abstract：PURPOSE:The long-term effect of low and moderate doses of ionizing radiation on the lens is still a matter of debate and needs to be evaluated in more detail. MATERIAL AND METHODS:We conducted a detailed histological analysis of eyes from B6C3F1 mice cohorts after acute gamma irradiation (60Co source; 0.063 Gy/min) at...

journal_title：International journal of radiation biology

authors： Kunze S,Cecil A,Prehn C,Möller G,Ohlmann A,Wildner G,Thurau S,Unger K,Rößler U,Hölter SM,Tapio S,Wagner F,Beyerlein A,Theis F,Zitzelsberger H,Kulka U,Adamski J,Graw J,Dalke C

更新日期：2021-01-19 00:00:00

abstract：PURPOSE:The sequelae of premature loss of ovarian function can undoubtedly have undesirable effects for a woman although radiotherapy is one of the most relevant treatment modalities for various types of malignancies. The aim of this study was to determine the effect of different doses of radiation on ovarian folliculo...

journal_title：International journal of radiation biology

authors： Onder GO,Balcioglu E,Baran M,Ceyhan A,Cengiz O,Suna PA,Yıldız OG,Yay A

更新日期：2021-01-06 00:00:00

abstract：PURPOSE:DNA damage is one of the main consequences of exposure to ionizing irradiation (IR). Recent studies indicate that IR can modulate the expression of immune system-related genes. However, the effects of IR on the expression of genes and pathways of the B7-CD28 superfamily remain poorly defined. The aim of this st...

journal_title：International journal of radiation biology

authors： Silveira DA,Ribeiro FM,Simão ÉM,Mattos VLD,Góes EG

更新日期：2020-12-17 00:00:00

abstract：PURPOSE:The assessment of biological effects caused by radiation exposure has been currently carried out with the linear-quadratic (LQ) model as an extension of the linear non-threshold (LNT) model. In this study, we suggest a new mathematical model named as SeaSaw (SS) model, which describes proliferation and cell dea...

journal_title：International journal of radiation biology

authors： Bando M,Tsunoyama Y,Suzuki K,Toki H

更新日期：2020-12-15 00:00:00

abstract：PURPOSE:Ionizing radiation causes various types of DNA damage e.g. single strand breaks (SSB) and double strand breaks (DSB), whereby the SSB/DSB ratio is shifted toward the DSB with increasing LET. For the DNA-incorporated Auger electron emitter Iodine-125 a SSB/DSB ratio of 5.4:1 is calculated based on computer simul...

journal_title：International journal of radiation biology

authors： Unverricht-Yeboah M,Holtmann K,Kriehuber R

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Global warming directly influencing ozone layer depletion, which eventually is increasing ultraviolet radiation penetration having far-reaching impacts on living biota. This particularly influences the primary producer microalgae which are the basic unit of food webs in the aquatic habitats. Therefore, it is...

journal_title：International journal of radiation biology

authors： El-Sheekh MM,Alwaleed EA,Ibrahim A,Saber H

更新日期：2020-12-03 00:00:00

abstract：PURPOSE:The purpose of this study was to assess the long-term effects of gamma-radiation, including low-dose radiation, on growth parameters of onion (Allium cepa) seedling roots 6-10 days after irradiation. MATERIALS AND METHODS:Onion seedlings were exposed to a 137Cs gamma source at doses ranging from 0.1 to 10 gray...

journal_title：International journal of radiation biology

authors： Bolsunovsky A,Trofimova E,Dementyev D,Petrichenkov M

更新日期：2020-11-16 00:00:00

abstract：PURPOSE:Radioresistance is highly correlated with radiotherapy failure in clinical cancer treatment. In the current study, we sought to examine the efficacy of Celecoxib and Afatinib co-treatment as radiosensitizers in the management of non-small cell lung cancer (NSCLC) A549 cells. MATERIALS AND METHODS:Generally, A5...

journal_title：International journal of radiation biology

authors： Zhang P,Song E,Jiang M,Song Y

更新日期：2020-11-12 00:00:00

abstract：PURPOSE:We aimed for a quantitative evaluation that justifies guidelines for evacuation which take into consideration both the human and economic costs. To the best of our knowledge, such an evaluation has not been performed yet. The present guidelines published by the International Atomic Energy Agency (IAEA) are prob...

journal_title：International journal of radiation biology

authors： Yanovskiy M,Levi ON,Shaki YY,Socol Y

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:Since the exact development of posterior subcapsular cataracts (PSCs) is poorly understood, we review various risk factors and propose a two-stage etiology for PSCs. METHODS:The biological mechanisms associated with age-related cataracts (primarily nuclear cataracts, cortical cataracts and PSCs) were reviewed ...

