Angiotensin II receptor antagonists in the treatment and prevention of radiation nephropathy.

abstract：PURPOSE:Melanoma is mainly treated by surgery and rarely with radiation because of the high radioresistance of this tumor. Nevertheless, radiotherapy is the preferred treatment modality for unresectable lesions and avoiding cosmetic disfigurement caused by surgical excision. This study investigated the therapeutic adva...

journal_title：International journal of radiation biology

authors： Kim SR,Kim EH

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:The tumour suppressor protein p53 is considered to have an impact on the radiosensitivity of tumour cells. However, this concept does not easily translate to the tumour sensitivity in the clinics. The aim of the present study was to determine whether a functional or dysfunctional p53 is associated with a sensit...

journal_title：International journal of radiation biology

authors： Böhnke A,Westphal F,Schmidt A,El-Awady RA,Dahm-Daphi J

更新日期：2004-01-01 00:00:00

abstract：:Radiation survival curves have been obtained for crypts in the small and large intestine of male BDF1 mice using the microcolony assay. Four regions of the small intestine and three regions of the large intestine were studied. One of the major objectives was to determine the optimal conditions for the microcolony assa...

journal_title：International journal of radiation biology

authors： Cai WB,Roberts SA,Bowley E,Hendry JH,Potten CS

更新日期：1997-02-01 00:00:00

abstract：:The scission of pentadeoxythymidylic acid, d(pT)5, by monochromatic soft X-rays on (2153 eV) and below (2147 eV) the K-shell absorption peak of phosphorus was studied as a model of strand breakage in DNA. Samples dried on glass plates were irradiated by monochromatic soft X-rays in vacuo, and the products were analyse...

journal_title：International journal of radiation biology

authors： Yamada H,Kobayashi K,Hieda K

更新日期：1993-02-01 00:00:00

abstract：PURPOSE:To examine whether a simulated mobile telephone transmission at 915 MHz has an effect on cognitive function in man. MATERIALS AND METHODS:Thirty-six subjects in two groups were each given two training sessions and then three test sessions in a randomized three-way cross-over design. About 1 W mean power at 915...

journal_title：International journal of radiation biology

authors： Preece AW,Iwi G,Davies-Smith A,Wesnes K,Butler S,Lim E,Varey A

更新日期：1999-04-01 00:00:00

abstract：:The relationship between ionizing radiation-induced cell killing and DNA damage measured by the micronucleus and apoptosis assays was determined in three established cell lines (L929, HL-60, and Chang). Irradiation experiments revealed a dose-dependent increase of micronucleated cells until a certain dose was reached....

journal_title：International journal of radiation biology

authors： Abend M,Rhein A,Gilbertz KP,Blakely WF,Van Beuningen D

更新日期：1995-03-01 00:00:00

abstract：PURPOSE:To evaluate and optimize the radioprotective ability of the most potent fraction of an aqueous extract of Coronopus didymus in whole body gamma-irradiated Swiss albino mice and to evaluate the antioxidant status and lipid peroxidation of the livers of the surviving mice. To correlate the free radical scavenging...

journal_title：International journal of radiation biology

authors： Prabhakar KR,Veerapur VP,Parihar KV,Priyadarsini KI,Rao BS,Unnikrishnan MK

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:To test the importance of serotonin as a signaling molecule involved in the production and response of radiation-induced bystander effects. MATERIALS AND METHODS:HPV-G human keratinocyte cultures were spiked with various concentrations of Granisetron or Ketanserin and subject to either 0 Gy or 0.5 Gy X-irradia...

journal_title：International journal of radiation biology

authors： Fazzari J,Mersov A,Smith R,Seymour C,Mothersill C

更新日期：2012-10-01 00:00:00

abstract：:The in vitro cell survival of a human cervix carcinoma cell line (HX156c) has been assessed using 60Co gamma-rays administered at either high (150 cGy/min) or low (3.2 cGy/min) dose rate. Recovery during low dose-rate irradiation was observed; the dose reduction factor at 10(-2) cell kill for 150 versus 3.2 cGy/min wa...

journal_title：International journal of radiation biology

authors： Kelland LR,Steel GG

更新日期：1988-08-01 00:00:00

abstract：:Cell killing and the production of DNA double-strand breaks (dsbs) were measured in parallel for V79 cells and a human tumour cell line (Caski) following exposure to radiations of differing linear energy transfer (LET) including accelerated heavy ions. Dsb induction was assessed by neutral filter elution (pH 7.4) and ...

