Abstract：
:Murine bone marrow contains osteogenic precursor cells that undergo differentiation during in vitro cultivation. In vitro these cells are potential target cells for alpha-irradiation-induced bone tumour formation. Under defined tissue culture conditions these differentiating cells were directly exposed to alpha-particle irradiation from the radon daughter 210Po. Po deposits in soft tissue and it was shown to be associated with marrow cells and with the extracellular marrow tissue formed in vitro. These differentiating marrow cultures showed high sensitivity to alpha-irradiation. Cell death was observed at 210Po concentrations in tissue culture medium (TCM) > 7 Bq 210Po/ml. At lower concentrations (between 1 and 5 Bq 210Po per ml TCM) proliferation was enhanced as measured by uptake of 3H-thymidine, also differentiation was stimulated as measured by alkaline phosphatase activity and incorporation of 3H-proline in newly synthesized collagen. At several times of culture, the association of 210Po with the extracellular matrix and cells was measured. These retention data enabled us to calculate the daily alpha-particle fluence. At 1 Bq 210Po present per ml tissue culture, a daily alpha-particle fluence as low as 3-6 per 1000 cells seemed very efficient in changing the expression of osteogenic differentiation of marrow cells.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Schoeters GE,Vander Plaetse F,van den Heuvel RLdoi
10.1080/09553009414551111subject
Has Abstractpub_date
1994-08-01 00:00:00pages
207-14issue
2eissn
0955-3002issn
1362-3095pii
NH4DFCWXH3EBQ96Xjournal_volume
66pub_type
杂志文章abstract：:Tikvah Alper's interest in science was broad, from scrapie to mammalian cells and cancer. Much of her own work focused on cell lethality, like that of many other radiobiologists, but this was natural because of the simplicity of the endpoint cell survival and its relevance to cancer therapy. Tikvah had broader interes...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530097143662
更新日期：1997-06-01 00:00:00
abstract：:Human ovarian carcinoma parental and cisplatin-resistant cells were evaluated for their radiation sensitivity to high and low dose-rate irradiation and for the effectiveness of cisplatin in radiosensitization. The cisplatin resistant variant A2780cp showed increased radiation resistance for both low dose-rate (LDRI) a...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530096145634
更新日期：1996-05-01 00:00:00
abstract：:Cell cultures derived from skin biopsies of mouse fetuses X-irradiated at the zygote stage (2 Gy) were studied for the presence of chromosomal aberrations and micronuclei. In comparison with cells from control, unirradiated fetuses significantly higher spontaneous frequencies of aberrations per 100 metaphases and aber...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553008914550091
更新日期：1989-01-01 00:00:00
abstract：:Male SAS/4 mice were injected i.v. with 6.6 kBq 239Pu-citrate. After 1 or 24 h a single i.p. injection of 15 or 30 mumol kg-1 or repeated (three or four) daily injections of 30 mumol kg-1 of tetra-THB-spermine were given, and at 4 or 7 days Pu retention was measured in liver, kidneys and femur. Besides tetra-THB-sperm...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553008914550141
更新日期：1989-01-01 00:00:00
abstract：PURPOSE:To test the importance of serotonin as a signaling molecule involved in the production and response of radiation-induced bystander effects. MATERIALS AND METHODS:HPV-G human keratinocyte cultures were spiked with various concentrations of Granisetron or Ketanserin and subject to either 0 Gy or 0.5 Gy X-irradia...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2012.714519
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:To investigate the effect of lupeol, a pentacyclictriterpene, on the radiosensitivity of a human hepatocellular carcinoma (HCC) in vitro and in vivo xenografts. METHODS:SMMC-7721 cells were exposed to γ-radiation with or without lupeol and assayed for proliferation, clonogenic survival, apoptosis and cell cycl...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2015.966209
更新日期：2015-02-01 00:00:00
abstract：:This study evaluated the cell-mediated (CMI) and humoral immune responses in four Beagle dogs five to six years after single inhalation exposures to different monodisperse 239PuO2 aerosols (0.72-1.4 microns activity median aerodynamic diameter). These exposures resulted in initial lung burdens ranging from 19 to 35 kB...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553008914550311
更新日期：1989-02-01 00:00:00
abstract：:The radiation response of 15 mammalian cell lines comprising 11 human tumour, two human fibroblast and two murine lymphoma cell lines, has been analysed using the linear-quadratic equation. As well as using conventional analysis of acute dose-survival curves to derive values for alpha and beta (termed alpha ac and bet...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009214551241
更新日期：1992-04-01 00:00:00
abstract：:Purpose: Present study deals with the role of gamma irradiation in modulating lead (Pb) tolerance of Aspergillus niger van Tieghem. and Penicillium cyclopium Westling. Materials and methods: After being exposed to gamma absorbed doses those fungal strains were subjected to heavy metal uptake efficacies and anti-oxidat...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2019.1569769
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:To evaluate the radiomodulatory influence of a leaf extract of Mentha piperita (Linn) on hepatic antioxidant status and lipid peroxidation in Swiss albino mice. MATERIALS AND METHODS:Animals were given either double distilled water or leaf extract of M. piperita orally (1 g/kg bwt/day) once a day for three con...
