Induction of DNA double-strand breaks in CHO-K1 cells by carbon ions.

abstract：PURPOSE:The purpose of this work was to determine whether the cellular components of Hairless-rat skin are affected by a chronic local exposure to non-ionizing radiations of Global Mobile Phone System: GSM-900 or -1800 radiations at specific absorption rate (SAR) 2.5 and 5 W/kg. MATERIALS AND METHODS:A selected part o...

journal_title：International journal of radiation biology

authors： Sanchez S,Masuda H,Billaudel B,Haro E,Anane R,Lévêque P,Ruffie G,Lagroye I,Veyret B

更新日期：2006-09-01 00:00:00

abstract：:Free radical formation in aqueous solutions of ubiquinone (coenzyme Qo) induced by ultrasound was studied by EPR and spin trapping with 3,5-dibromo-4-nitrosobenzene sulphonate. When aqueous solutions of ubiquinone were sonicated with 50-kHz ultrasound in the presence of argon or nitrogen, radicals formed by addition o...

journal_title：International journal of radiation biology

authors： Kondo T,Riesz P

更新日期：1996-01-01 00:00:00

abstract：:The radiation response of 15 mammalian cell lines comprising 11 human tumour, two human fibroblast and two murine lymphoma cell lines, has been analysed using the linear-quadratic equation. As well as using conventional analysis of acute dose-survival curves to derive values for alpha and beta (termed alpha ac and bet...

journal_title：International journal of radiation biology

authors： Peacock JH,Eady JJ,Edwards SM,McMillan TJ,Steel GG

更新日期：1992-04-01 00:00:00

abstract：:Pulsed-field electrophoresis is being used extensively in the gene mapping studies and in the analysis of DNA strand breakage by ionizing radiation. We have evaluated the relationship between the fraction of S phase DNA in a cell population and its ability to modify the migration of DNA in pulsed-field gel electrophor...

journal_title：International journal of radiation biology

authors： Mateos S,Gordon AT,Steel GG,McMillan TJ

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:To give a state-of-the-art overview on the promise of three-dimensional (3-D) culture systems for anticancer drug development, with particular emphasis on multicellular tumor spheroids (MCTS). RESULTS AND CONCLUSIONS:Cell-based assays have become an integral component in many stages of routine anti-tumor drug ...

journal_title：International journal of radiation biology

authors： Friedrich J,Ebner R,Kunz-Schughart LA

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:Ionizing radiation causes various types of DNA damage e.g. single strand breaks (SSB) and double strand breaks (DSB), whereby the SSB/DSB ratio is shifted toward the DSB with increasing LET. For the DNA-incorporated Auger electron emitter Iodine-125 a SSB/DSB ratio of 5.4:1 is calculated based on computer simul...

journal_title：International journal of radiation biology

authors： Unverricht-Yeboah M,Holtmann K,Kriehuber R

更新日期：2020-12-03 00:00:00

abstract：PURPOSE:To determine the relative toxicity of alpha- and beta-radiations under conditions of controlled temporal and spatial dose distribution. METHODS:Fused aluminosilicate particles were radiolabelled with either (45)Ca (a beta-emitter) or (242)Cm (an alpha-emitter). These were injected into CBA/Ca mice to give life...

journal_title：International journal of radiation biology

authors： Priest ND,Hoel DG,Brooks PN

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:To examine whether a simulated mobile telephone transmission at 915 MHz has an effect on cognitive function in man. MATERIALS AND METHODS:Thirty-six subjects in two groups were each given two training sessions and then three test sessions in a randomized three-way cross-over design. About 1 W mean power at 915...

journal_title：International journal of radiation biology

authors： Preece AW,Iwi G,Davies-Smith A,Wesnes K,Butler S,Lim E,Varey A

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:To propose an improved version of RADACK, a stochastic simulation of radiolytic attack on DNA, that takes into account the reactivity of each amino acid of a specifically bound protein with hydroxyl radicals. To apply it to the natural lactose operator-repressor complex taking advantage of recently reported str...

journal_title：International journal of radiation biology

authors： Begusova M,Giliberto S,Gras J,Sy D,Charlier M,Spotheim-Maurizot M

更新日期：2003-06-01 00:00:00

abstract：:Purpose: A study is presented of the irradiation of cancerous cervical cell line HeLa loaded with a platinum salt, betamethasone and deoxyglucose. The presence of the platinum increases the free-radical concentration and augments the cell death rate, whereas betamethasone or deoxyglucose induces radiosensitization by ...

