Abstract:
PURPOSE:This study is part of a general search for the anatomical bases of the severe mental retardation syndrome caused by prenatal irradiation. More specifically, it seeks reasons for the high radiosensitivity of a white matter area, the cingulum of the corpus callosum. MATERIALS AND METHODS:Pregnant primiparous Wistar rats were exposed to X-rays at 12, 13, 14 or 15 days of gestation (E12, E13, E14 or E15) with single low doses of 180 mGy. A high dose of 500 mGy was given at E15 for a complementary study. The brains of the female offspring were collected at 1 and 3 months of age. The affinity of osmium tetroxide for the white matter was used to recognize and quantify cingulum areas in a series of coronal sections made at different positions along the antero-posterior axis of the brains. RESULTS:A 180 mGy dose of X-rays caused an atrophy of the cingulum; the effect was particularly significant in the 1-month-old brains after an exposure at E13 or at E14, and increased in the 3-month-old animals exposed at E15. The axonal size distribution was unchanged in the 3-month-old cingulums treated with 500 mGy at E15. CONCLUSIONS:The atrophy of the cingulum is due to a loss of axons, which are abundant in this area. As a consequence of axon loss, a reduction of the postnatal myelination enhances the volumetric decrease of the cingulum at 3 months of age.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Reyners H,Gianfelici de Reyners E,Yan J,De Saint-Georges L,Desaintes Cdoi
10.1080/095530099139494subject
Has Abstractpub_date
1999-10-01 00:00:00pages
1327-34issue
10eissn
0955-3002issn
1362-3095journal_volume
75pub_type
杂志文章abstract:PURPOSE:The linear nonthreshold (LNT) model has been used in radiation protection for over 40 years and has been hotly debated. It relies heavily on human epidemiology, with support from radiobiology. The scientific underpinnings include NCRP Report No. 136 ('Evaluation of the Linear-Nonthreshold Dose-Response Model fo...
journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
doi:10.1080/09553002.2017.1328750
更新日期:2017-10-01 00:00:00
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journal_title:International journal of radiation biology
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doi:10.1080/095530098142257
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abstract:PURPOSE:One of the most important issues regarding radiofrequency electromagnetic fields (RF-EMF) is their effect on genetic material. Therefore, we investigated the cytogenotoxic effects of 900 MHz radiofrequency electromagnetic fields (RF-EMF) and the effect of a recovery period after exposure to RF-EMF on bone marro...
journal_title:International journal of radiation biology
pub_type: 杂志文章
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abstract:PURPOSE:To investigate the radiosensitisation of gold nanoparticles (GNP) with an average diameter of 5 nm coated with the gadolinium chelating agent dithiolated diethylenetriaminepentaacetic gadolinium (Au@DTDTPA:Gd) in vitro and in mice bearing tumours (MC7-L1). MATERIALS AND METHODS:In vivo, the gadolinium chelate ...
journal_title:International journal of radiation biology
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abstract::Radiation-induced DNA double-strand breaks (dsb) were studied in Ehrlich ascites tumour cells (EATC) by sedimentation in neutral sucrose gradients at low centrifuge speed. Dsb induction was found to be linear with dose with a frequency of: ndsbmr-1D-1 = (11.7 +/- 2) x 10(-12)Gy-1 for 140 kV X-rays and ndsbmr-1D-1 = (1...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553008814552201
更新日期:1988-11-01 00:00:00
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.3109/09553002.2013.762136
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
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doi:10.3109/09553002.2010.487011
更新日期:2010-10-01 00:00:00
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journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
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journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009014551131
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abstract::Radioiodine ((131)I) induced a dose- and time-dependent increase in DNA single-strand breaks (DNA-ssb) in human (G0) mononuclear blood cells (MNC) in vitro. Incubation of MNC with 22MBq (131)I/ml at 4 degrees C caused a linear, time-dependent induction of DNA-ssb (increase in elution rate: 24.7 x 10(-3) h(-1) per 100 ...
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journal_title:International journal of radiation biology
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doi:10.1080/0955300031000137788
更新日期:2003-06-01 00:00:00
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journal_title:International journal of radiation biology
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更新日期:2005-11-01 00:00:00
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009314550411
更新日期:1993-03-01 00:00:00
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journal_title:International journal of radiation biology
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更新日期:2004-08-01 00:00:00