Abstract：
PURPOSE:To investigate physical and biophysical properties of proton tracks 1 keV-300 MeV using Monte Carlo track structure methods. MATERIALS AND METHODS:We present model calculations for cross sections and methods for simulations of full-slowing-down proton tracks. Protons and electrons were followed interaction-by-interaction to cut-off energies, considering elastic scattering, ionisation, excitation, and charge-transfer. RESULTS:Model calculations are presented for singly differential and total cross sections, and path lengths and stopping powers as a measure of the code evaluation. Depth-dose distributions for 160 MeV protons are compared with experimental data. Frequencies of energy loss by electron interactions increase from ∼ 3% for 10 keV to ∼ 77% for 300 MeV protons, and electrons deposit >70% of the dose in 160 MeV tracks. From microdosimetry calculations, 1 MeV protons were found to be more effective than 5-300 MeV in energy depositions greater than 25, 50, and 500 eV in cylinders of diameters and lengths 2, 10, and 100 nm, respectively. For lower-energy depositions, higher-energy protons are more effective. Decreasing the target size leads to the reduction of frequency- and dose-mean lineal energies for protons <1 MeV, and conversely for higher-energy protons. CONCLUSIONS:Descriptions of proton tracks at molecular levels facilitate investigations of track properties, energy loss, and microdosimetric parameters for radiation biophysics, radiation therapy, and space radiation research.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Liamsuwan T,Uehara S,Emfietzoglou D,Nikjoo Hdoi
10.3109/09553002.2010.518204subject
Has Abstractpub_date
2011-02-01 00:00:00pages
141-60issue
2eissn
0955-3002issn
1362-3095journal_volume
87pub_type
杂志文章abstract：:The effect of a siderophore analogue 3,4,3-LIHOPO has been investigated in rat after intramuscular injection of 238Pu, 239Pu and 241Am simulating puncture wounds. Various treatment regimens were used to remove the radioactivity from its injection site and to reduce its retention in body tissues. The local deposits cou...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530096145382
更新日期：1996-07-01 00:00:00
abstract：:Most estimates of the radiation dose lethal to 50 per cent of a human population are based on historical data taken from well-known experiences reflecting inadequately known physical and biological conditions, or from medical procedures where individual patients received advantages of modern clinical care. It has been...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553008914550481
更新日期：1989-03-01 00:00:00
abstract：PURPOSE:In this study we addressed the question whether radiation-induced adverse effects on T cell activation are associated with alterations of T cell checkpoint receptors. MATERIALS AND METHODS:Expression levels of checkpoint receptors on T cell subpopulations were analyzed at multiple post-radiation time points ra...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2017.1400192
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:Caveolin-1 is a membrane protein highly expressed in many tumors and plays an important role in tumor progression and metastasis. This review describes the structure of the Caveolin-1 protein and its pre-clinical and clinical significance, demonstrating that Caveolin-1 is a novel biomarker for radioresistance w...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.1080/09553002.2016.1222096
更新日期：2016-12-01 00:00:00
abstract：:Purpose: Projects evaluating the effects of radiation, within the National Institutes of Quantum and Radiological Science and Technology (QST), National Institute of Radiological Sciences (NIRS), have focused on risk analyses for life shortening and cancer prevalence using laboratory animals. Genetic and epigenetic al...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.1080/09553002.2019.1625458
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:A meta-analysis was conducted to obtain a 'quantitative' estimate of the extent of genetic damage in mammalian somatic cells exposed to non-ionizing radiation emitted from extremely low frequency electro-magnetic fields (ELF-EMF) and to compare with that in unexposed control cells. METHODS:The methods used for...
