Abstract：
:Ruthenium-106 in citrate solution was administered intravenously to rat at different stages of pregnancy and to guinea-pig either before conception or in late pregnancy. The results for rat showed that retention in the embryo/foetus measured at 3-5 days after administration increased from about 0.0002% of injected activity per embryo/foetus on day 12 of gestation to about 0.05% at birth. The relative concentrations of 106Ru in embryo/foetus and mother (Cf/Cm ratio) were about 0.1 in each case. Concentrations in the yolk sac on day 12 were about 1% g-1 compared with 0.01% g-1 in the foetus. Retention in the guinea-pig foetus in late gestation at 7 days after administration (days 50-57) was about 0.2% injected activity per foetus, corresponding to a Cf/Cm = 0.2. Retention in each foetoplacental unit was 2% of injected 106Ru with 50% in the yolk sac, 35% in the placenta and 10% in the foetus. For administration 4 weeks prior to conception, the level of 106Ru retained in the foetus on day 57 of gestation was two orders of magnitude lower than after short-term administration, with a Cf/Cm about 0.004.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Levack VM,Pottinger H,Harrison JDsubject
Has Abstractpub_date
1994-12-01 00:00:00pages
809-14issue
6eissn
0955-3002issn
1362-3095journal_volume
66pub_type
杂志文章abstract：PURPOSE:In a previous study, we found that exposure to a 50 Hz magnetic field (MF) could activate stress-activated protein kinase (SAPK) and P38 mitogen-activated protein (MAP) kinase (P38 MAPK) in Chinese hamster lung (CHL) fibroblast cells, and simultaneous exposure to a 'noise' MF of the same intensity inhibited the...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000801998875
更新日期：2008-05-01 00:00:00
abstract：:The dose-rate effect has been the topic of extensive radiobiological studies and has important implications in radiation therapy and in the field of radiation protection. Three examples will be discussed: two in radiation therapy and one in protection. First, continuous low dose-rate interstitial brachytherapy may be ...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.1080/09553009114550531
更新日期：1991-03-01 00:00:00
abstract：:Genetic analysis was performed on 72 Italian A-T families ascertained through 91 probands. The frequency of the A-T gene was estimated through Dahlberg's formula, which uses the frequencies of first cousin marriages among the patients' parents and in the general population were obtained from the collection of Catholic...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：PURPOSE:The space environment contains two major biologically significant influences; space radiations and microgravity. The 53 kDa tumour suppressor protein (p53) plays a role as a guardian of the genome through the activity of p53-centered signal transduction pathways. The aim of this study was to clarify the biologi...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553001003789596
更新日期：2010-08-01 00:00:00
abstract：PURPOSE:This review is a contribution to the memory of Dr William (Bill) Morgan and highlights an area of research and deliberation that he considered extremely important in support of the setting of protective radiation dose limits. Biological research has generally played a minor role in the estimation of adverse hea...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.1080/09553002.2017.1290848
更新日期：2017-10-01 00:00:00
abstract：PURPOSE:Although the significance of cell cycle checkpoints in overcoming low-dose hyper-radiosensitivity (HRS) has been proposed, the underlying mechanism of HRS in human hepatocellular cells remains unclear. Therefore, the aim of this study was to characterize HRS inhuman hepatocellular HepG2 cells and to explore the...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2016.1206235
更新日期：2016-10-01 00:00:00
abstract：:The repair activity of verbascoside (VER), isolated from Pedicularis spicata, towards the oxidizing hydroxyl radical adduct of dGMP and its reaction mechanism were studied using pulse radiolysis. Upon pulse radiolysis of nitrous oxide saturated aqueous solution of 2'-deoxyguanosine-5'-monophosphate (dGMP) and VER, it ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530096145779
更新日期：1996-04-01 00:00:00
abstract：PURPOSE:To investigate the hypothesis that the developmental phase at which an individual encounters radiation damage affects its long-term sensitivity to a subsequent tumourigenic insult. MATERIALS AND METHODS:Either the pregnant C57B16 mouse was exposed to 137Cs gamma-rays at 4 or 15 days post-conception (embryonic ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530000139032
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:To evaluate a transcriptomic approach to identify healthy women at increased risk of breast cancer due to G2-radiosensitivity and look at transcripts that are differentially expressed between individuals. MATERIALS AND METHODS:We perform the first study to assess the association of G2 radiosensitivity with bas...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000701317366
更新日期：2007-06-01 00:00:00
abstract：:We used the 'comet assay' to compare the amount of radiation-induced DNA damage in three tumour cell lines (MeWo, PECA 4451 and PECA 4197) and the extent of DNA repair in two of these lines (MeWo and PECA 4197). Tumour cells were irradiated with X-rays (0.1-10 Gy), embedded in agarose on slides, lysed with sodium dode...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009414550371
更新日期：1994-03-01 00:00:00
abstract：PURPOSE:Terrorist attacks, with their intent to maximize psychological and economic damage as well as inflicting sickness and death on given targeted populations, are an ever-growing worldwide concern in government and public sectors as they become more frequent, violent, and sensational. If given the chance, it is lik...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.1080/09553002.2017.1332440
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:The purpose of this work was to determine whether the cellular components of Hairless-rat skin are affected by a chronic local exposure to non-ionizing radiations of Global Mobile Phone System: GSM-900 or -1800 radiations at specific absorption rate (SAR) 2.5 and 5 W/kg. MATERIALS AND METHODS:A selected part o...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000600930087
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:The prolonged delivery times associated with intensity modulated radiation therapy (IMRT) may reduce treatment effectiveness of radiation therapy for cancers with short repair half-times. In this study, in vitro radiation experiments with DU-145 prostate cancer cells were designed to quantify the half-time of s...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000802061285
更新日期：2008-06-01 00:00:00
