当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF RADIATION BIOLOGY期刊下所有文献 > An interspecies comparison of the phagocytosis and dissolution of 241AmO2 particles by rat, dog and monkey alveolar macrophages in vitro.

An interspecies comparison of the phagocytosis and dissolution of 241AmO2 particles by rat, dog and monkey alveolar macrophages in vitro.

Abstract：

:Because of the role that alveolar macrophages (PAM) play in the pulmonary clearance of inhaled particles via mechanical transport and dissolution, understanding the uptake and dissolution of particles by these cells might provide insight into the mechanisms of particle dissolution in lungs of various species and hence facilitate the extrapolation of animal data to humans. Therefore, experiments were conducted to study the phagocytosis and dissolution of 241AmO2 particles by rat, dog and monkey PAM in vitro. Rat, dog and monkey PAM were exposed for up to 72 h to 0.19, 0.93 or 4.6 kBq/ml 241Am, after which cell viability was determined. The 241Am concentration, 4.63 kBq/ml, was used for the phagocytosis and dissolution experiments. The phagocytosis and dissolution of 241AmO2 particles were followed up to 20 and 72 h, respectively. Dog and monkey PAM took up 241AmO2 particles at similar rates, whereas rat PAM phagocytosed only 60% of the amount phagocytosed by dog and monkey PAM at 20 h. The PAM of the three species dissolved 241AmO2 particles at similar rates; 8-10% was dissolved by 72 h. The results of the 241AmO2 uptake in vitro may reflect in vivo situations, where the differences in uptake seen in vitro would probably diminish at later times after exposure. The dissolution results imply that the dissolution of 241AmO2 particles by alveolar macrophages of the three species might be species-independent. This, at least, might be true for dog and monkey, where in vivo data have shown that 241AmO2 was translocated similarly in both species. Finally, the alveolar macrophage culture system provides a useful simulation to investigate uptake and dissolution of inhaled particles.

journal_name

Int J Radiat Biol

journal_title

International journal of radiation biology

authors

Taya A,Carmack DB,Muggenburg BA,Mewhinney JA

doi

10.1080/09553009214551861

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

89-95

issue

1

eissn

0955-3002

issn

1362-3095

pii

KLEQFGTHVNEFFQHB

journal_volume

62

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY文献大全
  • Natural radionuclides in fish species from surface water of Bagjata and Banduhurang uranium mining areas, East Singhbhum, Jharkhand, India.

    abstract：PURPOSE:To study the natural radionuclides in the freshwater fish samples around the uranium mining areas of Bagjata and Banduhurang, East Singhbhum, Jharkhand, India. MATERIALS AND METHODS:The naturally occurring radioisotopes of uranium, U(nat), consisting of (234)U, (235)U and (238)U; (226)Ra, (230)Th and (210)Po w...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2010.492490

    authors： Giri S,Singh G,Jha VN,Tripathi RM

    更新日期：2010-11-01 00:00:00

  • Chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers.

    abstract：PURPOSE:The chromosomal radiosensitivity of a selected group of familial breast cancer patients carrying a mutation in BRCA1 (n=11) or BRCA2 (n=9) and a group of healthy mutation carriers (n=12) was investigated and compared to a reference group of breast cancer patients without a BRCA1/2 mutation (n=78) and a group of...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000400017937

    authors： Baeyens A,Thierens H,Claes K,Poppe B,de Ridder L,Vral A

    更新日期：2004-10-01 00:00:00

  • Comparative effects of UV A and UV B on clonogenic survival and delayed cell death in skin cell lines from humans and fish.

    abstract：:The effects of UV radiation on humans and animals are receiving increasing attention and much interest has recently been focused on the environmental effects of UV A and UV B. This study compares the in vitro effects of UV A and UV B on the clonogenic survival of two human skin keratinocyte cell lines, HaCaT which are...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530097143590

    authors： O'Reilly JP,Mothersill C

    更新日期：1997-07-01 00:00:00

  • Mechanisms of oxygen radiosensitization in irradiated yeast. I. DNA double-strand breakage.

