当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF RADIATION BIOLOGY期刊下所有文献 > Mechanisms of radiation-induced skin injury and implications for future clinical trials.

Mechanisms of radiation-induced skin injury and implications for future clinical trials.

Abstract：

PURPOSE:To summarize current knowledge regarding mechanisms of radiation-induced skin injury and medical countermeasures available to reduce its severity. Advances in radiation delivery using megavoltage and intensity modulated radiation therapy have permitted delivery of higher doses of radiation to well-defined tumor target tissues. Although skin is not a radiation dose-limiting tissue, injury to skin poses substantial morbidity risks in the curative treatment of cancers, especially when radiation is administered in combination with chemotherapy. In the continuum of radiation-induced skin injury, late effects are most severe being characterized by sub-cutaneous fibrosis and morbidity. The principal pathogenesis is initiated by depletion of acutely responding epithelial tissues and damage to vascular endothelial microvessels. Emerging concepts of radiation- induced skin injury suggest that the recovery of stromal stem cells and tissue repair remain chronically impaired by long-lived free radicals, reactive oxygen species, and pro-inflammatory cytokines/chemokines resulting in progressive damage after radiation exposure. CONCLUSIONS:As pathways underlying the cellular and molecular mechanisms of radiation-induced skin injury are becoming better understood, novel approaches are being developed for mitigating or treating the associated pathogenesis.

journal_name

Int J Radiat Biol

journal_title

International journal of radiation biology

authors

Kim JH,Kolozsvary AJ,Jenrow KA,Brown SL

doi

10.3109/09553002.2013.765055

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

311-8

issue

5

eissn

0955-3002

issn

1362-3095

journal_volume

89

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY文献大全
  • Low dose ionising radiation leads to a NF-κB dependent decreased secretion of active IL-1β by activated macrophages with a discontinuous dose-dependency.

    abstract：PURPOSE:Therapy with low doses of ionising radiation (X-rays) exerts anti-inflammatory effects. Little is known about whether and how low doses of X-ray treatment modulate the inflammatory phenotype of macrophages, especially the secretion of Interleukin-1beta (IL-1β). MATERIALS AND METHODS:Macrophages were differenti...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2012.689464

    authors： Lödermann B,Wunderlich R,Frey S,Schorn C,Stangl S,Rödel F,Keilholz L,Fietkau R,Gaipl US,Frey B

    更新日期：2012-10-01 00:00:00

  • Effects of 50 Hz magnetic fields on cancer induced by ionizing radiation in mice.

    abstract：PURPOSE:To evaluate the effects of 50 Hz magnetic fields (MF) on the development of cancer induced by ionizing radiation. MATERIALS AND METHODS:A total of 150 female CBA/S mice were randomized into three equal groups at the age of 3-5 weeks. One of the groups served as a 'cage-control group'. The two other groups were...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000010024696

    authors： Heikkinen P,Kosma VM,Huuskonen H,Komulainen H,Kumlin T,Penttilä I,Väänänen A,Juutilainen J

    更新日期：2001-04-01 00:00:00

  • Molecular dissection of the response of the rice Systemic Acquired Resistance Deficient 1 (SARD1) gene to different types of ionizing radiation.

    abstract：PURPOSE:Exposure to ionizing radiation induces plant defenses by regulating the expression of response genes. The systemic acquired resistance deficient 1 (SARD1) is a key gene in plant defense response. In this study, the function of Oryza sativa SARD1 (OsSARD1) was investigated after exposure of seeds/plants to ioniz...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2017.1297901

    authors： Jung IJ,Hwang JE,Han SM,Kim DS,Ahn JW,Choi HI,Kwon SJ,Kang SY,Kim JB

    更新日期：2017-07-01 00:00:00

  • The influence of glutathione on single-strand breakage in single-stranded DNA irradiated in aqueous solution in the absence and presence of oxygen.

    abstract：:The yields of strand break formation (Gssb) in single-stranded DNA (ssDNA) initiated by radiation-generated OH radicals have been determined using the method of low-angle laser light scattering (LALLS). The irradiations were carried out in aqueous, N2O-saturated solutions in the absence and presence of oxygen and at d...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009014551951

    authors： Liphard M,Bothe E,Schulte-Frohlinde D

    更新日期：1990-10-01 00:00:00

  • Radiation sensitization by an iodine-labelled DNA ligand.

    abstract：:An iodinated DNA ligand, iodo Hoechst 33258, which binds in the minor groove of DNA, enhances DNA strand breakage and cell killing by UV-A irradiation. The sites of UV-induced strand breaks reflect the known sequence specificity of the ligand. ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009014551061

    authors： Martin RF,Murray V,D'Cunha G,Pardee M,Kampouris E,Haigh A,Kelly DP,Hodgson GS

    更新日期：1990-05-01 00:00:00

  • Correlation of micronucleus and apoptosis assays with reproductive cell death.

    abstract：:The relationship between ionizing radiation-induced cell killing and DNA damage measured by the micronucleus and apoptosis assays was determined in three established cell lines (L929, HL-60, and Chang). Irradiation experiments revealed a dose-dependent increase of micronucleated cells until a certain dose was reached....