abstract：UNLABELLED:Abstract Purpose: Sensitizing cancer cells to irradiation is a major challenge in clinical oncology. We aimed to define the signal transduction pathways involved in poly(ADP-ribose) polymerase (PARP) inhibitor-induced radiosensitization in various mammalian cancer lines. MATERIALS AND METHODS:Clonogenic sur...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2014.934927
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:Ionizing radiation induces DNA damage, some of which are present in clusters, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. These clusters are thought to contribute to the detrimental effects of radiation, in part due to the compromised repair of c...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2014.899449
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:To test whether radiolysis-induced fragmentation in frozen aqueous protein solution is dependent on solvent access to the surface of the protein or to the molecular mass of the polypeptide chain. MATERIALS AND METHODS:60Co gamma-irradiation of three proteins at -78 degrees C: lysozyme, citrate synthase and alp...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530000138349
更新日期：2000-05-01 00:00:00
abstract：PURPOSE:Radiotherapy is an important treatment option for brain tumors, but the unavoidable irradiation of normal brain tissue can lead to delayed cognitive impairment. The mechanisms involved are still not well explained and, therefore, new tools to investigate the processes leading to the delayed symptoms of brain ir...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2020.1787542
更新日期：2020-09-01 00:00:00
abstract：:Survival of HT29 cells was measured after irradiation with single doses of X-rays (0.05-5 Gy) and neutrons (0.025-1.5 Gy), using a Dynamic Microscopic Imaging Processing Scanner (DMIPS) with which individual cells can be accurately located in tissue culture flasks, their positions recorded, and after an appropriate in...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009314450831
更新日期：1993-05-01 00:00:00
abstract：PURPOSE:To evaluate the effects of 50 Hz magnetic fields (MF) on the development of cancer induced by ionizing radiation. MATERIALS AND METHODS:A total of 150 female CBA/S mice were randomized into three equal groups at the age of 3-5 weeks. One of the groups served as a 'cage-control group'. The two other groups were...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000010024696
更新日期：2001-04-01 00:00:00
abstract：:The scission of pentadeoxythymidylic acid, d(pT)5, by monochromatic soft X-rays on (2153 eV) and below (2147 eV) the K-shell absorption peak of phosphorus was studied as a model of strand breakage in DNA. Samples dried on glass plates were irradiated by monochromatic soft X-rays in vacuo, and the products were analyse...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009314550201
更新日期：1993-02-01 00:00:00
abstract：PURPOSE:To study by fluorescence in situ hybridization (FISH) the involvement of Chinese hamster chromosomes 3, 4, 8, and 9, and their separate chromosome arms in X-ray-induced aberrations. MATERIALS AND METHODS:Male embryonic primary cells of Chinese hamster were used and metaphases were collected and scored at 20 h ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530099139700
更新日期：1999-08-01 00:00:00
abstract：:Cell death induced by various radiation doses in Molt-4 and L5178Y cells was studied. Molt-4 cells have a low threshold for induction of interphase death while L5178Y cells have a high threshold. Interphase death in Molt-4 cells at doses > 100 Gy and in L5178Y cells at doses > 300 Gy showed typical necrosis. In contra...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009314551101
更新日期：1993-07-01 00:00:00
abstract：PURPOSE:The fluorescent in situ hybridization (FISH) technique, which easily detects reciprocal translocations, is currently used to estimate doses in retrospective biological dosimetry, after suspected accidental overexposure to ionizing radiation (IR). This study of 42 cases aimed to verify the appropriateness of thi...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2018.1427903
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:The effect of boronophenylalanine (BPA)-mediated boron neutron capture therapy (BNCT) on human oral squamous cell carcinoma (SCC) xenografts in nude mice was examined. MATERIALS AND METHODS:Tumor-bearing mice were given BPA at a dose of 250 mg/kg body weight. The tumor (10)B concentration 2 h after an injectio...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000600570453
更新日期：2006-01-01 00:00:00
abstract：:Purpose: Radiotherapy prescription dose and dose fractionation protocols vary little between individual patients having the same tumor grade and stage. To personalize radiotherapy a predictive model is needed to simulate radiation response. Previous modeling attempts with multiple variables and parameters have been sh...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2019.1589013
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:To construct a quantitative model of the radiation-induced bystander effect based on diffusion-type spreading of bystander signal communication between the hit and non-hit cells. Cell inactivation and induced oncogenic transformation by broad- and microbeam irradiation systems are considered. MATERIALS AND MET...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：PURPOSE:To describe the design and dosimetric characterization of a simple and economical small animal irradiator. MATERIALS AND METHODS:A high dose rate (HDR) (192)Ir brachytherapy source from a commercially available afterloader was used with a 1.3 cm thick tungsten collimator to provide sharp beam penumbra suitable...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2014.922719
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:Ifosfamide as a chemotherapeutic drug is used for the treatment of different cancer types. The purpose of this study is the preparation of 99mTc-ifosfamide complex to be evaluated as a potential candidate for tumor imaging. MATERIALS AND METHODS:The radiolabeling of ifosfamide with technetium-99m was carried o...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2019.1524945
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:Solar energy has a number of short- and long-term detrimental effects on skin that can result in several skin disorders. The aim of this review is to summarise current knowledge on endogenous systems within the skin for protection from solar radiation and present research findings to date, on the exogenous opti...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.3109/09553002.2010.501842
更新日期：2010-12-01 00:00:00
abstract：PURPOSE:The LET position of the RBE maximum and its dependence on the cellular repair capacity was determined for carbon ions. Hamster cell lines of differing repair capacity were irradiated with monoenergetic carbon ions. RBE values for cell inactivation at different survival levels were determined and the differences...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530099139232
更新日期：1999-11-01 00:00:00
