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Daily exposure to inhomogeneous static magnetic field significantly reduces blood glucose level in diabetic mice.

Abstract：

PURPOSE:The present study was designed to reveal, whether the 30 min daily full body exposure of mice to an inhomogeneous static magnetic field (SMF) has a statistically significant effect on diabetic neuropathy. MATERIALS AND METHODS:Three different doses (100, 150, or 200 mg/kg) of streptozotocin (STZ) were administered intraperitoneally in groups of mice to induce diabetes. Body weight, blood glucose level and the nociceptive temperature threshold of mice were monitored for a period of 12 weeks. The group treated with 200 mg/kg i.p. STZ produced manifest diabetic neuropathy. Results were compared to non-treated (no SMF, no STZ) and SMF exposure without STZ-treatment group (SMF, no STZ) group. The inhomogeneous SMF was in the range of 2.8-476.7 mT peak-to-peak magnetic flux density. RESULTS:Whereas SMF exposure did not seem to affect body weight and nociceptive temperature threshold, it statistically significantly (p < 0.001) reduced blood glucose level in the 200 mg/kg STZ (n = 6) group. CONCLUSIONS:Daily SMF exposure repeated for several weeks is protective against the development of high blood glucose level in diabetic mice.

journal_name

Int J Radiat Biol

journal_title

International journal of radiation biology

authors

László JF,Szilvási J,Fényi A,Szalai A,Gyires K,Pórszász R

doi

10.3109/09553002.2010.518200

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

36-45

issue

1

eissn

0955-3002

issn

1362-3095

journal_volume

87

pub_type

杂志文章

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