Polyamines in the small intestine of rats after whole-body irradiation.

Abstract:

:The behaviour of polyamines (putrescine, spermidine and spermine) in the small intestine was studied in rats exposed to a single whole-body dose of 3 Gy administered at four different times of the day. Polyamine content decreased a few hours after irradiation but quickly returned to normal values. Putrescine levels reached the lowest values and returned to the control levels later than spermidine and spermine. A temporary increase in spermidine and spermine content was observed from 5 to 20 days. The postirradiation behaviour of the animals exposed at different times of the day showed no important differences. Polyamine modifications were studied in relation to [3H]thymidine uptake and other morphological and biochemical parameters. The results indicate that polyamine content can be used to monitor the damage and recovery phases of radiation injury in the small intestine.

journal_name

Int J Radiat Biol

authors

Becciolini A,Porciani S,Lanini A,Attanasio M

doi

10.1080/09553008914551191

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

67-73

issue

1

eissn

0955-3002

issn

1362-3095

pii

5YDWJFN8K1K6UAWK

journal_volume

56

pub_type

杂志文章
  • The combined effect of fludarabine monophosphate and radiation as well as gemcitabine and radiation on squamous carcinoma tumor cell lines in vitro.

    abstract:PURPOSE:Despite proven antitumor activity of gemcitabine in chemoradiotherapy of advanced head and neck cancer, many authors refer to severe acute and late local and haematological toxicity. Fludarabine does imply nearly the same mechanisms of action as gemcitabine, inhibiting various enzymes involved in DNA replicatio...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000802241754

    authors: Nitsche M,Christiansen H,Hermann RM,Lucke EM,Peters K,Rave-Frank M,Schmidberger H,Pradier O

    更新日期:2008-08-01 00:00:00

  • Correlation between mitotic delay and aberration burden, and their role for the analysis of chromosomal damage.

    abstract::The aim was to investigate further the relationship between radiation-induced mitotic delay and the expression of chromosome damage in V79 cells. Recently published data on the time-course of chromosome aberrations in V79 first-cycle metaphases after exposure to 10.4 MeV u(-1) Ar ions (LET = 1226 keV microm(-1)) were ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000400027902

    authors: Gudowska-Nowak E,Kleczkowski A,Nasonova E,Scholz M,Ritter S

    更新日期:2005-01-01 00:00:00

  • The long-term effects of γ-radiation on the growth of Allium cepa plants.

    abstract:PURPOSE:The purpose of this study was to assess the long-term effects of gamma-radiation, including low-dose radiation, on growth parameters of onion (Allium cepa) seedling roots 6-10 days after irradiation. MATERIALS AND METHODS:Onion seedlings were exposed to a 137Cs gamma source at doses ranging from 0.1 to 10 gray...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2021.1844337

    authors: Bolsunovsky A,Trofimova E,Dementyev D,Petrichenkov M

    更新日期:2020-11-16 00:00:00

  • Collaborative exercise on the use of FISH chromosome painting for retrospective biodosimetry of Mayak nuclear-industrial personnel.

    abstract:PURPOSE:To investigate within the framework of a multilaboratory study the suitability of FISH chromosome painting to measure so-called stable translocations in peripheral lymphocytes of Mayak nuclear-industrial workers (from the Southern Urals) and their use for retrospective biodosimetry. MATERIALS AND METHODS:Chrom...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,多中心研究

    doi:10.1080/09553000010018693

    authors: Bauchinger M,Braselmann H,Savage JR,Natarajan AT,Terzoudi GI,Pantelias GE,Darroudi F,Figgitt M,Griffin CS,Knehr S,Okladnikova ND,Santos S,Snigiryova G

    更新日期:2001-03-01 00:00:00

  • Effect of local exposure to inhomogeneous static magnetic field on stomatological pain sensation - a double-blind, randomized, placebo-controlled study.

    abstract:PURPOSE:Static magnetic field (SMF) exposure was shown experimentally to beneficially affect the healing process. The aim of this randomized, controlled trial was to evaluate the pain-inhibitory effect of local exposure to SMF on temporomandibular disorders, on alveolitis and on aphta in the oral mucosa. MATERIALS AND...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/09553002.2012.661916

    authors: László JF,Farkas P,Reiczigel J,Vágó P

    更新日期:2012-05-01 00:00:00

  • Cytotoxicity of cigarette smoke condensate is not due to DNA double strand breaks: Comparative studies using radiosensitive mutant and wild-type CHO cells.

