当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF RADIATION BIOLOGY期刊下所有文献 > The combined effect of fludarabine monophosphate and radiation as well as gemcitabine and radiation on squamous carcinoma tumor cell lines in vitro.

The combined effect of fludarabine monophosphate and radiation as well as gemcitabine and radiation on squamous carcinoma tumor cell lines in vitro.

Abstract：

PURPOSE:Despite proven antitumor activity of gemcitabine in chemoradiotherapy of advanced head and neck cancer, many authors refer to severe acute and late local and haematological toxicity. Fludarabine does imply nearly the same mechanisms of action as gemcitabine, inhibiting various enzymes involved in DNA replication. This investigation focuses on the combined effect of either fludarabine or gemcitabine and radiation on human squamous carcinoma cell lines in vitro, providing data for future decisions on head and neck chemoradiotherapy regimen. MATERIALS AND METHODS:ZMK-1, A549, BW-225, GR-145, OH-65 and CaSki cell lines were incubated with either drug at defined schedules and irradiated at a single fraction dose of 2 Gy every 24 hours up to 8 Gy. Cytotoxic effects were measured by colony-forming assays, quantitative determination of apoptosis and isobologram analysis. RESULTS:Incubation of fludarabine led to a radiosensitizing effect in the A549, CaSki and ZMK-1 cell lines and an additive effect in the BW-225, GR-145 and OH-65 cell lines. Treatment with gemcitabine only indicated significant radiosensitization in the CaSki cell line in combination with augmented resistance against gemcitabine application alone. CONCLUSIONS:Our results reveal a potential radiosensitizing effect of fludarabine and its possible application in chemoradiotherapy of advanced head and neck carcinoma and possibly other tumor entities.

journal_name

Int J Radiat Biol

journal_title

International journal of radiation biology

authors

Nitsche M,Christiansen H,Hermann RM,Lucke EM,Peters K,Rave-Frank M,Schmidberger H,Pradier O

doi

10.1080/09553000802241754

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

643-57

issue

8

eissn

0955-3002

issn

1362-3095

pii

795329330

journal_volume

84

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY文献大全
  • RBE for carbon track-segment irradiation in cell lines of differing repair capacity.

    abstract：PURPOSE:The LET position of the RBE maximum and its dependence on the cellular repair capacity was determined for carbon ions. Hamster cell lines of differing repair capacity were irradiated with monoenergetic carbon ions. RBE values for cell inactivation at different survival levels were determined and the differences...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530099139232

    authors： Weyrather WK,Ritter S,Scholz M,Kraft G

    更新日期：1999-11-01 00:00:00

  • Responses of the bacterial community to chronic gamma radiation in a rice paddy ecosystem.

    abstract：PURPOSE:Public concern about radiation protection of the environment and non-human species is increasing. The potential impact of chronic gamma radiation on the bacterial community in a rice paddy ecosystem was investigated. MATERIALS AND METHODS:Paddy field microcosm samples were continuously exposed at a dose rate o...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2010.549534

    authors： Ishii N,Fuma S,Tagami K,Honma-Takeda S,Shikano S

    更新日期：2011-07-01 00:00:00

  • Low dose ionising radiation leads to a NF-κB dependent decreased secretion of active IL-1β by activated macrophages with a discontinuous dose-dependency.

    abstract：PURPOSE:Therapy with low doses of ionising radiation (X-rays) exerts anti-inflammatory effects. Little is known about whether and how low doses of X-ray treatment modulate the inflammatory phenotype of macrophages, especially the secretion of Interleukin-1beta (IL-1β). MATERIALS AND METHODS:Macrophages were differenti...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2012.689464

    authors： Lödermann B,Wunderlich R,Frey S,Schorn C,Stangl S,Rödel F,Keilholz L,Fietkau R,Gaipl US,Frey B

