Correlation between mitotic delay and aberration burden, and their role for the analysis of chromosomal damage.

abstract：:The repair activity of verbascoside (VER), isolated from Pedicularis spicata, towards the oxidizing hydroxyl radical adduct of dGMP and its reaction mechanism were studied using pulse radiolysis. Upon pulse radiolysis of nitrous oxide saturated aqueous solution of 2'-deoxyguanosine-5'-monophosphate (dGMP) and VER, it ...

journal_title：International journal of radiation biology

authors： Li W,Zheng R,Su B,Jia Z,Li H,Jiang Y,Yao S,Lin N

更新日期：1996-04-01 00:00:00

abstract：PURPOSE:To evaluate the cumulative gamma-radiation personal exposure by analysing lymphocyte chromosome translocations using FISH painting and to compare FISH-derived biodoses with those derived from retrospective physical dose reconstruction in residents receiving chronic low dose-rate gamma-irradiation while living i...

journal_title：International journal of radiation biology

authors： Hsieh WA,Lucas JN,Hwang JJ,Chan CC,Chang WP

更新日期：2001-07-01 00:00:00

abstract：:Cell cycle dependence for the induction of 6-thioguanine-resistant mutation was investigated using synchronized mouse L5178Y cells after exposure to 4 Gy to 60Co gamma-rays or 1 Gy of 252Cf radiation (fission neutrons). Maximal mutation frequency was observed immediately after release from colcemid block (G2/M phase) ...

journal_title：International journal of radiation biology

authors： Tauchi H,Nakamura N,Sawada S

更新日期：1993-04-01 00:00:00

abstract：PURPOSE:Immune cells accumulate in and around cancers and cooperate with each other using specific cytokines to attack the cancer cells. The heavy-ion beams for cancer therapy may stimulate immune cells and affect on the immune system. However, it is still poorly understood how the immune cells are stimulated by ion-be...

journal_title：International journal of radiation biology

authors： Mutou-Yoshihara Y,Funayama T,Yokota Y,Kobayashi Y

更新日期：2012-03-01 00:00:00

abstract：:Dose responses for the effects of four calcium antagonists on SCCVII/St back and leg tumour sensitivity to 20 Gy X-rays, and on tumour perfusion indicated by relative uptake of 86rubidium, were determined. The effects of these agents on 86rubidium uptake in some normal tissues were also investigated. Flunarizine sensi...

journal_title：International journal of radiation biology

authors： Wood PJ,Hirst DG

更新日期：1989-09-01 00:00:00

abstract：PURPOSE:Chronic occupational exposure to ionizing radiation (IR) induces a wide spectrum of DNA damages. The aim of this study was to assess the frequencies of micronucleus (MN), sister chromatid exchanges (SCE) and to evaluate their association with XRCC1 399 Arg/Gln and XRCC3 241 Thr/Met polymorphisms in Hospital sta...

journal_title：International journal of radiation biology

authors： Doukali H,Ben Salah G,Ben Rhouma B,Hajjaji M,Jaouadi A,Belguith-Mahfouth N,Masmoudi ML,Ammar-Keskes L,Kamoun H

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:We examined the effects of manganese (III) meso-tetrakis (diethyl-2-5-imidazole) porphyrin, a metalloporphyrin antioxidant (MPA), on neural tissue radiation toxicity in vivo and on tumour cell radiosensitivity in vitro. MATERIALS AND METHODS:MPA was administered directly into the right lateral ventricle of you...

journal_title：International journal of radiation biology

authors： Pearlstein RD,Higuchi Y,Moldovan M,Johnson K,Fukuda S,Gridley DS,Crapo JD,Warner DS,Slater JM

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To evaluate the characteristic features of mechanical responses and the membrane potential changes induced by repetitive pulsed electromagnetic field (PEMF, 50 Hz, 5 mT) in thoracic aorta rings obtained from streptozotocin-induced diabetic and healthy control rats to determine if PEMF could ameliorate problems ...

journal_title：International journal of radiation biology

authors： Kavak S,Emre M,Meral I,Unlugenc H,Pelit A,Demirkazik A

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:Dose response and repair kinetics of phosphorylated histone H2A isoform X (gamma-H2AX) foci in T-lymphocytes were investigated in the low-dose range after in vitro irradiation of whole blood and T-lymphocytes with 100 kVp X-rays and (60)Co gamma-rays. MATERIALS AND METHODS:Whole blood or isolated T-lymphocytes...

journal_title：International journal of radiation biology

authors： Beels L,Werbrouck J,Thierens H

更新日期：2010-09-01 00:00:00

abstract：:To characterize further the radiosensitivity of severe combined immunodeficiency (scid) mice, the induction of micronuclei (MN) in polychromatic erythrocytes as well as cell killing and translocation induction in stem cell spermatogonia was studied. Scid mice turned out to be clearly hypersensitive for X-ray-induced c...

