当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF RADIATION BIOLOGY期刊下所有文献 > Modification of murine adult haemopoiesis and response to methyl nitrosourea following exposure to radiation at different developmental stages.

Modification of murine adult haemopoiesis and response to methyl nitrosourea following exposure to radiation at different developmental stages.

Abstract：

PURPOSE:To investigate the hypothesis that the developmental phase at which an individual encounters radiation damage affects its long-term sensitivity to a subsequent tumourigenic insult. MATERIALS AND METHODS:Either the pregnant C57B16 mouse was exposed to 137Cs gamma-rays at 4 or 15 days post-conception (embryonic and foetal stages respectively) or BDF1 offspring were irradiated at 4 or 21 days of age (neonatal and juvenile stages). Offspring were either assayed for changes in bone marrow stem cells and committed progenitors at 6, 12 and 18 weeks of age, or injected with the chemical carcinogen methyl nitrosourea (MNU) at 10 weeks of age and monitored for onset of neoplasia. RESULTS:Gamma-irradiation induced a persistent long-term deficit in stem cells in all irradiated animals, with the foetal stage appearing most radiosensitive. However, femoral cellularity, committed progenitor cell numbers and peripheral blood counts were unaffected. When offspring were exposed to MNU, the incidence of malignancy was significantly enhanced in animals irradiated at the foetal, neonatal and juvenile stages. CONCLUSIONS:This study has shown that exposure to ionizing radiation at the foetal, neonate or juvenile stages of development induces residual haemopoietic damage and increases oncogenic susceptibility to a subsequent exposure to MNU.

journal_name

Int J Radiat Biol

journal_title

International journal of radiation biology

authors

Hoyes KP,Hendry JH,Lord BI

doi

10.1080/095530000139032

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

77-85

issue

1

eissn

0955-3002

issn

1362-3095

journal_volume

76

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY文献大全
  • Role of a high throughput biodosimetry test in treatment prioritization after a nuclear incident.

    abstract：PURPOSE:We introduce and evaluate a high throughput biodosimetry test system (REDI-Dx) suitable for testing of thousands of potential radiation victims following a mass scale nuclear event caused by detonation of a nuclear device or a nuclear accident, as part of an overall strategy for effective medical management of ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2018.1532615

    authors： Jacobs AR,Guyon T,Headley V,Nair M,Ricketts W,Gray G,Wong JYC,Chao N,Terbrueggen R

    更新日期：2020-01-01 00:00:00

  • The roles of TGF-β3 and peroxynitrite in removal of hyper-radiosensitivity by priming irradiation.

    abstract：PURPOSE:To investigate the mechanisms inducing and maintaining the permanent elimination of low dose hyper-radiosensitivity (HRS) in cells given a dose of 0.3 Gy at low dose-rate (LDR) (0.3 Gy/h). MATERIALS AND METHODS:Two human HRS-positive cell lines (T-47D, T98G) were used. The effects of pretreatments with transfo...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2014.906767

    authors： Edin NJ,Sandvik JA,Cheng C,Bergersen L,Pettersen EO

    更新日期：2014-07-01 00:00:00

  • Transcriptomic profiling suggests a role for IGFBP5 in premature senescence of endothelial cells after chronic low dose rate irradiation.

    abstract：PURPOSE:Ionizing radiation has been recognized to increase the risk of cardiovascular diseases (CVD). However, there is no consensus concerning the dose-risk relationship for low radiation doses and a mechanistic understanding of low dose effects is needed. MATERIAL AND METHODS:Previously, human umbilical vein endothe...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2014.905724

    authors： Rombouts C,Aerts A,Quintens R,Baselet B,El-Saghire H,Harms-Ringdahl M,Haghdoost S,Janssen A,Michaux A,Yentrapalli R,Benotmane MA,Van Oostveldt P,Baatout S

    更新日期：2014-07-01 00:00:00

  • Identification of genes regulated by UV/salicylic acid.

