Dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression.

abstract：PURPOSE:To investigate cell cycle effects and relative biological effectiveness (RBE) of α-particles from the clinically relevant radionuclide Astatine-211 ((211)At), using X-rays as reference radiation. Double-strand breaks (DSB), non-DSB clusters containing oxidised purines and clonogenic survival were investigated. ...

journal_title：International journal of radiation biology

authors： Claesson K,Magnander K,Kahu H,Lindegren S,Hultborn R,Elmroth K

更新日期：2011-04-01 00:00:00

abstract：:Survival of HT29 cells was measured after irradiation with single doses of X-rays (0.05-5 Gy) and neutrons (0.025-1.5 Gy), using a Dynamic Microscopic Imaging Processing Scanner (DMIPS) with which individual cells can be accurately located in tissue culture flasks, their positions recorded, and after an appropriate in...

journal_title：International journal of radiation biology

authors： Lambin P,Marples B,Fertil B,Malaise EP,Joiner MC

更新日期：1993-05-01 00:00:00

abstract：PURPOSE:The molecular basis of gene regulation in cells exposed to ionising radiation is not fully understood. Gene regulation occurs at the transcriptional and post-transcriptional levels. Recent studies have suggested that micro-RNA (miRNA) plays a significant role at the post-transcriptional gene regulation. miRNA a...

journal_title：International journal of radiation biology

authors： Chaudhry MA,Kreger B,Omaruddin RA

更新日期：2010-07-01 00:00:00

abstract：:We used the 'comet assay' to compare the amount of radiation-induced DNA damage in three tumour cell lines (MeWo, PECA 4451 and PECA 4197) and the extent of DNA repair in two of these lines (MeWo and PECA 4197). Tumour cells were irradiated with X-rays (0.1-10 Gy), embedded in agarose on slides, lysed with sodium dode...

journal_title：International journal of radiation biology

authors： Müller WU,Bauch T,Streffer C,Niedereichholz F,Böcker W

更新日期：1994-03-01 00:00:00

abstract：:Radiation-induced DNA double-strand breaks (dsbs) were measured in CHO-K1 cells by means of an experimental approach involving constant-field gel electrophoresis and densitometric scanning of ethidium bromide stained gels. For X-irradiation, an induction efficiency of 36 +/- 5 dsbs (Gy x cell)-1 was determined. With t...

journal_title：International journal of radiation biology

authors： Heilmann J,Taucher-Scholz G,Kraft G

更新日期：1995-08-01 00:00:00

abstract：PURPOSE:The aim was to evaluate the utility of multiple blood-protein biomarkers for early-response assessment of radiation exposure using a murine radiation model system. MATERIAL AND METHODS:BALB/c male mice (8-10 weeks old) were exposed to whole-body 60Co gamma-rays (10 cGy min(-1)) over a broad dose range (0-7 Gy)...

journal_title：International journal of radiation biology

authors： Ossetrova NI,Blakely WF

更新日期：2009-01-01 00:00:00

abstract：:Electron transfer to 5-bromouracil (5-BrU) from nucleobase (N) electron adducts (and their protonated forms) has been studied by product analysis and pulse radiolysis. When an electron is transferred to 5-BrU, the ensuing 5-BrU radical anion rapidly loses a bromide ion; the uracilyl radical thus formed reacts with add...

journal_title：International journal of radiation biology

authors： Nese C,Yuan Z,Schuchmann MN,Von Sonntag C

更新日期：1992-11-01 00:00:00

abstract：:Intact Chinese hamster ovary cells were exposed to the restriction endonucleases (REs) AluI or BamHI. In metaphase spreads from these cells, 300 breakpoints per RE were localized in G-banded chromosome type aberrations (dicentrics, translocations, rings, terminal and interstitial deletions). The majority of breakpoint...

journal_title：International journal of radiation biology

authors： Folle GA,Obe G

更新日期：1995-10-01 00:00:00

abstract：:The dose-rate effect has been the topic of extensive radiobiological studies and has important implications in radiation therapy and in the field of radiation protection. Three examples will be discussed: two in radiation therapy and one in protection. First, continuous low dose-rate interstitial brachytherapy may be ...

journal_title：International journal of radiation biology

authors： Hall EJ

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:The fluorescent in situ hybridization (FISH) technique, which easily detects reciprocal translocations, is currently used to estimate doses in retrospective biological dosimetry, after suspected accidental overexposure to ionizing radiation (IR). This study of 42 cases aimed to verify the appropriateness of thi...

journal_title：International journal of radiation biology

authors： Grégoire E,Roy L,Buard V,Delbos M,Durand V,Martin-Bodiot C,Voisin P,Sorokine-Durm I,Vaurijoux A,Voisin P,Baldeyron C,Barquinero JF