    abstract：:The relative contributions of the OH-mediated and direct radiation effect on the induction of DNA double-strand breaks (dsbs) were evaluated in two haploid yeast cell lines (GSH+ and gsh-) irradiated under oxic or hypoxic conditions in the absence or presence of 6 M glycerol as an OH radical scavenger. Gsh- cells are ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009314551721

    authors： Frankenberg D,Frankenberg-Schwager M,Harbich R

    更新日期：1993-11-01 00:00:00

  • Modification of tumour response by calcium antagonists in the SCVII/St tumour implanted at two different sites.

    abstract：:Dose responses for the effects of four calcium antagonists on SCCVII/St back and leg tumour sensitivity to 20 Gy X-rays, and on tumour perfusion indicated by relative uptake of 86rubidium, were determined. The effects of these agents on 86rubidium uptake in some normal tissues were also investigated. Flunarizine sensi...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553008914551511

    authors： Wood PJ,Hirst DG

    更新日期：1989-09-01 00:00:00

  • Milestones in normal tissue radiation biology over the past 50 years: from clonogenic cell survival to cytokine networks and back to stem cell recovery.

    abstract：PURPOSE:To illustrate the progress in normal tissue radiation biology over the last five decades and its impact on radiotherapy. MATERIALS AND METHODS:Major milestones over the last 50 years and their consequences for radiation oncology are described: The identification of clonogenic cell survival and the (target) ste...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章,评审

    doi：10.1080/09553000902985136

    authors： Stewart FA,Dörr W

    更新日期：2009-07-01 00:00:00

  • Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by gammaH2AX staining.

    abstract：PURPOSE:To assess the potential of using the residual phosphorylation of histone H2AX (gammaH2AX) after irradiation as a marker of radiosensitivity in vitro. MATERIAL AND METHODS:Confluent cell cultures of FaDu and SKX human squamous cell carcinoma lines were irradiated with graded single doses. Twenty-four hours afte...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553000903242149

    authors： Menegakis A,Yaromina A,Eicheler W,Dörfler A,Beuthien-Baumann B,Thames HD,Baumann M,Krause M

    更新日期：2009-11-01 00:00:00

  • The ability of hypoxia to modify the gene expression of thymidylate synthase in tumour cells in vivo.

    abstract：PURPOSE:Hypoxic cells in tumours are resistant to 5-fluorouracil (5-FU). This in vivo study investigated the ability of hypoxia to regulate the gene expression of thymidylate synthase (TS), the target enzyme of 5-FU. MATERIALS AND METHODS:C3H mammary carcinomas, grown in the feet of female CDF1 mice, were used for all...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530099139944

    authors： Ehrnrooth E,von der Maase H,Sørensen BS,Poulsen JH,Horsman MR

    更新日期：1999-07-01 00:00:00

  • Effect of GSM-900 and -1800 signals on the skin of hairless rats. II: 12-week chronic exposures.

    abstract：PURPOSE:The purpose of this work was to determine whether the cellular components of Hairless-rat skin are affected by a chronic local exposure to non-ionizing radiations of Global Mobile Phone System: GSM-900 or -1800 radiations at specific absorption rate (SAR) 2.5 and 5 W/kg. MATERIALS AND METHODS:A selected part o...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000600930087

    authors： Sanchez S,Masuda H,Billaudel B,Haro E,Anane R,Lévêque P,Ruffie G,Lagroye I,Veyret B

    更新日期：2006-09-01 00:00:00

  • Repair of potentially lethal damage by introduction of T4 DNA ligase in eucaryotic cells.