    更新日期：2012-10-01 00:00:00

  • Computer evaluation of direct and indirect damage induced by free and DNA-bound iodine-125 in the chromatin fibre.

    abstract：PURPOSE:When Iodine-125 decays within chromatin, several in vivo experiments have shown that the radiobiological effects are caused mainly by indirect mechanisms and that more than one DNA double strand break (DSB) is produced per decay. We present calculations to evaluate the contribution of direct and indirect effect...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000400017622

    authors： Terrissol M,Edel S,Pomplun E

    更新日期：2004-11-01 00:00:00

  • The intrinsic alpha/beta ratio for human tumour cells: is it a constant?

    abstract：:The radiation response of 15 mammalian cell lines comprising 11 human tumour, two human fibroblast and two murine lymphoma cell lines, has been analysed using the linear-quadratic equation. As well as using conventional analysis of acute dose-survival curves to derive values for alpha and beta (termed alpha ac and bet...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009214551241

    authors： Peacock JH,Eady JJ,Edwards SM,McMillan TJ,Steel GG

    更新日期：1992-04-01 00:00:00

  • Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain.

    abstract：PURPOSE:We examined the effects of manganese (III) meso-tetrakis (diethyl-2-5-imidazole) porphyrin, a metalloporphyrin antioxidant (MPA), on neural tissue radiation toxicity in vivo and on tumour cell radiosensitivity in vitro. MATERIALS AND METHODS:MPA was administered directly into the right lateral ventricle of you...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553000903419965

    authors： Pearlstein RD,Higuchi Y,Moldovan M,Johnson K,Fukuda S,Gridley DS,Crapo JD,Warner DS,Slater JM

    更新日期：2010-02-01 00:00:00

  • Prior irradiation results in elevated programmed cell death protein 1 (PD-1) in T cells.

    abstract：PURPOSE:In this study we addressed the question whether radiation-induced adverse effects on T cell activation are associated with alterations of T cell checkpoint receptors. MATERIALS AND METHODS:Expression levels of checkpoint receptors on T cell subpopulations were analyzed at multiple post-radiation time points ra...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2017.1400192

    authors： Li D,Chen R,Wang YW,Fornace AJ Jr,Li HH

    更新日期：2018-05-01 00:00:00

  • Increased frequency of sister chromatid exchanges in lymphocytes of Chernobyl clean-up workers.

    abstract：:Sister chromatid exchanges (SCEs) were analysed in lymphocytes from 12 control persons and 33 Chernobyl clean-up workers. The group of Chernobyl clean-up workers consisted of civilians who were forced to go to Chernobyl to clean up environmental contamination caused by Chernobyl disaster. On average, they received 0.1...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009514550791

    authors： Lazutka JR,Dedonyte V

    更新日期：1995-06-01 00:00:00

  • Tracing the protective activity of Lactobacillus plantarum using technetium-99m-labeled zearalenone for organ toxicity.

    abstract：PURPOSE:Zearalenone is a potent estrogenic metabolite produced by some Fusarium and Gibberella species. Therefore, the aim of this study was to determine the accumulation of Technetium-[99m]-labeled zearalenone in mice organs as well as to study the protective effect of Lactobacillus plantarum. MATERIALS AND METHODS:T...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2019.1524990

    authors： Sanad MH,Fouzy ASM,Sobhy HM,Hathout AS,Hussain OA

    更新日期：2018-12-01 00:00:00

  • Establishing the Japan-Store house of animal radiobiology experiments (J-SHARE), a large-scale necropsy and histopathology archive providing international access to important radiobiology data.

    abstract：:Purpose: Projects evaluating the effects of radiation, within the National Institutes of Quantum and Radiological Science and Technology (QST), National Institute of Radiological Sciences (NIRS), have focused on risk analyses for life shortening and cancer prevalence using laboratory animals. Genetic and epigenetic al...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章,评审

    doi：10.1080/09553002.2019.1625458

    authors： Morioka T,Blyth BJ,Imaoka T,Nishimura M,Takeshita H,Shimomura T,Ohtake J,Ishida A,Schofield P,Grosche B,Kulka U,Shimada Y,Yamada Y,Kakinuma S

