Abstract:
PURPOSE:A meta-analysis was conducted to obtain a 'quantitative' estimate of the extent of genetic damage in mammalian somatic cells exposed to non-ionizing radiation emitted from extremely low frequency electro-magnetic fields (ELF-EMF) and to compare with that in unexposed control cells. METHODS:The methods used for the meta-analysis were recommended in several standard text books. Three specific variables related to ELF-EMF exposure characteristics were examined in the meta-analysis: (i) frequency (Hz), (ii) flux density (mT), and (iii) in occupationally exposed individuals. RESULT AND CONCLUSIONS:(1) The difference between ELF-EMF-exposed and control cells as well as the 'effect size' due to ELF-EMF exposure were biologically small (although statistically significant) with very few exceptions. (2) At certain ELF-EMF exposure conditions there was a statistically significant increase in genetic damage assessed from some end-points. (3) The mean indices for chromosomal aberrations and micronuclei end-points in ELF-EMF-exposed and control cells were within the spontaneous levels reported in historical database. (4) Considerable evidence for publication bias was found in the meta-analysis.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Vijayalaxmi,Prihoda TJdoi
10.1080/09553000902748575subject
Has Abstractpub_date
2009-03-01 00:00:00pages
196-213issue
3eissn
0955-3002issn
1362-3095pii
909663962journal_volume
85pub_type
杂志文章,meta分析abstract::A review is presented to the program of education and training setup within the DoReMi Network of Excellence. DoReMi was funded by Euratom under the EU 7th Framework Programme to coordinate the EU research into risks from low-dose ionizing radiation. It was seen to be necessary to form a network of expert institutions...
journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
doi:10.1080/09553002.2018.1454616
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:Exposition of best practice in management and experimental use of human stem cell lines in radiobiological research. This paper outlines the key challenges to be addressed by radiobiologists wishing to use human pluripotent stem cell (hPSC) lines in their research including human embryonic stem cell (hESC) line...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.3109/09553002.2012.714518
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:To investigate the relationship between the susceptibility of B-chronic lymphoid leukaemia (B-CLL) cells to DNA damage-induced apoptosis, the kinetics of DNA strand-break rejoining, and chromosome damage after exposure to ionizing irradiation. MATERIALS AND METHODS:Lymphocytes from B-CLL patients were gamma-ir...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000110120364
更新日期:2002-08-01 00:00:00
abstract::Pulsed-field electrophoresis is being used extensively in the gene mapping studies and in the analysis of DNA strand breakage by ionizing radiation. We have evaluated the relationship between the fraction of S phase DNA in a cell population and its ability to modify the migration of DNA in pulsed-field gel electrophor...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530096145427
更新日期:1996-06-01 00:00:00
abstract::Only a small percentage of the DNA damage set by ionizing radiation in the living cell manifests itself as lethal. It is now increasingly accepted that clustered lesions may constitute the kind of damage that the repair enzymes cannot adequately deal with. The question is raised as to whether damage amplification reac...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009414551501
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abstract::CHEF-electrophoresis was used as a technique to detect radiation-induced DNA breakage with special emphasis to biological relevant X-ray doses (0-10 Gy). Fluorescence detection of DNA-fragments using a sensitive image analysis system was directly compared with conventional scintillation counting of 3H-thymidine prelab...
journal_title:International journal of radiation biology
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abstract::Diploid elongated spermatids of mice were enriched by flow cytometry and cell sorting using a new type of sorter (Partec). The sorted abnormal spermatids were identified morphologically and by nuclear area integration. The radiation-induced increase in the frequency of diploid elongated spermatids was monitored with t...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553008914550841
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abstract:PURPOSE:To investigate the mechanisms inducing and maintaining the permanent elimination of low dose hyper-radiosensitivity (HRS) in cells given a dose of 0.3 Gy at low dose-rate (LDR) (0.3 Gy/h). MATERIALS AND METHODS:Two human HRS-positive cell lines (T-47D, T98G) were used. The effects of pretreatments with transfo...
