Influence of track directions on the biological consequences in cells irradiated with high LET heavy ions.

abstract：PURPOSE:To examine the protective effects of histamine on intestinal damage produced by gamma-radiation. MATERIALS AND METHODS:56 mice were divided into 4 groups. Histamine and Histamine-10 Gy groups received a daily subcutaneous histamine injection (0.1 mg/kg) starting 20 hours before irradiation and continued until ...

journal_title：International journal of radiation biology

authors： Medina VA,Croci M,Mohamad NA,Massari N,Garbarino G,Cricco GP,Núñez MA,Martín GA,Crescenti EJ,Bergoc RM,Rivera ES

更新日期：2007-10-01 00:00:00

abstract：:A radionuclide release assay for measuring the in vitro kinetics of cell death has been developed. CHO cells were labelled for 24 h with 3.0 hBq/ml of [125I] iododeoxyuridine (125IUdR) and the fate of the labelled cells and their progeny was monitored at daily intervals by measuring the rate of 125I release. Prelabell...

journal_title：International journal of radiation biology

authors： Schneiderman MH,Hofer KG,Schneiderman GS

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:We aimed for a quantitative evaluation that justifies guidelines for evacuation which take into consideration both the human and economic costs. To the best of our knowledge, such an evaluation has not been performed yet. The present guidelines published by the International Atomic Energy Agency (IAEA) are prob...

journal_title：International journal of radiation biology

authors： Yanovskiy M,Levi ON,Shaki YY,Socol Y

更新日期：2020-11-01 00:00:00

abstract：:The radiation survival response of asynchronously-dividing populations of the cell line V79-WNRE indicates substructure in the low dose region that can be better characterized by separately fitting the data within the low and high dose regions to the linear-quadratic (LQ) equation. Flow cytometry and cell sorting tech...

journal_title：International journal of radiation biology

authors： Skwarchuk MW,Wouters BG,Skarsgard LD

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:To investigate the radiosensitisation of gold nanoparticles (GNP) with an average diameter of 5 nm coated with the gadolinium chelating agent dithiolated diethylenetriaminepentaacetic gadolinium (Au@DTDTPA:Gd) in vitro and in mice bearing tumours (MC7-L1). MATERIALS AND METHODS:In vivo, the gadolinium chelate ...

journal_title：International journal of radiation biology

authors： Hébert EM,Debouttière PJ,Lepage M,Sanche L,Hunting DJ

更新日期：2010-08-01 00:00:00

abstract：:Induction of mutations to 6-thioguanine resistance (TGr) by gamma-rays at three different dose-rates and molecular changes in the HPRT gene were studied in human lymphoblastoid WIL2-NS cells. Mutant induction showed a curvilinear dose-response for acute irradiation (30 Gy/h). The total mutant frequency was lower after...

journal_title：International journal of radiation biology

authors： Furuno-Fukushi I,Tatsumi K,Takahagi M,Tachibana A

更新日期：1996-08-01 00:00:00

abstract：PURPOSE:The assessment of biological effects caused by radiation exposure has been currently carried out with the linear-quadratic (LQ) model as an extension of the linear non-threshold (LNT) model. In this study, we suggest a new mathematical model named as SeaSaw (SS) model, which describes proliferation and cell dea...

journal_title：International journal of radiation biology

authors： Bando M,Tsunoyama Y,Suzuki K,Toki H

更新日期：2020-12-15 00:00:00

abstract：PURPOSE:The purpose of this work was to determine whether the cellular components of Hairless-rat skin are affected by a chronic local exposure to non-ionizing radiations of Global Mobile Phone System: GSM-900 or -1800 radiations at specific absorption rate (SAR) 2.5 and 5 W/kg. MATERIALS AND METHODS:A selected part o...

journal_title：International journal of radiation biology

authors： Sanchez S,Masuda H,Billaudel B,Haro E,Anane R,Lévêque P,Ruffie G,Lagroye I,Veyret B

更新日期：2006-09-01 00:00:00

abstract：:Pulsed-field electrophoresis is being used extensively in the gene mapping studies and in the analysis of DNA strand breakage by ionizing radiation. We have evaluated the relationship between the fraction of S phase DNA in a cell population and its ability to modify the migration of DNA in pulsed-field gel electrophor...

journal_title：International journal of radiation biology

authors： Mateos S,Gordon AT,Steel GG,McMillan TJ

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:To test the importance of serotonin as a signaling molecule involved in the production and response of radiation-induced bystander effects. MATERIALS AND METHODS:HPV-G human keratinocyte cultures were spiked with various concentrations of Granisetron or Ketanserin and subject to either 0 Gy or 0.5 Gy X-irradia...

