Preferential tumour accumulation of gold nanoparticles, visualised by Magnetic Resonance Imaging: radiosensitisation studies in vivo and in vitro.

abstract：PURPOSE:To compare colony-forming and comet assays on fibroblasts and lymphocytes of 32 breast cancer patients irradiated after breast-conserving operations and to correlate the results with acute clinical radiation reactions in the skin. MATERIAL AND METHODS:Skin fibroblasts were isolated and cultivated before radiot...

journal_title：International journal of radiation biology

authors： Oppitz U,Schulte S,Stopper H,Baier K,Müller M,Wulf J,Schakowski R,Flentje M

更新日期：2002-07-01 00:00:00

abstract：:It follows from the present work that the vascularization of the normal tissue present in the treatment volume limits the temperatures achieved during heat treatment of invasive ductal breast carcinoma. The temperatures can often be increased by giving fractionated heat treatment because heat treatment may reduce the ...

journal_title：International journal of radiation biology

authors： Lyng H,Monge OR,Bøhler PJ,Rofstad EK

更新日期：1991-07-01 00:00:00

abstract：:Radioiodine ((131)I) induced a dose- and time-dependent increase in DNA single-strand breaks (DNA-ssb) in human (G0) mononuclear blood cells (MNC) in vitro. Incubation of MNC with 22MBq (131)I/ml at 4 degrees C caused a linear, time-dependent induction of DNA-ssb (increase in elution rate: 24.7 x 10(-3) h(-1) per 100 ...

journal_title：International journal of radiation biology

authors： Hengstler JG,Bockisch A,Fuchs J,Grimm W,Zapf AO,Lade K,Meinert R,Oesch-Bartlomowicz B,Tanner B,Oesch F

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:To determine the involvement of c-Jun NH(2)-terminal kinase-1 (JNK1) and possibly of HSP27 in heat-induced apoptosis of human monoblastic leukaemia U937 cells. MATERIALS AND METHODS:Dominant negative JNK1 (APF), in which the phosphorylation sites Thr-Pro-Tyr were changed to Ala-Pro-Phe, was overexpressed in U9...

journal_title：International journal of radiation biology

authors： Enomoto A,Suzuki N,Liu C,Kang Y,Zhu J,Serizawa S,Matsumoto Y,Morita A,Ito M,Hosoi Y

更新日期：2001-08-01 00:00:00

abstract：:Genetic analysis was performed on 72 Italian A-T families ascertained through 91 probands. The frequency of the A-T gene was estimated through Dahlberg's formula, which uses the frequencies of first cousin marriages among the patients' parents and in the general population were obtained from the collection of Catholic...

journal_title：International journal of radiation biology

authors： Chessa L,Lisa A,Fiorani O,Zei G

更新日期：1994-12-01 00:00:00

abstract：:Lethal mutations are induced in mammalian cells mainly, perhaps wholly, within the dose range encompassing the 'shoulder,' and may well be attributable to error-prone Q-repair. ...

journal_title：International journal of radiation biology

authors： Alper T,Mothersill C,Seymour CB

更新日期：1988-10-01 00:00:00

abstract：PURPOSE:The actinides are chemical poisons and radiological hazards. One challenge to better appraise their toxicity and develop countermeasures in case of exposure of living organisms is to better assess pathways of contamination. Because of the high chemical affinity of those actinide elements for phosphate groups an...

journal_title：International journal of radiation biology

authors： Mostapha S,Fontaine-Vive F,Berthon L,Boubals N,Zorz N,Solari PL,Charbonnel MC,Den Auwer C

更新日期：2014-11-01 00:00:00

abstract：:The effects of a low dose (0.1-20 mGy) preirradiation with X-rays followed by a higher dose (2 Gy) of the same radiation on the recovery of the genetic damage induced as dominant lethals in mature oocytes (stage 14) of different strains of Drosophila melanogaster were investigated. The response was shown to be depende...

journal_title：International journal of radiation biology

authors： Schäppi-Büchi C

更新日期：1994-04-01 00:00:00

abstract：:Radiation survival curves have been obtained for crypts in the small and large intestine of male BDF1 mice using the microcolony assay. Four regions of the small intestine and three regions of the large intestine were studied. One of the major objectives was to determine the optimal conditions for the microcolony assa...

journal_title：International journal of radiation biology

authors： Cai WB,Roberts SA,Bowley E,Hendry JH,Potten CS

更新日期：1997-02-01 00:00:00

abstract：:The dose-rate effect has been the topic of extensive radiobiological studies and has important implications in radiation therapy and in the field of radiation protection. Three examples will be discussed: two in radiation therapy and one in protection. First, continuous low dose-rate interstitial brachytherapy may be ...

