The expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight.

abstract：PURPOSE:To examine the protective effects of histamine on intestinal damage produced by gamma-radiation. MATERIALS AND METHODS:56 mice were divided into 4 groups. Histamine and Histamine-10 Gy groups received a daily subcutaneous histamine injection (0.1 mg/kg) starting 20 hours before irradiation and continued until ...

journal_title：International journal of radiation biology

authors： Medina VA,Croci M,Mohamad NA,Massari N,Garbarino G,Cricco GP,Núñez MA,Martín GA,Crescenti EJ,Bergoc RM,Rivera ES

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:Zearalenone is a potent estrogenic metabolite produced by some Fusarium and Gibberella species. Therefore, the aim of this study was to determine the accumulation of Technetium-[99m]-labeled zearalenone in mice organs as well as to study the protective effect of Lactobacillus plantarum. MATERIALS AND METHODS:T...

journal_title：International journal of radiation biology

authors： Sanad MH,Fouzy ASM,Sobhy HM,Hathout AS,Hussain OA

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:The increased bioactivity 'windows' of GSM 900 and 1800 MHz radiations, (Global System for Mobile telecommunications) revealed recently by us and published in this issue, manifesting themselves as a maximum decrease in the reproductive capacity of the insect Drosophila melanogaster, were examined to discover wh...

journal_title：International journal of radiation biology

authors： Panagopoulos DJ,Margaritis LH

更新日期：2010-05-01 00:00:00

abstract：:The radiation response of 15 mammalian cell lines comprising 11 human tumour, two human fibroblast and two murine lymphoma cell lines, has been analysed using the linear-quadratic equation. As well as using conventional analysis of acute dose-survival curves to derive values for alpha and beta (termed alpha ac and bet...

journal_title：International journal of radiation biology

authors： Peacock JH,Eady JJ,Edwards SM,McMillan TJ,Steel GG

更新日期：1992-04-01 00:00:00

abstract：PURPOSE:To investigate the induction of chromosomal aberrations in mouse m5S cells after exposure to power-line frequency magnetic fields (extremely low frequency magnetic fields; ELFMF) at high-flux densities. MATERIAL AND METHOD:m5S cells were either untreated or pretreated during the G1 phase with mitomycin C (MMC,...

journal_title：International journal of radiation biology

authors： Yaguchi H,Yoshida M,Ding GR,Shingu K,Miyakoshi J

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:To examine whether the levels of micronuclei induction, as a marker for genomic instability in the progeny of X-irradiated cells, correlates with DNA repair function. MATERIALS AND METHODS:Two repair deficient cell lines (X-ray repair cross-complementing 1 [XRCC1] deficient cell line [EM9] and X-ray repair cro...

journal_title：International journal of radiation biology

authors： Kashino G,Suzuki K,Kodama S,Watanabe M,Prise KM

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether the effects of gamma rays on the regeneration of hair follicles are carried over to later hair cycles. MATERIALS AND METHODS:The whole bodies of C57BL/10JHir mice in the 1st telogen phase were irradiated with (60)Co γ-rays. Mice were examined for the effects o...

journal_title：International journal of radiation biology

authors： Sugaya K,Ishihara Y,Inoue S,Hirobe T

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Many strategies have been investigated to exclude the several side-effects of pharmacological or invasive treatments. Non-invasive pulsed magnetic field (PMF) treatment with no toxicity or side-effects can be an alternative to pharmacologic treatments. The purpose of this study was, therefore, to investigate th...

journal_title：International journal of radiation biology

authors： Mert T,Ocal I,Cinar E,Yalcin MS,Gunay I

更新日期：2014-01-01 00:00:00

abstract：:The in vitro cell survival of a human cervix carcinoma cell line (HX156c) has been assessed using 60Co gamma-rays administered at either high (150 cGy/min) or low (3.2 cGy/min) dose rate. Recovery during low dose-rate irradiation was observed; the dose reduction factor at 10(-2) cell kill for 150 versus 3.2 cGy/min wa...

journal_title：International journal of radiation biology

authors： Kelland LR,Steel GG

更新日期：1988-08-01 00:00:00

abstract：PURPOSE:Exposure to ionizing radiation induces plant defenses by regulating the expression of response genes. The systemic acquired resistance deficient 1 (SARD1) is a key gene in plant defense response. In this study, the function of Oryza sativa SARD1 (OsSARD1) was investigated after exposure of seeds/plants to ioniz...

