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In vitro determination of radiation sensitivity parameters for DU-145 prostate cancer cells.

Abstract：

PURPOSE:The prolonged delivery times associated with intensity modulated radiation therapy (IMRT) may reduce treatment effectiveness of radiation therapy for cancers with short repair half-times. In this study, in vitro radiation experiments with DU-145 prostate cancer cells were designed to quantify the half-time of sublethal damage repair. METHOD AND MATERIALS:A series of single-fraction and split-dose clonogenic survival experiments were performed and analyzed using the linear-quadratic (LQ) survival model with mono-/two-component exponential and reciprocal-time repair kinetic models. RESULTS:Our data indicate that DU-145 cells are very radiosensitive (alpha = 0.44 Gy(-1), standard CI: 0.41-0.49 Gy(-1)) and are relatively insensitive to dose fractionation (alpha/beta = 16 Gy, standard CI: 12-34 Gy). The estimated repair half-time is 23 min (standard CI: 10-97 min) with some evidence that a small portion of the sublethal damage is repaired more slowly. CONCLUSION:The reported radiosensitivity parameters (alpha and alpha/beta) are larger than those derived from other in vitro experiments and clinical data. In contrast, the half-time for sublethal damage repair ( approximately 23 min) is close to the one derived from clinical data ( approximately 16 min). For such short repair half-times, the effectiveness of IMRT treatments may be substantially improved by decreasing the fraction delivery time.

journal_name

Int J Radiat Biol

journal_title

International journal of radiation biology

authors

Wang JZ,Rhee JG,Shi P,Stewart RD,Allen Li X

doi

10.1080/09553000802061285

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

515-22

issue

6

eissn

0955-3002

issn

1362-3095

pii

793020320

journal_volume

84

pub_type

杂志文章

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