journal_title：International journal of radiation biology
pub_type： 杂志文章,meta分析
doi：10.1080/09553000902748575
更新日期：2009-03-01 00:00:00
abstract：:Studies of early physical interactions of ionizing radiation in biological medium have evolved from water cylinders or spheres to structured volumes representing nucleosomal DNA, based on spatial co-ordinates for each individual atom. Regarding the physico-chemical and chemical stages, the models of DNA have evolved f...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009414551441
更新日期：1994-11-01 00:00:00
abstract：:Objective: To quantify DNA damage in patients undergoing non-contrast and contrast-enhanced 18F-FDG PET/CT whole body positron emission tomography/computed tomography (WB PET/CT) investigations using comet assay technique and micronucleus assay, and to study the effect of other baseline parameters of patients on DNA d...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2019.1577569
更新日期：2019-06-01 00:00:00
abstract：:Mouse C3H 10T1/2 cells are most sensitive to radiation-induced neoplastic transformation in the G2/M-phase of the cell cycle. When synchronized 10T1/2 cells were exposed to phorbol 12-myristate 13-acetate (TPA) after irradiation, transformation of cells not in the transformation-sensitive window was enhanced, but tran...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009314551971
更新日期：1993-12-01 00:00:00
abstract：:The relationship between ionizing radiation-induced cell killing and DNA damage measured by the micronucleus and apoptosis assays was determined in three established cell lines (L929, HL-60, and Chang). Irradiation experiments revealed a dose-dependent increase of micronucleated cells until a certain dose was reached....
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009514550371
更新日期：1995-03-01 00:00:00
abstract：PURPOSE:The effects of radiation +/- hypogravity on immunologic function were investigated using the Partial Weight Suspension (PWS) model ( Wagner et al. 2010 ). MATERIALS AND METHODS:Mice were exposed to 0.5, 1, or 2 Gray (Gy) dose of gamma radiation and then placed in the PWS system for 4, 24, 48 hours, or 4 days. ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2011.595875
更新日期：2011-10-01 00:00:00
abstract：:237Np nitrate was injected intravenously into 4-week-old (young) and 10-12-week-old (adult) female albino Sprague-Dawley rats. The amounts given were 52 (young), 5.2 (adult) and 26 kBq kg-1 body weight (adult). The microscopic distribution in the femur and the lumbar vertebrae was studied. Initially, neptunium was dis...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009314550511
更新日期：1993-03-01 00:00:00
abstract：PURPOSE:The effect of extremely low frequency electromagnetic fields (ELF-EMF) on bacteria has attracted attention due to its potential for beneficial uses. This research aimed to determine the effect of ELF-EMF on bacterial membrane namely the membrane potential, surface potential, hydrophobicity, respiratory activity...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2015.1101500
更新日期：2016-01-01 00:00:00
abstract：:The aim was to identify the decorporation and anti-oxidation efficacy of prompt and delayed consecutive administration of the catecholicpolyaminopolycarboxylate ligands 9501 and 7601 for radiothorium in vivo. The chelating agents 9501 or 7601 were administered intramuscularly to ICR mice 3 min or 3 days after intraper...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000500141124
更新日期：2005-04-01 00:00:00
abstract：PURPOSE:Radiotherapy of cancer carries a perceived risk of inducing secondary cancer and other damage due to dose delivered to normal tissue. While expectedly small, this risk must be carefully analysed for all modalities. Especially in the use of exotic particles like pions and antiprotons, which annihilate and produc...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553000903242081
更新日期：2009-12-01 00:00:00
abstract：:This study evaluated the cell-mediated (CMI) and humoral immune responses in four Beagle dogs five to six years after single inhalation exposures to different monodisperse 239PuO2 aerosols (0.72-1.4 microns activity median aerodynamic diameter). These exposures resulted in initial lung burdens ranging from 19 to 35 kB...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553008914550311
更新日期：1989-02-01 00:00:00
abstract：PURPOSE:The relationship between cellular telephone use and excretion of the melatonin metabolite 6-hydroxymelatonin sulfate (6-OHMS) was evaluated in two populations of male electric utility workers (Study 1, n=149; Study 2, n=77). MATERIALS AND METHODS:Participants collected urine samples and recorded cellular telep...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000210166561
更新日期：2002-11-01 00:00:00
abstract：:The aim was to review and summarize the results of 40 years of study concerning the response to ionizing radiation of the pair of L5178Y (LY) sublines, LY-R and LY-S, that differ in sensitivity to various DNA-damaging agents, among them X- and gamma-rays. The reviewed data indicate the key importance of DNA damage rep...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.1080/09553000500143534