journal_title：International journal of radiation biology
pub_type： 杂志文章,收录出版
doi：10.1080/09553000600771523
更新日期：2006-05-01 00:00:00
abstract：:This paper presents a summary of our understanding to date of the formation of DNA strand breaks induced by highly energetic particle beams (high-LET radiation). We have compared our own recent data on the formation of strand breaks induced in DNA in an aqueous solution with our previous data and those of others avail...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.1080/09553009014551431
更新日期：1990-07-01 00:00:00
abstract：PURPOSE:To evaluate whether immunotherapy based on adoptively transferred cytotoxic T-cells (CTL) can improve the antitumour efficacy of irradiation. MATERIAL AND METHODS:The experiments were performed using the human squamous cell carcinoma line UT-SCC-15, which expresses human leukocyte antigen (HLA)-A2. The UT-SCC-...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000701570196
更新日期：2007-11-01 00:00:00
abstract：:An iodinated DNA ligand, iodo Hoechst 33258, which binds in the minor groove of DNA, enhances DNA strand breakage and cell killing by UV-A irradiation. The sites of UV-induced strand breaks reflect the known sequence specificity of the ligand. ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009014551061
更新日期：1990-05-01 00:00:00
abstract：PURPOSE:To study the natural radionuclides in the freshwater fish samples around the uranium mining areas of Bagjata and Banduhurang, East Singhbhum, Jharkhand, India. MATERIALS AND METHODS:The naturally occurring radioisotopes of uranium, U(nat), consisting of (234)U, (235)U and (238)U; (226)Ra, (230)Th and (210)Po w...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2010.492490
更新日期：2010-11-01 00:00:00
abstract：:To characterize further the radiosensitivity of severe combined immunodeficiency (scid) mice, the induction of micronuclei (MN) in polychromatic erythrocytes as well as cell killing and translocation induction in stem cell spermatogonia was studied. Scid mice turned out to be clearly hypersensitive for X-ray-induced c...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009514550661
更新日期：1995-05-01 00:00:00
abstract：PURPOSE:The radiation-induced bystander effect (RIBE) has important implications for the efficiency of radiotherapy but the underlying role of cellular metabolism is widely unknown. The roles of synthesis of cytochrome c oxidase 2 (SCO2), a key effector for respiratory chain, and related signaling factors in α-particle...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2013.817706
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:Up to 90% of hereditary breast cancer cases are linked to germ-line mutations in one of the two copies of the BRCA1 or BRCA2 genes. Brca1 and Brca2 proteins are both involved in the cellular defence against DNA damage, although the precise function of the proteins is still not known. Some studies on a small num...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000110097974
更新日期：2002-04-01 00:00:00
abstract：PURPOSE:The aim was to evaluate the utility of multiple blood-protein biomarkers for early-response assessment of radiation exposure using a murine radiation model system. MATERIAL AND METHODS:BALB/c male mice (8-10 weeks old) were exposed to whole-body 60Co gamma-rays (10 cGy min(-1)) over a broad dose range (0-7 Gy)...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:Mouse C3H 10T1/2 cells are most sensitive to radiation-induced neoplastic transformation in the G2/M-phase of the cell cycle. When synchronized 10T1/2 cells were exposed to phorbol 12-myristate 13-acetate (TPA) after irradiation, transformation of cells not in the transformation-sensitive window was enhanced, but tran...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009314551971
更新日期：1993-12-01 00:00:00
abstract：PURPOSE:To seek the delayed appearance of chromosomal abnormalities in human fibroblasts exposed to the Auger electron emitter 125I. MATERIALS AND METHODS:Normal untransformed human fibroblasts, HF19, were exposed to a concentration of [I125]IUdR, which allowed the survival of 37% of clonogens. Chromosomal analysis us...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000050050972
更新日期：2000-07-01 00:00:00