    abstract:PURPOSE:To determine whether cigarette smoke condensate (CSC) without metabolic activation induces direct DNA double strand breaks (DSB) in the G1 phase of various radiosensitive mutants of CHO cells and whether these breaks display collateral hypersensitivity to CSC with respect to cell killing. MATERIALS & METHODS:W...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000701481790

    authors: Kato T,Nagasawa H,Warner C,Okayasu R,Bedford JS

    更新日期:2007-09-01 00:00:00

  • Low-dose hyper-radiosensitivity of progressive and regressive cells isolated from a rat colon tumour: impact of DNA repair.

    abstract:PURPOSE:To ask whether highly metastatic sublines show more marked low-dose hyper-radiosensitivity (HRS) response than poorly metastatic ones. MATERIALS AND METHODS:The progressive (PRO) subline showing tumourigenicity and metastatic potential and the regressive (REG) subline showing neither tumourigenicity nor metast...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000802195331

    authors: Thomas C,Charrier J,Massart C,Cherel M,Fertil B,Barbet J,Foray N

    更新日期:2008-07-01 00:00:00

  • Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans - joint RENEB and EURADOS inter-laboratory comparisons.

    abstract:PURPOSE:RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2016.1206233

    authors: Ainsbury E,Badie C,Barnard S,Manning G,Moquet J,Abend M,Antunes AC,Barrios L,Bassinet C,Beinke C,Bortolin E,Bossin L,Bricknell C,Brzoska K,Buraczewska I,Castaño CH,Čemusová Z,Christiansson M,Cordero SM,Cosler G,Mo

    更新日期:2017-01-01 00:00:00

  • Expression of genes and pathways associated with the B7-CD28 superfamily in response to irradiation of blood cells using 137Cs.

    abstract:PURPOSE:DNA damage is one of the main consequences of exposure to ionizing irradiation (IR). Recent studies indicate that IR can modulate the expression of immune system-related genes. However, the effects of IR on the expression of genes and pathways of the B7-CD28 superfamily remain poorly defined. The aim of this st...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2021.1857454

    authors: Silveira DA,Ribeiro FM,Simão ÉM,Mattos VLD,Góes EG

    更新日期:2020-12-17 00:00:00

  • Automated micronucleus (MN) scoring for population triage in case of large scale radiation events.

    abstract:PURPOSE:In case of a large-scale radiation accident when hundreds of people may be exposed, it is important to distinguish the severely exposed individuals (> or =1 gray), who require early medical treatment, from those less exposed. The aim of our study was to develop a quick population triage method based on automate...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553000903264481

    authors: Willems P,August L,Slabbert J,Romm H,Oestreicher U,Thierens H,Vral A

    更新日期:2010-01-01 00:00:00

  • Putative determinants of the cellular response to hyperthermia.

    abstract::Recently, it has been demonstrated that two different thermal resistant states found in Chinese hamster cells, one transient, associated with thermotolerance, and the other permanent, associated with the increased expression of the cognate member of the hsp 70 family, are characterized by faster recovery from heat-ind...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009314450751

    authors: Laszlo A,Davidson T,Hu A,Landry J,Bedford J

    更新日期:1993-05-01 00:00:00

  • Capabilities of the RENEB network for research and large scale radiological and nuclear emergency situations.

    abstract:PURPOSE:To identify and assess, among the participants in the RENEB (Realizing the European Network of Biodosimetry) project, the emergency preparedness, response capabilities and resources that can be deployed in the event of a radiological or nuclear accident/incident affecting a large number of individuals. These ca...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2016.1227107

    authors: Monteiro Gil O,Vaz P,Romm H,De Angelis C,Antunes AC,Barquinero JF,Beinke C,Bortolin E,Burbidge CI,Cucu A,Della Monaca S,Domene MM,Fattibene P,Gregoire E,Hadjidekova V,Kulka U,Lindholm C,Meschini R,M'Kacher R,Moquet

    更新日期:2017-01-01 00:00:00

  • Detection and sequencing of ionizing radiation-induced DNA rearrangements using the inverse polymerase chain reaction.

    abstract:PURPOSE:To develop a procedure, using the inverse polymerase chain reaction, to detect and sequence ionizing radiation-induced DNA rearrangements without prior phenotypic selection of mutant cells. METHOD:Normal human fibroblast cells (IMR-90) were given 30Gy of gamma-irradiation and then incubated at 37 degrees C for...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530098141672

    authors: Forrester HB,Radford IR

    更新日期:1998-07-01 00:00:00

  • Hypoxic cell sensitization: low-dose intrinsic radiosensitivity is predictive for etanidazole efficacy in a panel of human tumour cell lines.

    abstract::We used a cell sorter assay to evaluate the efficacy of the hypoxic cell sensitizer etanidazole over 3-4 logs of cell inactivation, with particular attention to the clinically relevant low-dose survival region. Analysis of the radiation responses in a panel of six human tumour cell lines under conditions of hypoxia an...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530096144617

    authors: Wouters BG,Sy AM,Skarsgard LD

    更新日期:1996-12-01 00:00:00

  • The in vivo effects of low-intensity radiofrequency fields on the motor activity of protozoa.