journal_title：International journal of radiation biology

authors： Usami N,Hirayama R,Kobayashi K,Furusawa Y,Le Sech C

更新日期：2020-05-01 00:00:00

abstract：:The structure of mouse skin collagen fibrils after treatment with 0.5, 1 and 2.5 Gy gamma-irradiation was studied by electron microscopy. Animals were sacrificed 1, 4 and 8 weeks after irradiation. Although there were areas where the normal parallel packing of fibrils was retained in some regions packing was interrupt...

journal_title：International journal of radiation biology

authors： Tzaphlidou M,Kounadi E,Leontiou I,Matthopoulos DP,Glaros D

更新日期：1997-01-01 00:00:00

abstract：:The rate of recovery from radiation damage, as a function of dose per fraction, was investigated in mouse skin. Two different experimental designs were used, both incorporating the neutron top-up technique which enables the X-ray dose per fraction to be kept constant whilst changing the interfraction interval. Either ...

journal_title：International journal of radiation biology

authors： Rojas A,Joiner MC,Johns H

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:Terrorist attacks, with their intent to maximize psychological and economic damage as well as inflicting sickness and death on given targeted populations, are an ever-growing worldwide concern in government and public sectors as they become more frequent, violent, and sensational. If given the chance, it is lik...

journal_title：International journal of radiation biology

authors： Singh VK,Hanlon BK,Santiago PT,Seed TM

更新日期：2017-09-01 00:00:00

abstract：:Purpose: Ionizing radiation is a risk factor to the whole organism, including the heart. Cardiac damage is considered to be a late effect of radiation exposure. While the acute cardiotoxicity of high doses is well characterized, the knowledge about nature and magnitude of the cardiac risk following lower doses exposur...

journal_title：International journal of radiation biology

authors： Gramatyka M,Sokół M

更新日期：2020-03-01 00:00:00

abstract：:This paper presents a summary of our understanding to date of the formation of DNA strand breaks induced by highly energetic particle beams (high-LET radiation). We have compared our own recent data on the formation of strand breaks induced in DNA in an aqueous solution with our previous data and those of others avail...

journal_title：International journal of radiation biology

authors： Roots R,Holley W,Chatterjee A,Irizarry M,Kraft G

更新日期：1990-07-01 00:00:00

abstract：PURPOSE:To investigate whether radiation survival of cells irradiated aerobically in the oxygen-sensitive restriction point in late G1 is dependent on where in the cell cycle the cells first were rendered hypoxic. MATERIALS AND METHODS:Human cervix carcinoma, NHIK 3025 cells, were synchronized and rendered hypoxic whi...

journal_title：International journal of radiation biology

authors： Koritzinsky M,Furre T,Amellem O,Pettersen EO

更新日期：1998-10-01 00:00:00

abstract：PURPOSE:Estimating the absorbed dose to tumour relative to normal tissues has often been used in the assessment of the therapeutic efficacy of radiolabelled antibodies for radioimmunotherapy. Typically, the calculations assume a uniform dose deposition and response throughout the tumour. However, the heterogeneity of t...

journal_title：International journal of radiation biology

authors： Flynn AA,Pedley RB,Green AJ,Boxer GM,Boden R,Bhatia J,Morris R,Begent RH

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:To evaluate the radioprotective activity of C3, a regioisomer of water-soluble carboxyfullerene and a potent free radical scavenger, on both normal and tumour cells. MATERIALS AND METHODS:The murine committed bone-marrow stem cells for both granulocytes and monocytes (GM-CFC) were used to represent normal cell...

journal_title：International journal of radiation biology

authors： Lin HS,Lin TS,Lai RS,D'Rosario T,Luh TY

更新日期：2001-02-01 00:00:00

abstract：:Wet heat shock (60 degrees C, 90 s) and caffeine (3.8 X 10(-4) M) afford significant radioprotection against post-irradiation O2-dependent damage which develops in seeds of approximately 3.5% moisture content. The damage was assessed in terms of seedling injury on the eighth day of growth. An increase in seedling inju...

journal_title：International journal of radiation biology

authors： Singh SP,Kesavan PC

更新日期：1991-05-01 00:00:00

abstract：:Purpose: To study the response of neuronal-like cells to an applied static or low-frequency magnetic field. Materials and methods: Fourier Transform Infrared (FTIR) Spectroscopy was used to investigate the overall behavior of SH-SY5Y neuronal-like cells exposed to a static or 50 Hz magnetic fields at intensities up to...

journal_title：International journal of radiation biology

authors： Calabrò E,Magazù S

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:The chromosomal radiosensitivity of a selected group of familial breast cancer patients carrying a mutation in BRCA1 (n=11) or BRCA2 (n=9) and a group of healthy mutation carriers (n=12) was investigated and compared to a reference group of breast cancer patients without a BRCA1/2 mutation (n=78) and a group of...

