Delayed effects of prenatal low-dose irradiation in the white matter of the rat brain.

Abstract:

PURPOSE:This study is part of a general search for the anatomical bases of the severe mental retardation syndrome caused by prenatal irradiation. More specifically, it seeks reasons for the high radiosensitivity of a white matter area, the cingulum of the corpus callosum. MATERIALS AND METHODS:Pregnant primiparous Wistar rats were exposed to X-rays at 12, 13, 14 or 15 days of gestation (E12, E13, E14 or E15) with single low doses of 180 mGy. A high dose of 500 mGy was given at E15 for a complementary study. The brains of the female offspring were collected at 1 and 3 months of age. The affinity of osmium tetroxide for the white matter was used to recognize and quantify cingulum areas in a series of coronal sections made at different positions along the antero-posterior axis of the brains. RESULTS:A 180 mGy dose of X-rays caused an atrophy of the cingulum; the effect was particularly significant in the 1-month-old brains after an exposure at E13 or at E14, and increased in the 3-month-old animals exposed at E15. The axonal size distribution was unchanged in the 3-month-old cingulums treated with 500 mGy at E15. CONCLUSIONS:The atrophy of the cingulum is due to a loss of axons, which are abundant in this area. As a consequence of axon loss, a reduction of the postnatal myelination enhances the volumetric decrease of the cingulum at 3 months of age.

journal_name

Int J Radiat Biol

authors

Reyners H,Gianfelici de Reyners E,Yan J,De Saint-Georges L,Desaintes C

doi

10.1080/095530099139494

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

1327-34

issue

10

eissn

0955-3002

issn

1362-3095

journal_volume

75

pub_type

杂志文章
  • The linear nonthreshold (LNT) model as used in radiation protection: an NCRP update.

    abstract:PURPOSE:The linear nonthreshold (LNT) model has been used in radiation protection for over 40 years and has been hotly debated. It relies heavily on human epidemiology, with support from radiobiology. The scientific underpinnings include NCRP Report No. 136 ('Evaluation of the Linear-Nonthreshold Dose-Response Model fo...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553002.2017.1328750

    authors: Boice JD Jr

    更新日期:2017-10-01 00:00:00

  • Angiotensin II receptor antagonists in the treatment and prevention of radiation nephropathy.

    abstract:PURPOSE:Angiotensin-converting enzyme (ACE) inhibitors are effective in the prophylaxis of radiation-induced renal and lung injury. Studies were designed to determine whether blocking the angiotensin II (AII) receptor, rather than blocking AII synthesis with ACE inhibitors, would also be effective. MATERIALS AND METHO...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530098142257

    authors: Moulder JE,Fish BL,Cohen EP

    更新日期:1998-04-01 00:00:00

  • A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part III. Countermeasures under early stages of development along with 'standard of care' medicinal and procedures not requiring regulatory approv

    abstract:PURPOSE:Terrorist attacks, with their intent to maximize psychological and economic damage as well as inflicting sickness and death on given targeted populations, are an ever-growing worldwide concern in government and public sectors as they become more frequent, violent, and sensational. If given the chance, it is lik...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553002.2017.1332440

    authors: Singh VK,Hanlon BK,Santiago PT,Seed TM

    更新日期:2017-09-01 00:00:00

  • Evaluation of the cytogenotoxic damage in immature and mature rats exposed to 900 MHz radiofrequency electromagnetic fields.

    abstract:PURPOSE:One of the most important issues regarding radiofrequency electromagnetic fields (RF-EMF) is their effect on genetic material. Therefore, we investigated the cytogenotoxic effects of 900 MHz radiofrequency electromagnetic fields (RF-EMF) and the effect of a recovery period after exposure to RF-EMF on bone marro...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2013.809170

    authors: Atlı Şekeroğlu Z,Akar A,Şekeroğlu V

    更新日期:2013-11-01 00:00:00

  • Preferential tumour accumulation of gold nanoparticles, visualised by Magnetic Resonance Imaging: radiosensitisation studies in vivo and in vitro.

