DNA strand-break yields after post-irradiation incubation with base excision repair endonucleases implicate hydroxyl radical pairs in double-strand break formation.

abstract：:Experimental data for acute radiation-induced skin reactions are reviewed. These show that for dose fractionation schedules with gaps, repopulation is initiated after a lag period. After this lag period, the isoeffective dose for a given level of skin reaction first increases rapidly, but then slows. The timing of the...

journal_title：International journal of radiation biology

authors： Hopewell JW,Nyman J,Turesson I

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:In radiation biology, rats are often irradiated, but the precise dose distributions are often lacking, particularly in areas that receive scatter radiation. We used a non-dedicated set of resources to calculate detailed dose distributions, including doses to peripheral organs well outside of the primary field, ...

journal_title：International journal of radiation biology

authors： Kirkby C,Ghasroddashti E,Kovalchuk A,Kolb B,Kovalchuk O

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:In order to understand the molecular mechanism of nucleobase damage caused by ultrasoft X-ray irradiation, guanine radicals have been studied using an X-band EPR (electron paramagnetic resonance) spectrometer installed in a synchrotron soft X-ray beamline. MATERIALS AND METHODS:Guanine pellets were irradiated ...

journal_title：International journal of radiation biology

authors： Yokoya A,Akamatsu K,Fujii K,Ukai M

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:To examine the protective effects of histamine on intestinal damage produced by gamma-radiation. MATERIALS AND METHODS:56 mice were divided into 4 groups. Histamine and Histamine-10 Gy groups received a daily subcutaneous histamine injection (0.1 mg/kg) starting 20 hours before irradiation and continued until ...

journal_title：International journal of radiation biology

authors： Medina VA,Croci M,Mohamad NA,Massari N,Garbarino G,Cricco GP,Núñez MA,Martín GA,Crescenti EJ,Bergoc RM,Rivera ES

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:Ionizing radiation induces DNA damage, some of which are present in clusters, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. These clusters are thought to contribute to the detrimental effects of radiation, in part due to the compromised repair of c...

journal_title：International journal of radiation biology

authors： Cunniffe S,Walker A,Stabler R,O'Neill P,Lomax ME

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:The deleterious processes triggered by heavy ions on DNA were studied through the determination of the yield of a series of oxidized bases. Emphasis was placed on the estimation of the respective contribution of direct ionization and indirect effects, mostly by comparison with low linear energy transfer (LET) g...

journal_title：International journal of radiation biology

authors： Douki T,Ravanat JL,Pouget JP,Testard I,Cadet J

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:Chironomus ramosus is one of the recently reported radiotolerant insects. Salivary gland cells of fourth instar larvae respond to ionizing radiations with increases in the levels of antioxidant enzymes and chaperone proteins. Here we made an attempt to study the state of nuclear DNA after exposure of larvae to ...

journal_title：International journal of radiation biology

authors： Datkhile KD,Gaikwad PS,Ghaskadbi SS,Mukhopadhyaya R,Nath BB

更新日期：2015-01-01 00:00:00

abstract：:A/J and C57BL/6J mice, strains which differ in susceptibility to chemical-induced lung tumours, were examined for differential sensitivity to radon-induced lung cancer. Sixty weeks after exposure to 952 WLM radon (3.34 J h1 m-3), no lung tumours were found in the control, sham- (one dust-) exposed, or radon-exposed C5...

journal_title：International journal of radiation biology

authors： Groch KM,Khan MA,Brooks AL,Saffer JD

更新日期：1997-03-01 00:00:00

abstract：PURPOSE:A meta-analysis was conducted to obtain a 'quantitative' estimate of the extent of genetic damage in mammalian somatic cells exposed to non-ionizing radiation emitted from extremely low frequency electro-magnetic fields (ELF-EMF) and to compare with that in unexposed control cells. METHODS:The methods used for...

journal_title：International journal of radiation biology

authors： Vijayalaxmi,Prihoda TJ

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To investigate physical and biophysical properties of proton tracks 1 keV-300 MeV using Monte Carlo track structure methods. MATERIALS AND METHODS:We present model calculations for cross sections and methods for simulations of full-slowing-down proton tracks. Protons and electrons were followed interaction-by-...

journal_title：International journal of radiation biology

authors： Liamsuwan T,Uehara S,Emfietzoglou D,Nikjoo H

更新日期：2011-02-01 00:00:00

abstract：:I calculate the probability that a single high-energy ionizing particle or photon makes two widely spaced double-strand breaks in the same DNA molecule. Deletions (or inversions) between two breaks formed by the same incident particle are linear in radiation dose and occur even at extremely low dose-rates; deletions b...