更新日期：2005-05-01 00:00:00
abstract：PURPOSE:Ionizing radiation induces DNA damage, some of which are present in clusters, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. These clusters are thought to contribute to the detrimental effects of radiation, in part due to the compromised repair of c...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2014.899449
更新日期：2014-06-01 00:00:00
abstract：:Purpose: Ionizing radiation is a risk factor to the whole organism, including the heart. Cardiac damage is considered to be a late effect of radiation exposure. While the acute cardiotoxicity of high doses is well characterized, the knowledge about nature and magnitude of the cardiac risk following lower doses exposur...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.1080/09553002.2020.1704299
更新日期：2020-03-01 00:00:00
abstract：:We studied the extent of split-dose recovery in seven non-transformed human fibroblast cell lines of different intrinsic radiosensitivity (HF19, 1BR3, 149BR, 84BR, GM739, 180BR and AT2EM). Experiments were performed on both growing and plateau-phase cells. The seven cell lines displayed a wide range of intrinsic radio...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530096146075
更新日期：1996-02-01 00:00:00
abstract：:The bacterial enzyme PvuII, which generates blunt-ended DNA double-strand breaks, and T4 DNA ligase, which seals adjacent DNA fragments in coupling to ATP cleavage, were introduced in mouse C3H10T1/2 fibroblasts using osmolytic shock of pinocytic vesicles. Cells were then assayed for their clonogenic ability. In agree...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009114550851
更新日期：1991-04-01 00:00:00
abstract：:The aim was to investigate further the relationship between radiation-induced mitotic delay and the expression of chromosome damage in V79 cells. Recently published data on the time-course of chromosome aberrations in V79 first-cycle metaphases after exposure to 10.4 MeV u(-1) Ar ions (LET = 1226 keV microm(-1)) were ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000400027902
更新日期：2005-01-01 00:00:00
abstract：:Intact Chinese hamster ovary cells were exposed to the restriction endonucleases (REs) AluI or BamHI. In metaphase spreads from these cells, 300 breakpoints per RE were localized in G-banded chromosome type aberrations (dicentrics, translocations, rings, terminal and interstitial deletions). The majority of breakpoint...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009514551401
更新日期：1995-10-01 00:00:00
abstract：PURPOSE:Zearalenone is a potent estrogenic metabolite produced by some Fusarium and Gibberella species. Therefore, the aim of this study was to determine the accumulation of Technetium-[99m]-labeled zearalenone in mice organs as well as to study the protective effect of Lactobacillus plantarum. MATERIALS AND METHODS:T...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2019.1524990
更新日期：2018-12-01 00:00:00
abstract：:During previous studies on the relationship between thermosensitivity and intracellular pH (pHi) regulation in mammalian cells, we observed that the thermoresistant TR-4 cells appeared to be resistant to manipulations of the Na+/H+ antiport, one of the two primary membrane regulators of pHi. We hypothesized that this ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530096144969
更新日期：1996-10-01 00:00:00
abstract：BACKGROUND:Element-specific biokinetic models are used to reconstruct doses to systemic tissues from internal emitters. Typically, a systemic model for a radionuclide explicitly depicts only its dominant repositories. Remaining tissues and fluids are aggregated into a pool called Other tissue in which the radionuclide ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2018.1554923
更新日期：2018-12-04 00:00:00
abstract：:It is well established from clinical, epidemiological and laboratory studies that specific human germ line mutation can predispose to spontaneously arising cancer. Some of the responsible genes have been characterized at the molecular level and evidence is rapidly accumulating on mechanistic aspects of the problem. A ...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.1080/09553009414551761
更新日期：1994-11-01 00:00:00
abstract：PURPOSE:Gamma-irradiation leads to activation of p53 tumour suppressor gene and to p53-dependant stimulation of a large panel of cellular genes including proapoptotic genes involved in intrinsic and extrinsic pathways. Most in vivo published data referred to high (lethal) irradiation doses. The present study was perfor...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000600949624
更新日期：2006-11-01 00:00:00
abstract：PURPOSE:To determine whether chromosomal instability is induced in human diploid fibroblasts by ionizing radiation and to investigate the effects of radiation quality by comparing X-rays, neutrons and alpha-particles. MATERIALS AND METHODS:Cells from two human diploid fibroblast lines, HF12 and HF19, were irradiated a...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530098142518
更新日期：1998-02-01 00:00:00