    abstract:PURPOSE:To investigate the radiosensitisation of gold nanoparticles (GNP) with an average diameter of 5 nm coated with the gadolinium chelating agent dithiolated diethylenetriaminepentaacetic gadolinium (Au@DTDTPA:Gd) in vitro and in mice bearing tumours (MC7-L1). MATERIALS AND METHODS:In vivo, the gadolinium chelate ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553001003746067

    authors: Hébert EM,Debouttière PJ,Lepage M,Sanche L,Hunting DJ

    更新日期:2010-08-01 00:00:00

  • DNA double-strand break repair determines the RBE of alpha-particles.

    abstract::Radiation-induced DNA double-strand breaks (dsb) were studied in Ehrlich ascites tumour cells (EATC) by sedimentation in neutral sucrose gradients at low centrifuge speed. Dsb induction was found to be linear with dose with a frequency of: ndsbmr-1D-1 = (11.7 +/- 2) x 10(-12)Gy-1 for 140 kV X-rays and ndsbmr-1D-1 = (1...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553008814552201

    authors: Blöcher D

    更新日期:1988-11-01 00:00:00

  • Proliferation saturation index in an adaptive Bayesian approach to predict patient-specific radiotherapy responses.

    abstract::Purpose: Radiotherapy prescription dose and dose fractionation protocols vary little between individual patients having the same tumor grade and stage. To personalize radiotherapy a predictive model is needed to simulate radiation response. Previous modeling attempts with multiple variables and parameters have been sh...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2019.1589013

    authors: Sunassee ED,Tan D,Ji N,Brady R,Moros EG,Caudell JJ,Yartsev S,Enderling H

    更新日期:2019-10-01 00:00:00

  • Effects on micronuclei formation of 60-Hz electromagnetic field exposure with ionizing radiation, hydrogen peroxide, or c-Myc overexpression.

    abstract:PURPOSE:Epidemiological studies have demonstrated a possible correlation between exposure to extremely low-frequency magnetic fields (ELF-MF) and cancer. However, this correlation has yet to be definitively confirmed by epidemiological studies. The principal objective of this study was to assess the effects of 60 Hz ma...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2012.652724

    authors: Jin YB,Kang GY,Lee JS,Choi JI,Lee JW,Hong SC,Myung SH,Lee YS

    更新日期:2012-04-01 00:00:00

  • Electron transfer from nucleobase electron adducts to 5-bromouracil. Is guanine an ultimate sink for the electron in irradiated DNA?

    abstract::Electron transfer to 5-bromouracil (5-BrU) from nucleobase (N) electron adducts (and their protonated forms) has been studied by product analysis and pulse radiolysis. When an electron is transferred to 5-BrU, the ensuing 5-BrU radical anion rapidly loses a bromide ion; the uracilyl radical thus formed reacts with add...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009214552451

    authors: Nese C,Yuan Z,Schuchmann MN,Von Sonntag C

    更新日期:1992-11-01 00:00:00

  • Cytogenetic monitoring of hospital staff exposed to ionizing radiation: optimize protocol considering DNA repair genes variability.

    abstract:PURPOSE:Chronic occupational exposure to ionizing radiation (IR) induces a wide spectrum of DNA damages. The aim of this study was to assess the frequencies of micronucleus (MN), sister chromatid exchanges (SCE) and to evaluate their association with XRCC1 399 Arg/Gln and XRCC3 241 Thr/Met polymorphisms in Hospital sta...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2017.1377361

    authors: Doukali H,Ben Salah G,Ben Rhouma B,Hajjaji M,Jaouadi A,Belguith-Mahfouth N,Masmoudi ML,Ammar-Keskes L,Kamoun H

    更新日期:2017-11-01 00:00:00

  • Influence of heat on Na(+)-dependent HCO3-/Cl- exchanger function in a thermoresistant cell line.