journal_title：International journal of radiation biology

authors： Hall EJ

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:To find detectable cytogenetic biomarkers that can offer information about the radiation quality of in vivo exposure retrospectively. MATERIALS AND METHODS:Chromosome-type aberrations of peripheral lymphocytes of uterine cancer patients that received internal gamma- and external X-ray therapy or carbon beam th...

journal_title：International journal of radiation biology

authors： Kanda R,Minamihisamatsu M,Tsuji S,Ohmachi Y,Hiraoka T,Shimada Y,Ogiu T,Ohno T,Hayata I

更新日期：2006-07-01 00:00:00

abstract：:Because of the role that alveolar macrophages (PAM) play in the pulmonary clearance of inhaled particles via mechanical transport and dissolution, understanding the uptake and dissolution of particles by these cells might provide insight into the mechanisms of particle dissolution in lungs of various species and hence...

journal_title：International journal of radiation biology

authors： Taya A,Carmack DB,Muggenburg BA,Mewhinney JA

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:To evaluate the impact of oral administration of purslane (Portulaca oleracea) extract or fish oil and their co-treatments in the modulation of radiation-induced damage. MATERIAL AND METHODS:Purslane (P) (400 mg/kg body weight) or fish oil (Fo) (60 mg/kg body weight) was administrated to male albino rats via g...

journal_title：International journal of radiation biology

authors： Abd El-Azime AS,Hussein EM,Ashry OM

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Following ionizing radiation exposure, intestinal crypt regeneration is possible but it is still not known if regenerating crypts give rise to differentiated functional epithelial cells on villi. The aim of this study was to demonstrate that irradiated progeny of enterocytic precursor cells are capable of proli...

journal_title：International journal of radiation biology

authors： Haton C,Lebrun F,Benderitter M,Griffiths NM

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:The purpose of this study was to assess the effect of a lavage solution containing methoxypolyethylene glycol 4-(3,4-dihydroxyphenethylamino)-4-oxobutanoate (MDO) for whole lung lavage (WLL) in dogs after the inhalation of depleted uranium (DU) dust at a dose of 30 mgUkg-1. MATERIALS AND METHODS:WLL was perfor...

journal_title：International journal of radiation biology

authors： Ren J,Hao Y,Gao R,Zhang Y,Ran Y,Liu J,Dai X,Xiong W,Su Y,Li R

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:To illustrate the progress in normal tissue radiation biology over the last five decades and its impact on radiotherapy. MATERIALS AND METHODS:Major milestones over the last 50 years and their consequences for radiation oncology are described: The identification of clonogenic cell survival and the (target) ste...

journal_title：International journal of radiation biology

authors： Stewart FA,Dörr W

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:The effect of extremely low frequency electromagnetic fields (ELF-EMF) on bacteria has attracted attention due to its potential for beneficial uses. This research aimed to determine the effect of ELF-EMF on bacterial membrane namely the membrane potential, surface potential, hydrophobicity, respiratory activity...

journal_title：International journal of radiation biology

authors： Oncul S,Cuce EM,Aksu B,Inhan Garip A

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:To investigate the relationship between the susceptibility of B-chronic lymphoid leukaemia (B-CLL) cells to DNA damage-induced apoptosis, the kinetics of DNA strand-break rejoining, and chromosome damage after exposure to ionizing irradiation. MATERIALS AND METHODS:Lymphocytes from B-CLL patients were gamma-ir...

journal_title：International journal of radiation biology

authors： Blaise R,Alapetite C,Masdehors P,Merle-Beral H,Roulin C,Delic J,Sabatier L

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:To investigate the hypothesis that the developmental phase at which an individual encounters radiation damage affects its long-term sensitivity to a subsequent tumourigenic insult. MATERIALS AND METHODS:Either the pregnant C57B16 mouse was exposed to 137Cs gamma-rays at 4 or 15 days post-conception (embryonic ...

journal_title：International journal of radiation biology

authors： Hoyes KP,Hendry JH,Lord BI

更新日期：2000-01-01 00:00:00

abstract：:Context: Some individuals are reporting being sensitive to electromagnetic fields. They report some unspecific symptoms like headeache, sleep disruption, heart palpitations, itching, etc. The lack of scientific objective links between EHS symptoms and EMF exposure renders the diagnosis of EHS more complex. Purpose: Ou...