journal_title:International journal of radiation biology
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更新日期:2014-07-01 00:00:00
abstract:PURPOSE:Human embryonic stem cells (hESC) hold a great potential for regenerative medicine because, in principle, they can differentiate into any cell type found in the human body. In addition, studying the effect of ionizing radiation (IR) on hESC may provide valuable information about the response of human cells to I...
journal_title:International journal of radiation biology
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doi:10.3109/09553002.2012.700435
更新日期:2012-12-01 00:00:00
abstract::During previous studies on the relationship between thermosensitivity and intracellular pH (pHi) regulation in mammalian cells, we observed that the thermoresistant TR-4 cells appeared to be resistant to manipulations of the Na+/H+ antiport, one of the two primary membrane regulators of pHi. We hypothesized that this ...
journal_title:International journal of radiation biology
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doi:10.1080/095530096144969
更新日期:1996-10-01 00:00:00
abstract:PURPOSE:To evaluate the radioprotective effect of dieckol, a component of the brown algae Ecklonia cava. MATERIALS AND METHODS:Mice were lethally irradiated, treated with dieckol and surveyed for survival and the mechanism of radioprotection. RESULTS:Dieckol treatment lengthened the survival of irradiated mice and si...
journal_title:International journal of radiation biology
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更新日期:2010-10-01 00:00:00
abstract::Purpose: Projects evaluating the effects of radiation, within the National Institutes of Quantum and Radiological Science and Technology (QST), National Institute of Radiological Sciences (NIRS), have focused on risk analyses for life shortening and cancer prevalence using laboratory animals. Genetic and epigenetic al...
journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
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abstract::Two novel nitroimidazole-carboranes were examined for their uptake and retention in two experimental murine solid tumours and in some normal tissues, using in vivo 11B magnetic resonance spectroscopy. The compounds were injected i.p. at 0.8mmol/kg into mice bearing either the SCCVII/Ha squamous cell carcinoma or KHT s...
journal_title:International journal of radiation biology
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doi:10.1080/095530096144798
更新日期:1996-11-01 00:00:00
abstract:PURPOSE:To resolve the difficulty in counting merged DNA damage foci in high-LET (linear energy transfer) ion-induced patterns. MATERIALS AND METHODS:The analysis of patterns of RIF (radiation-induced foci) produced by high-LET Fe and Ti ions were conducted by using a Monte Carlo model that combines the heavy ion trac...
journal_title:International journal of radiation biology
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doi:10.3109/09553001003717175
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:Public concern about radiation protection of the environment and non-human species is increasing. The potential impact of chronic gamma radiation on the bacterial community in a rice paddy ecosystem was investigated. MATERIALS AND METHODS:Paddy field microcosm samples were continuously exposed at a dose rate o...
journal_title:International journal of radiation biology
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doi:10.3109/09553002.2010.549534
更新日期:2011-07-01 00:00:00
abstract:PURPOSE:To investigate the ability of electromagnetic (EM) field pre-exposures to induce protection in chick embryos against subsequent ultraviolet (UV) light exposure. MATERIALS AND METHOD:Chick embryos in the 4th day of gestation were exposed for 20 minutes (short term) or 96 hours (long term) to 60 Hz, 8 microT mag...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530099139142
更新日期:1999-12-01 00:00:00
abstract::Purpose Radiolabeled antibodies and peptides hold promise for molecular radiotherapy but are often limited by a low payload resulting in inadequate delivery of radioactivity to tumour tissue and, therefore, modest therapeutic effect. We developed a facile synthetic method of radiolabeling indium-111 (111In) to epiderm...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.3109/09553002.2016.1145360
更新日期:2016-11-01 00:00:00
abstract::Photoirradiation of aqueous solutions of DNA in the presence of Al- or Zn-tetrasulphonated phthalocyanines (AIPcS4 and ZnPcS4) causes formation of strand breaks and liberation of nucleobases. The effect of added D2O, which enhances singlet oxygen (1O2) lifetime, radical scavengers including alcohols and the spin-trap ...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::Calibration of the non-denaturing (pH 9.6) filter elution technique by 125I decays has been used to examine the relationship between X-ray-induced DNA double-strand breaks (dsb) and cellular survival of CHO cells and human fibroblasts. DNA dsb induction varies markedly between the two cell lines, reflecting the differ...
