Transcriptomic profiling suggests a role for IGFBP5 in premature senescence of endothelial cells after chronic low dose rate irradiation.

abstract：PURPOSE:Chronic occupational exposure to ionizing radiation (IR) induces a wide spectrum of DNA damages. The aim of this study was to assess the frequencies of micronucleus (MN), sister chromatid exchanges (SCE) and to evaluate their association with XRCC1 399 Arg/Gln and XRCC3 241 Thr/Met polymorphisms in Hospital sta...

journal_title：International journal of radiation biology

authors： Doukali H,Ben Salah G,Ben Rhouma B,Hajjaji M,Jaouadi A,Belguith-Mahfouth N,Masmoudi ML,Ammar-Keskes L,Kamoun H

更新日期：2017-11-01 00:00:00

abstract：:Radiation-induced DNA double-strand breaks (dsbs) were measured in CHO-K1 cells by means of an experimental approach involving constant-field gel electrophoresis and densitometric scanning of ethidium bromide stained gels. For X-irradiation, an induction efficiency of 36 +/- 5 dsbs (Gy x cell)-1 was determined. With t...

journal_title：International journal of radiation biology

authors： Heilmann J,Taucher-Scholz G,Kraft G

更新日期：1995-08-01 00:00:00

abstract：:The relative efficiencies of two types of densely ionizing particles were compared for the induction of mutations at two distinct genetic loci in human cells. Mutations to 6-thioguanine resistance (hgprt locus) or to trifluorothymidine resistance (tk) locus were scored in TK6 human lymphoblastoid cells exposed to grad...

journal_title：International journal of radiation biology

authors： Kronenberg A,Little JB

更新日期：1989-06-01 00:00:00

abstract：PURPOSE:The molecular basis of gene regulation in cells exposed to ionising radiation is not fully understood. Gene regulation occurs at the transcriptional and post-transcriptional levels. Recent studies have suggested that micro-RNA (miRNA) plays a significant role at the post-transcriptional gene regulation. miRNA a...

journal_title：International journal of radiation biology

authors： Chaudhry MA,Kreger B,Omaruddin RA

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:The purpose of this study was to assess the effect of a lavage solution containing methoxypolyethylene glycol 4-(3,4-dihydroxyphenethylamino)-4-oxobutanoate (MDO) for whole lung lavage (WLL) in dogs after the inhalation of depleted uranium (DU) dust at a dose of 30 mgUkg-1. MATERIALS AND METHODS:WLL was perfor...

journal_title：International journal of radiation biology

authors： Ren J,Hao Y,Gao R,Zhang Y,Ran Y,Liu J,Dai X,Xiong W,Su Y,Li R

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:The nature of the transferrable factor which goes from irradiated objects to bystander objects remains undefined. Most agree that a chemical entity is the likely 'factor' although some authors have produced in vitro evidence for the involvement of a physical component or a very potent volatile capable of travel...

journal_title：International journal of radiation biology

authors： Mothersill C,Smith RW,Fazzari J,McNeill F,Prestwich W,Seymour CB

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:Public concern about radiation protection of the environment and non-human species is increasing. The potential impact of chronic gamma radiation on the bacterial community in a rice paddy ecosystem was investigated. MATERIALS AND METHODS:Paddy field microcosm samples were continuously exposed at a dose rate o...

journal_title：International journal of radiation biology

authors： Ishii N,Fuma S,Tagami K,Honma-Takeda S,Shikano S

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:Conditionally Replicative Adenovirus (CRAd) has been previously demonstrated to augment the activity of radiation, resulting in synergy of cell kill. However, previous models combining radiation with CRAd have not focused on the methods of radiation delivery. MATERIALS AND METHODS:We model the combination of a...

journal_title：International journal of radiation biology

authors： Liu C,Zhang Y,Liu MM,Zhou H,Chowdhury W,Lupold SE,Deweese TL,Rodriguez R

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:The impact of the damage distribution to cellular survival and chromosomal aberrations following high Linear Energy Transfer (LET) radiation was investigated. MATERIALS AND METHODS:High LET iron-ions (500 MeV/n, LET 200 keV/μm) were delivered to G1-phase synchronized Chinese Hamster Ovary (CHO) cells located a...

journal_title：International journal of radiation biology

authors： Fujii Y,Yurkon CR,Maeda J,Genet SC,Okayasu R,Kitamura H,Fujimori A,Kato TA

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:To determine the efficacy of a caffeine derivative 1-methylxanthine (1-MTX) in increasing radiosensitivity of cancer cells and elucidate the underlying mechanisms in vitro. MATERIALS AND METHODS:RKO human colorectal cancer cells carrying wild type protein 53 kDa (p53) were incubated with 3 mM 1-MTX for 30 min,...

