Monte Carlo-based dose reconstruction in a rat model for scattered ionizing radiation investigations.

abstract：:The relationship between cellular radiosensitivity and normal-tissue response to radiotherapy in individual cancer patients has attracted increasing attention over the last few years. Recent work has suggested that a correlation exists between fibroblast sensitivity and normal-tissue reactions. We have examined the ra...

journal_title：International journal of radiation biology

authors： Burnet NG,Wurm R,Peacock JH

更新日期：1996-09-01 00:00:00

abstract：PURPOSE:To investigate the effect of gamma radiation-induced alterations in antioxidant defence of radioresistant Sf9 insect cells. MATERIALS AND METHODS:Sf9 cells were irradiated at doses ranging from 0.5-200 Gy. Lipid peroxidation and protein carbonylation levels were observed at 4 h post-exposure along with reduced...

journal_title：International journal of radiation biology

authors： Suman S,Khan Z,Zarin M,Chandna S,Seth RK

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Dose response and repair kinetics of phosphorylated histone H2A isoform X (gamma-H2AX) foci in T-lymphocytes were investigated in the low-dose range after in vitro irradiation of whole blood and T-lymphocytes with 100 kVp X-rays and (60)Co gamma-rays. MATERIALS AND METHODS:Whole blood or isolated T-lymphocytes...

journal_title：International journal of radiation biology

authors： Beels L,Werbrouck J,Thierens H

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:Design of cancer radiotherapy protocol to reduce radiation dose and increase treatment efficacy in Lewis lung cancer (LLC) model. METHODS:C57BL/6J mice subcutaneously implanted with LLC were treated by conventional radiotherapy (2Gy x 6) combined with LDWBI (low dose whole-body irradiation; the second, third, ...

journal_title：International journal of radiation biology

authors： Wu N,Jin SZ,Pan XN,Liu SZ

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:To examine whether a simulated mobile telephone transmission at 915 MHz has an effect on cognitive function in man. MATERIALS AND METHODS:Thirty-six subjects in two groups were each given two training sessions and then three test sessions in a randomized three-way cross-over design. About 1 W mean power at 915...

journal_title：International journal of radiation biology

authors： Preece AW,Iwi G,Davies-Smith A,Wesnes K,Butler S,Lim E,Varey A

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:Many strategies have been investigated to exclude the several side-effects of pharmacological or invasive treatments. Non-invasive pulsed magnetic field (PMF) treatment with no toxicity or side-effects can be an alternative to pharmacologic treatments. The purpose of this study was, therefore, to investigate th...

journal_title：International journal of radiation biology

authors： Mert T,Ocal I,Cinar E,Yalcin MS,Gunay I

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:The chromosomal radiosensitivity of a selected group of familial breast cancer patients carrying a mutation in BRCA1 (n=11) or BRCA2 (n=9) and a group of healthy mutation carriers (n=12) was investigated and compared to a reference group of breast cancer patients without a BRCA1/2 mutation (n=78) and a group of...

journal_title：International journal of radiation biology

authors： Baeyens A,Thierens H,Claes K,Poppe B,de Ridder L,Vral A

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:Conditionally Replicative Adenovirus (CRAd) has been previously demonstrated to augment the activity of radiation, resulting in synergy of cell kill. However, previous models combining radiation with CRAd have not focused on the methods of radiation delivery. MATERIALS AND METHODS:We model the combination of a...

journal_title：International journal of radiation biology

authors： Liu C,Zhang Y,Liu MM,Zhou H,Chowdhury W,Lupold SE,Deweese TL,Rodriguez R

更新日期：2010-03-01 00:00:00

abstract：:This study evaluated the cell-mediated (CMI) and humoral immune responses in four Beagle dogs five to six years after single inhalation exposures to different monodisperse 239PuO2 aerosols (0.72-1.4 microns activity median aerodynamic diameter). These exposures resulted in initial lung burdens ranging from 19 to 35 kB...

journal_title：International journal of radiation biology

authors： Galvin JB,Bice DE,Guilmette RA,Muggenburg BA,Haley PJ

更新日期：1989-02-01 00:00:00

abstract：PURPOSE:The effect of extremely low frequency electromagnetic fields (ELF-EMF) on bacteria has attracted attention due to its potential for beneficial uses. This research aimed to determine the effect of ELF-EMF on bacterial membrane namely the membrane potential, surface potential, hydrophobicity, respiratory activity...