journal_title：International journal of radiation biology

authors： Van Buul PP,De Rooij DG,Zandman IM,Grigorova M,Van Duyn-Goedhart A

更新日期：1995-05-01 00:00:00

abstract：PURPOSE:To examine the relationship between cell killing and residual chromatin breaks after irradiation with qualitatively different types of radiation in six human cell lines. MATERIALS AND METHODS:Six human tumour cell lines and normal human cells were irradiated with 200 kV X-rays and two carbon-ion beams accelera...

journal_title：International journal of radiation biology

authors： Suzuki M,Kase Y,Kanai T,Ando K

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:The low dose (<1 Gy) survival curve of mammalian cells is characterized by a region of hypersensitivity (HRS) followed by increased resistance (IRR). Above 1 Gy, the survival response can be described with a smooth downward-bending curve. Indirect evidence has indicated that the IRR response might reflect an in...

journal_title：International journal of radiation biology

authors： Marples B,Joiner MC

更新日期：2000-03-01 00:00:00

abstract：:The behaviour of polyamines (putrescine, spermidine and spermine) in the small intestine was studied in rats exposed to a single whole-body dose of 3 Gy administered at four different times of the day. Polyamine content decreased a few hours after irradiation but quickly returned to normal values. Putrescine levels re...

journal_title：International journal of radiation biology

authors： Becciolini A,Porciani S,Lanini A,Attanasio M

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:The increased bioactivity 'windows' of GSM 900 and 1800 MHz radiations, (Global System for Mobile telecommunications) revealed recently by us and published in this issue, manifesting themselves as a maximum decrease in the reproductive capacity of the insect Drosophila melanogaster, were examined to discover wh...

journal_title：International journal of radiation biology

authors： Panagopoulos DJ,Margaritis LH

更新日期：2010-05-01 00:00:00

abstract：:Purpose: Cancer is one of the most common causes of mortality and morbidity worldwide. Vaccines have been emerged as an attractive approach for their capacity of eliciting long-term immune response targeting cancer cells. Attenuated avirulent Toxoplasma gondii stimulate immunity and activate antitumor cells thereby el...

journal_title：International journal of radiation biology

authors： Hafez EN,Youssef HMG,El-Kabany HA

更新日期：2020-06-01 00:00:00

abstract：:During previous studies on the relationship between thermosensitivity and intracellular pH (pHi) regulation in mammalian cells, we observed that the thermoresistant TR-4 cells appeared to be resistant to manipulations of the Na+/H+ antiport, one of the two primary membrane regulators of pHi. We hypothesized that this ...

journal_title：International journal of radiation biology

authors： Liu FF,Lee C,Li JH

更新日期：1996-10-01 00:00:00

abstract：PURPOSE:The recent rapid increase of hadron therapy applications requires the development of high performance, reliable in vivo models for preclinical research on the biological effects of high linear energy transfer (LET) particle radiation. AIM:The aim of this paper was to test the relative biological effectiveness ...

journal_title：International journal of radiation biology

authors： Szabó ER,Reisz Z,Polanek R,Tőkés T,Czifrus S,Pesznyák C,Biró B,Fenyvesi A,Király B,Molnár J,Brunner S,Daroczi B,Varga Z,Hideghéty K

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:To determine the efficacy of a caffeine derivative 1-methylxanthine (1-MTX) in increasing radiosensitivity of cancer cells and elucidate the underlying mechanisms in vitro. MATERIALS AND METHODS:RKO human colorectal cancer cells carrying wild type protein 53 kDa (p53) were incubated with 3 mM 1-MTX for 30 min,...

journal_title：International journal of radiation biology

authors： Youn H,Hee Kook Y,Oh ET,Jeong SY,Kim C,Kyung Choi E,Uk Lim B,Park HJ

更新日期：2009-02-01 00:00:00

abstract：:Murine bone marrow contains osteogenic precursor cells that undergo differentiation during in vitro cultivation. In vitro these cells are potential target cells for alpha-irradiation-induced bone tumour formation. Under defined tissue culture conditions these differentiating cells were directly exposed to alpha-partic...

journal_title：International journal of radiation biology

authors： Schoeters GE,Vander Plaetse F,van den Heuvel RL

更新日期：1994-08-01 00:00:00

abstract：:Because of the role that alveolar macrophages (PAM) play in the pulmonary clearance of inhaled particles via mechanical transport and dissolution, understanding the uptake and dissolution of particles by these cells might provide insight into the mechanisms of particle dissolution in lungs of various species and hence...