    abstract::During previous studies on the relationship between thermosensitivity and intracellular pH (pHi) regulation in mammalian cells, we observed that the thermoresistant TR-4 cells appeared to be resistant to manipulations of the Na+/H+ antiport, one of the two primary membrane regulators of pHi. We hypothesized that this ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530096144969

    authors: Liu FF,Lee C,Li JH

    更新日期:1996-10-01 00:00:00

  • Involvement of c-Jun NH2-terminal kinase-1 in heat-induced apoptotic cell death of human monoblastic leukaemia U937 cells.

    abstract:PURPOSE:To determine the involvement of c-Jun NH(2)-terminal kinase-1 (JNK1) and possibly of HSP27 in heat-induced apoptosis of human monoblastic leukaemia U937 cells. MATERIALS AND METHODS:Dominant negative JNK1 (APF), in which the phosphorylation sites Thr-Pro-Tyr were changed to Ala-Pro-Phe, was overexpressed in U9...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000110062512

    authors: Enomoto A,Suzuki N,Liu C,Kang Y,Zhu J,Serizawa S,Matsumoto Y,Morita A,Ito M,Hosoi Y

    更新日期:2001-08-01 00:00:00

  • Low-dose hyper-radiosensitivity in human hepatocellular HepG2 cells is associated with Cdc25C-mediated G2/M cell cycle checkpoint control.

    abstract:PURPOSE:Although the significance of cell cycle checkpoints in overcoming low-dose hyper-radiosensitivity (HRS) has been proposed, the underlying mechanism of HRS in human hepatocellular cells remains unclear. Therefore, the aim of this study was to characterize HRS inhuman hepatocellular HepG2 cells and to explore the...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2016.1206235

    authors: Xue J,Zong Y,Li PD,Wang LX,Li YQ,Niu YF

    更新日期:2016-10-01 00:00:00

  • DNA lesion complexity and induction of apoptosis by ionizing radiation.

    abstract:PURPOSE:To determine whether murine lymphoid cell lines can discriminate between high- and low-LET (linear energy transfer) radiation-induced DNA lesions. MATERIALS AND METHODS:Sensitivity to killing by DNA-incorporated 3H and 125I decays, accumulated during storage in the gas phase of a liquid nitrogen tank, was dete...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000110120337

    authors: Radford IR

    更新日期:2002-06-01 00:00:00

  • Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain.

    abstract:PURPOSE:We examined the effects of manganese (III) meso-tetrakis (diethyl-2-5-imidazole) porphyrin, a metalloporphyrin antioxidant (MPA), on neural tissue radiation toxicity in vivo and on tumour cell radiosensitivity in vitro. MATERIALS AND METHODS:MPA was administered directly into the right lateral ventricle of you...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553000903419965

    authors: Pearlstein RD,Higuchi Y,Moldovan M,Johnson K,Fukuda S,Gridley DS,Crapo JD,Warner DS,Slater JM

    更新日期:2010-02-01 00:00:00

  • Inhibitory effects of Rhenium-188-labeled Herceptin on prostate cancer cell growth: a possible radioimmunotherapy to prostate carcinoma.

    abstract:PURPOSE:Herceptin is widely used in treating Her2-overexpressing breast cancer. However, the application of Herceptin in prostate cancer is still controversial. Our previous results have indicated the relevance of Her2 in the transition of the androgen requirement in prostate cancer cells. In this study, the effects of...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2013.762136

    authors: Wang HY,Lin WY,Chen MC,Lin T,Chao CH,Hsu FN,Lin E,Huang CY,Luo TY,Lin H

    更新日期:2013-05-01 00:00:00

  • Increased γ-H2AX by exposure to a 60-Hz magnetic fields combined with ionizing radiation, but not hydrogen peroxide, in non-tumorigenic human cell lines.

