Abstract:
:Two novel nitroimidazole-carboranes were examined for their uptake and retention in two experimental murine solid tumours and in some normal tissues, using in vivo 11B magnetic resonance spectroscopy. The compounds were injected i.p. at 0.8mmol/kg into mice bearing either the SCCVII/Ha squamous cell carcinoma or KHT sarcoma implanted intradermally on the mouse back. Boron from a polyether-isoxazole linked nitroimidazole-carborane (compound 1) was detectable in both SCCVII/Ha and KHT tumours at 3 and 7 h after injection. The signal from the liver at these times was greater than that from the tumour but only a weak signal was obtained from the brain. At 24 h after injection the tumour signal was still present, as was that from the liver, which appeared to have increased over that for the earlier times. Signal from the brain had disappeared by 24 h. Boron from a polyether-carbamate linked nitroimidazole-carborane (compound 2) was also detectable in both tumours at all times tested, and again was present in the liver. In addition, the 11B signal was detectable from the mouse brain, at early times, but was undetectable at 24 h. These preliminary data indicate that nitroimidazole-carboranes are taken up and retained in experimental murine tumours in sufficient amounts to be detectable by in vivo 11B MRS and further that at 24 h after treatment there is differential retention between tumours and the brain.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Wood PJ,Scobie M,Threadgill MDdoi
10.1080/095530096144798subject
Has Abstractpub_date
1996-11-01 00:00:00pages
587-92issue
5eissn
0955-3002issn
1362-3095journal_volume
70pub_type
杂志文章abstract:PURPOSE:To determine the efficacy of a caffeine derivative 1-methylxanthine (1-MTX) in increasing radiosensitivity of cancer cells and elucidate the underlying mechanisms in vitro. MATERIALS AND METHODS:RKO human colorectal cancer cells carrying wild type protein 53 kDa (p53) were incubated with 3 mM 1-MTX for 30 min,...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000902741190
更新日期:2009-02-01 00:00:00
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journal_title:International journal of radiation biology
pub_type: 杂志文章,随机对照试验
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journal_title:International journal of radiation biology
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更新日期:2020-11-12 00:00:00
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journal_title:International journal of radiation biology
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更新日期:1994-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/095530099139331
更新日期:1999-11-01 00:00:00
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journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553002.2016.1206223
更新日期:2016-10-01 00:00:00
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
pub_type: 杂志文章
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更新日期:1992-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/09553009414550601
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journal_title:International journal of radiation biology
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更新日期:1999-08-01 00:00:00
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journal_title:International journal of radiation biology
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doi:10.1080/095530096144699
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journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009314551471
更新日期:1993-09-01 00:00:00
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更新日期:1998-04-01 00:00:00
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journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
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更新日期:2003-07-01 00:00:00
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更新日期:2006-02-01 00:00:00
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journal_title:International journal of radiation biology
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更新日期:2000-06-01 00:00:00
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journal_title:International journal of radiation biology
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更新日期:2011-02-01 00:00:00
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
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更新日期:2012-10-01 00:00:00
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journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009114550121
更新日期:1991-01-01 00:00:00
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journal_title:International journal of radiation biology
pub_type: 杂志文章
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更新日期:1992-05-01 00:00:00