journal_title：International journal of radiation biology

authors： Fazzari J,Mersov A,Smith R,Seymour C,Mothersill C

更新日期：2012-10-01 00:00:00

abstract：:Purpose To study the effect of microwave (MW) irradiation and consistent action of microwaves and static magnetic field (MF) on the giant chromosomes endoreduplication in Drosophila melanogaster Meig. Materials and methods Experiments were carried out on inbred wild type Canton-S strain. Exposure to microwaves (freque...

journal_title：International journal of radiation biology

authors： Dyka LD,Shakina LA,Strashnyuk VY,Shckorbatov YG

更新日期：2016-01-01 00:00:00

abstract：:One of the important temporal stages of radiation action in cellular systems is the chemical phase, where oxygen fixation reactions compete with chemical repair reactions involving reducing agents such as GSH. Using the gas explosion technique it is possible to follow the kinetics of these fast (greater than 1 ms) rea...

journal_title：International journal of radiation biology

authors： Prise KM,Davies S,Michael BD

更新日期：1992-06-01 00:00:00

abstract：PURPOSE:To investigate whether an adaptive response can be induced in mice which were pre-exposed to 900 MHz radiofrequency fields. MATERIALS AND METHODS:Adult male Kunming mice were exposed to 900 MHz radiofrequency fields (RF) at power intensities of 12, 120 and 1200 μW/cm(2) for 1 h/day for 14 days and then subject...

journal_title：International journal of radiation biology

authors： Cao Y,Xu Q,Jin ZD,Zhou Z,Nie JH,Tong J

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To assess the possibility that extremely low frequency (ELF) magnetic fields obstruct the damage repair process, the gene conversion frequency and cell cycle kinetics in a DNA repair-proficient and nucleotide excision repair (NER)-deficient strain of diploid yeast Saccharomyces cerevisiae. MATERIALS AND METHOD...

journal_title：International journal of radiation biology

authors： Takashima Y,Ikehata M,Miyakoshi J,Koana T

更新日期：2003-11-01 00:00:00

abstract：:Calibration of the non-denaturing (pH 9.6) filter elution technique by 125I decays has been used to examine the relationship between X-ray-induced DNA double-strand breaks (dsb) and cellular survival of CHO cells and human fibroblasts. DNA dsb induction varies markedly between the two cell lines, reflecting the differ...

journal_title：International journal of radiation biology

authors： Baumstark-Khan C

更新日期：1993-03-01 00:00:00

abstract：:Sample preparation procedures for the pulsed-field gel electrophoresis (PFGE) assay usually involve a lysis step at temperatures as high as 50 degrees C. During this warm-lysis procedure, multiply damaged sites containing heat-labile sites (HLS) can be converted into double-strand breaks (DSB). Once formed, these DSB ...

journal_title：International journal of radiation biology

authors： Ratnayake RK,Semenenko VA,Stewart RD

更新日期：2005-06-01 00:00:00

abstract：:The relative contributions of the OH-mediated and direct radiation effect on the induction of DNA double-strand breaks (dsbs) were evaluated in two haploid yeast cell lines (GSH+ and gsh-) irradiated under oxic or hypoxic conditions in the absence or presence of 6 M glycerol as an OH radical scavenger. Gsh- cells are ...

journal_title：International journal of radiation biology

authors： Frankenberg D,Frankenberg-Schwager M,Harbich R

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:To follow plasma Flt3-ligand (FL) concentrations in irradiated animals in order to evaluate it as an indicator of bone marrow damage for the management of accidental radiation-induced aplasia. MATERIALS AND METHODS:Non-human primates were irradiated at doses ranging from 2 to 8 Gy, using whole- or partial-body...

journal_title：International journal of radiation biology

authors： Bertho JM,Demarquay C,Frick J,Joubert C,Arenales S,Jacquet N,Sorokine-Durm I,Chau Q,Lopez M,Aigueperse J,Gorin NC,Gourmelon P

更新日期：2001-06-01 00:00:00

abstract：:Objective: To quantify DNA damage in patients undergoing non-contrast and contrast-enhanced 18F-FDG PET/CT whole body positron emission tomography/computed tomography (WB PET/CT) investigations using comet assay technique and micronucleus assay, and to study the effect of other baseline parameters of patients on DNA d...

journal_title：International journal of radiation biology

authors： Nautiyal A,Mondal T,Mukherjee A,Mitra D,Kaushik A,Goel HC,Goel A,Dey SK

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:To determine the radiosensitivity difference of human Cluster of Differentiation (CD)4(+)CD25(+) regulatory T cells (Treg) and effector T cells to low dose gamma ray and elucidate the underlying mechanisms in vitro. MATERIALS AND METHODS:Blood samples were collected from five health subjects and five patients ...