journal_title：International journal of radiation biology

authors： Jung IJ,Hwang JE,Han SM,Kim DS,Ahn JW,Choi HI,Kwon SJ,Kang SY,Kim JB

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:To compare the chromosomal radiosensitivity of C3H mouse acute myeloid leukaemia (AML) cell lines 7926 and 8709 and to investigate the mechanistic basis of the radiosensitivity observed in 7926. MATERIALS AND METHODS:Yields of chromosome aberrations following X-irradiation were determined in Giemsa-stained met...

journal_title：International journal of radiation biology

authors： Finnon P,Wong HP,Silver AR,Slijepcevic P,Bouffler SD

更新日期：2001-12-01 00:00:00

abstract：:An iodinated DNA ligand, iodo Hoechst 33258, which binds in the minor groove of DNA, enhances DNA strand breakage and cell killing by UV-A irradiation. The sites of UV-induced strand breaks reflect the known sequence specificity of the ligand. ...

journal_title：International journal of radiation biology

authors： Martin RF,Murray V,D'Cunha G,Pardee M,Kampouris E,Haigh A,Kelly DP,Hodgson GS

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:To ask whether highly metastatic sublines show more marked low-dose hyper-radiosensitivity (HRS) response than poorly metastatic ones. MATERIALS AND METHODS:The progressive (PRO) subline showing tumourigenicity and metastatic potential and the regressive (REG) subline showing neither tumourigenicity nor metast...

journal_title：International journal of radiation biology

authors： Thomas C,Charrier J,Massart C,Cherel M,Fertil B,Barbet J,Foray N

更新日期：2008-07-01 00:00:00

abstract：:Two novel nitroimidazole-carboranes were examined for their uptake and retention in two experimental murine solid tumours and in some normal tissues, using in vivo 11B magnetic resonance spectroscopy. The compounds were injected i.p. at 0.8mmol/kg into mice bearing either the SCCVII/Ha squamous cell carcinoma or KHT s...

journal_title：International journal of radiation biology

authors： Wood PJ,Scobie M,Threadgill MD

更新日期：1996-11-01 00:00:00

abstract：:Experimental data for acute radiation-induced skin reactions are reviewed. These show that for dose fractionation schedules with gaps, repopulation is initiated after a lag period. After this lag period, the isoeffective dose for a given level of skin reaction first increases rapidly, but then slows. The timing of the...

journal_title：International journal of radiation biology

authors： Hopewell JW,Nyman J,Turesson I

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:Gamma-irradiation leads to activation of p53 tumour suppressor gene and to p53-dependant stimulation of a large panel of cellular genes including proapoptotic genes involved in intrinsic and extrinsic pathways. Most in vivo published data referred to high (lethal) irradiation doses. The present study was perfor...

journal_title：International journal of radiation biology

authors： Alvarez S,Drané P,Meiller A,Bras M,Deguin-Chambon V,Bouvard V,May E

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:Ionizing radiation has been recognized to increase the risk of cardiovascular diseases (CVD). However, there is no consensus concerning the dose-risk relationship for low radiation doses and a mechanistic understanding of low dose effects is needed. MATERIAL AND METHODS:Previously, human umbilical vein endothe...

journal_title：International journal of radiation biology

authors： Rombouts C,Aerts A,Quintens R,Baselet B,El-Saghire H,Harms-Ringdahl M,Haghdoost S,Janssen A,Michaux A,Yentrapalli R,Benotmane MA,Van Oostveldt P,Baatout S

更新日期：2014-07-01 00:00:00

abstract：:Purpose: Radiotherapy prescription dose and dose fractionation protocols vary little between individual patients having the same tumor grade and stage. To personalize radiotherapy a predictive model is needed to simulate radiation response. Previous modeling attempts with multiple variables and parameters have been sh...

journal_title：International journal of radiation biology

authors： Sunassee ED,Tan D,Ji N,Brady R,Moros EG,Caudell JJ,Yartsev S,Enderling H

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and...

journal_title：International journal of radiation biology

authors： Dinčić M,Krstić DZ,Čolović MB,Nešović Ostojić J,Kovačević S,De Luka SR,Djordjević DM,Ćirković S,Brkić P,Todorović J

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:The need to determine a reliable relative biological effectiveness (RBE) value for alpha exposures has become important as reports remain controversial. Although a radiation-weighting factor of 20 has been designated for alpha particles, uncertainty exists on realistic value of the RBE of alpha radiation. The a...

