Abstract:
PURPOSE:As the most recent epidemiological studies provide no definite conclusions about the effects of 50/60 Hz magnetic fields (MFs) on the incidence of leukaemia in humans, animal models in a well-controlled environment are useful for evaluating the possibility of an association between MFs and leukaemia. The present study was designed to determine whether 50 Hz magnetic fields can alter the progression of leukaemia. MATERIALS AND METHODS:A well-characterized model of transplantable acute myeloid leukaemia in rats was used for the first time. This model is closely related to human acute myeloid leukaemia, the type most frequently reported in epidemiological studies of adults. After leukaemic cell implantation, rats were exposed to a sinusoidal 50 Hz MF of 100 microT for 18 h a day, 7 days a week, throughout leukaemia progression. The parameters investigated were: survival time, body weight, haematologic parameters, infiltration of blood, bone marrow, spleen and liver by leukaemic cells. RESULTS:The results showed no significant changes (p > 0.05) in leukaemic MF-exposed versus unexposed rats for any of the parameters involved in leukaemia progression. CONCLUSION:These data do not support the hypothesis that 50 Hz magnetic fields influence leukaemia progression in humans.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Devevey L,Patinot C,Debray M,Thierry D,Brugere H,Lambrozo J,Guillosson JJ,Nafziger Jdoi
10.1080/09553000050029011subject
Has Abstractpub_date
2000-06-01 00:00:00pages
853-62issue
6eissn
0955-3002issn
1362-3095journal_volume
76pub_type
杂志文章abstract:PURPOSE:When Iodine-125 decays within chromatin, several in vivo experiments have shown that the radiobiological effects are caused mainly by indirect mechanisms and that more than one DNA double strand break (DSB) is produced per decay. We present calculations to evaluate the contribution of direct and indirect effect...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000400017622
更新日期:2004-11-01 00:00:00
abstract::We have re-examined the effect of detergent type, pH and temperature of lysis on the shape of the DNA elution dose response under non-denaturing conditions using plateau-phase CHO cells. Results practically identical to those previously published (Okayasu and Iliakis, 1989) were obtained, with a 1 h incubation at 60 d...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009214551211
更新日期:1992-04-01 00:00:00
abstract:PURPOSE:To evaluate the cumulative gamma-radiation personal exposure by analysing lymphocyte chromosome translocations using FISH painting and to compare FISH-derived biodoses with those derived from retrospective physical dose reconstruction in residents receiving chronic low dose-rate gamma-irradiation while living i...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000110053873
更新日期:2001-07-01 00:00:00
abstract:PURPOSE:Since previous research found an increase in the rate of aneuploidies in human lymphocytes exposed to radiofrequencies, it seems important to perform further studies. The objective of this study was then to investigate whether the exposure to RF (radiofrequency) radiation similar to that emitted by mobile phone...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.3109/09553002.2011.542543
更新日期:2011-04-01 00:00:00
abstract::The rate of recovery from radiation damage, as a function of dose per fraction, was investigated in mouse skin. Two different experimental designs were used, both incorporating the neutron top-up technique which enables the X-ray dose per fraction to be kept constant whilst changing the interfraction interval. Either ...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009114550461
更新日期:1991-02-01 00:00:00
abstract::The relationship between ionizing radiation-induced cell killing and DNA damage measured by the micronucleus and apoptosis assays was determined in three established cell lines (L929, HL-60, and Chang). Irradiation experiments revealed a dose-dependent increase of micronucleated cells until a certain dose was reached....
