human-like H1 viruses isolated from U.S. swine in 2005 and 2007. All four isolates were characterized as triple reassortants with an internal gene constellation similar to contemporary U.S. swine influenza virus (SIV), with HA and neuraminidase (NA) most similar to human influenza virus lineages. A 2007 human-like H1N1 was evaluated in a pathogenesis and transmission model and compared to a 2004 reassortant H1N1 SIV isolate with swine lineage HA and NA. The 2007 isolate induced disease typical of influenza virus and was transmitted to contact pigs; however, the kinetics and magnitude differed from the 2004 H1N1 SIV. This study indicates that the human-like H1 SIV can efficiently replicate and transmit in the swine host and now co-circulates with contemporary SIVs as a distinct genetic cluster of H1 SIV.

journal_name

Virus Genes

journal_title

Virus genes

authors

Vincent AL,Ma W,Lager KM,Gramer MR,Richt JA,Janke BH

doi

10.1007/s11262-009-0386-6

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

176-85

issue

2

eissn

0920-8569

issn

1572-994X

journal_volume

39

pub_type

杂志文章
  • Role of SH3b binding domain in a natural deletion mutant of Kayvirus endolysin LysF1 with a broad range of lytic activity.

    abstract::The spontaneous host-range mutants 812F1 and K1/420 are derived from polyvalent phage 812 that is almost identical to phage K, belonging to family Myoviridae and genus Kayvirus. Phage K1/420 is used for the phage therapy of staphylococcal infections. Endolysin of these mutants designated LysF1, consisting of an N-term...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-017-1507-2

    authors: Benešík M,Nováček J,Janda L,Dopitová R,Pernisová M,Melková K,Tišáková L,Doškař J,Žídek L,Hejátko J,Pantůček R

    更新日期:2018-02-01 00:00:00

  • Sequence analysis of porcine adenovirus serotype 5 fibre gene: evidence for recombination.

    abstract::The nucleic acid and deduced amino acid sequence of the fibre gene of the HNF-61 strain of porcine adenovirus serotype 5 (PAdV-5) was determined and compared to that of the HNF-70 strain of the same serotype (Nagy et al., J Gen Virol 82, 525-529, 2001) and also to adenovirus fibre genes from the genera Mastadenovirus ...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1023/a:1014580802250

    authors: Nagy M,Nagy E,Tuboly T

    更新日期:2002-03-01 00:00:00

  • Wuhan large pig roundworm virus identified in human feces in Brazil.

    abstract::We report here the complete genome sequence of a bipartite virus, herein denoted WLPRV/human/BRA/TO-34/201, from a sample collected in 2015 from a two-year-old child in Brazil presenting acute gastroenteritis. The virus has 98-99% identity (segments 2 and 1, respectively) with the Wuhan large pig roundworm virus (uncl...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-018-1557-0

    authors: Luchs A,Leal E,Komninakis SV,de Pádua Milagres FA,Brustulin R,da Aparecida Rodrigues Teles M,Gill DE,Deng X,Delwart E,Sabino EC,da Costa AC

    更新日期:2018-06-01 00:00:00

  • Complete genome analysis of velogenic Newcastle disease virus reference strain "Chimalhuacan": evolution of viral lineages in Mexico.

    abstract::Newcastle disease virus with velogenic characteristics circulates in the poultry industry in Mexico and various other American countries. In Mexico, vaccine efficacy testing to obtain commercial registration is reliant on a challenge with a velogenic strain known colloquially as Chimalhuacan due to the site where it w...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-014-1082-8

    authors: Absalón AE,Mariano-Matías A,García LJ,Morales-Garzón A,Toscano-Contreras A,Lucio-Decanini E,Cortés-Espinosa DV

    更新日期:2014-10-01 00:00:00

  • A sensitive duplex nanoparticle-assisted PCR assay for identifying porcine epidemic diarrhea virus and porcine transmissible gastroenteritis virus from clinical specimens.

    abstract::In this study, a novel duplex nanoparticle-assisted polymerase chain reaction (nanoPCR) assay was developed to detect porcine epidemic diarrhea virus (PEDV) and porcine transmissible gastroenteritis virus (TGEV). Two pairs of primers were designed based on the conserved region within the N gene of PEDV and TGEV. In a ...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-016-1405-z

    authors: Zhu Y,Liang L,Luo Y,Wang G,Wang C,Cui Y,Ai X,Cui S

    更新日期:2017-02-01 00:00:00

  • Characterization of an early gene (wsv477) from shrimp white spot syndrome virus (WSSV).

    abstract::White spot syndrome virus (WSSV) is one of the most virulent pathogens causing high mortality in shrimp. The viral early genes play a key role in DNA replication and virus proliferation. In this study, a WSSV gene (wsv477) encoding 208 amino acid peptides was characterized as an early gene. The temporal analysis showe...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-006-0053-0

    authors: Han F,Xu J,Zhang X

    更新日期:2007-04-01 00:00:00

  • Cleavage of transcripts of foot and mouth disease virus (FMDV), Asia1 serotype, by ribozymes targeted to the VP3 and VP4 genes.