journal_title：International journal of radiation biology

authors： Meenakshi C,Mohankumar MN

更新日期：2015-08-01 00:00:00

abstract：:The literature suggests that the function of radiation-induced G2 arrest is to allow repair of potentially lethal damage before cell-entry into, and damage expression in, mitosis. The nature of the damage repaired is not known, but chromosome aberrations have been considered. To examine this possibility in G2 cells, t...

journal_title：International journal of radiation biology

authors： Rowley R

更新日期：1990-09-01 00:00:00

abstract：PURPOSE:The relationship between cellular telephone use and excretion of the melatonin metabolite 6-hydroxymelatonin sulfate (6-OHMS) was evaluated in two populations of male electric utility workers (Study 1, n=149; Study 2, n=77). MATERIALS AND METHODS:Participants collected urine samples and recorded cellular telep...

journal_title：International journal of radiation biology

authors： Burch JB,Reif JS,Noonan CW,Ichinose T,Bachand AM,Koleber TL,Yost MG

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:To test the importance of serotonin as a signaling molecule involved in the production and response of radiation-induced bystander effects. MATERIALS AND METHODS:HPV-G human keratinocyte cultures were spiked with various concentrations of Granisetron or Ketanserin and subject to either 0 Gy or 0.5 Gy X-irradia...

journal_title：International journal of radiation biology

authors： Fazzari J,Mersov A,Smith R,Seymour C,Mothersill C

更新日期：2012-10-01 00:00:00

abstract：:BW12C, which was developed as an agent for the treatment of sickle cell anaemia, increases the binding of oxygen to haemoglobin and hence reduces the availability of oxygen to tissues. Due to these changes in oxygen availability BW12C could act as a protector against radiation-induced injury to normal tissues. In this...

journal_title：International journal of radiation biology

authors： van den Aardweg GJ,Hopewell JW,Adams GE,Barnes DW,Sansom JM,Stratford IJ,Nethersell AB

更新日期：1991-04-01 00:00:00

abstract：PURPOSE:The low dose (<1 Gy) survival curve of mammalian cells is characterized by a region of hypersensitivity (HRS) followed by increased resistance (IRR). Above 1 Gy, the survival response can be described with a smooth downward-bending curve. Indirect evidence has indicated that the IRR response might reflect an in...

journal_title：International journal of radiation biology

authors： Marples B,Joiner MC

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To determine whether chromosomal instability is induced in human diploid fibroblasts by ionizing radiation and to investigate the effects of radiation quality by comparing X-rays, neutrons and alpha-particles. MATERIALS AND METHODS:Cells from two human diploid fibroblast lines, HF12 and HF19, were irradiated a...

journal_title：International journal of radiation biology

authors： Kadhim MA,Marsden SJ,Wright EG

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:To resolve the difficulty in counting merged DNA damage foci in high-LET (linear energy transfer) ion-induced patterns. MATERIALS AND METHODS:The analysis of patterns of RIF (radiation-induced foci) produced by high-LET Fe and Ti ions were conducted by using a Monte Carlo model that combines the heavy ion trac...

journal_title：International journal of radiation biology

authors： Ponomarev AL,Huff J,Cucinotta FA

更新日期：2010-06-01 00:00:00

abstract：:SR 2508 (etanidazole) (1 mM) or buthionine sulphoximine (BSO, 50 microM) or both drugs together did not radiosensitize oxic V79 Chinese hamster cells irradiated at either an acute dose rate (2.35 Gy/min) or at a low dose rate (0.117 Gy/min). BSO pretreatment (15 h at 37 degrees C) depleted cellular glutathione (GSH) t...

journal_title：International journal of radiation biology

authors： Wong RS,Basas RA,Ling CC

更新日期：1991-01-01 00:00:00

abstract：:A review is presented to the program of education and training setup within the DoReMi Network of Excellence. DoReMi was funded by Euratom under the EU 7th Framework Programme to coordinate the EU research into risks from low-dose ionizing radiation. It was seen to be necessary to form a network of expert institutions...

journal_title：International journal of radiation biology

authors： Ottolenghi A,Trott KR,Smyth V

更新日期：2019-01-01 00:00:00

abstract：:We used a cell sorter assay to evaluate the efficacy of the hypoxic cell sensitizer etanidazole over 3-4 logs of cell inactivation, with particular attention to the clinically relevant low-dose survival region. Analysis of the radiation responses in a panel of six human tumour cell lines under conditions of hypoxia an...

journal_title：International journal of radiation biology

authors： Wouters BG,Sy AM,Skarsgard LD

更新日期：1996-12-01 00:00:00