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009514550371

    authors： Abend M,Rhein A,Gilbertz KP,Blakely WF,Van Beuningen D

    更新日期：1995-03-01 00:00:00

  • Daily exposure to inhomogeneous static magnetic field significantly reduces blood glucose level in diabetic mice.

    abstract：PURPOSE:The present study was designed to reveal, whether the 30 min daily full body exposure of mice to an inhomogeneous static magnetic field (SMF) has a statistically significant effect on diabetic neuropathy. MATERIALS AND METHODS:Three different doses (100, 150, or 200 mg/kg) of streptozotocin (STZ) were administ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2010.518200

    authors： László JF,Szilvási J,Fényi A,Szalai A,Gyires K,Pórszász R

    更新日期：2011-01-01 00:00:00

  • Effect of a 915-MHz simulated mobile phone signal on cognitive function in man.

    abstract：PURPOSE:To examine whether a simulated mobile telephone transmission at 915 MHz has an effect on cognitive function in man. MATERIALS AND METHODS:Thirty-six subjects in two groups were each given two training sessions and then three test sessions in a randomized three-way cross-over design. About 1 W mean power at 915...

    journal_title：International journal of radiation biology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1080/095530099140375

    authors： Preece AW,Iwi G,Davies-Smith A,Wesnes K,Butler S,Lim E,Varey A

    更新日期：1999-04-01 00:00:00

  • Pulmonary immune response of dogs after exposure to 239PuO2.

    abstract：:This study evaluated the cell-mediated (CMI) and humoral immune responses in four Beagle dogs five to six years after single inhalation exposures to different monodisperse 239PuO2 aerosols (0.72-1.4 microns activity median aerodynamic diameter). These exposures resulted in initial lung burdens ranging from 19 to 35 kB...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553008914550311

    authors： Galvin JB,Bice DE,Guilmette RA,Muggenburg BA,Haley PJ

    更新日期：1989-02-01 00:00:00

  • Cytotoxicity of cigarette smoke condensate is not due to DNA double strand breaks: Comparative studies using radiosensitive mutant and wild-type CHO cells.

    abstract：PURPOSE:To determine whether cigarette smoke condensate (CSC) without metabolic activation induces direct DNA double strand breaks (DSB) in the G1 phase of various radiosensitive mutants of CHO cells and whether these breaks display collateral hypersensitivity to CSC with respect to cell killing. MATERIALS & METHODS:W...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000701481790

    authors： Kato T,Nagasawa H,Warner C,Okayasu R,Bedford JS

    更新日期：2007-09-01 00:00:00

  • Effect of GSM-900 and -1800 signals on the skin of hairless rats. II: 12-week chronic exposures.

    abstract：PURPOSE:The purpose of this work was to determine whether the cellular components of Hairless-rat skin are affected by a chronic local exposure to non-ionizing radiations of Global Mobile Phone System: GSM-900 or -1800 radiations at specific absorption rate (SAR) 2.5 and 5 W/kg. MATERIALS AND METHODS:A selected part o...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000600930087

    authors： Sanchez S,Masuda H,Billaudel B,Haro E,Anane R,Lévêque P,Ruffie G,Lagroye I,Veyret B

    更新日期：2006-09-01 00:00:00

  • Polyamines in the small intestine of rats after whole-body irradiation.

    abstract：:The behaviour of polyamines (putrescine, spermidine and spermine) in the small intestine was studied in rats exposed to a single whole-body dose of 3 Gy administered at four different times of the day. Polyamine content decreased a few hours after irradiation but quickly returned to normal values. Putrescine levels re...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553008914551191

    authors： Becciolini A,Porciani S,Lanini A,Attanasio M

    更新日期：1989-07-01 00:00:00

  • Quantitative study of wound infection in irradiated mice.

    abstract：:Bacterial infection of simple wounds was studied directly and quantitatively in adult mice given 6.5 Gy 60Co. Three days later, when neutropenia was evident, the skin and the medial gluteus muscle of anaesthetized mice were incised. A suspension of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae or Stre...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009014551671

    authors： Elliott TB,Brook I,Stiefel SM

    更新日期：1990-08-01 00:00:00

  • Effect of radiation on glyoxalase I and glyoxalase II activities in spleen and liver of mice.