    abstract:PURPOSE:Genotoxic effects have been considered the gold standard to determine if an environmental factor is a carcinogen, but the currently available data for extremely low frequency time-varying magnetic fields (ELF-MF) remain controversial. As an environmental stimulus, the effect of ELF-MF on cellular DNA may be sub...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2014.887866

    authors: Yoon HE,Lee JS,Myung SH,Lee YS

    更新日期:2014-04-01 00:00:00

  • Dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression.

    abstract:PURPOSE:To evaluate the radioprotective effect of dieckol, a component of the brown algae Ecklonia cava. MATERIALS AND METHODS:Mice were lethally irradiated, treated with dieckol and surveyed for survival and the mechanism of radioprotection. RESULTS:Dieckol treatment lengthened the survival of irradiated mice and si...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2010.487011

    authors: Park E,Ahn G,Yun JS,Kim MJ,Bing SJ,Kim DS,Lee J,Lee NH,Park JW,Jee Y

    更新日期:2010-10-01 00:00:00

  • Delayed effects of a single-dose whole-brain radiation therapy on glucose metabolism and myelin density: a longitudinal PET study.

    abstract:PURPOSE:Radiotherapy is an important treatment option for brain tumors, but the unavoidable irradiation of normal brain tissue can lead to delayed cognitive impairment. The mechanisms involved are still not well explained and, therefore, new tools to investigate the processes leading to the delayed symptoms of brain ir...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2020.1787542

    authors: Parente A,Maciel ES,J O Dierckx RA,Langendijk JA,de Vries EFJ,Doorduin J

    更新日期:2020-09-01 00:00:00

  • Radiation-induced instability and its relation to radiation carcinogenesis.

    abstract:PURPOSE:A model that identifies radiation-induced genetic instability as the earliest cellular event in the multi-step sequence leading to radiation-induced cancer was previously proposed. In this paper ongoing experiments are discussed which are designed to test this model and its predictions in mouse mammary epitheli...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/095530098141023

    authors: Ullrich RL,Ponnaiya B

    更新日期:1998-12-01 00:00:00

  • A 700 MHz 1H-NMR study reveals apoptosis-like behavior in human K562 erythroleukemic cells exposed to a 50 Hz sinusoidal magnetic field.

    abstract:PURPOSE:To study cell damage and possible apoptosis in K562 human erythroleukemic cells exposed for 2 h to an extremely low frequency (ELF) 50 Hz sinusoidal magnetic field with a magnetic induction of either 1 or 5 mT using high resolution proton nuclear magnetic resonance (1H-NMR) spectroscopy. MATERIALS AND METHODS:...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000500102985

    authors: Santini MT,Ferrante A,Romano R,Rainaldi G,Motta A,Donelli G,Vecchia P,Indovina PL

    更新日期:2005-02-01 00:00:00

  • Endothelial cell proliferation in the rat heart following local heart irradiation.

    abstract::Radiation-induced myocardial degeneration in the rat is preceded by changes in capillary structure and function, which may be a major factor in the pathogenesis of radiation-induced heart disease. In order to investigate the mechanism of capillary damage we studied endothelial cell proliferation in untreated control r...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009014551131

    authors: Lauk S,Trott KR

    更新日期:1990-05-01 00:00:00

  • Increase in DNA single-strand break rejoining by continuous exposure of human mononuclear blood cells to radioiodine ((131)I) in vitro.

    abstract::Radioiodine ((131)I) induced a dose- and time-dependent increase in DNA single-strand breaks (DNA-ssb) in human (G0) mononuclear blood cells (MNC) in vitro. Incubation of MNC with 22MBq (131)I/ml at 4 degrees C caused a linear, time-dependent induction of DNA-ssb (increase in elution rate: 24.7 x 10(-3) h(-1) per 100 ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530097143103

    authors: Hengstler JG,Bockisch A,Fuchs J,Grimm W,Zapf AO,Lade K,Meinert R,Oesch-Bartlomowicz B,Tanner B,Oesch F