journal_title：International journal of radiation biology

authors： Oncul S,Cuce EM,Aksu B,Inhan Garip A

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:The low dose (<1 Gy) survival curve of mammalian cells is characterized by a region of hypersensitivity (HRS) followed by increased resistance (IRR). Above 1 Gy, the survival response can be described with a smooth downward-bending curve. Indirect evidence has indicated that the IRR response might reflect an in...

journal_title：International journal of radiation biology

authors： Marples B,Joiner MC

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:The deleterious processes triggered by heavy ions on DNA were studied through the determination of the yield of a series of oxidized bases. Emphasis was placed on the estimation of the respective contribution of direct ionization and indirect effects, mostly by comparison with low linear energy transfer (LET) g...

journal_title：International journal of radiation biology

authors： Douki T,Ravanat JL,Pouget JP,Testard I,Cadet J

更新日期：2006-02-01 00:00:00

abstract：:A radionuclide release assay for measuring the in vitro kinetics of cell death has been developed. CHO cells were labelled for 24 h with 3.0 hBq/ml of [125I] iododeoxyuridine (125IUdR) and the fate of the labelled cells and their progeny was monitored at daily intervals by measuring the rate of 125I release. Prelabell...

journal_title：International journal of radiation biology

authors： Schneiderman MH,Hofer KG,Schneiderman GS

更新日期：1991-02-01 00:00:00

abstract：:The chemical instability of DNA under physiological conditions requires that cells have highly developed processes for repairing stochastic single-strand damage. It is proposed here that provided ionizing-radiation-induced single-strand damage does not occur at a rate sufficient to perturb the dynamic steady state bet...

journal_title：International journal of radiation biology

authors： Baverstock KF

更新日期：1991-10-01 00:00:00

abstract：PURPOSE:Human embryonic stem cells (hESC) hold a great potential for regenerative medicine because, in principle, they can differentiate into any cell type found in the human body. In addition, studying the effect of ionizing radiation (IR) on hESC may provide valuable information about the response of human cells to I...

journal_title：International journal of radiation biology

authors： Panyutin IV,Eniafe R,Panyutin IG,Neumann RD

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:The actinides are chemical poisons and radiological hazards. One challenge to better appraise their toxicity and develop countermeasures in case of exposure of living organisms is to better assess pathways of contamination. Because of the high chemical affinity of those actinide elements for phosphate groups an...

journal_title：International journal of radiation biology

authors： Mostapha S,Fontaine-Vive F,Berthon L,Boubals N,Zorz N,Solari PL,Charbonnel MC,Den Auwer C

更新日期：2014-11-01 00:00:00

abstract：:We have re-examined the effect of detergent type, pH and temperature of lysis on the shape of the DNA elution dose response under non-denaturing conditions using plateau-phase CHO cells. Results practically identical to those previously published (Okayasu and Iliakis, 1989) were obtained, with a 1 h incubation at 60 d...

journal_title：International journal of radiation biology

authors： Okayasu R,Iliakis G

更新日期：1992-04-01 00:00:00

abstract：PURPOSE:To investigate the hypothesis that the developmental phase at which an individual encounters radiation damage affects its long-term sensitivity to a subsequent tumourigenic insult. MATERIALS AND METHODS:Either the pregnant C57B16 mouse was exposed to 137Cs gamma-rays at 4 or 15 days post-conception (embryonic ...

journal_title：International journal of radiation biology

authors： Hoyes KP,Hendry JH,Lord BI

更新日期：2000-01-01 00:00:00

abstract：:The resonant recognition model (RRM) is a model of protein-protein and protein-DNA interaction based on a significant correlation between spectra of numerical presentation of the amino acid or nucleotide sequences and their biological activity. Having compared absorption characteristics of photosensitive proteins with...

journal_title：International journal of radiation biology

authors： Cosic I,Vojisavljevic V,Pavlovic M

更新日期：1989-08-01 00:00:00

abstract：PURPOSE:Multicellular tumour spheroids are being used with increasing frequency in various aspects of tumour biology, including studies dealing with radiation biology. This review attempts to outline recent studies using these three-dimensional systems in radiation biology with particular reference made to papers testi...

journal_title：International journal of radiation biology

authors： Santini MT,Rainaldi G,Indovina PL

更新日期：1999-07-01 00:00:00

abstract：:Sister chromatid exchanges (SCEs) were analysed in lymphocytes from 12 control persons and 33 Chernobyl clean-up workers. The group of Chernobyl clean-up workers consisted of civilians who were forced to go to Chernobyl to clean up environmental contamination caused by Chernobyl disaster. On average, they received 0.1...