    abstract：PURPOSE:Previous work from the authors' group and others has demonstrated that some of the effects of UV irradiation on gene expression are modulated in response to the addition of salicylic acid to irradiated cells. The presumed effector molecule responsible for this modulation is NF-kappaB. In the experiments describ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530000138844

    authors： Paunesku T,Chang-Liu CM,Shearin-Jones P,Watson C,Milton J,Oryhon J,Salbego D,Milosavljevic A,Woloschak GE

    更新日期：2000-02-01 00:00:00

  • TGF-beta1-mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced fibrotic phenotype.

    abstract：PURPOSE:To study the influence of TGF-beta1 and TGF-beta-neutralizing antibodies on the clonogenic activity and terminal differentiation of rat lung fibroblasts following radiation exposure. MATERIAL AND METHODS:Early passage rat lung fibroblasts were used in this study. Colony formation assays were applied to determi...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530000138501

    authors： Hakenjos L,Bamberg M,Rodemann HP

    更新日期：2000-04-01 00:00:00

  • Liposome-based delivery of a boron-containing cholesteryl ester for high-LET particle-induced damage of prostate cancer cells: a boron neutron capture therapy study.

    abstract：PURPOSE:The efficacy of a boron-containing cholesteryl ester compound (BCH) as a boron neutron capture therapy (BNCT) agent for the targeted irradiation of PC-3 human prostate cancer cells was examined. MATERIALS AND METHODS:Liposome-based delivery of BCH was quantified with inductively coupled plasma-mass spectrometr...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2014.901579

    authors： Gifford I,Vreeland W,Grdanovska S,Burgett E,Kalinich J,Vergara V,Wang CK,Maimon E,Poster D,Al-Sheikhly M

    更新日期：2014-06-01 00:00:00

  • Increased mutability and decreased repairability of a three-lesion clustered DNA-damaged site comprised of an AP site and bi-stranded 8-oxoG lesions.

    abstract：PURPOSE:Ionizing radiation induces DNA damage, some of which are present in clusters, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. These clusters are thought to contribute to the detrimental effects of radiation, in part due to the compromised repair of c...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2014.899449

    authors： Cunniffe S,Walker A,Stabler R,O'Neill P,Lomax ME

    更新日期：2014-06-01 00:00:00

  • Correlation between cell killing and residual chromatin breaks measured by PCC in six human cell lines irradiated with different radiation types.

    abstract：PURPOSE:To examine the relationship between cell killing and residual chromatin breaks after irradiation with qualitatively different types of radiation in six human cell lines. MATERIALS AND METHODS:Six human tumour cell lines and normal human cells were irradiated with 200 kV X-rays and two carbon-ion beams accelera...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000050134429

    authors： Suzuki M,Kase Y,Kanai T,Ando K

    更新日期：2000-09-01 00:00:00

  • In vitro rejoining of double strand breaks induced in cellular DNA by bleomycin and restriction endonucleases.

    abstract：:We have previously described a cell-free assay that can be employed to study rejoining of radiation-induced DNA double-stranded breaks (dsb) in 'naked' DNA prepared from agarose-embedded cells using an extract of HeLa cells as a source of enzymes. Rejoining of dsb in this assay is absolutely dependent on cell extract ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530097143987

    authors： Cheong N,Iliakis G

    更新日期：1997-04-01 00:00:00

  • Pain-relieving effects of pulsed magnetic fields in a rat model of carrageenan-induced hindpaw inflammation.

    abstract：PURPOSE:Many strategies have been investigated to exclude the several side-effects of pharmacological or invasive treatments. Non-invasive pulsed magnetic field (PMF) treatment with no toxicity or side-effects can be an alternative to pharmacologic treatments. The purpose of this study was, therefore, to investigate th...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2013.835501

    authors： Mert T,Ocal I,Cinar E,Yalcin MS,Gunay I

    更新日期：2014-01-01 00:00:00

  • Age-dependent changes in oxygen tension, radiation dose and sensitivity within normal and diseased coronary arteries-Part B: modeling oxygen diffusion into vessel walls.