abstract：:The behaviour of polyamines (putrescine, spermidine and spermine) in the small intestine was studied in rats exposed to a single whole-body dose of 3 Gy administered at four different times of the day. Polyamine content decreased a few hours after irradiation but quickly returned to normal values. Putrescine levels re...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553008914551191
更新日期：1989-07-01 00:00:00
abstract：:Lambda-prophage induction in repair-deficient and wild-type E. coli strains by heavy ions and gamma-rays has been investigated. The dose dependence of the fraction of induced cells has been measured and its initial slope (lambda-induction potency) determined. The induction by gamma-rays was found to be more efficient ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009014551111
更新日期：1990-05-01 00:00:00
abstract：PURPOSE:Zearalenone is a potent estrogenic metabolite produced by some Fusarium and Gibberella species. Therefore, the aim of this study was to determine the accumulation of Technetium-[99m]-labeled zearalenone in mice organs as well as to study the protective effect of Lactobacillus plantarum. MATERIALS AND METHODS:T...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2019.1524990
更新日期：2018-12-01 00:00:00
abstract：:Most estimates of the radiation dose lethal to 50 per cent of a human population are based on historical data taken from well-known experiences reflecting inadequately known physical and biological conditions, or from medical procedures where individual patients received advantages of modern clinical care. It has been...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553008914550481
更新日期：1989-03-01 00:00:00
abstract：:Chromosomes are located within the interphase nucleus in regions called domains. Using fluorescence in situ hybridization with whole chromosome paints, a pain of homologous chromosomes can be visualized as two discrete domains and their relative spatial location determined. This study examines the effects of an ionizi...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530097143293
更新日期：1997-09-01 00:00:00
abstract：:A radionuclide release assay for measuring the in vitro kinetics of cell death has been developed. CHO cells were labelled for 24 h with 3.0 hBq/ml of [125I] iododeoxyuridine (125IUdR) and the fate of the labelled cells and their progeny was monitored at daily intervals by measuring the rate of 125I release. Prelabell...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009114550361
更新日期：1991-02-01 00:00:00
abstract：:Recent evidence indicates that isoeffect doses for spinal cord and kidney may be overestimated for fraction sizes as small as 1 or 2 Gy when calculated from a linear-quadratic (LQ) model fitted to data obtained for fraction sizes larger than 2 Gy. Reasons for this are unknown, but possible interpretations include exha...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553008814551461
更新日期：1988-07-01 00:00:00
abstract：PURPOSE:To examine whether the levels of micronuclei induction, as a marker for genomic instability in the progeny of X-irradiated cells, correlates with DNA repair function. MATERIALS AND METHODS:Two repair deficient cell lines (X-ray repair cross-complementing 1 [XRCC1] deficient cell line [EM9] and X-ray repair cro...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2013.752596
更新日期：2013-04-01 00:00:00
abstract：:The relationship between ionizing radiation-induced cell killing and DNA damage measured by the micronucleus and apoptosis assays was determined in three established cell lines (L929, HL-60, and Chang). Irradiation experiments revealed a dose-dependent increase of micronucleated cells until a certain dose was reached....
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009514550371
更新日期：1995-03-01 00:00:00
abstract：:A study has been made of the intrinsic radiosensitivity of peripheral blood lymphocytes from normal individuals. Cell survival following in vitro high (1.55 Gy min-1) and low (0.0098 Gy min-1) dose-rate irradiation was obtained for single lymphocyte samples from three individuals in six experiments. Despite wide inter...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009314551571
更新日期：1993-10-01 00:00:00