    abstract:PURPOSE:To analyze the direct and transgenerational effects of exposure to low-dose 1 GHz (mobile phone/wireless telecommunication range) and 10 GHz (radar/satellite communication range) radiofrequency electromagnetic fields (RF-EMF) on the motility of ciliates Spirostomum ambiguum. MATERIALS AND METHODS:S. ambiguum w...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2014.868612

    authors: Sarapultseva EI,Igolkina JV,Tikhonov VN,Dubrova YE

    更新日期:2014-03-01 00:00:00

  • Gamma and pulse radiolysis investigation of the reaction of desferrioxamine with superoxide anions.

    abstract::The kinetic scheme of the reaction of desferrioxamine (DFO) with O2-. was studied using pulse and gamma-radiolysis. The rate constant k(O2-. + DFO) is equal to 1.3 +/- 0.1 x 10(6) dm3 mol-1s-1 at pH 7.4. Studying the competition between DFO and ferricytochrome-c for O2-. generated by gamma-radiolysis, we observed that...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553008914552381

    authors: Sabourault D,Ribiere C,Nordmann R,Houee-Levin C,Ferradini C

    更新日期:1989-12-01 00:00:00

  • Consequences of a large-scale nuclear accident and guidelines for evacuation: a cost-effectiveness analysis.

    abstract:PURPOSE:We aimed for a quantitative evaluation that justifies guidelines for evacuation which take into consideration both the human and economic costs. To the best of our knowledge, such an evaluation has not been performed yet. The present guidelines published by the International Atomic Energy Agency (IAEA) are prob...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2020.1779962

    authors: Yanovskiy M,Levi ON,Shaki YY,Socol Y

    更新日期:2020-11-01 00:00:00

  • Ataxia-telangiectasia in Italy: genetic analysis.

    abstract::Genetic analysis was performed on 72 Italian A-T families ascertained through 91 probands. The frequency of the A-T gene was estimated through Dahlberg's formula, which uses the frequencies of first cousin marriages among the patients' parents and in the general population were obtained from the collection of Catholic...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:

    authors: Chessa L,Lisa A,Fiorani O,Zei G

    更新日期:1994-12-01 00:00:00

  • RBE of α-particles from (211)At for complex DNA damage and cell survival in relation to cell cycle position.

    abstract:PURPOSE:To investigate cell cycle effects and relative biological effectiveness (RBE) of α-particles from the clinically relevant radionuclide Astatine-211 ((211)At), using X-rays as reference radiation. Double-strand breaks (DSB), non-DSB clusters containing oxidised purines and clonogenic survival were investigated. ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2011.538127

    authors: Claesson K,Magnander K,Kahu H,Lindegren S,Hultborn R,Elmroth K

    更新日期:2011-04-01 00:00:00

  • Fullerenes as a new class of radioprotectors.

    abstract:PURPOSE:To evaluate the radioprotective activity of C3, a regioisomer of water-soluble carboxyfullerene and a potent free radical scavenger, on both normal and tumour cells. MATERIALS AND METHODS:The murine committed bone-marrow stem cells for both granulocytes and monocytes (GM-CFC) were used to represent normal cell...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530001750068966

    authors: Lin HS,Lin TS,Lai RS,D'Rosario T,Luh TY

    更新日期:2001-02-01 00:00:00

  • Chromosome painting of radiation-induced micronuclei.

    abstract::In this report, in situ hybridization with whole chromosome painting probes was used to paint radiation-induced micronuclei (MN) in three lymphoblastoid cells lines to investigate the frequency of radiation-induced MN. The results obtained for four different chromosomes showed that there was a significant deviation of...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530096144860

    authors: Slavotinek A,Sauer-Nehls S,Braselmann H,Taylor GM,Nüsse M

    更新日期:1996-10-01 00:00:00

  • Cell signalling and radiation survival: the impact of protein phosphatases.

    abstract:PURPOSE:This review will examine the role of phosphatases in cancer cell signalling and also outline emerging findings regarding the influence of phosphatases on tumor cell survival after ionising radiation. CONCLUSION:The exposure of tumour cells to clinically relevant doses of ionising radiation causes DNA damage an...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.3109/09553000903232827

    authors: Hamilton J,Bernhard EJ

    更新日期:2009-11-01 00:00:00

  • Lupeol enhances radiosensitivity of human hepatocellular carcinoma cell line SMMC-7721 in vitro and in vivo.

