The roles of TGF-β3 and peroxynitrite in removal of hyper-radiosensitivity by priming irradiation.

abstract：:Purpose: Ionizing radiation is a risk factor to the whole organism, including the heart. Cardiac damage is considered to be a late effect of radiation exposure. While the acute cardiotoxicity of high doses is well characterized, the knowledge about nature and magnitude of the cardiac risk following lower doses exposur...

journal_title：International journal of radiation biology

authors： Gramatyka M,Sokół M

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:To investigate the effect of lupeol, a pentacyclictriterpene, on the radiosensitivity of a human hepatocellular carcinoma (HCC) in vitro and in vivo xenografts. METHODS:SMMC-7721 cells were exposed to γ-radiation with or without lupeol and assayed for proliferation, clonogenic survival, apoptosis and cell cycl...

journal_title：International journal of radiation biology

authors： Jin Y,Lyu Y,Tang X,Zhang Y,Chen J,Zheng D,Liang Y

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:To propose an improved version of RADACK, a stochastic simulation of radiolytic attack on DNA, that takes into account the reactivity of each amino acid of a specifically bound protein with hydroxyl radicals. To apply it to the natural lactose operator-repressor complex taking advantage of recently reported str...

journal_title：International journal of radiation biology

authors： Begusova M,Giliberto S,Gras J,Sy D,Charlier M,Spotheim-Maurizot M

更新日期：2003-06-01 00:00:00

abstract：:The radiation chemistry of the oligomer d(TpApCpG) X-irradiated in aqueous solution containing glutathione was studied. Four products were isolated by HPLC and characterized by NMR spectroscopy. Two of the major products are isomers of a 5-hydroxy-5,6-dihydrothymine modification of d(TpApCpG). A dihydrothymine modific...

journal_title：International journal of radiation biology

authors： Paul CR,Budzinski EE,Maccubbin A,Wallace JC,Box HC

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:To test whether radiolysis-induced fragmentation in frozen aqueous protein solution is dependent on solvent access to the surface of the protein or to the molecular mass of the polypeptide chain. MATERIALS AND METHODS:60Co gamma-irradiation of three proteins at -78 degrees C: lysozyme, citrate synthase and alp...

journal_title：International journal of radiation biology

authors： Audette M,Chen X,Houée-Levin C,Potier M,Le Maire M

更新日期：2000-05-01 00:00:00

abstract：:Purpose To investigate the effect of increasing the overall treatment time as well as delivering the compensating doses on the Balb/c breast adenocarcinoma (4T1) tumor. Materials and methods A total of 72 mice were divided into two aliquots (classes A and B) based on the initial size of their induced tumor. Each class...

journal_title：International journal of radiation biology

authors： Nikzad S,Hashemi B,Hasan ZS,Mozdarani H,Baradaran-Ghahfarokhi M,Amini P

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Ionizing radiation (IR) produced a dose-dependent increase in apoptosis in U937/pCEP4 cells which was attenuated by the stable over expression of Bcl-2 (U937/Bcl-2). A dose of 2 Gy IR was selected for further analyses to determine if subsequent exposure to 10nM bryostatin- would overcome the resistance to IR-in...

journal_title：International journal of radiation biology

authors： Cartee L,Davis C,Lin PS,Grant S

更新日期：2000-10-01 00:00:00

abstract：:Purpose: A study is presented of the irradiation of cancerous cervical cell line HeLa loaded with a platinum salt, betamethasone and deoxyglucose. The presence of the platinum increases the free-radical concentration and augments the cell death rate, whereas betamethasone or deoxyglucose induces radiosensitization by ...

journal_title：International journal of radiation biology

authors： Usami N,Hirayama R,Kobayashi K,Furusawa Y,Le Sech C

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:The recent rapid increase of hadron therapy applications requires the development of high performance, reliable in vivo models for preclinical research on the biological effects of high linear energy transfer (LET) particle radiation. AIM:The aim of this paper was to test the relative biological effectiveness ...

journal_title：International journal of radiation biology

authors： Szabó ER,Reisz Z,Polanek R,Tőkés T,Czifrus S,Pesznyák C,Biró B,Fenyvesi A,Király B,Molnár J,Brunner S,Daroczi B,Varga Z,Hideghéty K

更新日期：2018-11-01 00:00:00

abstract：:The mitogen phytohemagglutinin (PHA) works well in both human and cynomolgus monkey (Macaca fascicularis) lymphocyte cultures to stimulate T cell proliferation. T cells from rhesus monkeys (Macaca mulatta) are less responsive than human cells, producing few metaphases when thousands are required, e.g. in biological do...