journal_title：International journal of radiation biology

authors： Lazutka JR,Dedonyte V

更新日期：1995-06-01 00:00:00

abstract：PURPOSE:To develop a reproducible single-cell gel electrophoresis assay for DNA damage and repair in buccal mucosa and sublingual exfoliated cells. MATERIALS AND METHODS:Buccal mucosa and sublingual cells and lymphocytes from six individuals (three males, three females, aged 34-45 years) were challenged with increasin...

journal_title：International journal of radiation biology

authors： Dhillon VS,Thomas P,Fenech M

更新日期：2004-07-01 00:00:00

abstract：:Photoirradiation of aqueous solutions of DNA in the presence of Al- or Zn-tetrasulphonated phthalocyanines (AIPcS4 and ZnPcS4) causes formation of strand breaks and liberation of nucleobases. The effect of added D2O, which enhances singlet oxygen (1O2) lifetime, radical scavengers including alcohols and the spin-trap ...

journal_title：International journal of radiation biology

authors： Gantchev TG,Gowans BJ,Hunting DJ,Wagner JR,van Lier JE

更新日期：1994-12-01 00:00:00

abstract：PURPOSE:To understand the mechanisms of life-shortening due to early neoplastic death caused by chronic low dose-rate (LDR; 20 mGy/22 h/day) radiation which accumulates to a high dose (HD; 8 Gy) (LDR/HD) as reported previously. MATERIALS AND METHODS:Female B6C3F(1) mice were continuously exposed to LDR/HD gamma-rays u...

journal_title：International journal of radiation biology

authors： Takai D,Todate A,Yanai T,Ichinohe K,Oghiso Y

更新日期：2011-07-01 00:00:00

abstract：:Resolving the molecular mechanisms of radiation oncogenesis represents an important but daunting challenge in radiation research. This brief review outlines the principal oncogenic mechanisms that need to be considered in the context of radiation effects on the genome, how these might relate to specific gene and chrom...

journal_title：International journal of radiation biology

authors： Cox R

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:To assess health, growth and reproductive success of mammals exposed for multiple generations to levels of radium-226 known to occur in environments surrounding uranium mines and mills in Canada. METHODS:The study consisted of a control group and four treatment groups each containing 40 mice (20 males and 20 f...

journal_title：International journal of radiation biology

authors： Walsh S,Satkunam M,Su B,Festarini A,Bugden M,Peery H,Mothersill C,Stuart M

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Solar energy has a number of short- and long-term detrimental effects on skin that can result in several skin disorders. The aim of this review is to summarise current knowledge on endogenous systems within the skin for protection from solar radiation and present research findings to date, on the exogenous opti...

journal_title：International journal of radiation biology

authors： Svobodová A,Vostálová J

更新日期：2010-12-01 00:00:00

abstract：:Intraoperative irradiation (IORT) is used to enhance local tumour control by using large, single doses while removing critical structures from the treatment field. Peripheral nerve remains a dose-limiting normal tissue that often cannot be removed from the field. To assess ultrastructural changes in canine sciatic ner...

journal_title：International journal of radiation biology

authors： Vujaskovic Z,Gillette SM,Powers BE,Thurmond DN,Gillette EL,Colacchio TA

更新日期：1995-07-01 00:00:00

abstract：:This paper presents a summary of our understanding to date of the formation of DNA strand breaks induced by highly energetic particle beams (high-LET radiation). We have compared our own recent data on the formation of strand breaks induced in DNA in an aqueous solution with our previous data and those of others avail...

journal_title：International journal of radiation biology

authors： Roots R,Holley W,Chatterjee A,Irizarry M,Kraft G

更新日期：1990-07-01 00:00:00

abstract：PURPOSE:To compare colony-forming and comet assays on fibroblasts and lymphocytes of 32 breast cancer patients irradiated after breast-conserving operations and to correlate the results with acute clinical radiation reactions in the skin. MATERIAL AND METHODS:Skin fibroblasts were isolated and cultivated before radiot...

journal_title：International journal of radiation biology

authors： Oppitz U,Schulte S,Stopper H,Baier K,Müller M,Wulf J,Schakowski R,Flentje M

更新日期：2002-07-01 00:00:00