Thiocytosine as a radiation energy trap in a single crystal of cytosine hydrochloride.

abstract：:The mechanisms of radiation damage production are used to examine the following premises: (1) the number of DNA double-strand breaks per unit dose increases with dose; (2) cell type to cell type variations in yield of DNA dsb per dose occur. Two stages of damage production are identified as possible sources of damage ...

journal_title：International journal of radiation biology

authors： Ward JF

更新日期：1990-06-01 00:00:00

abstract：PURPOSE:Detection of gene targets applicable to biological dosimetry and early detection of radiation-induced cell damage. MATERIALS AND METHODS:MCF-7 human mammary carcinoma cells were exposed to 2 and 6 Gy X-rays. Expression of 1176 genes was traced with the Atlas Human 1.2 Array (Clontech). RESULTS:(1) Based on da...

journal_title：International journal of radiation biology

authors： Stassen T,Port M,Nuyken I,Abend M

更新日期：2003-05-01 00:00:00

abstract：:Purpose Radiolabeled antibodies and peptides hold promise for molecular radiotherapy but are often limited by a low payload resulting in inadequate delivery of radioactivity to tumour tissue and, therefore, modest therapeutic effect. We developed a facile synthetic method of radiolabeling indium-111 (111In) to epiderm...

journal_title：International journal of radiation biology

authors： Song L,Falzone N,Vallis KA

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:Conditionally Replicative Adenovirus (CRAd) has been previously demonstrated to augment the activity of radiation, resulting in synergy of cell kill. However, previous models combining radiation with CRAd have not focused on the methods of radiation delivery. MATERIALS AND METHODS:We model the combination of a...

journal_title：International journal of radiation biology

authors： Liu C,Zhang Y,Liu MM,Zhou H,Chowdhury W,Lupold SE,Deweese TL,Rodriguez R

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:Ionizing radiation (IR) produced a dose-dependent increase in apoptosis in U937/pCEP4 cells which was attenuated by the stable over expression of Bcl-2 (U937/Bcl-2). A dose of 2 Gy IR was selected for further analyses to determine if subsequent exposure to 10nM bryostatin- would overcome the resistance to IR-in...

journal_title：International journal of radiation biology

authors： Cartee L,Davis C,Lin PS,Grant S

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:The actinides are chemical poisons and radiological hazards. One challenge to better appraise their toxicity and develop countermeasures in case of exposure of living organisms is to better assess pathways of contamination. Because of the high chemical affinity of those actinide elements for phosphate groups an...

journal_title：International journal of radiation biology

authors： Mostapha S,Fontaine-Vive F,Berthon L,Boubals N,Zorz N,Solari PL,Charbonnel MC,Den Auwer C

更新日期：2014-11-01 00:00:00

abstract：:Murine bone marrow contains osteogenic precursor cells that undergo differentiation during in vitro cultivation. In vitro these cells are potential target cells for alpha-irradiation-induced bone tumour formation. Under defined tissue culture conditions these differentiating cells were directly exposed to alpha-partic...

journal_title：International journal of radiation biology

authors： Schoeters GE,Vander Plaetse F,van den Heuvel RL

更新日期：1994-08-01 00:00:00

abstract：PURPOSE:To evaluate the impact of oral administration of purslane (Portulaca oleracea) extract or fish oil and their co-treatments in the modulation of radiation-induced damage. MATERIAL AND METHODS:Purslane (P) (400 mg/kg body weight) or fish oil (Fo) (60 mg/kg body weight) was administrated to male albino rats via g...

journal_title：International journal of radiation biology

authors： Abd El-Azime AS,Hussein EM,Ashry OM

更新日期：2014-12-01 00:00:00

abstract：:The past recommendations of the ICRP about dose limits to the skin are reviewed. Recently, an ICRP Task Group has been revisiting the old arguments and setting them against new data. With the exception of the function of cells in the skin associated with immunocompetence, non-stochastic effects have been well characte...

journal_title：International journal of radiation biology

authors： Fry RJ

更新日期：1990-04-01 00:00:00

abstract：:Chinese hamster ovary cells were exposed to various heat treatments followed by X-irradiation, and the induction and repair of DNA strand breaks was studied using the alkaline unwinding technique. Heat treatments alone were found to cause DNA strand breakage only for temperatures greater than or equal to 43 degrees C,...

journal_title：International journal of radiation biology

authors： Dikomey E,Franzke J

更新日期：1992-02-01 00:00:00

abstract：PURPOSE:This review is a contribution to the memory of Dr William (Bill) Morgan and highlights an area of research and deliberation that he considered extremely important in support of the setting of protective radiation dose limits. Biological research has generally played a minor role in the estimation of adverse hea...

