Effect of radiation on glyoxalase I and glyoxalase II activities in spleen and liver of mice.

abstract：:The dose-rate effect has been the topic of extensive radiobiological studies and has important implications in radiation therapy and in the field of radiation protection. Three examples will be discussed: two in radiation therapy and one in protection. First, continuous low dose-rate interstitial brachytherapy may be ...

journal_title：International journal of radiation biology

authors： Hall EJ

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:To determine the efficacy of a caffeine derivative 1-methylxanthine (1-MTX) in increasing radiosensitivity of cancer cells and elucidate the underlying mechanisms in vitro. MATERIALS AND METHODS:RKO human colorectal cancer cells carrying wild type protein 53 kDa (p53) were incubated with 3 mM 1-MTX for 30 min,...

journal_title：International journal of radiation biology

authors： Youn H,Hee Kook Y,Oh ET,Jeong SY,Kim C,Kyung Choi E,Uk Lim B,Park HJ

更新日期：2009-02-01 00:00:00

abstract：:Determinations of cell sensitivity in terms of survival fraction after doses employed in clinical radiation therapy, say 1-3 Gy, are of increasing interest to clinicians as they provide direct experimental data which can be employed without reference to models of cell inactivation. SF2 values are expected ultimately t...

journal_title：International journal of radiation biology

authors： Suit HD,Baumann M,Skates S,Convery K

更新日期：1989-11-01 00:00:00

abstract：PURPOSE:To investigate the p53 ionizing radiation-induced response, G1/S cell-cycle block and cytogenetic damage in Nijmegen breakage syndrome (NBS) cells characterized by different haplotypes. MATERIAL AND METHODS:Lymphoblastoid cell lines derived from three normals, five NBS and two ataxia telangiectasia (AT) indivi...

journal_title：International journal of radiation biology

authors： Antoccia A,Stumm M,Saar K,Ricordy R,Maraschio P,Tanzarella C

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:In radiation biology, rats are often irradiated, but the precise dose distributions are often lacking, particularly in areas that receive scatter radiation. We used a non-dedicated set of resources to calculate detailed dose distributions, including doses to peripheral organs well outside of the primary field, ...

journal_title：International journal of radiation biology

authors： Kirkby C,Ghasroddashti E,Kovalchuk A,Kolb B,Kovalchuk O

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:When Iodine-125 decays within chromatin, several in vivo experiments have shown that the radiobiological effects are caused mainly by indirect mechanisms and that more than one DNA double strand break (DSB) is produced per decay. We present calculations to evaluate the contribution of direct and indirect effect...

journal_title：International journal of radiation biology

authors： Terrissol M,Edel S,Pomplun E

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:To evaluate the impact of oral administration of purslane (Portulaca oleracea) extract or fish oil and their co-treatments in the modulation of radiation-induced damage. MATERIAL AND METHODS:Purslane (P) (400 mg/kg body weight) or fish oil (Fo) (60 mg/kg body weight) was administrated to male albino rats via g...

journal_title：International journal of radiation biology

authors： Abd El-Azime AS,Hussein EM,Ashry OM

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:To determine the radiosensitivity difference of human Cluster of Differentiation (CD)4(+)CD25(+) regulatory T cells (Treg) and effector T cells to low dose gamma ray and elucidate the underlying mechanisms in vitro. MATERIALS AND METHODS:Blood samples were collected from five health subjects and five patients ...

journal_title：International journal of radiation biology

authors： Cao M,Cabrera R,Xu Y,Liu C,Nelson D

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:This review will examine the role of phosphatases in cancer cell signalling and also outline emerging findings regarding the influence of phosphatases on tumor cell survival after ionising radiation. CONCLUSION:The exposure of tumour cells to clinically relevant doses of ionising radiation causes DNA damage an...

journal_title：International journal of radiation biology

authors： Hamilton J,Bernhard EJ

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To investigate the mechanism of methylene blue-induced radiosensitization in Escherichia coli cells. MATERIALS AND METHODS:Bacteriophage lambda15 was irradiated with X-rays in the presence or absence of methylene blue (MB) and infected into bacteria with different repair capabilities preincubated with or witho...

journal_title：International journal of radiation biology

authors： Menezes S,Costa JA

更新日期：2000-09-01 00:00:00

abstract：:In the last decade the 'comet assay' or 'single cell gel electrophoresis assay' has been established as a sensitive method for the detection of DNA damage and the measurement of its recovery. The results published in the literature have often been obtained with different methods for comet structure measurement. In mos...