journal_title：International journal of radiation biology

authors： Hill FS,Cox AB,Salmon YL,Cantu AO,Lucas JN

更新日期：1994-10-01 00:00:00

abstract：PURPOSE:Human embryonic stem cells (hESC) hold a great potential for regenerative medicine because, in principle, they can differentiate into any cell type found in the human body. In addition, studying the effect of ionizing radiation (IR) on hESC may provide valuable information about the response of human cells to I...

journal_title：International journal of radiation biology

authors： Panyutin IV,Eniafe R,Panyutin IG,Neumann RD

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:To study the relationship between cell reproductive death and exchange frequency in SW-1573 human lung tumour cells with and without incorporated iodo-deoxyuridine (IdUrd) following irradiation of plateau-phase cultures with y-rays. METHOD:Linear-quadratic (LQ) analysis was performed for the data on clonogenic...

journal_title：International journal of radiation biology

authors： Franken NA,Ruurs P,Ludwików G,van Bree C,Kipp JB,Darroudi F,Barendsen GW

更新日期：1999-03-01 00:00:00

abstract：:Experimental data for acute radiation-induced skin reactions are reviewed. These show that for dose fractionation schedules with gaps, repopulation is initiated after a lag period. After this lag period, the isoeffective dose for a given level of skin reaction first increases rapidly, but then slows. The timing of the...

journal_title：International journal of radiation biology

authors： Hopewell JW,Nyman J,Turesson I

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:Since the number of cancer patients treated by proton irradiation has increased in the last few years, it seems appropriate to study dose-dependent effects of proton irradiation on mammalian tissues in more detail. MATERIALS AND METHODS:Tissue samples of normal skin of mouse and swine, of a human tumour model ...

journal_title：International journal of radiation biology

authors： Synytsya A,Alexa P,Besserer J,De Boer J,Froschauer S,Gerlach R,Loewe M,Moosburger M,Obstová I,Quicken P,Sosna B,Volka K,Würkner M

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:To evaluate the radiomodulatory influence of a leaf extract of Mentha piperita (Linn) on hepatic antioxidant status and lipid peroxidation in Swiss albino mice. MATERIALS AND METHODS:Animals were given either double distilled water or leaf extract of M. piperita orally (1 g/kg bwt/day) once a day for three con...

journal_title：International journal of radiation biology

authors： Samarth RM,Panwar M,Kumar M,Kumar A

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and...

journal_title：International journal of radiation biology

authors： Dinčić M,Krstić DZ,Čolović MB,Nešović Ostojić J,Kovačević S,De Luka SR,Djordjević DM,Ćirković S,Brkić P,Todorović J

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:The purpose of this study was to assess the long-term effects of gamma-radiation, including low-dose radiation, on growth parameters of onion (Allium cepa) seedling roots 6-10 days after irradiation. MATERIALS AND METHODS:Onion seedlings were exposed to a 137Cs gamma source at doses ranging from 0.1 to 10 gray...

journal_title：International journal of radiation biology

authors： Bolsunovsky A,Trofimova E,Dementyev D,Petrichenkov M

更新日期：2020-11-16 00:00:00

abstract：PURPOSE:The LET position of the RBE maximum and its dependence on the cellular repair capacity was determined for carbon ions. Hamster cell lines of differing repair capacity were irradiated with monoenergetic carbon ions. RBE values for cell inactivation at different survival levels were determined and the differences...

journal_title：International journal of radiation biology

authors： Weyrather WK,Ritter S,Scholz M,Kraft G

更新日期：1999-11-01 00:00:00

abstract：:In this report, in situ hybridization with whole chromosome painting probes was used to paint radiation-induced micronuclei (MN) in three lymphoblastoid cells lines to investigate the frequency of radiation-induced MN. The results obtained for four different chromosomes showed that there was a significant deviation of...

journal_title：International journal of radiation biology

authors： Slavotinek A,Sauer-Nehls S,Braselmann H,Taylor GM,Nüsse M

更新日期：1996-10-01 00:00:00

abstract：PURPOSE:To develop a procedure, using the inverse polymerase chain reaction, to detect and sequence ionizing radiation-induced DNA rearrangements without prior phenotypic selection of mutant cells. METHOD:Normal human fibroblast cells (IMR-90) were given 30Gy of gamma-irradiation and then incubated at 37 degrees C for...