    abstract::Two ribozyme genes were designed to cut within the VP4 and VP3 sequences of foot and mouth disease virus (FMDV) Asia1 serotype genome. The two genes were synthesized and cloned into pBluescript under the control of the T3 promoter. The ribozyme designed to cut the VP4 gene contained two catalytic sequences targeted to...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/BF01702658

    authors: Stram Y,Molad T

    更新日期:1995-01-01 00:00:00

  • Molecular evidence for the existence of two distinct subgroups in cucumber mosaic cucumovirus.

    abstract::Infectious full-length cDNA clones from the genomic RNAs of a subgroup II cucumber mosaic cucumovirus strain (Trk7) were obtained. Sequence analysis of the whole genome revealed strong homology (99%) to the genome of Q-CMV, the only subgroup II strain whose entire genomic nucleotide sequence had been available in the ...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1023/a:1008016202128

    authors: Szilassy D,Salánki K,Balázs E

    更新日期:1999-01-01 00:00:00

  • Transcriptional suppression of IE180 and TK promoters by the EP0 of pseudorabies virus strains Ea and Fa.

    abstract::In our transient expression assays, the IE180 and TK promoters were markedly suppressed by the EP0 of the pseudorabies virus strains Ea and Fa (EP0/Ea, EP0/Fa). This is in contrast with the transactivating activity of EP0 from strain YS-81 (EP0/YS-81) in previous studies. Amino acid sequence alignment revealed several...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-008-0320-3

    authors: Guo H,Zhou R,Xi Y,Xiao S,Chen H

    更新日期:2009-04-01 00:00:00

  • Insights into Jumonji C-domain containing protein 6 (JMJD6): a multifactorial role in foot-and-mouth disease virus replication in cells.

    abstract::The Jumonji C-domain containing protein 6 (JMJD6) has had a convoluted history, and recent reports indicating a multifactorial role in foot-and-mouth disease virus (FMDV) infection have further complicated the functionality of this protein. It was first identified as the phosphatidylserine receptor on the cell surface...

    journal_title:Virus genes

    pub_type: 杂志文章,评审

    doi:10.1007/s11262-017-1449-8

    authors: Lawrence P,Rieder E

    更新日期:2017-06-01 00:00:00

  • Evolution of surface and nonstructural-1 genes of influenza B viruses isolated in the Province of Québec, Canada, during the 1998-2001 period.

    abstract::After 2 minor winter seasons, influenza B viruses were predominantly isolated in the Province of Quebec, Canada, during the 2000-2001 season representing 74% of laboratory-confirmed influenza viruses. We performed an antigenic study of the hemagglutinin (HA) protein and a molecular characterization of the HA1 region, ...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1023/a:1025768308631

    authors: Abed Y,Coulthart MB,Li Y,Boivin G

    更新日期:2003-10-01 00:00:00

  • Complete nucleotide sequence of Nootka lupine vein-clearing virus.

    abstract::The complete genome sequence of Nootka lupine vein-clearing virus (NLVCV) was determined to be 4,172 nucleotides in length containing four open reading frames (ORFs) with a similar genetic organization of virus species in the genus Carmovirus, family Tombusviridae. The order and gene product size, starting from the 5'...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-007-0139-3

    authors: Robertson NL,Côté F,Paré C,Leblanc E,Bergeron MG,Leclerc D

    更新日期:2007-12-01 00:00:00

  • Herpesvirus homologues of cellular genes.

    abstract::For millions of years viruses have adapted strategies to interfere with the immune defense of the host, which in turn has to deal with this challenge. In general the antiviral defense remains one step behind the pathogen. To achieve this strategic advantage large DNA-containing Viruses encode cellular homologues that ...

    journal_title:Virus genes

    pub_type: 杂志文章,评审

    doi:

    authors: Raftery M,Müller A,Schönrich G

    更新日期:2000-01-01 00:00:00

  • Comparative analysis of American Dengue virus type 1 full-genome sequences.

    abstract::Dengue virus (DENV; Genus Flavivirus, Family Flaviviridae) has been circulating in Brazil since at least the mid-1980s and continues to be responsible for sporadic cases of Dengue fever and Dengue hemorrhagic fever throughout this country. Here, we describe the full genomes of two new Brazilian DENV-serotype 1 (DENV-1...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-009-0428-0

    authors: Carvalho SE,Martin DP,Oliveira LM,Ribeiro BM,Nagata T

    更新日期:2010-02-01 00:00:00

  • A local strain of Paprika mild mottle virus breaks L3 resistance in peppers and is accelerated in Tomato brown rugose fruit virus-infected Tm-22-resistant tomatoes.