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To study the oxidative stress-induced changes by sublethal doses of cadmium chloride (CdCl2) and gamma irradiation, two redox-inducing agents, on metallothionein (MT) gene and protein expression in Plantago ovata Forsk (P. ovata). MATERIALS AND METHODS:Chlorophyll content was estimated to study the stress resp...

journal_title：International journal of radiation biology

authors： Ghoshal N,Talapatra S,Moulick A,Chakraborty A,Raychaudhuri SS

更新日期：2013-07-01 00:00:00

abstract：:It is well established from clinical, epidemiological and laboratory studies that specific human germ line mutation can predispose to spontaneously arising cancer. Some of the responsible genes have been characterized at the molecular level and evidence is rapidly accumulating on mechanistic aspects of the problem. A ...

journal_title：International journal of radiation biology

authors： Cox R

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:To seek the delayed appearance of chromosomal abnormalities in human fibroblasts exposed to the Auger electron emitter 125I. MATERIALS AND METHODS:Normal untransformed human fibroblasts, HF19, were exposed to a concentration of [I125]IUdR, which allowed the survival of 37% of clonogens. Chromosomal analysis us...

journal_title：International journal of radiation biology

authors： Griffin CS,Neshasateh-Riz A,Mairs RJ,Wright EG,Wheldon TE

更新日期：2000-07-01 00:00:00

abstract：:High doses of rHIL-1 protected C3H/HeN mice against lethal radiation damage. The optimum time of radioprotection was found when this cytokine was administered at 4 h and at 20 h before irradiation. The dose reduction factors when the IL-1 was administered at those times were about 1.30. The radioprotection at the opti...

journal_title：International journal of radiation biology

authors： Wu SG,Tuboi A,Miyamoto T

更新日期：1989-10-01 00:00:00

abstract：:We have compared the repair kinetics of X-ray-induced sublethal damage (SLD) and potentially lethal damage (PLD) in V79 cells during postirradiation incubation in growth medium at 37 degrees C. Kinetics of SLD repair were studied by dose fractionation (D1 + D2 = 2 + 2, 4 + 2, 4 + 4, 10 + 4 and 10 + 7 Gy). Kinetics of ...

journal_title：International journal of radiation biology

authors： Reddy NM,Lange CS

更新日期：1989-09-01 00:00:00

abstract：PURPOSE:To investigate whether mobile phone radiation might affect snail nociception, employing radiofrequency (RF) electromagnetic fields (EMF) which, to our knowledge, have hitherto not been studied in a snail model. Exposure to extremely low frequency (ELF) magnetic fields has however been shown to significantly aff...

journal_title：International journal of radiation biology

authors： Nittby H,Moghadam MK,Sun W,Malmgren L,Eberhardt J,Persson BR,Salford LG

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:To investigate within the framework of a multilaboratory study the suitability of FISH chromosome painting to measure so-called stable translocations in peripheral lymphocytes of Mayak nuclear-industrial workers (from the Southern Urals) and their use for retrospective biodosimetry. MATERIALS AND METHODS:Chrom...

journal_title：International journal of radiation biology

authors： Bauchinger M,Braselmann H,Savage JR,Natarajan AT,Terzoudi GI,Pantelias GE,Darroudi F,Figgitt M,Griffin CS,Knehr S,Okladnikova ND,Santos S,Snigiryova G

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:High dose ionizing radiation exposure is associated with myelo-depression leading to pancytopenia and the expected clinical manifestations of acute radiation syndrome (ARS). Herein, we evaluated the efficacy of sargramostim (Leukine®, yeast-derived rhu GM-CSF), with regimens delivered at 48, 72, 96, or 120 h...

journal_title：International journal of radiation biology

authors： Zhong Y,Pouliot M,Downey AM,Mockbee C,Roychowdhury D,Wierzbicki W,Authier S

更新日期：2020-09-22 00:00:00

abstract：PURPOSE:Public concern about radiation protection of the environment and non-human species is increasing. The potential impact of chronic gamma radiation on the bacterial community in a rice paddy ecosystem was investigated. MATERIALS AND METHODS:Paddy field microcosm samples were continuously exposed at a dose rate o...

journal_title：International journal of radiation biology

authors： Ishii N,Fuma S,Tagami K,Honma-Takeda S,Shikano S

更新日期：2011-07-01 00:00:00

abstract：:The effect of a siderophore analogue 3,4,3-LIHOPO has been investigated in rat after intramuscular injection of 238Pu, 239Pu and 241Am simulating puncture wounds. Various treatment regimens were used to remove the radioactivity from its injection site and to reduce its retention in body tissues. The local deposits cou...