journal_title：International journal of radiation biology

authors： Cao M,Cabrera R,Xu Y,Liu C,Nelson D

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:It has been proposed previously that the ratio of complete to incomplete translocations as seen by fluorescence in situ hybridization (FISH), the S value, can be a cytogenetic fingerprint of exposure to radiation of different qualities. Results from a previous study suggested that the S value is approximately 1...

journal_title：International journal of radiation biology

authors： Nakano M,Kodama Y,Ohtaki K,Itoh M,Nakamura N

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:The nature of the transferrable factor which goes from irradiated objects to bystander objects remains undefined. Most agree that a chemical entity is the likely 'factor' although some authors have produced in vitro evidence for the involvement of a physical component or a very potent volatile capable of travel...

journal_title：International journal of radiation biology

authors： Mothersill C,Smith RW,Fazzari J,McNeill F,Prestwich W,Seymour CB

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:Ionizing radiation causes various types of DNA damage e.g. single strand breaks (SSB) and double strand breaks (DSB), whereby the SSB/DSB ratio is shifted toward the DSB with increasing LET. For the DNA-incorporated Auger electron emitter Iodine-125 a SSB/DSB ratio of 5.4:1 is calculated based on computer simul...

journal_title：International journal of radiation biology

authors： Unverricht-Yeboah M,Holtmann K,Kriehuber R

更新日期：2020-12-03 00:00:00

abstract：:We have examined the timing of gamma-irradiation-induced death in relation to cell cycle progression using a panel of mouse lymphoid or myeloid cell lines. Death was found to occur immediately after irradiation ('rapid interphase' death), or after arrest in G2 phase ('delayed interphase' death). In part II of this ser...

journal_title：International journal of radiation biology

authors： Radford IR,Murphy TK

更新日期：1994-02-01 00:00:00

abstract：PURPOSE:To evaluate the radioprotective effect of dieckol, a component of the brown algae Ecklonia cava. MATERIALS AND METHODS:Mice were lethally irradiated, treated with dieckol and surveyed for survival and the mechanism of radioprotection. RESULTS:Dieckol treatment lengthened the survival of irradiated mice and si...

journal_title：International journal of radiation biology

authors： Park E,Ahn G,Yun JS,Kim MJ,Bing SJ,Kim DS,Lee J,Lee NH,Park JW,Jee Y

更新日期：2010-10-01 00:00:00

abstract：:The mechanisms of radiation damage production are used to examine the following premises: (1) the number of DNA double-strand breaks per unit dose increases with dose; (2) cell type to cell type variations in yield of DNA dsb per dose occur. Two stages of damage production are identified as possible sources of damage ...

journal_title：International journal of radiation biology

authors： Ward JF

更新日期：1990-06-01 00:00:00

abstract：PURPOSE:This study evaluates early changes in human mesenchymal stem cells (MSC) isolated from dental pulp and periodontal ligament after γ-irradiation and the effect of ataxia-telangiectasia mutated (ATM) inhibition. METHODS:MSC were irradiated with 2 and 20 Gy by (60)Co. For ATM inhibition, specific inhibitor KU5593...

journal_title：International journal of radiation biology

authors： Cmielova J,Havelek R,Kohlerova R,Soukup T,Bruckova L,Suchanek J,Vavrova J,Mokry J,Rezacova M

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:The efficacy of a boron-containing cholesteryl ester compound (BCH) as a boron neutron capture therapy (BNCT) agent for the targeted irradiation of PC-3 human prostate cancer cells was examined. MATERIALS AND METHODS:Liposome-based delivery of BCH was quantified with inductively coupled plasma-mass spectrometr...

journal_title：International journal of radiation biology

authors： Gifford I,Vreeland W,Grdanovska S,Burgett E,Kalinich J,Vergara V,Wang CK,Maimon E,Poster D,Al-Sheikhly M

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:Adverse effects on human health caused by electromagnetic fields (EMF) associated with the use of mobile phones, particularly among young people, are increasing all the time. The potential deleterious effects of EMF exposure resulting from mobile phones being used in close proximity to the brain require particu...

journal_title：International journal of radiation biology

authors： Erdem Koç G,Kaplan S,Altun G,Gümüş H,Gülsüm Deniz Ö,Aydin I,Emin Onger M,Altunkaynak Z

更新日期：2016-10-01 00:00:00

abstract：:CHEF-electrophoresis was used as a technique to detect radiation-induced DNA breakage with special emphasis to biological relevant X-ray doses (0-10 Gy). Fluorescence detection of DNA-fragments using a sensitive image analysis system was directly compared with conventional scintillation counting of 3H-thymidine prelab...

journal_title：International journal of radiation biology

authors： Rosemann M,Kanon B,Konings AW,Kampinga HH

更新日期：1993-08-01 00:00:00