journal_title：International journal of radiation biology

authors： Taya A,Carmack DB,Muggenburg BA,Mewhinney JA

更新日期：1992-07-01 00:00:00

abstract：:The aim was to identify the decorporation and anti-oxidation efficacy of prompt and delayed consecutive administration of the catecholicpolyaminopolycarboxylate ligands 9501 and 7601 for radiothorium in vivo. The chelating agents 9501 or 7601 were administered intramuscularly to ICR mice 3 min or 3 days after intraper...

journal_title：International journal of radiation biology

authors： Chen H,Luo M,Sun M,Hu Y,Wang Y,Jin M,Cheng W

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:The deleterious processes triggered by heavy ions on DNA were studied through the determination of the yield of a series of oxidized bases. Emphasis was placed on the estimation of the respective contribution of direct ionization and indirect effects, mostly by comparison with low linear energy transfer (LET) g...

journal_title：International journal of radiation biology

authors： Douki T,Ravanat JL,Pouget JP,Testard I,Cadet J

更新日期：2006-02-01 00:00:00

abstract：:The effect of heat (43-45 degrees C) on the induction and the repair of DNA double-strand breaks (dsb) was studied in CHO cells after 60 Gy of X-rays using constant-field gel electrophoresis. Heat given prior to irradiation was found not to alter the number of dsb when measured immediately after irradiation. In non-he...

journal_title：International journal of radiation biology

authors： Dahm-Daphi J,Brammer I,Dikomey E

更新日期：1997-08-01 00:00:00

abstract：PURPOSE:Cells derived from individuals in which the ataxia telangiectasia (ATM) gene is mutated are hypersensitive to ionizing radiation. Whether differences in ATM protein levels exist among human malignant glioma cell lines and whether such differences are correlated with cellular radiosensitivity were determined. M...

journal_title：International journal of radiation biology

authors： Chan DW,Gately DP,Urban S,Galloway AM,Lees-Miller SP,Yen T,Allalunis-Turner J

更新日期：1998-08-01 00:00:00

abstract：PURPOSE:Human embryonic stem cells (hESC) hold a great potential for regenerative medicine because, in principle, they can differentiate into any cell type found in the human body. In addition, studying the effect of ionizing radiation (IR) on hESC may provide valuable information about the response of human cells to I...

journal_title：International journal of radiation biology

authors： Panyutin IV,Eniafe R,Panyutin IG,Neumann RD

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:To investigate the influence of chromatin organization and scavenging capacity in relation to irradiation temperature on the induction of double-strand breaks (DSB) in structures derived from human diploid fibroblasts. MATERIALS AND METHODS:Agarose plugs with different chromatin structures (intact cells+/-wort...

journal_title：International journal of radiation biology

authors： Elmroth K,Nygren J,Stenerlöw B,Hultborn R

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:Conditionally Replicative Adenovirus (CRAd) has been previously demonstrated to augment the activity of radiation, resulting in synergy of cell kill. However, previous models combining radiation with CRAd have not focused on the methods of radiation delivery. MATERIALS AND METHODS:We model the combination of a...

journal_title：International journal of radiation biology

authors： Liu C,Zhang Y,Liu MM,Zhou H,Chowdhury W,Lupold SE,Deweese TL,Rodriguez R

更新日期：2010-03-01 00:00:00

abstract：:We used a cell sorter assay to evaluate the efficacy of the hypoxic cell sensitizer etanidazole over 3-4 logs of cell inactivation, with particular attention to the clinically relevant low-dose survival region. Analysis of the radiation responses in a panel of six human tumour cell lines under conditions of hypoxia an...

journal_title：International journal of radiation biology

authors： Wouters BG,Sy AM,Skarsgard LD

更新日期：1996-12-01 00:00:00

abstract：:Purpose: Dose assessment plays an important role in case of radiological accidents and can be performed by scoring structural changes of chromosome morphology induced in cells by ionizing radiation. The results of such a test are biased by scorer experience, therefore, simple to learn assays are recommended to be used...

journal_title：International journal of radiation biology

authors： Gałecki M,Tartas A,Szymanek A,Sims E,Lundholm L,Sollazzo A,Cheng L,Fujishima Y,Yoshida MA,Żygierewicz J,Wojcik A,Brzozowska-Wardecka B

更新日期：2019-09-01 00:00:00

abstract：:The induction of chromosome aberrations by X-rays was investigated in synchronized quiescent and proliferating CHO-K1 cells. Kinetics of chromosome lesion repair was studied using the method of fractionated irradiation. In both cell types the time-course of repair during fractionation intervals followed first-order ki...

journal_title：International journal of radiation biology

authors： Volkmer B,Virsik-Peuckert RP

更新日期：1990-12-01 00:00:00