journal_title：International journal of radiation biology

authors： Youn H,Hee Kook Y,Oh ET,Jeong SY,Kim C,Kyung Choi E,Uk Lim B,Park HJ

更新日期：2009-02-01 00:00:00

abstract：:The repair of DNA double-strand breaks was measured by pH 7.2 filter elution in cells incubated at 25-45 degrees C either before or after X-irradiation. Exposure to 45 degrees C for 15 minutes immediately prior to X-irradiation significantly increased both the half-time for DNA double-strand break closure and the numb...

journal_title：International journal of radiation biology

authors： Warters RL,Axtell J

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Despite proven antitumor activity of gemcitabine in chemoradiotherapy of advanced head and neck cancer, many authors refer to severe acute and late local and haematological toxicity. Fludarabine does imply nearly the same mechanisms of action as gemcitabine, inhibiting various enzymes involved in DNA replicatio...

journal_title：International journal of radiation biology

authors： Nitsche M,Christiansen H,Hermann RM,Lucke EM,Peters K,Rave-Frank M,Schmidberger H,Pradier O

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:The long-term effect of low and moderate doses of ionizing radiation on the lens is still a matter of debate and needs to be evaluated in more detail. MATERIAL AND METHODS:We conducted a detailed histological analysis of eyes from B6C3F1 mice cohorts after acute gamma irradiation (60Co source; 0.063 Gy/min) at...

journal_title：International journal of radiation biology

authors： Kunze S,Cecil A,Prehn C,Möller G,Ohlmann A,Wildner G,Thurau S,Unger K,Rößler U,Hölter SM,Tapio S,Wagner F,Beyerlein A,Theis F,Zitzelsberger H,Kulka U,Adamski J,Graw J,Dalke C

更新日期：2021-01-19 00:00:00

abstract：:237Np nitrate was injected intravenously into 4-week-old (young) and 10-12-week-old (adult) female albino Sprague-Dawley rats. The amounts given were 52 (young), 5.2 (adult) and 26 kBq kg-1 body weight (adult). The microscopic distribution in the femur and the lumbar vertebrae was studied. Initially, neptunium was dis...

journal_title：International journal of radiation biology

authors： Sontag W

更新日期：1993-03-01 00:00:00

abstract：:The kinetic scheme of the reaction of desferrioxamine (DFO) with O2-. was studied using pulse and gamma-radiolysis. The rate constant k(O2-. + DFO) is equal to 1.3 +/- 0.1 x 10(6) dm3 mol-1s-1 at pH 7.4. Studying the competition between DFO and ferricytochrome-c for O2-. generated by gamma-radiolysis, we observed that...

journal_title：International journal of radiation biology

authors： Sabourault D,Ribiere C,Nordmann R,Houee-Levin C,Ferradini C

更新日期：1989-12-01 00:00:00

abstract：PURPOSE:Zearalenone is a potent estrogenic metabolite produced by some Fusarium and Gibberella species. Therefore, the aim of this study was to determine the accumulation of Technetium-[99m]-labeled zearalenone in mice organs as well as to study the protective effect of Lactobacillus plantarum. MATERIALS AND METHODS:T...

journal_title：International journal of radiation biology

authors： Sanad MH,Fouzy ASM,Sobhy HM,Hathout AS,Hussain OA

更新日期：2018-12-01 00:00:00

abstract：:Radiation-induced DNA double-strand breaks (dsb) were studied in Ehrlich ascites tumour cells (EATC) by sedimentation in neutral sucrose gradients at low centrifuge speed. Dsb induction was found to be linear with dose with a frequency of: ndsbmr-1D-1 = (11.7 +/- 2) x 10(-12)Gy-1 for 140 kV X-rays and ndsbmr-1D-1 = (1...

journal_title：International journal of radiation biology

authors： Blöcher D

更新日期：1988-11-01 00:00:00

abstract：PURPOSE:Epidemiological studies have demonstrated a possible correlation between exposure to extremely low-frequency magnetic fields (ELF-MF) and cancer. However, this correlation has yet to be definitively confirmed by epidemiological studies. The principal objective of this study was to assess the effects of 60 Hz ma...

journal_title：International journal of radiation biology

authors： Jin YB,Kang GY,Lee JS,Choi JI,Lee JW,Hong SC,Myung SH,Lee YS

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:To investigate the relationship between the susceptibility of B-chronic lymphoid leukaemia (B-CLL) cells to DNA damage-induced apoptosis, the kinetics of DNA strand-break rejoining, and chromosome damage after exposure to ionizing irradiation. MATERIALS AND METHODS:Lymphocytes from B-CLL patients were gamma-ir...

journal_title：International journal of radiation biology

authors： Blaise R,Alapetite C,Masdehors P,Merle-Beral H,Roulin C,Delic J,Sabatier L

更新日期：2002-08-01 00:00:00

abstract：:We have examined the timing of gamma-irradiation-induced death in relation to cell cycle progression using a panel of mouse lymphoid or myeloid cell lines. Death was found to occur immediately after irradiation ('rapid interphase' death), or after arrest in G2 phase ('delayed interphase' death). In part II of this ser...