    abstract:PURPOSE:To investigate the effect of lupeol, a pentacyclictriterpene, on the radiosensitivity of a human hepatocellular carcinoma (HCC) in vitro and in vivo xenografts. METHODS:SMMC-7721 cells were exposed to γ-radiation with or without lupeol and assayed for proliferation, clonogenic survival, apoptosis and cell cycl...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2015.966209

    authors: Jin Y,Lyu Y,Tang X,Zhang Y,Chen J,Zheng D,Liang Y

    更新日期:2015-02-01 00:00:00

  • Hypoxia-specific inhibition of recovery from radiation damage by a novel 2-nitroimidazole with a theophylline side chain.

    abstract::A novel 2-nitroimidazole with a theophylline side-chain, 7-(4'-(2-nitroimidazol-1-yl)-butyl)-theophylline, (NITP) was as efficient a hypoxic-cell radiosensitizer as misonidazole. However, if cells were irradiated with NITP under hypoxic conditions and then exposed to the drug under aerobic conditions, a much larger ra...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009214551671

    authors: Hodgkiss RJ,Kelleher E,Parrick J

    更新日期:1992-06-01 00:00:00

  • Molecular hydrogen attenuates radiation-induced nucleobase damage to DNA in aerated aqueous solutions.

    abstract:PURPOSE:The main aim of the present study is to gain mechanistic insights into the modulating effect of molecular hydrogen on the γ-radiation-induced alteration pathways of DNA nucleobases. MATERIALS AND METHODS:Aerated aqueous solutions of calf thymus DNA were exposed to a (60)Co source at doses ranging from 0 to 55 ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2016.1206234

    authors: Abou-Hamdan M,Gardette B,Cadet J,Gharib B,De Reggi M,Douki T,Triantaphylides C

    更新日期:2016-09-01 00:00:00

  • Radioprotection of the rat intestinal mucosa by tirilazad.

    abstract:PURPOSE:To assess intestinal radioprotection by systemic or lumenal tirilazad mesylate and to test potential tumour radioprotection. MATERIALS AND METHODS:Segments of the mid small bowel were surgically exteriorized. Tirilazad was given either intravenously or intralumenally 30 min prior to 11 Gy of X-irradiation to t...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530098142617

    authors: Felemovicius I,Bonsack ME,Griffin RJ,Delaney JP

    更新日期:1998-02-01 00:00:00

  • Uptake and retention of nitroimidazole-carboranes designed for boron neutron capture therapy in experimental murine tumours: detection by 11B magnetic resonance spectroscopy.

    abstract::Two novel nitroimidazole-carboranes were examined for their uptake and retention in two experimental murine solid tumours and in some normal tissues, using in vivo 11B magnetic resonance spectroscopy. The compounds were injected i.p. at 0.8mmol/kg into mice bearing either the SCCVII/Ha squamous cell carcinoma or KHT s...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530096144798

    authors: Wood PJ,Scobie M,Threadgill MD

    更新日期:1996-11-01 00:00:00

  • Induction and persistence of chromosomal exchanges in mouse bone marrow cells following whole-body exposure to X-rays.

    abstract:PURPOSE:To investigate the induction and persistence of chromosome aberrations in mouse bone marrow cells after X-ray exposure and to detect differential involvement of individual chromosomes in translocations. MATERIALS AND METHODS:Male and female Swiss mice were exposed to 1 and 3 Gy of X-rays. Chromosome aberration...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530099139593

    authors: Xiao Y,Darroudi F,Grigorova M,Natarajan AT

    更新日期:1999-09-01 00:00:00

  • Experimental anti-tumor therapy in 3-D: spheroids--old hat or new challenge?

    abstract:PURPOSE:To give a state-of-the-art overview on the promise of three-dimensional (3-D) culture systems for anticancer drug development, with particular emphasis on multicellular tumor spheroids (MCTS). RESULTS AND CONCLUSIONS:Cell-based assays have become an integral component in many stages of routine anti-tumor drug ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553000701727531

    authors: Friedrich J,Ebner R,Kunz-Schughart LA

    更新日期:2007-11-01 00:00:00

  • DNA strand-break yields after post-irradiation incubation with base excision repair endonucleases implicate hydroxyl radical pairs in double-strand break formation.

    abstract:PURPOSE:To determine the increases in SSB and DSB yields after post gamma-irradiation incubation of plasmid DNA with the Escherichia coli base excision repair endonucleases formamidopyrimidine-DNA N-glycosylase (FPG) and endonuclease III (endo III). MATERIALS AND METHODS:Aqueous solutions of plasmid DNA were irradiate...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000050176234

    authors: Milligan JR,Aguilera JA,Nguyen TT,Paglinawan RA,Ward JF

    更新日期:2000-11-01 00:00:00