journal_title：International journal of radiation biology

authors： Volf V,Burgada R,Raymond KN,Durbin PW

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:DNA damage is one of the main consequences of exposure to ionizing irradiation (IR). Recent studies indicate that IR can modulate the expression of immune system-related genes. However, the effects of IR on the expression of genes and pathways of the B7-CD28 superfamily remain poorly defined. The aim of this st...

journal_title：International journal of radiation biology

authors： Silveira DA,Ribeiro FM,Simão ÉM,Mattos VLD,Góes EG

更新日期：2020-12-17 00:00:00

abstract：:Radiation-induced myocardial degeneration in the rat is preceded by changes in capillary structure and function, which may be a major factor in the pathogenesis of radiation-induced heart disease. In order to investigate the mechanism of capillary damage we studied endothelial cell proliferation in untreated control r...

journal_title：International journal of radiation biology

authors： Lauk S,Trott KR

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:Up to 90% of hereditary breast cancer cases are linked to germ-line mutations in one of the two copies of the BRCA1 or BRCA2 genes. Brca1 and Brca2 proteins are both involved in the cellular defence against DNA damage, although the precise function of the proteins is still not known. Some studies on a small num...

journal_title：International journal of radiation biology

authors： Nieuwenhuis B,Van Assen-Bolt AJ,Van Waarde-Verhagen MA,Sijmons RH,Van der Hout AH,Bauch T,Streffer C,Kampinga HH

更新日期：2002-04-01 00:00:00

abstract：:Murine bone marrow contains osteogenic precursor cells that undergo differentiation during in vitro cultivation. In vitro these cells are potential target cells for alpha-irradiation-induced bone tumour formation. Under defined tissue culture conditions these differentiating cells were directly exposed to alpha-partic...

journal_title：International journal of radiation biology

authors： Schoeters GE,Vander Plaetse F,van den Heuvel RL

更新日期：1994-08-01 00:00:00

abstract：PURPOSE:To investigate the consequence of continuous low dose-rate exposure to gamma-rays on ornithine decarboxylase (ODC EC 4.1.1.17) activity in organs of rat. MATERIALS AND METHODS:Young male Wistar rats were irradiated at 1.1, 2.1 and 12.9 cGy/day in the dose ranges of 9-165, 17-315 and 100-2000 cGy, respectively,...

journal_title：International journal of radiation biology

authors： Slozhenikina LV,Fialkovskaya LA,Kolomiytseva IK

更新日期：1999-02-01 00:00:00

abstract：:Purpose: Cancer is one of the most common causes of mortality and morbidity worldwide. Vaccines have been emerged as an attractive approach for their capacity of eliciting long-term immune response targeting cancer cells. Attenuated avirulent Toxoplasma gondii stimulate immunity and activate antitumor cells thereby el...

journal_title：International journal of radiation biology

authors： Hafez EN,Youssef HMG,El-Kabany HA

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:To ask whether highly metastatic sublines show more marked low-dose hyper-radiosensitivity (HRS) response than poorly metastatic ones. MATERIALS AND METHODS:The progressive (PRO) subline showing tumourigenicity and metastatic potential and the regressive (REG) subline showing neither tumourigenicity nor metast...

journal_title：International journal of radiation biology

authors： Thomas C,Charrier J,Massart C,Cherel M,Fertil B,Barbet J,Foray N

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:The present study was designed to reveal, whether the 30 min daily full body exposure of mice to an inhomogeneous static magnetic field (SMF) has a statistically significant effect on diabetic neuropathy. MATERIALS AND METHODS:Three different doses (100, 150, or 200 mg/kg) of streptozotocin (STZ) were administ...

journal_title：International journal of radiation biology

authors： László JF,Szilvási J,Fényi A,Szalai A,Gyires K,Pórszász R

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:Theoretical modelling techniques are often used to simulate the action of ionizing radiations on cells at the nanometre level. Using monoenergetic vacuum-UV (VUV) radiation to irradiate DNA either dry or humidified, the action spectra for the induction of DNA damage by low energy photons and the role of water a...

journal_title：International journal of radiation biology

authors： Folkard M,Prise KM,Vojnovic B,Brocklehurst B,Michael BD

更新日期：2000-06-01 00:00:00

abstract：:Nitrous oxide reacts during irradiation to increase the yield of .OH, a radical many believe to be a major cause of lethality. Logically, one would expect N2O to be a radiation sensitizer. In some instances it is, while in others it is not. In some cases we can explain why N2O fails to sensitize; factors such as dose ...

journal_title：International journal of radiation biology

authors： Ewing D,Walton HL,Guilfoil DS,Ohm MB

更新日期：1991-03-01 00:00:00