journal_title：International journal of radiation biology

authors： Baeyens A,Thierens H,Claes K,Poppe B,de Ridder L,Vral A

更新日期：2004-10-01 00:00:00

abstract：:Radioiodine ((131)I) induced a dose- and time-dependent increase in DNA single-strand breaks (DNA-ssb) in human (G0) mononuclear blood cells (MNC) in vitro. Incubation of MNC with 22MBq (131)I/ml at 4 degrees C caused a linear, time-dependent induction of DNA-ssb (increase in elution rate: 24.7 x 10(-3) h(-1) per 100 ...

journal_title：International journal of radiation biology

authors： Hengstler JG,Bockisch A,Fuchs J,Grimm W,Zapf AO,Lade K,Meinert R,Oesch-Bartlomowicz B,Tanner B,Oesch F

更新日期：1997-11-01 00:00:00

abstract：:Radiologic accidents or terrorist acts involving radioactive material, as well as radiation exposure in medical or industrial procedures are potential sources of risk for human health. All these risks share a common element, exposure to ionizing radiation. The extent of ionizing radiation injury will depend on a numbe...

journal_title：International journal of radiation biology

authors： Soriano JL,Calpena AC,Souto EB,Clares B

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To find detectable cytogenetic biomarkers that can offer information about the radiation quality of in vivo exposure retrospectively. MATERIALS AND METHODS:Chromosome-type aberrations of peripheral lymphocytes of uterine cancer patients that received internal gamma- and external X-ray therapy or carbon beam th...

journal_title：International journal of radiation biology

authors： Kanda R,Minamihisamatsu M,Tsuji S,Ohmachi Y,Hiraoka T,Shimada Y,Ogiu T,Ohno T,Hayata I

更新日期：2006-07-01 00:00:00

abstract：:Two novel nitroimidazole-carboranes were examined for their uptake and retention in two experimental murine solid tumours and in some normal tissues, using in vivo 11B magnetic resonance spectroscopy. The compounds were injected i.p. at 0.8mmol/kg into mice bearing either the SCCVII/Ha squamous cell carcinoma or KHT s...

journal_title：International journal of radiation biology

authors： Wood PJ,Scobie M,Threadgill MD

更新日期：1996-11-01 00:00:00

abstract：PURPOSE:We already reported that levels of interferon (IFN)-γ have been shown to be markedly reduced in mice seven weeks after irradiation, resulting in a T helper (Th) 1/Th2 imbalance. To investigate whether the single or fractionated γ-irradiation induced an immune imbalance, we analysed the Th1-related immune respon...

journal_title：International journal of radiation biology

authors： Park HR,Jo SK,Eom HS

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:To determine the involvement of c-Jun NH(2)-terminal kinase-1 (JNK1) and possibly of HSP27 in heat-induced apoptosis of human monoblastic leukaemia U937 cells. MATERIALS AND METHODS:Dominant negative JNK1 (APF), in which the phosphorylation sites Thr-Pro-Tyr were changed to Ala-Pro-Phe, was overexpressed in U9...

journal_title：International journal of radiation biology

authors： Enomoto A,Suzuki N,Liu C,Kang Y,Zhu J,Serizawa S,Matsumoto Y,Morita A,Ito M,Hosoi Y

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:Caveolin-1 is a membrane protein highly expressed in many tumors and plays an important role in tumor progression and metastasis. This review describes the structure of the Caveolin-1 protein and its pre-clinical and clinical significance, demonstrating that Caveolin-1 is a novel biomarker for radioresistance w...

journal_title：International journal of radiation biology

authors： Mahmood J,Zaveri SR,Murti SC,Alexander AA,Connors CQ,Shukla HD,Vujaskovic Z

更新日期：2016-12-01 00:00:00

abstract：:Ionizing radiation induces both quantitative and qualitative changes in the lymphoid cells of both man and experimental animals, including inhibition of antibody responses. However, the cellular basis of this immunological lesion is not clear. In the present study, groups of mice were exposed to 2.0 Gy gamma-rays or s...

journal_title：International journal of radiation biology

authors： Goud SN

更新日期：1995-04-01 00:00:00

abstract：:The repair activity of verbascoside (VER), isolated from Pedicularis spicata, towards the oxidizing hydroxyl radical adduct of dGMP and its reaction mechanism were studied using pulse radiolysis. Upon pulse radiolysis of nitrous oxide saturated aqueous solution of 2'-deoxyguanosine-5'-monophosphate (dGMP) and VER, it ...

journal_title：International journal of radiation biology

authors： Li W,Zheng R,Su B,Jia Z,Li H,Jiang Y,Yao S,Lin N

更新日期：1996-04-01 00:00:00