    更新日期:1997-11-01 00:00:00

  • DNA radiolysis in DNA-protein complexes: a stochastic simulation of attack by hydroxyl radicals.

    abstract:PURPOSE:To propose an improved version of RADACK, a stochastic simulation of radiolytic attack on DNA, that takes into account the reactivity of each amino acid of a specifically bound protein with hydroxyl radicals. To apply it to the natural lactose operator-repressor complex taking advantage of recently reported str...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/0955300031000137788

    authors: Begusova M,Giliberto S,Gras J,Sy D,Charlier M,Spotheim-Maurizot M

    更新日期:2003-06-01 00:00:00

  • Agarose overlay selectively improves macrocolony formation and radiosensitivity assessment in primary fibroblasts.

    abstract:PURPOSE:Primary fibroblasts are not suitable for in vitro macrocolony assay due to their inability to form distinct colonies. Here we present a modification of agarose overlay that yielded extensive improvement in their colony formation and assessment of radiosensitivity. MATERIALS AND METHODS:Macrocolony formation wa...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2014.894650

    authors: Chandna S,Dagur RS,Mathur A,Natarajan AT,Harms-Ringdahl M,Haghdoost S

    更新日期:2014-05-01 00:00:00

  • Ultra-low dose beta-irradiation induces constriction of rabbit carotid arteries via the endothelium.

    abstract:PURPOSE:To investigate the action of ultra-low dose beta-radiation (ULDBR) on isolated segments of blood vessels. MATERIALS AND METHODS:We used the pharmacological model of isolated rabbit carotid arteries with intact or mechanically removed endothelium. Specific vascular responses to beta-irradiation were registered ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000600562229

    authors: Zhirnov VV,Iakovenko IN

    更新日期:2005-11-01 00:00:00

  • Biochemical effects of heat shock and caffeine on post-irradiation oxic and anoxic damage in barley seeds of low and high water content.

    abstract::Wet heat shock (60 degrees C, 90 s) and caffeine (3.8 X 10(-4) M) afford significant radioprotection against post-irradiation O2-dependent damage which develops in seeds of approximately 3.5% moisture content. The damage was assessed in terms of seedling injury on the eighth day of growth. An increase in seedling inju...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009114551101

    authors: Singh SP,Kesavan PC

    更新日期:1991-05-01 00:00:00

  • X-ray-induced DNA double-strand breaks as lethal lesions in diploid human fibroblasts compared to Chinese hamster ovary cells.

    abstract::Calibration of the non-denaturing (pH 9.6) filter elution technique by 125I decays has been used to examine the relationship between X-ray-induced DNA double-strand breaks (dsb) and cellular survival of CHO cells and human fibroblasts. DNA dsb induction varies markedly between the two cell lines, reflecting the differ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009314550411

    authors: Baumstark-Khan C

    更新日期:1993-03-01 00:00:00

  • The shape of DNA elution dose-response curves under non-denaturing conditions: the contribution of the degree of chromatin condensation.

    abstract::We have re-examined the effect of detergent type, pH and temperature of lysis on the shape of the DNA elution dose response under non-denaturing conditions using plateau-phase CHO cells. Results practically identical to those previously published (Okayasu and Iliakis, 1989) were obtained, with a 1 h incubation at 60 d...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009214551211

    authors: Okayasu R,Iliakis G

    更新日期:1992-04-01 00:00:00

  • Raman spectroscopy of tissue samples irradiated by protons.

    abstract:PURPOSE:Since the number of cancer patients treated by proton irradiation has increased in the last few years, it seems appropriate to study dose-dependent effects of proton irradiation on mammalian tissues in more detail. MATERIALS AND METHODS:Tissue samples of normal skin of mouse and swine, of a human tumour model ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000412331283515

    authors: Synytsya A,Alexa P,Besserer J,De Boer J,Froschauer S,Gerlach R,Loewe M,Moosburger M,Obstová I,Quicken P,Sosna B,Volka K,Würkner M

    更新日期:2004-08-01 00:00:00