journal_title：International journal of radiation biology

authors： Hutchinson F

更新日期：1996-11-01 00:00:00

abstract：:Intraoperative irradiation (IORT) is used to enhance local tumour control by using large, single doses while removing critical structures from the treatment field. Peripheral nerve remains a dose-limiting normal tissue that often cannot be removed from the field. To assess ultrastructural changes in canine sciatic ner...

journal_title：International journal of radiation biology

authors： Vujaskovic Z,Gillette SM,Powers BE,Thurmond DN,Gillette EL,Colacchio TA

更新日期：1995-07-01 00:00:00

abstract：:The accumulation and repair of radiation-induced DNA double-strand breaks (dsbs) were determined by neutral filter elution on 20 primary cultures obtained from ovarian cancer and malignant melanoma clinical specimens. The initial frequency of DNA dsbs after exposure to 50 Gy gamma-irradiation varied greatly for the in...

journal_title：International journal of radiation biology

authors： Zaffaroni N,Orlandi L,Villa R,Bearzatto A,Rofstad EK,Silvestrini R

更新日期：1994-09-01 00:00:00

abstract：PURPOSE:To evaluate the radiomodulatory influence of a leaf extract of Mentha piperita (Linn) on hepatic antioxidant status and lipid peroxidation in Swiss albino mice. MATERIALS AND METHODS:Animals were given either double distilled water or leaf extract of M. piperita orally (1 g/kg bwt/day) once a day for three con...

journal_title：International journal of radiation biology

authors： Samarth RM,Panwar M,Kumar M,Kumar A

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:To test whether radiolysis-induced fragmentation in frozen aqueous protein solution is dependent on solvent access to the surface of the protein or to the molecular mass of the polypeptide chain. MATERIALS AND METHODS:60Co gamma-irradiation of three proteins at -78 degrees C: lysozyme, citrate synthase and alp...

journal_title：International journal of radiation biology

authors： Audette M,Chen X,Houée-Levin C,Potier M,Le Maire M

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:Caveolin-1 is a membrane protein highly expressed in many tumors and plays an important role in tumor progression and metastasis. This review describes the structure of the Caveolin-1 protein and its pre-clinical and clinical significance, demonstrating that Caveolin-1 is a novel biomarker for radioresistance w...

journal_title：International journal of radiation biology

authors： Mahmood J,Zaveri SR,Murti SC,Alexander AA,Connors CQ,Shukla HD,Vujaskovic Z

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:To examine whether the levels of micronuclei induction, as a marker for genomic instability in the progeny of X-irradiated cells, correlates with DNA repair function. MATERIALS AND METHODS:Two repair deficient cell lines (X-ray repair cross-complementing 1 [XRCC1] deficient cell line [EM9] and X-ray repair cro...

journal_title：International journal of radiation biology

authors： Kashino G,Suzuki K,Kodama S,Watanabe M,Prise KM

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:Ionizing radiation causes various types of DNA damage e.g. single strand breaks (SSB) and double strand breaks (DSB), whereby the SSB/DSB ratio is shifted toward the DSB with increasing LET. For the DNA-incorporated Auger electron emitter Iodine-125 a SSB/DSB ratio of 5.4:1 is calculated based on computer simul...

journal_title：International journal of radiation biology

authors： Unverricht-Yeboah M,Holtmann K,Kriehuber R

更新日期：2020-12-03 00:00:00

abstract：PURPOSE:Since the exact development of posterior subcapsular cataracts (PSCs) is poorly understood, we review various risk factors and propose a two-stage etiology for PSCs. METHODS:The biological mechanisms associated with age-related cataracts (primarily nuclear cataracts, cortical cataracts and PSCs) were reviewed ...

journal_title：International journal of radiation biology

authors： Richardson RB,Ainsbury EA,Prescott CR,Lovicu FJ

更新日期：2020-11-01 00:00:00

abstract：:Tikvah Alper's interest in science was broad, from scrapie to mammalian cells and cancer. Much of her own work focused on cell lethality, like that of many other radiobiologists, but this was natural because of the simplicity of the endpoint cell survival and its relevance to cancer therapy. Tikvah had broader interes...

journal_title：International journal of radiation biology

authors： Elkind MM

更新日期：1997-06-01 00:00:00

abstract：PURPOSE:To evaluate and optimize the radioprotective ability of the most potent fraction of an aqueous extract of Coronopus didymus in whole body gamma-irradiated Swiss albino mice and to evaluate the antioxidant status and lipid peroxidation of the livers of the surviving mice. To correlate the free radical scavenging...