    abstract::During October 2014, unfamiliar mild mosaic and mottling symptoms were identified on leaves of pepper (Capsicum chinense cv. Habanero) seedlings grown in the Arava valley in Israel 2-3 weeks post planting. Symptomatic plants were tested positive by ELISA using laboratory-produced antisera for tobamovirus species. Typi...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-018-1539-2

    authors: Luria N,Smith E,Sela N,Lachman O,Bekelman I,Koren A,Dombrovsky A

    更新日期:2018-04-01 00:00:00

  • Genomic characterization of two Orf virus isolates from Jilin province in China.

    abstract::Orf virus (ORFV), a typical member of the Parapoxvirus genus within the family Poxviridae, which is the causative agent of Orf, a common epitheliotropic viral disease of sheep, goats, wild ruminants, and humans. In the present study, we sequenced the complete genomic sequences of two ORFV strains (ORFV-SY17, isolated ...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-019-01666-y

    authors: Zhong J,Guan J,Zhou Y,Cui S,Wang Z,Zhou S,Xu M,Wei X,Gao Y,Zhai S,Song D,He W,Gao F,Zhao K

    更新日期:2019-08-01 00:00:00

  • Complete sequences of the neuraminidase genes of swine influenza viruses (H1N1) associated with the respiratory disease in pigs.

    abstract::The complete nucleotide sequences of neuraminidase (NA) of two swine influenza viruses (H1N1) are presented. A/Sw/Quebec/5393/91 (SwQc91) virus, associated with the chronic respiratory disease and A/Sw/ Quebec/192/81 (SwQc81) virus, associated with the acute respiratory disease, were used. The deduced amino acid seque...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1023/a:1007944228967

    authors: Arora DS,Tijssen P,Dea S,Henrichon M

    更新日期:1997-01-01 00:00:00

  • Homology differences between complete Sacbrood virus genomes from infected Apis mellifera and Apis cerana honeybees in Korea.

    abstract::Sacbrood virus (SBV) represents a serious threat to the health of managed honeybees. We determined four complete SBV genomic sequences (AmSBV-Kor1, AmSBV-Kor2, AcSBV-Kor3, and AcSBV-Kor4) isolated from Apis mellifera and Apis cerana in various regions of South Korea. A phylogenetic tree was constructed from the comple...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-015-1268-8

    authors: Reddy KE,Yoo MS,Kim YH,Kim NH,Ramya M,Jung HN,Thao le TB,Lee HS,Kang SW

    更新日期:2016-04-01 00:00:00

  • Identification and characterization of the UL24 gene product of herpes simplex virus type 2.

    abstract::The UL24 gene of herpes simplex virus type 2 (HSV-2) is predicted to encode a 281 amino acid protein with a molecular mass of 30.5 kDa. In this study, the HSV-2 UL24 gene product has been identified by using a rabbit polyclonal antiserum produced against a recombinant protein containing the full-length UL24 gene produ...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1023/a:1011118424474

    authors: Hong-Yan Z,Murata T,Goshima F,Takakuwa H,Koshizuka T,Yamauchi Y,Nishiyama Y

    更新日期:2001-06-01 00:00:00

  • Genetic typing of classical swine fever viruses from Lao PDR by analysis of the 5' non-coding region.

    abstract::The 5' non-coding region (5'-NCR) of 27 classical swine fever virus (CSFV) isolates from Lao People's Democratic Republic (Lao PDR) during 1997 and 1999 were amplified by RT-PCR. A 150-bp region of the 5'-NCR amplicons was analysed and compared with reference CSFV of European and Asian origin and a phylogenetic dendro...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-005-3253-0

    authors: Blacksell SD,Khounsy S,Boyle DB,Gleeson LJ,Westbury HA,Mackenzie JS

    更新日期:2005-12-01 00:00:00

  • Genetic structure of Pacific Flyway avian influenza viruses is shaped by geographic location, host species, and sampling period.

    abstract::The eight gene segments of avian influenza virus (AIV) reassort frequently and rapidly to generate novel genotypes and subtypes that are transmissible to a broad range of hosts. There is evidence that AIV can have a restricted host range and can segregate in space and time. Host-virus relationships at the species, geo...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-011-0706-5

    authors: Girard YA,Runstadler JA,Aldehoff F,Boyce W

    更新日期:2012-06-01 00:00:00

  • In vitro isolation and molecular identification of reptarenavirus in Malaysia.

    abstract::Boid inclusion body disease (BIBD) is a viral disease of boids caused by reptarenavirus. In this study, tissue from naturally infected boid snakes were homogenized and propagated in African Monkey kidney (Vero) and rat embryonic fibroblast (REF) cells. Virus replication was determined by the presence of cytopathic eff...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-016-1345-7

    authors: Abba Y,Hassim H,Hamzah H,Ibrahim OE,Ilyasu Y,Bande F,Mohd Lila MA,Noordin MM