journal_title：International journal of radiation biology

authors： Andrianome S,Yahia-Cherif L,Selmaoui B

更新日期：2019-06-01 00:00:00

abstract：:In mice, external X- or gamma-irradiation may induce thymic lymphomas or myeloid leukaemias, while bone-seeking alpha-emitters may induce osteosarcomas and, to a lesser extent, acute myeloid leukaemia. The present paper aims to review briefly some of the experimental data with respect to the molecular mechanisms under...

journal_title：International journal of radiation biology

authors： Janowski M,Cox R,Strauss PG

更新日期：1990-04-01 00:00:00

abstract：PURPOSE:The detection of long-term persistent chromosome aberrations in circulating haemopoietic stem cells after accidental radiation exposure. MATERIAL AND METHODS:Peripheral blood samples from highly exposed persons were collected 7-25 years after the radiation accidents in Moscow (1971), Kazan (1975) and Chernobyl...

journal_title：International journal of radiation biology

authors： Kreja L,Greulich KM,Fliedner TM,Heinze B

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:Cells derived from individuals in which the ataxia telangiectasia (ATM) gene is mutated are hypersensitive to ionizing radiation. Whether differences in ATM protein levels exist among human malignant glioma cell lines and whether such differences are correlated with cellular radiosensitivity were determined. M...

journal_title：International journal of radiation biology

authors： Chan DW,Gately DP,Urban S,Galloway AM,Lees-Miller SP,Yen T,Allalunis-Turner J

更新日期：1998-08-01 00:00:00

abstract：:Ruthenium-106 in citrate solution was administered intravenously to rat at different stages of pregnancy and to guinea-pig either before conception or in late pregnancy. The results for rat showed that retention in the embryo/foetus measured at 3-5 days after administration increased from about 0.0002% of injected act...

journal_title：International journal of radiation biology

authors： Levack VM,Pottinger H,Harrison JD

更新日期：1994-12-01 00:00:00

abstract：:Purpose To study the effect of microwave (MW) irradiation and consistent action of microwaves and static magnetic field (MF) on the giant chromosomes endoreduplication in Drosophila melanogaster Meig. Materials and methods Experiments were carried out on inbred wild type Canton-S strain. Exposure to microwaves (freque...

journal_title：International journal of radiation biology

authors： Dyka LD,Shakina LA,Strashnyuk VY,Shckorbatov YG

更新日期：2016-01-01 00:00:00

abstract：:Calibration of the non-denaturing (pH 9.6) filter elution technique by 125I decays has been used to examine the relationship between X-ray-induced DNA double-strand breaks (dsb) and cellular survival of CHO cells and human fibroblasts. DNA dsb induction varies markedly between the two cell lines, reflecting the differ...

journal_title：International journal of radiation biology

authors： Baumstark-Khan C

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:To evaluate how irradiation affects thyroid autoimmunity in mouse models of Hashimoto's thyroiditis and Graves' hyperthyroidism. MATERIALS AND METHODS:Non-obese diabetic (NOD)-H2(h4) mice spontaneously develop anti-thyroglobulin (Tg) antibodies and thyroiditis when supplied with sodium iodine (NaI) in the drin...

journal_title：International journal of radiation biology

authors： Nagayama Y,Kaminoda K,Mizutori Y,Saitoh O,Abiru N

更新日期：2008-09-01 00:00:00

abstract：:Purpose: A study is presented of the irradiation of cancerous cervical cell line HeLa loaded with a platinum salt, betamethasone and deoxyglucose. The presence of the platinum increases the free-radical concentration and augments the cell death rate, whereas betamethasone or deoxyglucose induces radiosensitization by ...

journal_title：International journal of radiation biology

authors： Usami N,Hirayama R,Kobayashi K,Furusawa Y,Le Sech C

更新日期：2020-05-01 00:00:00

abstract：:Pre-implantation embryos of the mouse were studied for the occurrence of an adaptive response, i.e. induction of radio-resistance by a previous low dose. Various experimental designs were checked (initial doses between 3 and 10 cGy; second dose 2-6 Gy at 6-24 h after the first dose). Some of the experiments were carri...

journal_title：International journal of radiation biology

authors： Müller WU,Streffer C,Niedereichholz F

更新日期：1992-08-01 00:00:00

abstract：:In the last decade the 'comet assay' or 'single cell gel electrophoresis assay' has been established as a sensitive method for the detection of DNA damage and the measurement of its recovery. The results published in the literature have often been obtained with different methods for comet structure measurement. In mos...

journal_title：International journal of radiation biology

authors： Böcker W,Bauch T,Müller WU,Streffer C

更新日期：1997-10-01 00:00:00