journal_title：International journal of radiation biology

authors： Prabhakar KR,Veerapur VP,Parihar KV,Priyadarsini KI,Rao BS,Unnikrishnan MK

更新日期：2006-08-01 00:00:00

abstract：:Ionizing radiation induces both quantitative and qualitative changes in the lymphoid cells of both man and experimental animals, including inhibition of antibody responses. However, the cellular basis of this immunological lesion is not clear. In the present study, groups of mice were exposed to 2.0 Gy gamma-rays or s...

journal_title：International journal of radiation biology

authors： Goud SN

更新日期：1995-04-01 00:00:00

abstract：PURPOSE:To calculate survival of human haemopoietic stem cells irradiated by alpha particles from 149Tb (initial energy 3.97 MeV) and 211At (average initial energy 6.87 MeV). METHODS:Following as closely as possible radiobiological data, Monte Carlo methods were used to calculate passages of alpha particles (originati...

journal_title：International journal of radiation biology

authors： Charlton DE,Utteridge TD,Allen BJ

更新日期：1998-07-01 00:00:00

abstract：:Genetic analysis was performed on 72 Italian A-T families ascertained through 91 probands. The frequency of the A-T gene was estimated through Dahlberg's formula, which uses the frequencies of first cousin marriages among the patients' parents and in the general population were obtained from the collection of Catholic...

journal_title：International journal of radiation biology

authors： Chessa L,Lisa A,Fiorani O,Zei G

更新日期：1994-12-01 00:00:00

abstract：PURPOSE:To examine the heat sensitivity of DNA-dependent protein kinase (DNA-PK) activity in a variety of cultured mouse, hamster and human cell lines. MATERIALS AND METHODS:Eight cell lines, which have been routinely used in our laboratory, were examined. Cells were heated at 44.0 +/- 0.05 degrees C and DNA-PK activi...

journal_title：International journal of radiation biology

authors： Umeda N,Matsumoto Y,Yin HL,Tomita M,Enomoto A,Morita A,Mizukoshi T,Sakai K,Hosoi Y,Suzuki N

更新日期：2003-08-01 00:00:00

abstract：:Recent evidence indicates that isoeffect doses for spinal cord and kidney may be overestimated for fraction sizes as small as 1 or 2 Gy when calculated from a linear-quadratic (LQ) model fitted to data obtained for fraction sizes larger than 2 Gy. Reasons for this are unknown, but possible interpretations include exha...

journal_title：International journal of radiation biology

authors： Thames HD,Ang KK,Stewart FA,van der Schueren E

更新日期：1988-07-01 00:00:00

abstract：:Wet heat shock (60 degrees C, 90 s) and caffeine (3.8 X 10(-4) M) afford significant radioprotection against post-irradiation O2-dependent damage which develops in seeds of approximately 3.5% moisture content. The damage was assessed in terms of seedling injury on the eighth day of growth. An increase in seedling inju...

journal_title：International journal of radiation biology

authors： Singh SP,Kesavan PC

更新日期：1991-05-01 00:00:00

abstract：PURPOSE:To study the natural radionuclides in the freshwater fish samples around the uranium mining areas of Bagjata and Banduhurang, East Singhbhum, Jharkhand, India. MATERIALS AND METHODS:The naturally occurring radioisotopes of uranium, U(nat), consisting of (234)U, (235)U and (238)U; (226)Ra, (230)Th and (210)Po w...

journal_title：International journal of radiation biology

authors： Giri S,Singh G,Jha VN,Tripathi RM

更新日期：2010-11-01 00:00:00

abstract：:237Np nitrate was injected intravenously into 4-week-old (young) and 10-12-week-old (adult) female albino Sprague-Dawley rats. The amounts given were 52 (young), 5.2 (adult) and 26 kBq kg-1 body weight (adult). The microscopic distribution in the femur and the lumbar vertebrae was studied. Initially, neptunium was dis...

journal_title：International journal of radiation biology

authors： Sontag W

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:We already reported that levels of interferon (IFN)-γ have been shown to be markedly reduced in mice seven weeks after irradiation, resulting in a T helper (Th) 1/Th2 imbalance. To investigate whether the single or fractionated γ-irradiation induced an immune imbalance, we analysed the Th1-related immune respon...

journal_title：International journal of radiation biology

authors： Park HR,Jo SK,Eom HS

更新日期：2011-05-01 00:00:00