Abstract：
:Existing models of chromosome aberrations produced by ionizing-radiation predict equal numbers of dicentrics and translocations if the dose is so low that complex aberrations can be ignored. We show that, for a specific subset of aberrations detected by FISH, dicentric/translocation equality is predicted even at higher doses. Assuming one-colour whole-chromosome painting (with unpainted chromosomes counterstained and centromeres recognizable) the relevant restriction is that the final metaphase pattern be, in the terminology of Simpson and Savage, 'apparently simple'. This means that the painted pattern is required to have the colour/centromere appearance corresponding to a single complete reciprocal exchange but its actual formation, as reflected for example in lengths, is allowed to be more complicated. The restriction to apparent simplicity is significantly less limiting than ignoring all complex aberrations. Our analysis of predicted dicentric/translocation equality in this case uses examples, a combinatorial counting method, Monte Carlo computer programs, and a duality proof. However, we argue that for 'visibly complex' dicentrics or translocations, no similar equality is expected in general. Corresponding experimental results are briefly surveyed. Checking dicentric/translocation equality experimentally can provide a significant test of current chromosome aberration models.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Lucas JN,Chen AM,Sachs RKdoi
10.1080/095530096145977subject
Has Abstractpub_date
1996-02-01 00:00:00pages
145-53issue
2eissn
0955-3002issn
1362-3095journal_volume
69pub_type
杂志文章abstract：PURPOSE:To test whether radiolysis-induced fragmentation in frozen aqueous protein solution is dependent on solvent access to the surface of the protein or to the molecular mass of the polypeptide chain. MATERIALS AND METHODS:60Co gamma-irradiation of three proteins at -78 degrees C: lysozyme, citrate synthase and alp...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530000138349
更新日期：2000-05-01 00:00:00
abstract：:Human ovarian carcinoma parental and cisplatin-resistant cells were evaluated for their radiation sensitivity to high and low dose-rate irradiation and for the effectiveness of cisplatin in radiosensitization. The cisplatin resistant variant A2780cp showed increased radiation resistance for both low dose-rate (LDRI) a...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530096145634
更新日期：1996-05-01 00:00:00
abstract：PURPOSE:To estimate gamma-ray doses received by Hiroshima atomic bomb survivors using electron spin resonance (ESR) of tooth enamel and to compare the results with cytogenetic data. MATERIALS AND METHODS:Tooth enamel ESR was performed for 100 teeth donated from 69 Hiroshima survivors, and conventional cytogenetic exam...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530098141870
更新日期：1998-06-01 00:00:00
abstract：PURPOSE:To investigate within the framework of a multilaboratory study the suitability of FISH chromosome painting to measure so-called stable translocations in peripheral lymphocytes of Mayak nuclear-industrial workers (from the Southern Urals) and their use for retrospective biodosimetry. MATERIALS AND METHODS:Chrom...
journal_title：International journal of radiation biology
pub_type： 杂志文章,多中心研究
doi：10.1080/09553000010018693
更新日期：2001-03-01 00:00:00
abstract：PURPOSE:Animal models that accurately reflect human responses to radiation injury are needed for advanced mechanistic investigation and development of effective therapeutics. The rabbit is an established animal model accepted by the FDA for studies of cardiovascular disease, lipid metabolism, the development of anticoa...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2020.1820606
更新日期：2020-10-26 00:00:00
abstract：PURPOSE:The chromosomal radiosensitivity of a selected group of familial breast cancer patients carrying a mutation in BRCA1 (n=11) or BRCA2 (n=9) and a group of healthy mutation carriers (n=12) was investigated and compared to a reference group of breast cancer patients without a BRCA1/2 mutation (n=78) and a group of...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000400017937
更新日期：2004-10-01 00:00:00
abstract：PURPOSE:Dose response and repair kinetics of phosphorylated histone H2A isoform X (gamma-H2AX) foci in T-lymphocytes were investigated in the low-dose range after in vitro irradiation of whole blood and T-lymphocytes with 100 kVp X-rays and (60)Co gamma-rays. MATERIALS AND METHODS:Whole blood or isolated T-lymphocytes...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2010.484479
更新日期：2010-09-01 00:00:00