journal_title：International journal of radiation biology

authors： Richardson RB,Ainsbury EA,Prescott CR,Lovicu FJ

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:Animal models that accurately reflect human responses to radiation injury are needed for advanced mechanistic investigation and development of effective therapeutics. The rabbit is an established animal model accepted by the FDA for studies of cardiovascular disease, lipid metabolism, the development of anticoa...

journal_title：International journal of radiation biology

authors： Paredes A,Lindeblad M,Patil R,Neal MD,Hong Y,Smith B,Nanda JP,Mousafeiris V,Moulder J,Bosland MC,Lyubimov A,Bartholomew A

更新日期：2020-10-26 00:00:00

abstract：PURPOSE:The hemorrhagic syndrome is a major cause of morbidity and mortality associated with the acute radiation syndrome (ARS). We previously characterized the dose-response relationship for total body irradiation (TBI)-induced ARS in the New Zealand White (NZW) rabbit. Thrombocytopenia, hemorrhage, and anemia were st...

journal_title：International journal of radiation biology

authors： Jackson IL,Gurung G,Ayompe E,Fown ER,Triesler S,Mali B,Casildo A,Gibbs A,Poirier Y,Cohen EP,Newman D,Vujaskovic Z

更新日期：2020-10-16 00:00:00

abstract：BACKGROUND:High dose ionizing radiation exposure is associated with myelo-depression leading to pancytopenia and the expected clinical manifestations of acute radiation syndrome (ARS). Herein, we evaluated the efficacy of sargramostim (Leukine®, yeast-derived rhu GM-CSF), with regimens delivered at 48, 72, 96, or 120 h...

journal_title：International journal of radiation biology

authors： Zhong Y,Pouliot M,Downey AM,Mockbee C,Roychowdhury D,Wierzbicki W,Authier S

更新日期：2020-09-22 00:00:00

abstract：PURPOSE:Radiotherapy is an important treatment option for brain tumors, but the unavoidable irradiation of normal brain tissue can lead to delayed cognitive impairment. The mechanisms involved are still not well explained and, therefore, new tools to investigate the processes leading to the delayed symptoms of brain ir...

journal_title：International journal of radiation biology

authors： Parente A,Maciel ES,J O Dierckx RA,Langendijk JA,de Vries EFJ,Doorduin J

更新日期：2020-09-01 00:00:00

abstract：:Purpose: Cancer is one of the most common causes of mortality and morbidity worldwide. Vaccines have been emerged as an attractive approach for their capacity of eliciting long-term immune response targeting cancer cells. Attenuated avirulent Toxoplasma gondii stimulate immunity and activate antitumor cells thereby el...

journal_title：International journal of radiation biology

authors： Hafez EN,Youssef HMG,El-Kabany HA

更新日期：2020-06-01 00:00:00

abstract：:Purpose: This review discusses recent developments in our understanding of biological and physiological mechanisms underlying radiation cataractogenesis. The areas discussed include effects of low-dose exposures to the lens including potential relevance of non-targeted effects, the development of new personal-protecti...

journal_title：International journal of radiation biology

authors： Laskowski L,Williams D,Seymour C,Mothersill C

更新日期：2020-05-26 00:00:00

abstract：:Purpose: A study is presented of the irradiation of cancerous cervical cell line HeLa loaded with a platinum salt, betamethasone and deoxyglucose. The presence of the platinum increases the free-radical concentration and augments the cell death rate, whereas betamethasone or deoxyglucose induces radiosensitization by ...

journal_title：International journal of radiation biology

authors： Usami N,Hirayama R,Kobayashi K,Furusawa Y,Le Sech C

更新日期：2020-05-01 00:00:00

abstract：:Purpose: To summarize existing knowledge and to understand individual response to radiation exposure, the MELODI Association together with CONCERT European Joint Programme has organized a workshop in March 2018 on radiation sensitivity and susceptibility.Methods: The workshop reviewed the current evidence on this matt...

journal_title：International journal of radiation biology

authors： Seibold P,Auvinen A,Averbeck D,Bourguignon M,Hartikainen JM,Hoeschen C,Laurent O,Noël G,Sabatier L,Salomaa S,Blettner M

更新日期：2020-03-01 00:00:00

abstract：:Purpose: Ionizing radiation is a risk factor to the whole organism, including the heart. Cardiac damage is considered to be a late effect of radiation exposure. While the acute cardiotoxicity of high doses is well characterized, the knowledge about nature and magnitude of the cardiac risk following lower doses exposur...

journal_title：International journal of radiation biology

authors： Gramatyka M,Sokół M

更新日期：2020-03-01 00:00:00

abstract：:Purpose: To evaluate the antioxidant and radio-protective effects of Nigella sativa oil (NSO) and thymoquinone (TQ) on radiation-induced oxidative stress in brain tissue.Materials and methods: Fifty-four Sprague-Dawley rats were divided into six groups to test the radio-protective effectiveness of Nigella sativa oil a...