journal_title：International journal of radiation biology

authors： Weber KJ,Flentje M

更新日期：1993-08-01 00:00:00

abstract：PURPOSE:To investigate whether extremely low frequency electromagnetic field (ELF-EMF) exposure could induce oxidative stress in workers performing tour-inspection near transformers and distribution power lines. MATERIALS AND METHODS:Occupational short-term 'spot' measurements were performed. In total, 310 inspection ...

journal_title：International journal of radiation biology

authors： Li L,Xiong DF,Liu JW,Li ZX,Zeng GC,Li HL

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:To summarize current knowledge regarding mechanisms of radiation-induced skin injury and medical countermeasures available to reduce its severity. Advances in radiation delivery using megavoltage and intensity modulated radiation therapy have permitted delivery of higher doses of radiation to well-defined tumor...

journal_title：International journal of radiation biology

authors： Kim JH,Kolozsvary AJ,Jenrow KA,Brown SL

更新日期：2013-05-01 00:00:00

abstract：:Despite the extensive utilization of radiotherapy in cancer treatments, clinicians often face challenges in achieving desired outcomes. This is because of the existence of secondary radiation effects like bystander phenomenon that influence radiation nontargeted cells and tissues. The concept of bystander effects of r...

journal_title：International journal of radiation biology

authors： Mukherjee S,Chakraborty A

更新日期：2019-03-01 00:00:00

abstract：:Nitrous oxide reacts during irradiation to increase the yield of .OH, a radical many believe to be a major cause of lethality. Logically, one would expect N2O to be a radiation sensitizer. In some instances it is, while in others it is not. In some cases we can explain why N2O fails to sensitize; factors such as dose ...

journal_title：International journal of radiation biology

authors： Ewing D,Walton HL,Guilfoil DS,Ohm MB

更新日期：1991-03-01 00:00:00

abstract：:Evidence for the roles of proteins and metal ions in the microheterogeneity of DNA damage is reviewed. Decondensation of chromatin in hypotonic buffers markedly sensitizes the DNA to radiation, while treatment of nuclei with hypertonic buffers strips the DNA of histones and other nuclear proteins and enhances the radi...

journal_title：International journal of radiation biology

authors： Oleinick NL,Balasubramaniam U,Xue L,Chiu S

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:Adverse effects on human health caused by electromagnetic fields (EMF) associated with the use of mobile phones, particularly among young people, are increasing all the time. The potential deleterious effects of EMF exposure resulting from mobile phones being used in close proximity to the brain require particu...

journal_title：International journal of radiation biology

authors： Erdem Koç G,Kaplan S,Altun G,Gümüş H,Gülsüm Deniz Ö,Aydin I,Emin Onger M,Altunkaynak Z

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To determine whether murine lymphoid cell lines can discriminate between high- and low-LET (linear energy transfer) radiation-induced DNA lesions. MATERIALS AND METHODS:Sensitivity to killing by DNA-incorporated 3H and 125I decays, accumulated during storage in the gas phase of a liquid nitrogen tank, was dete...

journal_title：International journal of radiation biology

authors： Radford IR

更新日期：2002-06-01 00:00:00

abstract：:In mice, external X- or gamma-irradiation may induce thymic lymphomas or myeloid leukaemias, while bone-seeking alpha-emitters may induce osteosarcomas and, to a lesser extent, acute myeloid leukaemia. The present paper aims to review briefly some of the experimental data with respect to the molecular mechanisms under...

journal_title：International journal of radiation biology

authors： Janowski M,Cox R,Strauss PG

更新日期：1990-04-01 00:00:00

abstract：:Because of the role that alveolar macrophages (PAM) play in the pulmonary clearance of inhaled particles via mechanical transport and dissolution, understanding the uptake and dissolution of particles by these cells might provide insight into the mechanisms of particle dissolution in lungs of various species and hence...

journal_title：International journal of radiation biology

authors： Taya A,Carmack DB,Muggenburg BA,Mewhinney JA

更新日期：1992-07-01 00:00:00

abstract：:Single crystals of cytosine hydrochloride with thiocytosine as an impurity were found suitable for the study of a possible new mechanism of long-range migration of energy deposited by ionizing radiation. In a crystal containing thiocytosine, two kinds of chlorine-containing paramagnetic centres are present that are co...

journal_title：International journal of radiation biology

authors： Herak JN,Sankovic K,Hütterman J

更新日期：1994-07-01 00:00:00

abstract：PURPOSE:To clarify the experimental conditions that might influence the release of cytokines in the culture medium and give some basic input for building a model for cytokine (e.g., Interleukin-6, IL-6) regulation in the case of 'sham irradiation' and after ionising radiation exposure. MATERIALS AND METHODS:The influe...