    更新日期:2016-10-01 00:00:00

  • Hepatitis B virus subgenotype A1, occurrence of subgenotype D4, and S gene mutations among voluntary blood donors in Kenya.

    abstract::Kenya is one of the high endemic zones for hepatitis B virus (HBV) infection. The consensuses on prevalence of the HBV genotypes and the existence of their variants have not been fully established in Kenya. Hence, there is a need to further monitor the diversity of HBV. This study aimed to extend the current molecular...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-013-0976-1

    authors: Kwange SO,Budambula NL,Kiptoo MK,Okoth F,Ochwoto M,Oduor M,Kimotho JH

    更新日期:2013-12-01 00:00:00

  • The characteristics and genome analysis of vB_ApiP_XC38, a novel phage infecting Acinetobacter pittii.

    abstract::Acinetobacter pittii is an important pathogen causing nosocomial infection worldwide. In this study, a multidrug-resistant A. pittii ABC38 was used as host bacterium to isolate the lytic phage vB_ApiP_XC38. The biological characteristics of vB_ApiP_XC38 were studied and the genome was sequenced and analyzed. vB_ApiP_X...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-020-01766-0

    authors: Cheng M,Luo M,Xi H,Zhao Y,Le S,Chen LK,Tan D,Guan Y,Wang T,Han W,Wu N,Zhu T,Gu J

    更新日期:2020-08-01 00:00:00

  • Sequence of rice hoja blanca tenuivirus RNA-2.

    abstract::The sequence of rice hoja blanca tenuivirus RNA-2 is analysed and compared to its counter-part in rice stripe tenuivirus. The RNA encodes two proteins, in an ambisense arrangement. The 94 kD pc2, located in the complementary sense RNA, has several features typical of viral membrane (glyco)proteins, and also has region...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/BF00284643

    authors: De Miranda JR,Muñoz M,Wu R,Hull R,Espinoza AM

    更新日期:1996-01-01 00:00:00

  • Nuclear localization signals of varicella zoster virus ORF4.

    abstract::The varicella zoster virus (VZV) ORF4 protein, one of immediate-early genes protein, is associated with the tegument in purified virions. ORF4 protein functions at both transcriptional and post-transcriptional levels, present during different phase of whole VZV life cycle. ORF4 protein acts as a nucleocytoplasm shuttl...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-013-1006-z

    authors: Huang Y,Zhang J,Halawa MA,Yao S

    更新日期:2014-04-01 00:00:00

  • Characterization and complete genome sequence analysis of Staphylococcus aureus bacteriophage SA12.

    abstract::Staphylococcus aureus is a well-known pathogen that causes several serious diseases in humans and animals. As part of the efforts to control this pathogen, a newly isolated bacteriophage, SA12, which specifically targets S. aureus, was characterized, and its genome was completely sequenced. Host range and bacteriophag...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-013-0938-7

    authors: Chang Y,Lee JH,Shin H,Heu S,Ryu S

    更新日期:2013-10-01 00:00:00

  • Identification of a thymidylate synthase gene within the genome of Chilo iridescent virus.

    abstract::The thymidylate synthase (TS, EC 2.1.1.45) is essential for the de novo synthesis of dTMP in pro- and eucaryotic organisms. Consequently it plays a major role in the replication of the DNA genome of a cell or a DNA virus. The gene encoding the TS of Chilo iridescent virus (CIV) was identified by nucleotide sequence an...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1023/a:1008017820941

    authors: Müller K,Tidona CA,Bahr U,Darai G

    更新日期:1998-01-01 00:00:00

  • Arenavirus phylogeny: a new insight.

    abstract::Arenaviridae is a worldwide distributed family, of enveloped, single stranded, RNA viruses. The arenaviruses were divided in two major groups (Old World and New World), based on serological properties and genetic data, as well as the geographic distribution. In this study the phylogenetic relationship among the member...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1023/a:1007993525052

    authors: Albariño CG,Posik DM,Ghiringhelli PD,Lozano ME,Romanowski V

    更新日期:1998-01-01 00:00:00

  • Genetic diversity of Apodemus agrarius-borne hantaan virus in Korea.

    abstract::Hantaan (HTN) virus, the etiologic agent of clinically severe hemorrhagic fever with renal syndrome (HFRS), was first isolated in 1976 from lung tissues of striped field mice (Apodemus agrarius) captured in Songnae-ri, Kyungki-do, Korea. To clarify the genetic diversity and phylogenetic relationship among Korean strai...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1023/a:1008199800011

    authors: Song JW,Baek LJ,Kim SH,Kho EY,Kim JH,Yanagihara R,Song KJ

    更新日期:2000-10-01 00:00:00