journal_title：International journal of radiation biology

authors： Demir E,Taysi S,Ulusal H,Kaplan DS,Cinar K,Tarakcioglu M

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:We introduce and evaluate a high throughput biodosimetry test system (REDI-Dx) suitable for testing of thousands of potential radiation victims following a mass scale nuclear event caused by detonation of a nuclear device or a nuclear accident, as part of an overall strategy for effective medical management of ...

journal_title：International journal of radiation biology

authors： Jacobs AR,Guyon T,Headley V,Nair M,Ricketts W,Gray G,Wong JYC,Chao N,Terbrueggen R

更新日期：2020-01-01 00:00:00

abstract：:Purpose: The key to increasing our understanding of low dose effects of ionizing radiation is cooperation and communication between research organizations around the world. The purpose of this article is to describe the Electric Power Research Institute (EPRI) program for such cooperation. Materials and methods: EPRI ...

journal_title：International journal of radiation biology

authors： Cool DA

更新日期：2019-10-01 00:00:00

abstract：:Purpose: Radiotherapy prescription dose and dose fractionation protocols vary little between individual patients having the same tumor grade and stage. To personalize radiotherapy a predictive model is needed to simulate radiation response. Previous modeling attempts with multiple variables and parameters have been sh...

journal_title：International journal of radiation biology

authors： Sunassee ED,Tan D,Ji N,Brady R,Moros EG,Caudell JJ,Yartsev S,Enderling H

更新日期：2019-10-01 00:00:00

abstract：:Purpose: Projects evaluating the effects of radiation, within the National Institutes of Quantum and Radiological Science and Technology (QST), National Institute of Radiological Sciences (NIRS), have focused on risk analyses for life shortening and cancer prevalence using laboratory animals. Genetic and epigenetic al...

journal_title：International journal of radiation biology

authors： Morioka T,Blyth BJ,Imaoka T,Nishimura M,Takeshita H,Shimomura T,Ohtake J,Ishida A,Schofield P,Grosche B,Kulka U,Shimada Y,Yamada Y,Kakinuma S

更新日期：2019-10-01 00:00:00

abstract：:Purpose: Dose assessment plays an important role in case of radiological accidents and can be performed by scoring structural changes of chromosome morphology induced in cells by ionizing radiation. The results of such a test are biased by scorer experience, therefore, simple to learn assays are recommended to be used...

journal_title：International journal of radiation biology

authors： Gałecki M,Tartas A,Szymanek A,Sims E,Lundholm L,Sollazzo A,Cheng L,Fujishima Y,Yoshida MA,Żygierewicz J,Wojcik A,Brzozowska-Wardecka B

更新日期：2019-09-01 00:00:00

abstract：:Context: Some individuals are reporting being sensitive to electromagnetic fields. They report some unspecific symptoms like headeache, sleep disruption, heart palpitations, itching, etc. The lack of scientific objective links between EHS symptoms and EMF exposure renders the diagnosis of EHS more complex. Purpose: Ou...

journal_title：International journal of radiation biology

authors： Andrianome S,Yahia-Cherif L,Selmaoui B

更新日期：2019-06-01 00:00:00

abstract：:Objective: To quantify DNA damage in patients undergoing non-contrast and contrast-enhanced 18F-FDG PET/CT whole body positron emission tomography/computed tomography (WB PET/CT) investigations using comet assay technique and micronucleus assay, and to study the effect of other baseline parameters of patients on DNA d...

journal_title：International journal of radiation biology

authors： Nautiyal A,Mondal T,Mukherjee A,Mitra D,Kaushik A,Goel HC,Goel A,Dey SK

更新日期：2019-06-01 00:00:00

abstract：:Purpose: To examine the effects of low-dose exposure to uranium with a systems biology approach, a multiscale high-throughput multi-omics analysis was applied with a protocol for chronic exposure to the rat kidney. Methods: Male and female rats were contaminated for nine months through their drinking water with a nont...

journal_title：International journal of radiation biology

authors： Grison S,Kereselidze D,Cohen D,Gloaguen C,Elie C,Lestaevel P,Legendre A,Manens L,Habchi B,Benadjaoud MA,Tarlet G,Milliat F,Martin JC,Lobaccaro JM,Souidi M

更新日期：2019-06-01 00:00:00

abstract：:Purpose: To study the response of neuronal-like cells to an applied static or low-frequency magnetic field. Materials and methods: Fourier Transform Infrared (FTIR) Spectroscopy was used to investigate the overall behavior of SH-SY5Y neuronal-like cells exposed to a static or 50 Hz magnetic fields at intensities up to...