abstract：PURPOSE:To investigate the action of ultra-low dose beta-radiation (ULDBR) on isolated segments of blood vessels. MATERIALS AND METHODS:We used the pharmacological model of isolated rabbit carotid arteries with intact or mechanically removed endothelium. Specific vascular responses to beta-irradiation were registered ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000600562229
更新日期：2005-11-01 00:00:00
abstract：PURPOSE:To determine the increases in SSB and DSB yields after post gamma-irradiation incubation of plasmid DNA with the Escherichia coli base excision repair endonucleases formamidopyrimidine-DNA N-glycosylase (FPG) and endonuclease III (endo III). MATERIALS AND METHODS:Aqueous solutions of plasmid DNA were irradiate...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000050176234
更新日期：2000-11-01 00:00:00
abstract：PURPOSE:Since the number of cancer patients treated by proton irradiation has increased in the last few years, it seems appropriate to study dose-dependent effects of proton irradiation on mammalian tissues in more detail. MATERIALS AND METHODS:Tissue samples of normal skin of mouse and swine, of a human tumour model ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000412331283515
更新日期：2004-08-01 00:00:00
abstract：PURPOSE:The sequelae of premature loss of ovarian function can undoubtedly have undesirable effects for a woman although radiotherapy is one of the most relevant treatment modalities for various types of malignancies. The aim of this study was to determine the effect of different doses of radiation on ovarian folliculo...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2021.1864497
更新日期：2021-01-06 00:00:00
abstract：:Samples of human rib were collected at autopsy and 20 were selected for marrow fat cell measurement, representing an age range of 16-96 years. The mean diameter of fat cells in red bone marrow of human rib was found to increase from around 48 microns at ages 16-29 years to around 65 microns at ages 82-96 years. There ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009514551681
更新日期：1995-12-01 00:00:00
abstract：PURPOSE:The purpose of this study was to determine whether the effects of gamma rays on the regeneration of hair follicles are carried over to later hair cycles. MATERIALS AND METHODS:The whole bodies of C57BL/10JHir mice in the 1st telogen phase were irradiated with (60)Co γ-rays. Mice were examined for the effects o...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2015.1101647
更新日期：2015-01-01 00:00:00
abstract：:Purpose: Present study deals with the role of gamma irradiation in modulating lead (Pb) tolerance of Aspergillus niger van Tieghem. and Penicillium cyclopium Westling. Materials and methods: After being exposed to gamma absorbed doses those fungal strains were subjected to heavy metal uptake efficacies and anti-oxidat...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2019.1569769
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:Multicellular tumour spheroids are being used with increasing frequency in various aspects of tumour biology, including studies dealing with radiation biology. This review attempts to outline recent studies using these three-dimensional systems in radiation biology with particular reference made to papers testi...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.1080/095530099139845
更新日期：1999-07-01 00:00:00
abstract：PURPOSE:This review examines the evidence for the hypothesis that epigenetics are involved in the initiation and perpetuation of radiation-induced genomic instability (RIGI). CONCLUSION:In addition to the extensively studied targeted effects of radiation, it is now apparent that non-targeted delayed effects such as RI...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.3109/09553002.2010.522686
更新日期：2011-02-01 00:00:00
abstract：:Free radical formation in aqueous solutions of ubiquinone (coenzyme Qo) induced by ultrasound was studied by EPR and spin trapping with 3,5-dibromo-4-nitrosobenzene sulphonate. When aqueous solutions of ubiquinone were sonicated with 50-kHz ultrasound in the presence of argon or nitrogen, radicals formed by addition o...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530096146246
更新日期：1996-01-01 00:00:00
abstract：:The bacterial enzyme PvuII, which generates blunt-ended DNA double-strand breaks, and T4 DNA ligase, which seals adjacent DNA fragments in coupling to ATP cleavage, were introduced in mouse C3H10T1/2 fibroblasts using osmolytic shock of pinocytic vesicles. Cells were then assayed for their clonogenic ability. In agree...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009114550851
更新日期：1991-04-01 00:00:00
abstract：:Recently, it has been demonstrated that two different thermal resistant states found in Chinese hamster cells, one transient, associated with thermotolerance, and the other permanent, associated with the increased expression of the cognate member of the hsp 70 family, are characterized by faster recovery from heat-ind...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009314450751