    更新日期：2019-10-01 00:00:00

  • Radiation-induced diploid spermatids in mice.

    abstract：:Diploid elongated spermatids of mice were enriched by flow cytometry and cell sorting using a new type of sorter (Partec). The sorted abnormal spermatids were identified morphologically and by nuclear area integration. The radiation-induced increase in the frequency of diploid elongated spermatids was monitored with t...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553008914550841

    authors： Hacker-Klom U,Heiden T,Otto FJ,Mauro F,Göhde W

    更新日期：1989-05-01 00:00:00

  • Gold nanoparticles as dose-enhancement agent for kilovoltage X-ray therapy of melanoma.

    abstract：PURPOSE:Melanoma is mainly treated by surgery and rarely with radiation because of the high radioresistance of this tumor. Nevertheless, radiotherapy is the preferred treatment modality for unresectable lesions and avoiding cosmetic disfigurement caused by surgical excision. This study investigated the therapeutic adva...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2017.1276309

    authors： Kim SR,Kim EH

    更新日期：2017-05-01 00:00:00

  • Monte Carlo-based dose reconstruction in a rat model for scattered ionizing radiation investigations.

    abstract：PURPOSE:In radiation biology, rats are often irradiated, but the precise dose distributions are often lacking, particularly in areas that receive scatter radiation. We used a non-dedicated set of resources to calculate detailed dose distributions, including doses to peripheral organs well outside of the primary field, ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2013.791407

    authors： Kirkby C,Ghasroddashti E,Kovalchuk A,Kolb B,Kovalchuk O

    更新日期：2013-09-01 00:00:00

  • Weiss lecture. The dose-rate factor in radiation biology.

    abstract：:The dose-rate effect has been the topic of extensive radiobiological studies and has important implications in radiation therapy and in the field of radiation protection. Three examples will be discussed: two in radiation therapy and one in protection. First, continuous low dose-rate interstitial brachytherapy may be ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章,评审

    doi：10.1080/09553009114550531

    authors： Hall EJ

    更新日期：1991-03-01 00:00:00

  • Radiosensitization by misonidazole, pimonidazole and azomycin and intracellular uptake in human tumour cell lines.

    abstract：:The radiosensitization of two human tumour in vitro cell lines, HT-1080 and LoVo, has been compared with that of the Chinese hamster cell line V79-379A. Although the two human tumour cell lines were more radiosensitive than the V79 cell line sensitizer, enhancement ratios for misonidazole, pimonidazole and azomycin we...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009014552461

    authors： Watts ME,Dennis MF,Roberts IJ

    更新日期：1990-02-01 00:00:00

  • Alterations in water and electrolyte absorption in the rat colon following neutron irradiation: influence of neutron component and irradiation dose.

    abstract：PURPOSE:To study the absorptive function of rat colon following whole-body exposure to neutron irradiation, either to the same total dose with varying proportion of neutrons or to the same neutron proportion with an increasing irradiation dose. MATERIALS AND METHODS:Different proportions of neutron irradiation were pr...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/0955300021000019221

    authors： Dublineau I,Ksas B,Joubert C,Aigueperse J,Gourmelon P,Griffiths NM

    更新日期：2002-12-01 00:00:00

  • A novel vertebrate system for the examination and direct comparison of the relative biological effectiveness for different radiation qualities and sources.

    abstract：PURPOSE:The recent rapid increase of hadron therapy applications requires the development of high performance, reliable in vivo models for preclinical research on the biological effects of high linear energy transfer (LET) particle radiation. AIM:The aim of this paper was to test the relative biological effectiveness ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2018.1511928

    authors： Szabó ER,Reisz Z,Polanek R,Tőkés T,Czifrus S,Pesznyák C,Biró B,Fenyvesi A,Király B,Molnár J,Brunner S,Daroczi B,Varga Z,Hideghéty K