journal_title：International journal of radiation biology

authors： Calabrò E,Magazù S

更新日期：2019-06-01 00:00:00

abstract：:Purpose: Present study deals with the role of gamma irradiation in modulating lead (Pb) tolerance of Aspergillus niger van Tieghem. and Penicillium cyclopium Westling. Materials and methods: After being exposed to gamma absorbed doses those fungal strains were subjected to heavy metal uptake efficacies and anti-oxidat...

journal_title：International journal of radiation biology

authors： Das D,Chakraborty A,Santra SC

更新日期：2019-06-01 00:00:00

abstract：:Radiologic accidents or terrorist acts involving radioactive material, as well as radiation exposure in medical or industrial procedures are potential sources of risk for human health. All these risks share a common element, exposure to ionizing radiation. The extent of ionizing radiation injury will depend on a numbe...

journal_title：International journal of radiation biology

authors： Soriano JL,Calpena AC,Souto EB,Clares B

更新日期：2019-05-01 00:00:00

abstract：:Despite the extensive utilization of radiotherapy in cancer treatments, clinicians often face challenges in achieving desired outcomes. This is because of the existence of secondary radiation effects like bystander phenomenon that influence radiation nontargeted cells and tissues. The concept of bystander effects of r...

journal_title：International journal of radiation biology

authors： Mukherjee S,Chakraborty A

更新日期：2019-03-01 00:00:00

abstract：:A review is presented to the program of education and training setup within the DoReMi Network of Excellence. DoReMi was funded by Euratom under the EU 7th Framework Programme to coordinate the EU research into risks from low-dose ionizing radiation. It was seen to be necessary to form a network of expert institutions...

journal_title：International journal of radiation biology

authors： Ottolenghi A,Trott KR,Smyth V

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Element-specific biokinetic models are used to reconstruct doses to systemic tissues from internal emitters. Typically, a systemic model for a radionuclide explicitly depicts only its dominant repositories. Remaining tissues and fluids are aggregated into a pool called Other tissue in which the radionuclide ...

journal_title：International journal of radiation biology

authors： Leggett RW,Tolmachev SY,Boice JD Jr

更新日期：2018-12-04 00:00:00

abstract：PURPOSE:Zearalenone is a potent estrogenic metabolite produced by some Fusarium and Gibberella species. Therefore, the aim of this study was to determine the accumulation of Technetium-[99m]-labeled zearalenone in mice organs as well as to study the protective effect of Lactobacillus plantarum. MATERIALS AND METHODS:T...

journal_title：International journal of radiation biology

authors： Sanad MH,Fouzy ASM,Sobhy HM,Hathout AS,Hussain OA

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Ifosfamide as a chemotherapeutic drug is used for the treatment of different cancer types. The purpose of this study is the preparation of 99mTc-ifosfamide complex to be evaluated as a potential candidate for tumor imaging. MATERIALS AND METHODS:The radiolabeling of ifosfamide with technetium-99m was carried o...

journal_title：International journal of radiation biology

authors： Motaleb MA,El-Safoury DM,Abd-Alla WH,Awad GAS,Sakr TM

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and...

journal_title：International journal of radiation biology

authors： Dinčić M,Krstić DZ,Čolović MB,Nešović Ostojić J,Kovačević S,De Luka SR,Djordjević DM,Ćirković S,Brkić P,Todorović J

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:The recent rapid increase of hadron therapy applications requires the development of high performance, reliable in vivo models for preclinical research on the biological effects of high linear energy transfer (LET) particle radiation. AIM:The aim of this paper was to test the relative biological effectiveness ...

journal_title：International journal of radiation biology

authors： Szabó ER,Reisz Z,Polanek R,Tőkés T,Czifrus S,Pesznyák C,Biró B,Fenyvesi A,Király B,Molnár J,Brunner S,Daroczi B,Varga Z,Hideghéty K

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:The purpose of this study was to assess the effect of a lavage solution containing methoxypolyethylene glycol 4-(3,4-dihydroxyphenethylamino)-4-oxobutanoate (MDO) for whole lung lavage (WLL) in dogs after the inhalation of depleted uranium (DU) dust at a dose of 30 mgUkg-1. MATERIALS AND METHODS:WLL was perfor...

journal_title：International journal of radiation biology

authors： Ren J,Hao Y,Gao R,Zhang Y,Ran Y,Liu J,Dai X,Xiong W,Su Y,Li R

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:In this study we addressed the question whether radiation-induced adverse effects on T cell activation are associated with alterations of T cell checkpoint receptors. MATERIALS AND METHODS:Expression levels of checkpoint receptors on T cell subpopulations were analyzed at multiple post-radiation time points ra...

journal_title：International journal of radiation biology

authors： Li D,Chen R,Wang YW,Fornace AJ Jr,Li HH

更新日期：2018-05-01 00:00:00