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Modelling of radiation damage by 125I on a nucleosome.

Abstract：

:Studies of early physical interactions of ionizing radiation in biological medium have evolved from water cylinders or spheres to structured volumes representing nucleosomal DNA, based on spatial co-ordinates for each individual atom. Regarding the physico-chemical and chemical stages, the models of DNA have evolved from inactive geometrical objects to active participation of DNA in the reactions with the radical species. In this paper data are presented on the modelling of the interaction of low energy electrons with nucleosomal DNA. The nucleosome core unit has been modelled as a 146-bp helical DNA, containing > 9000 atoms, wound around the core unit. The yields of strand breaks for low energy electrons has been obtained by placing the nucleosome target in a liquid water environment and introducing a number of assumptions for the induction of strand breaks. The calculated results for the induction of ssb and dsb by 125I decays agree with experimental data, confirming the plausibility of this nucleosome model as well as the characterization of the interaction of ionizing radiation in terms of the energy deposition and the assumptions made for the strand breaks.

journal_name

Int J Radiat Biol

journal_title

International journal of radiation biology

authors

Terrissol M

doi

10.1080/09553009414551441

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

447-51

issue

5

eissn

0955-3002

issn

1362-3095

pii

J5FXNLLTLEBL82GD

journal_volume

66

pub_type

杂志文章

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