    更新日期：2018-11-01 00:00:00

  • Track structure calculations on intracellular targets responsible for signal release in bystander experiments with transfer of irradiated cell-conditioned medium.

    abstract：PURPOSE:To investigate alternative scenarios for the dose-dependent emission of bystander signals by irradiated cells in medium transfer experiments. METHODS:Energy deposition patterns to hypothetical intracellular targets whose hit by radiation initiates the emission of bystander signals have been simulated by Monte ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2011.595874

    authors： Kundrát P,Friedland W

    更新日期：2012-01-01 00:00:00

  • Sonolysis of ubiquinone in aqueous solutions. An EPR spin-trapping study.

    abstract：:Free radical formation in aqueous solutions of ubiquinone (coenzyme Qo) induced by ultrasound was studied by EPR and spin trapping with 3,5-dibromo-4-nitrosobenzene sulphonate. When aqueous solutions of ubiquinone were sonicated with 50-kHz ultrasound in the presence of argon or nitrogen, radicals formed by addition o...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530096146246

    authors： Kondo T,Riesz P

    更新日期：1996-01-01 00:00:00

  • Effects of in vitro alpha-particle irradiation on osteogenic bone marrow cultures.

    abstract：:Murine bone marrow contains osteogenic precursor cells that undergo differentiation during in vitro cultivation. In vitro these cells are potential target cells for alpha-irradiation-induced bone tumour formation. Under defined tissue culture conditions these differentiating cells were directly exposed to alpha-partic...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009414551111

    authors： Schoeters GE,Vander Plaetse F,van den Heuvel RL

    更新日期：1994-08-01 00:00:00

  • Applying a multiscale systems biology approach to study the effect of chronic low-dose exposure to uranium in rat kidneys.

    abstract：:Purpose: To examine the effects of low-dose exposure to uranium with a systems biology approach, a multiscale high-throughput multi-omics analysis was applied with a protocol for chronic exposure to the rat kidney. Methods: Male and female rats were contaminated for nine months through their drinking water with a nont...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2019.1577567

    authors： Grison S,Kereselidze D,Cohen D,Gloaguen C,Elie C,Lestaevel P,Legendre A,Manens L,Habchi B,Benadjaoud MA,Tarlet G,Milliat F,Martin JC,Lobaccaro JM,Souidi M

    更新日期：2019-06-01 00:00:00

  • Reactions of 5-methylcytosine cation radicals in DNA and model systems: thermal deprotonation from the 5-methyl group vs. excited state deprotonation from sugar.

    abstract：PURPOSE:To study the formation and subsequent reactions of the 5-methyl-2'-deoxycytidine cation radical (5-Me-2'-dC•(+)) in nucleosides and DNA-oligomers and compare to one-electron oxidized thymidine. MATERIALS AND METHODS:Employing electron spin resonance (ESR), cation radical formation and its reactions were invest...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2014.884293

    authors： Adhikary A,Kumar A,Palmer BJ,Todd AD,Heizer AN,Sevilla MD

    更新日期：2014-06-01 00:00:00

  • Multiple blood-proteins approach for early-response exposure assessment using an in vivo murine radiation model.

    abstract：PURPOSE:The aim was to evaluate the utility of multiple blood-protein biomarkers for early-response assessment of radiation exposure using a murine radiation model system. MATERIAL AND METHODS:BALB/c male mice (8-10 weeks old) were exposed to whole-body 60Co gamma-rays (10 cGy min(-1)) over a broad dose range (0-7 Gy)...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：

    authors： Ossetrova NI,Blakely WF

    更新日期：2009-01-01 00:00:00

  • Increased radiation tolerance of mouse tongue epithelium after local conditioning.