    abstract：PURPOSE:The aim is to assess the change with age and disease of the oxygen concentration within the coronary artery walls. MATERIALS AND METHODS:In an accompanying paper, Part A, the age-dependent morphology and composition for the wall layers of normal and diseased coronary arteries were developed from published data...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000802389645

    authors： Richardson RB

    更新日期：2008-10-01 00:00:00

  • Potential Improvements in Brain Dose Estimates For Internal Emitters.

    abstract：BACKGROUND:Element-specific biokinetic models are used to reconstruct doses to systemic tissues from internal emitters. Typically, a systemic model for a radionuclide explicitly depicts only its dominant repositories. Remaining tissues and fluids are aggregated into a pool called Other tissue in which the radionuclide ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2018.1554923

    authors： Leggett RW,Tolmachev SY,Boice JD Jr

    更新日期：2018-12-04 00:00:00

  • Rapid communication: effect of irradiation on lymphocyte proliferation and differentiation: potential of IL-6 in augmenting antibody responses in cultures of murine spleen cells.

    abstract：:Ionizing radiation induces both quantitative and qualitative changes in the lymphoid cells of both man and experimental animals, including inhibition of antibody responses. However, the cellular basis of this immunological lesion is not clear. In the present study, groups of mice were exposed to 2.0 Gy gamma-rays or s...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009514550531

    authors： Goud SN

    更新日期：1995-04-01 00:00:00

  • Absence of the effects of 50 Hz magnetic fields on the progression of acute myeloid leukaemia in rats.

    abstract：PURPOSE:As the most recent epidemiological studies provide no definite conclusions about the effects of 50/60 Hz magnetic fields (MFs) on the incidence of leukaemia in humans, animal models in a well-controlled environment are useful for evaluating the possibility of an association between MFs and leukaemia. The presen...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000050029011

    authors： Devevey L,Patinot C,Debray M,Thierry D,Brugere H,Lambrozo J,Guillosson JJ,Nafziger J

    更新日期：2000-06-01 00:00:00

  • Automated micronucleus (MN) scoring for population triage in case of large scale radiation events.

    abstract：PURPOSE:In case of a large-scale radiation accident when hundreds of people may be exposed, it is important to distinguish the severely exposed individuals (> or =1 gray), who require early medical treatment, from those less exposed. The aim of our study was to develop a quick population triage method based on automate...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553000903264481

    authors： Willems P,August L,Slabbert J,Romm H,Oestreicher U,Thierens H,Vral A

    更新日期：2010-01-01 00:00:00

  • Mechanism of protection against radiation-induced DNA damage in plasmid pBR322 by caffeine.

    abstract：PURPOSE:Caffeine (1,3,7-trimethyl xanthine), a dietary component, has been shown to have widely varying effects on DNA damage induced by UV and ionizing radiation, depending upon pre- or post-irradiation administration and its concentration. Caffeine administered post-UV irradiation is known to inhibit enzymatic repair...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000110034649

    authors： Kumar SS,Devasagayam TP,Jayashree B,Kesavan PC

    更新日期：2001-05-01 00:00:00

  • Increase in DNA single-strand break rejoining by continuous exposure of human mononuclear blood cells to radioiodine ((131)I) in vitro.

    abstract：:Radioiodine ((131)I) induced a dose- and time-dependent increase in DNA single-strand breaks (DNA-ssb) in human (G0) mononuclear blood cells (MNC) in vitro. Incubation of MNC with 22MBq (131)I/ml at 4 degrees C caused a linear, time-dependent induction of DNA-ssb (increase in elution rate: 24.7 x 10(-3) h(-1) per 100 ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530097143103

    authors： Hengstler JG,Bockisch A,Fuchs J,Grimm W,Zapf AO,Lade K,Meinert R,Oesch-Bartlomowicz B,Tanner B,Oesch F