journal_title：International journal of radiation biology

authors： Preston RJ

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Since the exact development of posterior subcapsular cataracts (PSCs) is poorly understood, we review various risk factors and propose a two-stage etiology for PSCs. METHODS:The biological mechanisms associated with age-related cataracts (primarily nuclear cataracts, cortical cataracts and PSCs) were reviewed ...

journal_title：International journal of radiation biology

authors： Richardson RB,Ainsbury EA,Prescott CR,Lovicu FJ

更新日期：2020-11-01 00:00:00

abstract：:A radionuclide release assay for measuring the in vitro kinetics of cell death has been developed. CHO cells were labelled for 24 h with 3.0 hBq/ml of [125I] iododeoxyuridine (125IUdR) and the fate of the labelled cells and their progeny was monitored at daily intervals by measuring the rate of 125I release. Prelabell...

journal_title：International journal of radiation biology

authors： Schneiderman MH,Hofer KG,Schneiderman GS

更新日期：1991-02-01 00:00:00

abstract：:Because of the role that alveolar macrophages (PAM) play in the pulmonary clearance of inhaled particles via mechanical transport and dissolution, understanding the uptake and dissolution of particles by these cells might provide insight into the mechanisms of particle dissolution in lungs of various species and hence...

journal_title：International journal of radiation biology

authors： Taya A,Carmack DB,Muggenburg BA,Mewhinney JA

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:Gamma-irradiation leads to activation of p53 tumour suppressor gene and to p53-dependant stimulation of a large panel of cellular genes including proapoptotic genes involved in intrinsic and extrinsic pathways. Most in vivo published data referred to high (lethal) irradiation doses. The present study was perfor...

journal_title：International journal of radiation biology

authors： Alvarez S,Drané P,Meiller A,Bras M,Deguin-Chambon V,Bouvard V,May E

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:The radiation-induced bystander effect (RIBE) has important implications for the efficiency of radiotherapy but the underlying role of cellular metabolism is widely unknown. The roles of synthesis of cytochrome c oxidase 2 (SCO2), a key effector for respiratory chain, and related signaling factors in α-particle...

journal_title：International journal of radiation biology

authors： Li J,He M,Shen B,Yuan D,Shao C

更新日期：2013-12-01 00:00:00

abstract：:Cell cultures derived from skin biopsies of mouse fetuses X-irradiated at the zygote stage (2 Gy) were studied for the presence of chromosomal aberrations and micronuclei. In comparison with cells from control, unirradiated fetuses significantly higher spontaneous frequencies of aberrations per 100 metaphases and aber...

journal_title：International journal of radiation biology

authors： Pampfer S,Streffer C

更新日期：1989-01-01 00:00:00

abstract：:The aim was to review and summarize the results of 40 years of study concerning the response to ionizing radiation of the pair of L5178Y (LY) sublines, LY-R and LY-S, that differ in sensitivity to various DNA-damaging agents, among them X- and gamma-rays. The reviewed data indicate the key importance of DNA damage rep...

journal_title：International journal of radiation biology

authors： Szumiel I

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:To evaluate whether immunotherapy based on adoptively transferred cytotoxic T-cells (CTL) can improve the antitumour efficacy of irradiation. MATERIAL AND METHODS:The experiments were performed using the human squamous cell carcinoma line UT-SCC-15, which expresses human leukocyte antigen (HLA)-A2. The UT-SCC-...

journal_title：International journal of radiation biology

authors： Krause M,Schmitz M,Noessner E,Skrablin PS,Wehner R,Rieber EP,Baumann M

更新日期：2007-11-01 00:00:00

abstract：:A novel 2-nitroimidazole with a theophylline side-chain, 7-(4'-(2-nitroimidazol-1-yl)-butyl)-theophylline, (NITP) was as efficient a hypoxic-cell radiosensitizer as misonidazole. However, if cells were irradiated with NITP under hypoxic conditions and then exposed to the drug under aerobic conditions, a much larger ra...

journal_title：International journal of radiation biology

authors： Hodgkiss RJ,Kelleher E,Parrick J

更新日期：1992-06-01 00:00:00

abstract：PURPOSE:Ifosfamide as a chemotherapeutic drug is used for the treatment of different cancer types. The purpose of this study is the preparation of 99mTc-ifosfamide complex to be evaluated as a potential candidate for tumor imaging. MATERIALS AND METHODS:The radiolabeling of ifosfamide with technetium-99m was carried o...