更新日期：1993-05-01 00:00:00
abstract：:The rate of recovery from radiation damage, as a function of dose per fraction, was investigated in mouse skin. Two different experimental designs were used, both incorporating the neutron top-up technique which enables the X-ray dose per fraction to be kept constant whilst changing the interfraction interval. Either ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009114550461
更新日期：1991-02-01 00:00:00
abstract：:The behaviour of polyamines (putrescine, spermidine and spermine) in the small intestine was studied in rats exposed to a single whole-body dose of 3 Gy administered at four different times of the day. Polyamine content decreased a few hours after irradiation but quickly returned to normal values. Putrescine levels re...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553008914551191
更新日期：1989-07-01 00:00:00
abstract：PURPOSE:To investigate the mechanism of NFkappaB activation by X-rays in normal primary rat astrocytes. MATERIALS AND METHODS:Primary cultures of type I astrocytes generated from the cortex of neonatal rats were exposed to X-rays with and without various kinase inhibitors and a protease inhibitor. The nuclear or cytop...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530098141195
更新日期：1998-11-01 00:00:00
abstract：PURPOSE:To determine whether cigarette smoke condensate (CSC) without metabolic activation induces direct DNA double strand breaks (DSB) in the G1 phase of various radiosensitive mutants of CHO cells and whether these breaks display collateral hypersensitivity to CSC with respect to cell killing. MATERIALS & METHODS:W...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000701481790
更新日期：2007-09-01 00:00:00
abstract：PURPOSE:To resolve the difficulty in counting merged DNA damage foci in high-LET (linear energy transfer) ion-induced patterns. MATERIALS AND METHODS:The analysis of patterns of RIF (radiation-induced foci) produced by high-LET Fe and Ti ions were conducted by using a Monte Carlo model that combines the heavy ion trac...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553001003717175
更新日期：2010-06-01 00:00:00
abstract：:Chinese hamster ovary cells were exposed to various heat treatments followed by X-irradiation, and the induction and repair of DNA strand breaks was studied using the alkaline unwinding technique. Heat treatments alone were found to cause DNA strand breakage only for temperatures greater than or equal to 43 degrees C,...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009214550851
更新日期：1992-02-01 00:00:00
abstract：PURPOSE:Melanoma is mainly treated by surgery and rarely with radiation because of the high radioresistance of this tumor. Nevertheless, radiotherapy is the preferred treatment modality for unresectable lesions and avoiding cosmetic disfigurement caused by surgical excision. This study investigated the therapeutic adva...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2017.1276309
更新日期：2017-05-01 00:00:00
abstract：PURPOSE:The behavioral responses of planaria to the exposures of a range of concentrations of morphine (μM to attoM) or the μ-opiate antagonist naloxone or to either of these compounds and a burst-firing magnetic field (5 μT) were studied. MATERIAL AND METHODS:The locomotor velocity (LMV) of planaria was measured afte...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2014.911421
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:In order to understand the molecular mechanism of nucleobase damage caused by ultrasoft X-ray irradiation, guanine radicals have been studied using an X-band EPR (electron paramagnetic resonance) spectrometer installed in a synchrotron soft X-ray beamline. MATERIALS AND METHODS:Guanine pellets were irradiated ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000400017689
更新日期：2004-11-01 00:00:00
abstract：PURPOSE:Hypoxic cells in tumours are resistant to 5-fluorouracil (5-FU). This in vivo study investigated the ability of hypoxia to regulate the gene expression of thymidylate synthase (TS), the target enzyme of 5-FU. MATERIALS AND METHODS:C3H mammary carcinomas, grown in the feet of female CDF1 mice, were used for all...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530099139944
更新日期：1999-07-01 00:00:00
abstract：:Photoirradiation of aqueous solutions of DNA in the presence of Al- or Zn-tetrasulphonated phthalocyanines (AIPcS4 and ZnPcS4) causes formation of strand breaks and liberation of nucleobases. The effect of added D2O, which enhances singlet oxygen (1O2) lifetime, radical scavengers including alcohols and the spin-trap ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