    abstract：:Swiss albino mice (7-8 weeks old) were irradiated with different doses (0-25 Gy) of gamma-radiation at a dose-rate of 0.05 Gy/s. The specific activities of glyoxalase I (GI) and glyoxalase II (GII) were determined in the spleen and liver immediately and on the 3rd and 6th day postirradiation. The results indicate that...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009314550301

    authors： Sharma R,Kale RK

    更新日期：1993-02-01 00:00:00

  • Radiosensitization by misonidazole, pimonidazole and azomycin and intracellular uptake in human tumour cell lines.

    abstract：:The radiosensitization of two human tumour in vitro cell lines, HT-1080 and LoVo, has been compared with that of the Chinese hamster cell line V79-379A. Although the two human tumour cell lines were more radiosensitive than the V79 cell line sensitizer, enhancement ratios for misonidazole, pimonidazole and azomycin we...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009014552461

    authors： Watts ME,Dennis MF,Roberts IJ

    更新日期：1990-02-01 00:00:00

  • Etiology of posterior subcapsular cataracts based on a review of risk factors including aging, diabetes, and ionizing radiation.

    abstract：PURPOSE:Since the exact development of posterior subcapsular cataracts (PSCs) is poorly understood, we review various risk factors and propose a two-stage etiology for PSCs. METHODS:The biological mechanisms associated with age-related cataracts (primarily nuclear cataracts, cortical cataracts and PSCs) were reviewed ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2020.1812759

    authors： Richardson RB,Ainsbury EA,Prescott CR,Lovicu FJ

    更新日期：2020-11-01 00:00:00

  • Cell survival characteristics of a human colon adenocarcinoma cell line after photodynamic treatment: a comparison of Photofrin II and TPPS.

    abstract：:A comparison has been made of the in vitro light-activated drug cytotoxicities of two different porphyrin compounds, Photofrin II and TPPS4. An early passage human colon adenocarcinoma cell line, WiDr, has been exposed to either drug for 24 h, the excess drug washed from the cells and the cells irradiated with light u...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553008814552061

    authors： West CM,Moore JV

    更新日期：1988-10-01 00:00:00

  • Proliferation saturation index in an adaptive Bayesian approach to predict patient-specific radiotherapy responses.

    abstract：:Purpose: Radiotherapy prescription dose and dose fractionation protocols vary little between individual patients having the same tumor grade and stage. To personalize radiotherapy a predictive model is needed to simulate radiation response. Previous modeling attempts with multiple variables and parameters have been sh...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2019.1589013

    authors： Sunassee ED,Tan D,Ji N,Brady R,Moros EG,Caudell JJ,Yartsev S,Enderling H

    更新日期：2019-10-01 00:00:00

  • Efficacy of delayed administration of sargramostim up to 120 hours post exposure in a nonhuman primate total body radiation model.

    abstract：BACKGROUND:High dose ionizing radiation exposure is associated with myelo-depression leading to pancytopenia and the expected clinical manifestations of acute radiation syndrome (ARS). Herein, we evaluated the efficacy of sargramostim (Leukine®, yeast-derived rhu GM-CSF), with regimens delivered at 48, 72, 96, or 120 h...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2019.1673499

    authors： Zhong Y,Pouliot M,Downey AM,Mockbee C,Roychowdhury D,Wierzbicki W,Authier S

    更新日期：2020-09-22 00:00:00

  • Angiotensin II receptor antagonists in the treatment and prevention of radiation nephropathy.

    abstract：PURPOSE:Angiotensin-converting enzyme (ACE) inhibitors are effective in the prophylaxis of radiation-induced renal and lung injury. Studies were designed to determine whether blocking the angiotensin II (AII) receptor, rather than blocking AII synthesis with ACE inhibitors, would also be effective. MATERIALS AND METHO...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530098142257

    authors： Moulder JE,Fish BL,Cohen EP

    更新日期：1998-04-01 00:00:00

  • The application of the linear quadratic model to compensate the effects of prolonged fraction delivery time on a Balb/C breast adenocarcinoma tumor: An in vivo study.

    abstract：:Purpose To investigate the effect of increasing the overall treatment time as well as delivering the compensating doses on the Balb/c breast adenocarcinoma (4T1) tumor. Materials and methods A total of 72 mice were divided into two aliquots (classes A and B) based on the initial size of their induced tumor. Each class...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2016.1117677

    authors： Nikzad S,Hashemi B,Hasan ZS,Mozdarani H,Baradaran-Ghahfarokhi M,Amini P

    更新日期：2016-01-01 00:00:00

  • The combined effects of reduced weightbearing and ionizing radiation on splenic lymphocyte population and function.