journal_title：International journal of radiation biology

authors： Motaleb MA,El-Safoury DM,Abd-Alla WH,Awad GAS,Sakr TM

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:The relationship between cellular telephone use and excretion of the melatonin metabolite 6-hydroxymelatonin sulfate (6-OHMS) was evaluated in two populations of male electric utility workers (Study 1, n=149; Study 2, n=77). MATERIALS AND METHODS:Participants collected urine samples and recorded cellular telep...

journal_title：International journal of radiation biology

authors： Burch JB,Reif JS,Noonan CW,Ichinose T,Bachand AM,Koleber TL,Yost MG

更新日期：2002-11-01 00:00:00

abstract：:High doses of rHIL-1 protected C3H/HeN mice against lethal radiation damage. The optimum time of radioprotection was found when this cytokine was administered at 4 h and at 20 h before irradiation. The dose reduction factors when the IL-1 was administered at those times were about 1.30. The radioprotection at the opti...

journal_title：International journal of radiation biology

authors： Wu SG,Tuboi A,Miyamoto T

更新日期：1989-10-01 00:00:00

abstract：PURPOSE:To investigate the relationship between the susceptibility of B-chronic lymphoid leukaemia (B-CLL) cells to DNA damage-induced apoptosis, the kinetics of DNA strand-break rejoining, and chromosome damage after exposure to ionizing irradiation. MATERIALS AND METHODS:Lymphocytes from B-CLL patients were gamma-ir...

journal_title：International journal of radiation biology

authors： Blaise R,Alapetite C,Masdehors P,Merle-Beral H,Roulin C,Delic J,Sabatier L

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:To investigate the p53 ionizing radiation-induced response, G1/S cell-cycle block and cytogenetic damage in Nijmegen breakage syndrome (NBS) cells characterized by different haplotypes. MATERIAL AND METHODS:Lymphoblastoid cell lines derived from three normals, five NBS and two ataxia telangiectasia (AT) indivi...

journal_title：International journal of radiation biology

authors： Antoccia A,Stumm M,Saar K,Ricordy R,Maraschio P,Tanzarella C

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:To examine the heat sensitivity of DNA-dependent protein kinase (DNA-PK) activity in a variety of cultured mouse, hamster and human cell lines. MATERIALS AND METHODS:Eight cell lines, which have been routinely used in our laboratory, were examined. Cells were heated at 44.0 +/- 0.05 degrees C and DNA-PK activi...

journal_title：International journal of radiation biology

authors： Umeda N,Matsumoto Y,Yin HL,Tomita M,Enomoto A,Morita A,Mizukoshi T,Sakai K,Hosoi Y,Suzuki N

更新日期：2003-08-01 00:00:00

abstract：:The effects of UV radiation on humans and animals are receiving increasing attention and much interest has recently been focused on the environmental effects of UV A and UV B. This study compares the in vitro effects of UV A and UV B on the clonogenic survival of two human skin keratinocyte cell lines, HaCaT which are...

journal_title：International journal of radiation biology

authors： O'Reilly JP,Mothersill C

更新日期：1997-07-01 00:00:00

abstract：PURPOSE:To assess the potential of using the residual phosphorylation of histone H2AX (gammaH2AX) after irradiation as a marker of radiosensitivity in vitro. MATERIAL AND METHODS:Confluent cell cultures of FaDu and SKX human squamous cell carcinoma lines were irradiated with graded single doses. Twenty-four hours afte...

journal_title：International journal of radiation biology

authors： Menegakis A,Yaromina A,Eicheler W,Dörfler A,Beuthien-Baumann B,Thames HD,Baumann M,Krause M

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To examine how folate status influences chromosomal damage following X-ray irradiation. MATERIAL AND METHODS:In an animal study, mice were fed either a low, basal, or high folic acid diet (0, 2, or 40 mg/kg diet, respectively) for 4 weeks, and then given total body irradiation (TBI) at 0.5 Gy. In a human study...

journal_title：International journal of radiation biology

authors： Endoh K,Murakami M,Araki R,Maruyama C,Umegaki K

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:To reduce retention and toxicity of the alpha particle emitter polonium-210 in rats by newly developed chelating agents. MATERIALS AND METHODS:Repeated subcutaneous chelation was conducted after intravenous injection of 210Po nitrate. For reduction of 210Po retention the treatment with vicinal dithiols meso-an...

journal_title：International journal of radiation biology

authors： Rencová J,Volf V,Jones MM,Singh PK

更新日期：2000-10-01 00:00:00