    更新日期：1997-11-01 00:00:00

  • An image analysis technique for detection of radiation-induced DNA fragmentation after CHEF electrophoresis.

    abstract：:CHEF-electrophoresis was used as a technique to detect radiation-induced DNA breakage with special emphasis to biological relevant X-ray doses (0-10 Gy). Fluorescence detection of DNA-fragments using a sensitive image analysis system was directly compared with conventional scintillation counting of 3H-thymidine prelab...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009314551361

    authors： Rosemann M,Kanon B,Konings AW,Kampinga HH

    更新日期：1993-08-01 00:00:00

  • Effects of 36.6 GHz and static magnetic field on degree of endoreduplication in Drosophila melanogaster polytene chromosomes.

    abstract：:Purpose To study the effect of microwave (MW) irradiation and consistent action of microwaves and static magnetic field (MF) on the giant chromosomes endoreduplication in Drosophila melanogaster Meig. Materials and methods Experiments were carried out on inbred wild type Canton-S strain. Exposure to microwaves (freque...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2016.1137105

    authors： Dyka LD,Shakina LA,Strashnyuk VY,Shckorbatov YG

    更新日期：2016-01-01 00:00:00

  • Cell signalling and radiation survival: the impact of protein phosphatases.

    abstract：PURPOSE:This review will examine the role of phosphatases in cancer cell signalling and also outline emerging findings regarding the influence of phosphatases on tumor cell survival after ionising radiation. CONCLUSION:The exposure of tumour cells to clinically relevant doses of ionising radiation causes DNA damage an...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章,评审

    doi：10.3109/09553000903232827

    authors： Hamilton J,Bernhard EJ

    更新日期：2009-11-01 00:00:00

  • Radiation-induced DNA double-strand break frequencies in human squamous cell carcinoma cell lines of different radiation sensitivities.

    abstract：:DNA neutral (pH 9.6) filter elution was used to measure radiation-induced DNA double-strand break (dsb) frequencies in eight human squamous cell carcinoma cell lines with radiosensitivities (D0) ranging from 1.07 to 2.66 Gy and D values ranging from 1.46 to 4.08 Gy. The elution profiles of unirradiated samples from mo...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009114551211

    authors： Schwartz JL,Mustafi R,Beckett MA,Czyzewski EA,Farhangi E,Grdina DJ,Rotmensch J,Weichselbaum RR

    更新日期：1991-06-01 00:00:00

  • Ultrastructural morphometric analysis of peripheral nerves after intraoperative irradiation.

    abstract：:Intraoperative irradiation (IORT) is used to enhance local tumour control by using large, single doses while removing critical structures from the treatment field. Peripheral nerve remains a dose-limiting normal tissue that often cannot be removed from the field. To assess ultrastructural changes in canine sciatic ner...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009514550941

    authors： Vujaskovic Z,Gillette SM,Powers BE,Thurmond DN,Gillette EL,Colacchio TA

    更新日期：1995-07-01 00:00:00

  • Milestones in normal tissue radiation biology over the past 50 years: from clonogenic cell survival to cytokine networks and back to stem cell recovery.

    abstract：PURPOSE:To illustrate the progress in normal tissue radiation biology over the last five decades and its impact on radiotherapy. MATERIALS AND METHODS:Major milestones over the last 50 years and their consequences for radiation oncology are described: The identification of clonogenic cell survival and the (target) ste...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章,评审

    doi：10.1080/09553000902985136

    authors： Stewart FA,Dörr W

    更新日期：2009-07-01 00:00:00

  • Biochemical effects of heat shock and caffeine on post-irradiation oxic and anoxic damage in barley seeds of low and high water content.