journal_title:International journal of radiation biology
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更新日期:1993-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was to assess the long-term effects of gamma-radiation, including low-dose radiation, on growth parameters of onion (Allium cepa) seedling roots 6-10 days after irradiation. MATERIALS AND METHODS:Onion seedlings were exposed to a 137Cs gamma source at doses ranging from 0.1 to 10 gray...
journal_title:International journal of radiation biology
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更新日期:2020-11-16 00:00:00
abstract:PURPOSE:To evaluate the characteristic features of mechanical responses and the membrane potential changes induced by repetitive pulsed electromagnetic field (PEMF, 50 Hz, 5 mT) in thoracic aorta rings obtained from streptozotocin-induced diabetic and healthy control rats to determine if PEMF could ameliorate problems ...
journal_title:International journal of radiation biology
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
abstract:PURPOSE:Chronic occupational exposure to ionizing radiation (IR) induces a wide spectrum of DNA damages. The aim of this study was to assess the frequencies of micronucleus (MN), sister chromatid exchanges (SCE) and to evaluate their association with XRCC1 399 Arg/Gln and XRCC3 241 Thr/Met polymorphisms in Hospital sta...
journal_title:International journal of radiation biology
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更新日期:2017-11-01 00:00:00
abstract:PURPOSE:The linear nonthreshold (LNT) model has been used in radiation protection for over 40 years and has been hotly debated. It relies heavily on human epidemiology, with support from radiobiology. The scientific underpinnings include NCRP Report No. 136 ('Evaluation of the Linear-Nonthreshold Dose-Response Model fo...
journal_title:International journal of radiation biology
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abstract::The scission of pentadeoxythymidylic acid, d(pT)5, by monochromatic soft X-rays on (2153 eV) and below (2147 eV) the K-shell absorption peak of phosphorus was studied as a model of strand breakage in DNA. Samples dried on glass plates were irradiated by monochromatic soft X-rays in vacuo, and the products were analyse...
journal_title:International journal of radiation biology
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更新日期:1993-02-01 00:00:00
abstract:PURPOSE:To evaluate whether immunotherapy based on adoptively transferred cytotoxic T-cells (CTL) can improve the antitumour efficacy of irradiation. MATERIAL AND METHODS:The experiments were performed using the human squamous cell carcinoma line UT-SCC-15, which expresses human leukocyte antigen (HLA)-A2. The UT-SCC-...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000701570196
更新日期:2007-11-01 00:00:00
abstract:PURPOSE:The radiation-induced bystander effect (RIBE) has important implications for the efficiency of radiotherapy but the underlying role of cellular metabolism is widely unknown. The roles of synthesis of cytochrome c oxidase 2 (SCO2), a key effector for respiratory chain, and related signaling factors in α-particle...
journal_title:International journal of radiation biology
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更新日期:2013-12-01 00:00:00
abstract:PURPOSE:Since the number of cancer patients treated by proton irradiation has increased in the last few years, it seems appropriate to study dose-dependent effects of proton irradiation on mammalian tissues in more detail. MATERIALS AND METHODS:Tissue samples of normal skin of mouse and swine, of a human tumour model ...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000412331283515
更新日期:2004-08-01 00:00:00
abstract:PURPOSE:It has been proposed previously that the ratio of complete to incomplete translocations as seen by fluorescence in situ hybridization (FISH), the S value, can be a cytogenetic fingerprint of exposure to radiation of different qualities. Results from a previous study suggested that the S value is approximately 1...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530099140799
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:We already reported that levels of interferon (IFN)-γ have been shown to be markedly reduced in mice seven weeks after irradiation, resulting in a T helper (Th) 1/Th2 imbalance. To investigate whether the single or fractionated γ-irradiation induced an immune imbalance, we analysed the Th1-related immune respon...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.3109/09553002.2011.542540
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:To investigate the possible role of cell cycle arrest in the radiosensitization of mouse spermatogonial stem cells due to small conditioning X-ray exposures. MATERIALS AND METHODS:A 24 h fractionation interval between conditioning (1 Gy) and challenging (8 or 9 Gy) exposures was used. Two approaches were follo...
journal_title:International journal of radiation biology
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更新日期:2001-03-01 00:00:00