    abstract：PURPOSE:The effects of radiation +/- hypogravity on immunologic function were investigated using the Partial Weight Suspension (PWS) model ( Wagner et al. 2010 ). MATERIALS AND METHODS:Mice were exposed to 0.5, 1, or 2 Gray (Gy) dose of gamma radiation and then placed in the PWS system for 4, 24, 48 hours, or 4 days. ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2011.595875

    authors： Sanzari JK,Wilson JM,Wagner EB,Kennedy AR

    更新日期：2011-10-01 00:00:00

  • Simulation of the relative damaging effects of Auger cascades with gel scintillators.

    abstract：PURPOSE:The aim of this work is to study the relative damaging effects of DNA-incorporated radionuclides by analyzing the behavior of the liquid-scintillation counting efficiency in volumes of nanometer size. METHODS:A liquid scintillation counter can detect changes in the micelle size when different percentages of an...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000802460156

    authors： Grau Carles A

    更新日期：2008-12-01 00:00:00

  • Decorporating efficacy of catecholaminocarboxylate chelating agents for thorium-234 and protective effects on associated radiation injury.

    abstract：:The aim was to identify the decorporation and anti-oxidation efficacy of prompt and delayed consecutive administration of the catecholicpolyaminopolycarboxylate ligands 9501 and 7601 for radiothorium in vivo. The chelating agents 9501 or 7601 were administered intramuscularly to ICR mice 3 min or 3 days after intraper...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000500141124

    authors： Chen H,Luo M,Sun M,Hu Y,Wang Y,Jin M,Cheng W

    更新日期：2005-04-01 00:00:00

  • Health, growth and reproductive success of mice exposed to environmentally relevant levels of Ra-226 via drinking water over multiple generations.

    abstract：PURPOSE:To assess health, growth and reproductive success of mammals exposed for multiple generations to levels of radium-226 known to occur in environments surrounding uranium mines and mills in Canada. METHODS:The study consisted of a control group and four treatment groups each containing 40 mice (20 males and 20 f...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2015.1028598

    authors： Walsh S,Satkunam M,Su B,Festarini A,Bugden M,Peery H,Mothersill C,Stuart M

    更新日期：2015-07-01 00:00:00

  • Characterization of the specific response to serotonin of mouse tumour-feeding arterioles.

    abstract：PURPOSE:To investigate the role of tumour versus non-tumour factors in the specific response to serotonin (5-HT) of tumour-feeding arterioles (TFA). MATERIALS AND METHODS:Using mouse models of intra-vital microscopy, the response to topical administration of 5-HT was studied in arterioles feeding tumours: fibrosarcoma...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530098141519

    authors： Laemmel E,Stücker O,Darmon PL,Vicaut E

    更新日期：1998-09-01 00:00:00

  • Radiation response of mouse lymphoid and myeloid cell lines. Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage.

    abstract：:We have examined the timing of gamma-irradiation-induced death in relation to cell cycle progression using a panel of mouse lymphoid or myeloid cell lines. Death was found to occur immediately after irradiation ('rapid interphase' death), or after arrest in G2 phase ('delayed interphase' death). In part II of this ser...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009414550261

    authors： Radford IR,Murphy TK

    更新日期：1994-02-01 00:00:00

  • DNA lesion complexity and induction of apoptosis by ionizing radiation.

    abstract：PURPOSE:To determine whether murine lymphoid cell lines can discriminate between high- and low-LET (linear energy transfer) radiation-induced DNA lesions. MATERIALS AND METHODS:Sensitivity to killing by DNA-incorporated 3H and 125I decays, accumulated during storage in the gas phase of a liquid nitrogen tank, was dete...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000110120337

    authors： Radford IR

    更新日期：2002-06-01 00:00:00

  • Multicellular tumour spheroids in radiation biology.

    abstract：PURPOSE:Multicellular tumour spheroids are being used with increasing frequency in various aspects of tumour biology, including studies dealing with radiation biology. This review attempts to outline recent studies using these three-dimensional systems in radiation biology with particular reference made to papers testi...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章,评审

    doi：10.1080/095530099139845

    authors： Santini MT,Rainaldi G,Indovina PL

    更新日期：1999-07-01 00:00:00

  • Dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression.

    abstract：PURPOSE:To evaluate the radioprotective effect of dieckol, a component of the brown algae Ecklonia cava. MATERIALS AND METHODS:Mice were lethally irradiated, treated with dieckol and surveyed for survival and the mechanism of radioprotection. RESULTS:Dieckol treatment lengthened the survival of irradiated mice and si...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2010.487011

    authors： Park E,Ahn G,Yun JS,Kim MJ,Bing SJ,Kim DS,Lee J,Lee NH,Park JW,Jee Y

    更新日期：2010-10-01 00:00:00