journal_title：International journal of radiation biology

authors： Böcker W,Bauch T,Müller WU,Streffer C

更新日期：1997-10-01 00:00:00

abstract：PURPOSE:To develop a procedure, using the inverse polymerase chain reaction, to detect and sequence ionizing radiation-induced DNA rearrangements without prior phenotypic selection of mutant cells. METHOD:Normal human fibroblast cells (IMR-90) were given 30Gy of gamma-irradiation and then incubated at 37 degrees C for...

journal_title：International journal of radiation biology

authors： Forrester HB,Radford IR

更新日期：1998-07-01 00:00:00

abstract：PURPOSE:To investigate the induction and persistence of chromosome aberrations in mouse bone marrow cells after X-ray exposure and to detect differential involvement of individual chromosomes in translocations. MATERIALS AND METHODS:Male and female Swiss mice were exposed to 1 and 3 Gy of X-rays. Chromosome aberration...

journal_title：International journal of radiation biology

authors： Xiao Y,Darroudi F,Grigorova M,Natarajan AT

更新日期：1999-09-01 00:00:00

abstract：:Radiation-resistant L5178Y-R (LY-R) and radiation-sensitive L5178Y-S (LY-S) murine lymphoma cells were X-irradiated and their free Ca2+ concentration was examined with Fura-2 in Ca2(+)-free salt solution. The release of free Ca2+ from intracellular stores was linear between 10 and 60 min after irradiation (1-5 Gy X-ra...

journal_title：International journal of radiation biology

authors： Szumiel I,Sochanowicz B,Buraczewska I

更新日期：1990-07-01 00:00:00

abstract：PURPOSE:To investigate physical and biophysical properties of proton tracks 1 keV-300 MeV using Monte Carlo track structure methods. MATERIALS AND METHODS:We present model calculations for cross sections and methods for simulations of full-slowing-down proton tracks. Protons and electrons were followed interaction-by-...

journal_title：International journal of radiation biology

authors： Liamsuwan T,Uehara S,Emfietzoglou D,Nikjoo H

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:Although the significance of cell cycle checkpoints in overcoming low-dose hyper-radiosensitivity (HRS) has been proposed, the underlying mechanism of HRS in human hepatocellular cells remains unclear. Therefore, the aim of this study was to characterize HRS inhuman hepatocellular HepG2 cells and to explore the...

journal_title：International journal of radiation biology

authors： Xue J,Zong Y,Li PD,Wang LX,Li YQ,Niu YF

更新日期：2016-10-01 00:00:00

abstract：:The relationship between ionizing radiation-induced cell killing and DNA damage measured by the micronucleus and apoptosis assays was determined in three established cell lines (L929, HL-60, and Chang). Irradiation experiments revealed a dose-dependent increase of micronucleated cells until a certain dose was reached....

journal_title：International journal of radiation biology

authors： Abend M,Rhein A,Gilbertz KP,Blakely WF,Van Beuningen D

更新日期：1995-03-01 00:00:00

abstract：PURPOSE:The purpose of this study was to assess the effect of a lavage solution containing methoxypolyethylene glycol 4-(3,4-dihydroxyphenethylamino)-4-oxobutanoate (MDO) for whole lung lavage (WLL) in dogs after the inhalation of depleted uranium (DU) dust at a dose of 30 mgUkg-1. MATERIALS AND METHODS:WLL was perfor...

journal_title：International journal of radiation biology

authors： Ren J,Hao Y,Gao R,Zhang Y,Ran Y,Liu J,Dai X,Xiong W,Su Y,Li R

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:As the most recent epidemiological studies provide no definite conclusions about the effects of 50/60 Hz magnetic fields (MFs) on the incidence of leukaemia in humans, animal models in a well-controlled environment are useful for evaluating the possibility of an association between MFs and leukaemia. The presen...

journal_title：International journal of radiation biology

authors： Devevey L,Patinot C,Debray M,Thierry D,Brugere H,Lambrozo J,Guillosson JJ,Nafziger J

更新日期：2000-06-01 00:00:00

abstract：:Existing models of chromosome aberrations produced by ionizing-radiation predict equal numbers of dicentrics and translocations if the dose is so low that complex aberrations can be ignored. We show that, for a specific subset of aberrations detected by FISH, dicentric/translocation equality is predicted even at highe...

journal_title：International journal of radiation biology

authors： Lucas JN,Chen AM,Sachs RK

更新日期：1996-02-01 00:00:00

abstract：:Lethal mutations are induced in mammalian cells mainly, perhaps wholly, within the dose range encompassing the 'shoulder,' and may well be attributable to error-prone Q-repair. ...

