Abstract:
PURPOSE:To describe the design and dosimetric characterization of a simple and economical small animal irradiator. MATERIALS AND METHODS:A high dose rate (HDR) (192)Ir brachytherapy source from a commercially available afterloader was used with a 1.3 cm thick tungsten collimator to provide sharp beam penumbra suitable for hemi-brain irradiation of mice. The unit was equipped with continuous gas anesthesia to allow robust animal immobilization. Dosimetric characterization of the device was performed with Gafchromic film measurements. RESULTS:The tungsten collimator provided a sharp penumbra suitable for hemi-brain irradiation, and dose rates on the order of 200 cGy/minute were achieved. The sharpness of the penumbra attainable with this device compares favorably to those measured experimentally for 6 MV photons, and 6 and 20 MeV electron beams from a linear accelerator, and was comparable to those measured for a 300 kVp orthovoltage beam and a Monte Carlo simulated 90 MeV proton beam. CONCLUSIONS:Due to its simplicity and low cost, the apparatus described is an attractive alternative for small animal irradiation experiments requiring steep dose gradients.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Grams MP,Wilson ZC,Sio TT,Beltran CJ,Tryggestad EJ,Gupta SK,Blackwell CR,McCollough KP,Sarkaria JN,Furutani KMdoi
10.3109/09553002.2014.922719subject
Has Abstractpub_date
2014-10-01 00:00:00pages
936-942issue
10eissn
0955-3002issn
1362-3095journal_volume
90pub_type
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journal_title:International journal of radiation biology
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