journal_title：International journal of radiation biology

authors： Facoetti A,Mariotti L,Ballarini F,Bertolotti A,Nano R,Pasi F,Ranza E,Ottolenghi A

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To find detectable cytogenetic biomarkers that can offer information about the radiation quality of in vivo exposure retrospectively. MATERIALS AND METHODS:Chromosome-type aberrations of peripheral lymphocytes of uterine cancer patients that received internal gamma- and external X-ray therapy or carbon beam th...

journal_title：International journal of radiation biology

authors： Kanda R,Minamihisamatsu M,Tsuji S,Ohmachi Y,Hiraoka T,Shimada Y,Ogiu T,Ohno T,Hayata I

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:To determine the contribution of intra-alveolar cells as opposed to cells fixed in the interstitium in the development of radiation-induced lung injury. MATERIALS AND METHODS:C3H/HeN mice were irradiated to the thorax with various doses of radiation. The cellular composition and cytokine production were assess...

journal_title：International journal of radiation biology

authors： Hong JH,Jung SM,Tsao TC,Wu CJ,Lee CY,Chen FH,Hsu CH,McBride WH,Chiang CS

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:To investigate whether mobile phone radiation might affect snail nociception, employing radiofrequency (RF) electromagnetic fields (EMF) which, to our knowledge, have hitherto not been studied in a snail model. Exposure to extremely low frequency (ELF) magnetic fields has however been shown to significantly aff...

journal_title：International journal of radiation biology

authors： Nittby H,Moghadam MK,Sun W,Malmgren L,Eberhardt J,Persson BR,Salford LG

更新日期：2012-03-01 00:00:00

abstract：:This study evaluated the cell-mediated (CMI) and humoral immune responses in four Beagle dogs five to six years after single inhalation exposures to different monodisperse 239PuO2 aerosols (0.72-1.4 microns activity median aerodynamic diameter). These exposures resulted in initial lung burdens ranging from 19 to 35 kB...

journal_title：International journal of radiation biology

authors： Galvin JB,Bice DE,Guilmette RA,Muggenburg BA,Haley PJ

更新日期：1989-02-01 00:00:00

abstract：:Lambda-prophage induction in repair-deficient and wild-type E. coli strains by heavy ions and gamma-rays has been investigated. The dose dependence of the fraction of induced cells has been measured and its initial slope (lambda-induction potency) determined. The induction by gamma-rays was found to be more efficient ...

journal_title：International journal of radiation biology

authors： Bonev MN,Kozubek S,Krasavin EA,Amirtajev KG

更新日期：1990-05-01 00:00:00

abstract：:Purpose: Present study deals with the role of gamma irradiation in modulating lead (Pb) tolerance of Aspergillus niger van Tieghem. and Penicillium cyclopium Westling. Materials and methods: After being exposed to gamma absorbed doses those fungal strains were subjected to heavy metal uptake efficacies and anti-oxidat...

journal_title：International journal of radiation biology

authors： Das D,Chakraborty A,Santra SC

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:To investigate whether an adaptive response can be induced in mice which were pre-exposed to 900 MHz radiofrequency fields. MATERIALS AND METHODS:Adult male Kunming mice were exposed to 900 MHz radiofrequency fields (RF) at power intensities of 12, 120 and 1200 μW/cm(2) for 1 h/day for 14 days and then subject...

journal_title：International journal of radiation biology

authors： Cao Y,Xu Q,Jin ZD,Zhou Z,Nie JH,Tong J

更新日期：2011-07-01 00:00:00

abstract：:Purpose: A study is presented of the irradiation of cancerous cervical cell line HeLa loaded with a platinum salt, betamethasone and deoxyglucose. The presence of the platinum increases the free-radical concentration and augments the cell death rate, whereas betamethasone or deoxyglucose induces radiosensitization by ...

journal_title：International journal of radiation biology

authors： Usami N,Hirayama R,Kobayashi K,Furusawa Y,Le Sech C

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:To propose an improved version of RADACK, a stochastic simulation of radiolytic attack on DNA, that takes into account the reactivity of each amino acid of a specifically bound protein with hydroxyl radicals. To apply it to the natural lactose operator-repressor complex taking advantage of recently reported str...

journal_title：International journal of radiation biology

authors： Begusova M,Giliberto S,Gras J,Sy D,Charlier M,Spotheim-Maurizot M

更新日期：2003-06-01 00:00:00