journal_title：International journal of radiation biology

authors： Alper T,Mothersill C,Seymour CB

更新日期：1988-10-01 00:00:00

abstract：:Chromosomes are located within the interphase nucleus in regions called domains. Using fluorescence in situ hybridization with whole chromosome paints, a pain of homologous chromosomes can be visualized as two discrete domains and their relative spatial location determined. This study examines the effects of an ionizi...

journal_title：International journal of radiation biology

authors： Dolling JA,Boreham DR,Brown DL,Raaphorst GP,Mitchel RE

更新日期：1997-09-01 00:00:00

abstract：:High doses of rHIL-1 protected C3H/HeN mice against lethal radiation damage. The optimum time of radioprotection was found when this cytokine was administered at 4 h and at 20 h before irradiation. The dose reduction factors when the IL-1 was administered at those times were about 1.30. The radioprotection at the opti...

journal_title：International journal of radiation biology

authors： Wu SG,Tuboi A,Miyamoto T

更新日期：1989-10-01 00:00:00

abstract：:Cell cycle dependence for the induction of 6-thioguanine-resistant mutation was investigated using synchronized mouse L5178Y cells after exposure to 4 Gy to 60Co gamma-rays or 1 Gy of 252Cf radiation (fission neutrons). Maximal mutation frequency was observed immediately after release from colcemid block (G2/M phase) ...

journal_title：International journal of radiation biology

authors： Tauchi H,Nakamura N,Sawada S

更新日期：1993-04-01 00:00:00

abstract：PURPOSE:To investigate the radiosensitisation of gold nanoparticles (GNP) with an average diameter of 5 nm coated with the gadolinium chelating agent dithiolated diethylenetriaminepentaacetic gadolinium (Au@DTDTPA:Gd) in vitro and in mice bearing tumours (MC7-L1). MATERIALS AND METHODS:In vivo, the gadolinium chelate ...

journal_title：International journal of radiation biology

authors： Hébert EM,Debouttière PJ,Lepage M,Sanche L,Hunting DJ

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:To examine whether the levels of micronuclei induction, as a marker for genomic instability in the progeny of X-irradiated cells, correlates with DNA repair function. MATERIALS AND METHODS:Two repair deficient cell lines (X-ray repair cross-complementing 1 [XRCC1] deficient cell line [EM9] and X-ray repair cro...

journal_title：International journal of radiation biology

authors： Kashino G,Suzuki K,Kodama S,Watanabe M,Prise KM

更新日期：2013-04-01 00:00:00

abstract：:The effect of local stimulation on mitotic activity and radiation tolerance was studied in mouse tongue mucosa. Silver nitrate solution (0.5-20%) was used for local conditioning. The most effective protocol comprised three daily treatments (days 0-2), yielding a delayed increase in 24 h mitotic counts by about 30% on ...

journal_title：International journal of radiation biology

authors： Dörr W,Kummermehr J

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:To investigate and compare the propensity of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCL) obtained from unaffected healthy individuals and ataxia telangectasia (A-T) patients to undergo apoptosis after X-ray exposure. MATERIAL AND METHODS:The LCL were exposed to 1-4 Gy X-rays at a dose-...

journal_title：International journal of radiation biology

authors： Meijer AE,Zhivotovsky B,Lewensohn R

更新日期：1999-06-01 00:00:00

abstract：:The past recommendations of the ICRP about dose limits to the skin are reviewed. Recently, an ICRP Task Group has been revisiting the old arguments and setting them against new data. With the exception of the function of cells in the skin associated with immunocompetence, non-stochastic effects have been well characte...

journal_title：International journal of radiation biology

authors： Fry RJ

更新日期：1990-04-01 00:00:00

abstract：PURPOSE:The long-term effect of low and moderate doses of ionizing radiation on the lens is still a matter of debate and needs to be evaluated in more detail. MATERIAL AND METHODS:We conducted a detailed histological analysis of eyes from B6C3F1 mice cohorts after acute gamma irradiation (60Co source; 0.063 Gy/min) at...

journal_title：International journal of radiation biology

authors： Kunze S,Cecil A,Prehn C,Möller G,Ohlmann A,Wildner G,Thurau S,Unger K,Rößler U,Hölter SM,Tapio S,Wagner F,Beyerlein A,Theis F,Zitzelsberger H,Kulka U,Adamski J,Graw J,Dalke C

更新日期：2021-01-19 00:00:00