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009514550371
更新日期:1995-03-01 00:00:00
abstract:PURPOSE:Hypoxic cells in tumours are resistant to 5-fluorouracil (5-FU). This in vivo study investigated the ability of hypoxia to regulate the gene expression of thymidylate synthase (TS), the target enzyme of 5-FU. MATERIALS AND METHODS:C3H mammary carcinomas, grown in the feet of female CDF1 mice, were used for all...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530099139944
更新日期:1999-07-01 00:00:00
abstract:PURPOSE:To test whether radiolysis-induced fragmentation in frozen aqueous protein solution is dependent on solvent access to the surface of the protein or to the molecular mass of the polypeptide chain. MATERIALS AND METHODS:60Co gamma-irradiation of three proteins at -78 degrees C: lysozyme, citrate synthase and alp...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530000138349
更新日期:2000-05-01 00:00:00
abstract::Purpose: Dose assessment plays an important role in case of radiological accidents and can be performed by scoring structural changes of chromosome morphology induced in cells by ionizing radiation. The results of such a test are biased by scorer experience, therefore, simple to learn assays are recommended to be used...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553002.2019.1625462
更新日期:2019-09-01 00:00:00
abstract::Lethal mutations are induced in mammalian cells mainly, perhaps wholly, within the dose range encompassing the 'shoulder,' and may well be attributable to error-prone Q-repair. ...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553008814551961
更新日期:1988-10-01 00:00:00
abstract::We have examined the timing of gamma-irradiation-induced death in relation to cell cycle progression using a panel of mouse lymphoid or myeloid cell lines. Death was found to occur immediately after irradiation ('rapid interphase' death), or after arrest in G2 phase ('delayed interphase' death). In part II of this ser...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009414550261
更新日期:1994-02-01 00:00:00
abstract::Cultures of JU-56 cells were irradiated in either G1 or G2 and examined either in their first post-irradiation metaphase (in diploids) or in their second post-irradiation metaphase (in colcemid-induced tetraploids). The timing of fixation, together with tritiated thymidine pulse labelling, allowed selection for scorin...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009314552131
更新日期:1993-06-01 00:00:00
abstract:PURPOSE:To determine the increases in SSB and DSB yields after post gamma-irradiation incubation of plasmid DNA with the Escherichia coli base excision repair endonucleases formamidopyrimidine-DNA N-glycosylase (FPG) and endonuclease III (endo III). MATERIALS AND METHODS:Aqueous solutions of plasmid DNA were irradiate...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000050176234
更新日期:2000-11-01 00:00:00
abstract::Lambda-prophage induction in repair-deficient and wild-type E. coli strains by heavy ions and gamma-rays has been investigated. The dose dependence of the fraction of induced cells has been measured and its initial slope (lambda-induction potency) determined. The induction by gamma-rays was found to be more efficient ...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009014551111
更新日期:1990-05-01 00:00:00
abstract::It follows from the present work that the vascularization of the normal tissue present in the treatment volume limits the temperatures achieved during heat treatment of invasive ductal breast carcinoma. The temperatures can often be increased by giving fractionated heat treatment because heat treatment may reduce the ...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009114551821
更新日期:1991-07-01 00:00:00
abstract:PURPOSE:The identification of fibroblast-like cells of the marrow stroma by means of alkaline phosphatase (ALP) cytochemistry reveals delicate ALP-positive structures interspersed among haematopoietic cells and arranged in a loosely meshed network. These cells are often referred to as 'reticular' cells and the network ...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/0955300031000085740
更新日期:2003-04-01 00:00:00
abstract:PURPOSE:To determine the efficacy of a caffeine derivative 1-methylxanthine (1-MTX) in increasing radiosensitivity of cancer cells and elucidate the underlying mechanisms in vitro. MATERIALS AND METHODS:RKO human colorectal cancer cells carrying wild type protein 53 kDa (p53) were incubated with 3 mM 1-MTX for 30 min,...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000902741190
更新日期:2009-02-01 00:00:00
abstract::The structure of mouse skin collagen fibrils after treatment with 0.5, 1 and 2.5 Gy gamma-irradiation was studied by electron microscopy. Animals were sacrificed 1, 4 and 8 weeks after irradiation. Although there were areas where the normal parallel packing of fibrils was retained in some regions packing was interrupt...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530097144481
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:To identify and assess, among the participants in the RENEB (Realizing the European Network of Biodosimetry) project, the emergency preparedness, response capabilities and resources that can be deployed in the event of a radiological or nuclear accident/incident affecting a large number of individuals. These ca...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553002.2016.1227107
更新日期:2017-01-01 00:00:00
abstract::We used three common fluorescent probes to measure pericentric inversion frequencies in 2.9 Gy 60Co gamma-irradiated human lymphocytes. For a given chromosome, the first probe is specific to one telomeric region, the second probe is specific to one subcentromeric region and the third probe is specific to the centromer...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530097144382
更新日期:1997-01-01 00:00:00
abstract::This paper presents a summary of our understanding to date of the formation of DNA strand breaks induced by highly energetic particle beams (high-LET radiation). We have compared our own recent data on the formation of strand breaks induced in DNA in an aqueous solution with our previous data and those of others avail...
journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
doi:10.1080/09553009014551431
更新日期:1990-07-01 00:00:00
abstract:PURPOSE:To develop a reproducible single-cell gel electrophoresis assay for DNA damage and repair in buccal mucosa and sublingual exfoliated cells. MATERIALS AND METHODS:Buccal mucosa and sublingual cells and lymphocytes from six individuals (three males, three females, aged 34-45 years) were challenged with increasin...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000410001723866
更新日期:2004-07-01 00:00:00
abstract::Sample preparation procedures for the pulsed-field gel electrophoresis (PFGE) assay usually involve a lysis step at temperatures as high as 50 degrees C. During this warm-lysis procedure, multiply damaged sites containing heat-labile sites (HLS) can be converted into double-strand breaks (DSB). Once formed, these DSB ...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000500156577
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553002.2018.1518611
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:This review examines the evidence for the hypothesis that epigenetics are involved in the initiation and perpetuation of radiation-induced genomic instability (RIGI). CONCLUSION:In addition to the extensively studied targeted effects of radiation, it is now apparent that non-targeted delayed effects such as RI...
journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
doi:10.3109/09553002.2010.522686
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:Up to 90% of hereditary breast cancer cases are linked to germ-line mutations in one of the two copies of the BRCA1 or BRCA2 genes. Brca1 and Brca2 proteins are both involved in the cellular defence against DNA damage, although the precise function of the proteins is still not known. Some studies on a small num...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000110097974
更新日期:2002-04-01 00:00:00
abstract::Terminally differentiated cells usually do not divide and are, thus, reproductively dead. To elucidate the significance of radiation-enhanced differentiation to reproductive cell death, murine erythroid progenitor cells were gamma-irradiated in plasma clot cultures and the development of haemoglobinized clones was stu...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530096145869
更新日期:1996-03-01 00:00:00
abstract::237Np nitrate was injected intravenously into 4-week-old (young) and 10-12-week-old (adult) female albino Sprague-Dawley rats. The amounts given were 52 (young), 5.2 (adult) and 26 kBq kg-1 body weight (adult). The microscopic distribution in the femur and the lumbar vertebrae was studied. Initially, neptunium was dis...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009314550511
更新日期:1993-03-01 00:00:00
abstract::One-cell mouse embryos were irradiated with X-rays or neutrons. Analysis of the first, second, and third postradiation mitoses revealed that the yields of structural aberrations increased linearly after exposure to both radiation qualities. For X-rays the aberration frequency decreased from the first to the third mito...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553008814551771
更新日期:1988-09-01 00:00:00
abstract::Transforming growth factor-beta (TGF beta 1) plays a central role in wound healing, so its perturbation by radiation may contribute to the acute and late effects seen in irradiated skin. TGF beta 1 mRNA expression was measured by PCR, in the skin of the CD1 and CBA mouse, exposed to Sr-90 beta from an 11-mm diameter s...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009514551231
更新日期:1995-09-01 00:00:00