journal_title：International journal of radiation biology

authors： Radford IR,Murphy TK

更新日期：1994-02-01 00:00:00

abstract：PURPOSE:In order to understand the molecular mechanism of nucleobase damage caused by ultrasoft X-ray irradiation, guanine radicals have been studied using an X-band EPR (electron paramagnetic resonance) spectrometer installed in a synchrotron soft X-ray beamline. MATERIALS AND METHODS:Guanine pellets were irradiated ...

journal_title：International journal of radiation biology

authors： Yokoya A,Akamatsu K,Fujii K,Ukai M

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:Recently, it was found that MK615 possessed an anti-proliferative ability on treated cancer cells as a consequence of triterpenoid compounds. It is well known that radiation affects cellular-mediated immunity in cancer patients who are treated with radiotherapy. Similarly, the ability of triterpenoid compounds ...

journal_title：International journal of radiation biology

authors： Al-Jahdari WS,Sakurai H,Yoshida Y,Mobaraki A,Suzuki Y,Nakano T

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There ...

journal_title：International journal of radiation biology

authors： Ainsbury E,Badie C,Barnard S,Manning G,Moquet J,Abend M,Antunes AC,Barrios L,Bassinet C,Beinke C,Bortolin E,Bossin L,Bricknell C,Brzoska K,Buraczewska I,Castaño CH,Čemusová Z,Christiansson M,Cordero SM,Cosler G,Mo

更新日期：2017-01-01 00:00:00

abstract：:I calculate the probability that a single high-energy ionizing particle or photon makes two widely spaced double-strand breaks in the same DNA molecule. Deletions (or inversions) between two breaks formed by the same incident particle are linear in radiation dose and occur even at extremely low dose-rates; deletions b...

journal_title：International journal of radiation biology

authors： Hutchinson F

更新日期：1996-11-01 00:00:00

abstract：PURPOSE:To ask whether highly metastatic sublines show more marked low-dose hyper-radiosensitivity (HRS) response than poorly metastatic ones. MATERIALS AND METHODS:The progressive (PRO) subline showing tumourigenicity and metastatic potential and the regressive (REG) subline showing neither tumourigenicity nor metast...

journal_title：International journal of radiation biology

authors： Thomas C,Charrier J,Massart C,Cherel M,Fertil B,Barbet J,Foray N

更新日期：2008-07-01 00:00:00

abstract：:Electron transfer to 5-bromouracil (5-BrU) from nucleobase (N) electron adducts (and their protonated forms) has been studied by product analysis and pulse radiolysis. When an electron is transferred to 5-BrU, the ensuing 5-BrU radical anion rapidly loses a bromide ion; the uracilyl radical thus formed reacts with add...

journal_title：International journal of radiation biology

authors： Nese C,Yuan Z,Schuchmann MN,Von Sonntag C

更新日期：1992-11-01 00:00:00

abstract：:We used the 'comet assay' to compare the amount of radiation-induced DNA damage in three tumour cell lines (MeWo, PECA 4451 and PECA 4197) and the extent of DNA repair in two of these lines (MeWo and PECA 4197). Tumour cells were irradiated with X-rays (0.1-10 Gy), embedded in agarose on slides, lysed with sodium dode...

journal_title：International journal of radiation biology

authors： Müller WU,Bauch T,Streffer C,Niedereichholz F,Böcker W

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:The present work summarises the history and current status of research into the importance of cancer stem cells for radiobiological research and for clinical radiation oncology. An effort is made to differentiate clonogenicity from stemness of cancer cells. CONCLUSION:In radiooncology, cancer stem cells have b...

journal_title：International journal of radiation biology

authors： Baumann M,Krause M,Thames H,Trott K,Zips D

更新日期：2009-05-01 00:00:00

abstract：:Induction of mutations to 6-thioguanine resistance (TGr) by gamma-rays at three different dose-rates and molecular changes in the HPRT gene were studied in human lymphoblastoid WIL2-NS cells. Mutant induction showed a curvilinear dose-response for acute irradiation (30 Gy/h). The total mutant frequency was lower after...

journal_title：International journal of radiation biology

authors： Furuno-Fukushi I,Tatsumi K,Takahagi M,Tachibana A

更新日期：1996-08-01 00:00:00

abstract：PURPOSE:To investigate the radiosensitisation of gold nanoparticles (GNP) with an average diameter of 5 nm coated with the gadolinium chelating agent dithiolated diethylenetriaminepentaacetic gadolinium (Au@DTDTPA:Gd) in vitro and in mice bearing tumours (MC7-L1). MATERIALS AND METHODS:In vivo, the gadolinium chelate ...

journal_title：International journal of radiation biology

authors： Hébert EM,Debouttière PJ,Lepage M,Sanche L,Hunting DJ

更新日期：2010-08-01 00:00:00