journal_title：International journal of radiation biology

authors： Forrester HB,Radford IR

更新日期：1998-07-01 00:00:00

abstract：PURPOSE:In case of a large-scale radiation accident when hundreds of people may be exposed, it is important to distinguish the severely exposed individuals (> or =1 gray), who require early medical treatment, from those less exposed. The aim of our study was to develop a quick population triage method based on automate...

journal_title：International journal of radiation biology

authors： Willems P,August L,Slabbert J,Romm H,Oestreicher U,Thierens H,Vral A

更新日期：2010-01-01 00:00:00

abstract：:Purpose: Dose assessment plays an important role in case of radiological accidents and can be performed by scoring structural changes of chromosome morphology induced in cells by ionizing radiation. The results of such a test are biased by scorer experience, therefore, simple to learn assays are recommended to be used...

journal_title：International journal of radiation biology

authors： Gałecki M,Tartas A,Szymanek A,Sims E,Lundholm L,Sollazzo A,Cheng L,Fujishima Y,Yoshida MA,Żygierewicz J,Wojcik A,Brzozowska-Wardecka B

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:To investigate the action of ultra-low dose beta-radiation (ULDBR) on isolated segments of blood vessels. MATERIALS AND METHODS:We used the pharmacological model of isolated rabbit carotid arteries with intact or mechanically removed endothelium. Specific vascular responses to beta-irradiation were registered ...

journal_title：International journal of radiation biology

authors： Zhirnov VV,Iakovenko IN

更新日期：2005-11-01 00:00:00

abstract：:Base damages, sugar damages, and single-strand breaks produced by free radicals are the preponderant lesions produced in DNA by ionizing radiation. These lesions have been individually introduced into substrate, template, and biologically active DNA molecules and enzymatic processing and biological consequences determ...

journal_title：International journal of radiation biology

authors： Wallace SS

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:In a previous study, we found that exposure to a 50 Hz magnetic field (MF) could activate stress-activated protein kinase (SAPK) and P38 mitogen-activated protein (MAP) kinase (P38 MAPK) in Chinese hamster lung (CHL) fibroblast cells, and simultaneous exposure to a 'noise' MF of the same intensity inhibited the...

journal_title：International journal of radiation biology

authors： Ke XQ,Sun WJ,Lu DQ,Fu YT,Chiang H

更新日期：2008-05-01 00:00:00

abstract：:Induction by gamma-radiation, UV radiation or hydroxyurea of RecA gene product synthesis in Escherichia coli, monitored as beta-D-galactosidase in recA-lacZ fusion strains, was shown to be inhibited if 2-mercaptoethylamine (MEA) was added before treatment with the inducing agents. If cysteine (Cys) at low concentratio...

journal_title：International journal of radiation biology

authors： Naslund M,Anderstam B,Granath F,Ehrenberg L

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Since the exact development of posterior subcapsular cataracts (PSCs) is poorly understood, we review various risk factors and propose a two-stage etiology for PSCs. METHODS:The biological mechanisms associated with age-related cataracts (primarily nuclear cataracts, cortical cataracts and PSCs) were reviewed ...

journal_title：International journal of radiation biology

authors： Richardson RB,Ainsbury EA,Prescott CR,Lovicu FJ

更新日期：2020-11-01 00:00:00

abstract：:The response to radiation of seven osteosarcoma cell lines was analysed by in vitro colony-forming assay and compared with that of eight human fibroblast strains. The values of D0, the surviving fraction after 2 Gy (S2Gy), and the mean inactivation dose (D) of osteosarcoma cells in log-phase culture were significantly...

journal_title：International journal of radiation biology

authors： Sugimoto M,Toguchida J,Kotoura Y,Yamamuro T,Utsumi H

更新日期：1992-10-01 00:00:00

abstract：PURPOSE:To investigate the p53 ionizing radiation-induced response, G1/S cell-cycle block and cytogenetic damage in Nijmegen breakage syndrome (NBS) cells characterized by different haplotypes. MATERIAL AND METHODS:Lymphoblastoid cell lines derived from three normals, five NBS and two ataxia telangiectasia (AT) indivi...

journal_title：International journal of radiation biology

authors： Antoccia A,Stumm M,Saar K,Ricordy R,Maraschio P,Tanzarella C

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:To summarize current knowledge regarding mechanisms of radiation-induced skin injury and medical countermeasures available to reduce its severity. Advances in radiation delivery using megavoltage and intensity modulated radiation therapy have permitted delivery of higher doses of radiation to well-defined tumor...

journal_title：International journal of radiation biology

authors： Kim JH,Kolozsvary AJ,Jenrow KA,Brown SL

更新日期：2013-05-01 00:00:00