    abstract：:Wet heat shock (60 degrees C, 90 s) and caffeine (3.8 X 10(-4) M) afford significant radioprotection against post-irradiation O2-dependent damage which develops in seeds of approximately 3.5% moisture content. The damage was assessed in terms of seedling injury on the eighth day of growth. An increase in seedling inju...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009114551101

    authors： Singh SP,Kesavan PC

    更新日期：1991-05-01 00:00:00

  • Molecular dissection of the response of the rice Systemic Acquired Resistance Deficient 1 (SARD1) gene to different types of ionizing radiation.

    abstract：PURPOSE:Exposure to ionizing radiation induces plant defenses by regulating the expression of response genes. The systemic acquired resistance deficient 1 (SARD1) is a key gene in plant defense response. In this study, the function of Oryza sativa SARD1 (OsSARD1) was investigated after exposure of seeds/plants to ioniz...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2017.1297901

    authors： Jung IJ,Hwang JE,Han SM,Kim DS,Ahn JW,Choi HI,Kwon SJ,Kang SY,Kim JB

    更新日期：2017-07-01 00:00:00

  • A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part III. Countermeasures under early stages of development along with 'standard of care' medicinal and procedures not requiring regulatory approv

    abstract：PURPOSE:Terrorist attacks, with their intent to maximize psychological and economic damage as well as inflicting sickness and death on given targeted populations, are an ever-growing worldwide concern in government and public sectors as they become more frequent, violent, and sensational. If given the chance, it is lik...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章,评审

    doi：10.1080/09553002.2017.1332440

    authors： Singh VK,Hanlon BK,Santiago PT,Seed TM

    更新日期：2017-09-01 00:00:00

  • "In situ" observation of guanine radicals induced by ultrasoft X-ray irradiation around the K-edge regions of nitrogen and oxygen.

    abstract：PURPOSE:In order to understand the molecular mechanism of nucleobase damage caused by ultrasoft X-ray irradiation, guanine radicals have been studied using an X-band EPR (electron paramagnetic resonance) spectrometer installed in a synchrotron soft X-ray beamline. MATERIALS AND METHODS:Guanine pellets were irradiated ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000400017689

    authors： Yokoya A,Akamatsu K,Fujii K,Ukai M

    更新日期：2004-11-01 00:00:00

  • The relevance of tumour and surrounding normal tissue vascular density in clinical hyperthermia of locally advanced breast carcinoma.

    abstract：:It follows from the present work that the vascularization of the normal tissue present in the treatment volume limits the temperatures achieved during heat treatment of invasive ductal breast carcinoma. The temperatures can often be increased by giving fractionated heat treatment because heat treatment may reduce the ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009114551821

    authors： Lyng H,Monge OR,Bøhler PJ,Rofstad EK

    更新日期：1991-07-01 00:00:00

  • Interaction between gene repair and mobile elements-induced activity systems after low-dose irradiation.

    abstract：PURPOSE:To analyze the role of mus-genes repair in system activation P-elements in Drosophila melanogaster induced by a chronic exposure to low doses. MATERIALS AND METHODS:The materials were dysgenic individuals of Drosophila melanogaster with mutations in repair genes (mus101, mus205, mus304, mus308, mus309) and sim...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2016.1206221

    authors： Yushkova E,Zainullin V

    更新日期：2016-09-01 00:00:00

  • Long but dysfunctional telomeres correlate with chromosomal radiosensitivity in a mouse AML cell line.

    abstract：PURPOSE:To compare the chromosomal radiosensitivity of C3H mouse acute myeloid leukaemia (AML) cell lines 7926 and 8709 and to investigate the mechanistic basis of the radiosensitivity observed in 7926. MATERIALS AND METHODS:Yields of chromosome aberrations following X-irradiation were determined in Giemsa-stained met...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000110075220

    authors： Finnon P,Wong HP,Silver AR,Slijepcevic P,Bouffler SD

    更新日期：2001-12-01 00:00:00