    abstract：:The effect of local stimulation on mitotic activity and radiation tolerance was studied in mouse tongue mucosa. Silver nitrate solution (0.5-20%) was used for local conditioning. The most effective protocol comprised three daily treatments (days 0-2), yielding a delayed increase in 24 h mitotic counts by about 30% on ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009214551061

    authors： Dörr W,Kummermehr J

    更新日期：1992-03-01 00:00:00

  • Accumulation of spermidine/spermine N1-acetyltransferase and alternatively spliced mRNAs as a delayed response of HeLa S3 cells following X-ray irradiation.

    abstract：PURPOSE:A key enzyme of polyamine catabolism, spermidine/spermine N(1)-acetyltransferase (SSAT), is responsive to antiproliferative agents. The role of SSAT in cellular responses to X-ray irradiation was examined. MATERIALS AND METHODS:Exponentially growing HeLa S3 cells were irradiated by X-rays, and mRNA levels for ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000410001695886

    authors： Mita K,Fukuchi K,Hamana K,Ichimura S,Nenoi M

    更新日期：2004-05-01 00:00:00

  • Late effects of radiation on the human immune system: an overview of immune response among the atomic-bomb survivors.

    abstract：:The studies of the late effects of atomic-bomb (A-bomb) radiation on the immune system were started about 20 years after the bombings in 1945. The most remarkable late effects of radiation are the functional and quantitative abnormalities of T and B cells in survivors exposed to high doses (> or = 1.0 Gy). Abnormaliti...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章,评审

    doi：10.1080/09553009514551491

    authors： Akiyama M

    更新日期：1995-11-01 00:00:00

  • Association of protein phosphorylation and cell cycle progression after X-irradiation of two-cell mouse embryos.

    abstract：:Studies of protein phosphorylation in the second cell cycle of mouse embryos were assessed by [32P]-incorporation and one- and two-dimensional electrophoresis. Unirradiated and X-irradiated embryos were compared. X-irradiation in the G2 phase led to a block in this cell cycle phase. The phosphorylation of proteins wit...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009114552351

    authors： Jung T,Streffer C

    更新日期：1991-09-01 00:00:00

  • Hypersensitivity of a human tumour cell line to very low radiation doses.

    abstract：:Survival of HT29 cells was measured after irradiation with single doses of X-rays (0.05-5 Gy) and neutrons (0.025-1.5 Gy), using a Dynamic Microscopic Imaging Processing Scanner (DMIPS) with which individual cells can be accurately located in tissue culture flasks, their positions recorded, and after an appropriate in...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009314450831

    authors： Lambin P,Marples B,Fertil B,Malaise EP,Joiner MC

    更新日期：1993-05-01 00:00:00

  • Low dose-rate fibroblast radiosensitivity and the prediction of patient response to radiotherapy.

    abstract：:The relationship between cellular radiosensitivity and normal-tissue response to radiotherapy in individual cancer patients has attracted increasing attention over the last few years. Recent work has suggested that a correlation exists between fibroblast sensitivity and normal-tissue reactions. We have examined the ra...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530096145021

    authors： Burnet NG,Wurm R,Peacock JH

    更新日期：1996-09-01 00:00:00

  • Preferential tumour accumulation of gold nanoparticles, visualised by Magnetic Resonance Imaging: radiosensitisation studies in vivo and in vitro.

    abstract：PURPOSE:To investigate the radiosensitisation of gold nanoparticles (GNP) with an average diameter of 5 nm coated with the gadolinium chelating agent dithiolated diethylenetriaminepentaacetic gadolinium (Au@DTDTPA:Gd) in vitro and in mice bearing tumours (MC7-L1). MATERIALS AND METHODS:In vivo, the gadolinium chelate ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553001003746067

    authors： Hébert EM,Debouttière PJ,Lepage M,Sanche L,Hunting DJ

    更新日期：2010-08-01 00:00:00