    abstract：:The bacterial enzyme PvuII, which generates blunt-ended DNA double-strand breaks, and T4 DNA ligase, which seals adjacent DNA fragments in coupling to ATP cleavage, were introduced in mouse C3H10T1/2 fibroblasts using osmolytic shock of pinocytic vesicles. Cells were then assayed for their clonogenic ability. In agree...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009114550851

    authors： Durante M,Grossi GF,Napolitano M,Gialanella G

    更新日期：1991-04-01 00:00:00

  • The expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight.

    abstract：PURPOSE:The space environment contains two major biologically significant influences; space radiations and microgravity. The 53 kDa tumour suppressor protein (p53) plays a role as a guardian of the genome through the activity of p53-centered signal transduction pathways. The aim of this study was to clarify the biologi...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553001003789596

    authors： Takahashi A,Suzuki H,Omori K,Seki M,Hashizume T,Shimazu T,Ishioka N,Ohnishi T

    更新日期：2010-08-01 00:00:00

  • Radiation response of mouse lymphoid and myeloid cell lines. Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage.

    abstract：:We have examined the timing of gamma-irradiation-induced death in relation to cell cycle progression using a panel of mouse lymphoid or myeloid cell lines. Death was found to occur immediately after irradiation ('rapid interphase' death), or after arrest in G2 phase ('delayed interphase' death). In part II of this ser...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009414550261

    authors： Radford IR,Murphy TK

    更新日期：1994-02-01 00:00:00

  • Association of protein phosphorylation and cell cycle progression after X-irradiation of two-cell mouse embryos.

    abstract：:Studies of protein phosphorylation in the second cell cycle of mouse embryos were assessed by [32P]-incorporation and one- and two-dimensional electrophoresis. Unirradiated and X-irradiated embryos were compared. X-irradiation in the G2 phase led to a block in this cell cycle phase. The phosphorylation of proteins wit...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009114552351

    authors： Jung T,Streffer C

    更新日期：1991-09-01 00:00:00

  • Cell-cycle sensitivity, recovery from radiation damage and a new paradigm for risk assessment.

    abstract：:Tikvah Alper's interest in science was broad, from scrapie to mammalian cells and cancer. Much of her own work focused on cell lethality, like that of many other radiobiologists, but this was natural because of the simplicity of the endpoint cell survival and its relevance to cancer therapy. Tikvah had broader interes...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530097143662

    authors： Elkind MM

    更新日期：1997-06-01 00:00:00

  • Applying a multiscale systems biology approach to study the effect of chronic low-dose exposure to uranium in rat kidneys.

    abstract：:Purpose: To examine the effects of low-dose exposure to uranium with a systems biology approach, a multiscale high-throughput multi-omics analysis was applied with a protocol for chronic exposure to the rat kidney. Methods: Male and female rats were contaminated for nine months through their drinking water with a nont...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2019.1577567

    authors： Grison S,Kereselidze D,Cohen D,Gloaguen C,Elie C,Lestaevel P,Legendre A,Manens L,Habchi B,Benadjaoud MA,Tarlet G,Milliat F,Martin JC,Lobaccaro JM,Souidi M

    更新日期：2019-06-01 00:00:00

  • Increased frequency of sister chromatid exchanges in lymphocytes of Chernobyl clean-up workers.

    abstract：:Sister chromatid exchanges (SCEs) were analysed in lymphocytes from 12 control persons and 33 Chernobyl clean-up workers. The group of Chernobyl clean-up workers consisted of civilians who were forced to go to Chernobyl to clean up environmental contamination caused by Chernobyl disaster. On average, they received 0.1...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009514550791

    authors： Lazutka JR,Dedonyte V

    更新日期：1995-06-01 00:00:00

  • Minor contribution of direct ionization to DNA base damage inducedby heavy ions.

    abstract：PURPOSE:The deleterious processes triggered by heavy ions on DNA were studied through the determination of the yield of a series of oxidized bases. Emphasis was placed on the estimation of the respective contribution of direct ionization and indirect effects, mostly by comparison with low linear energy transfer (LET) g...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000600573788

    authors： Douki T,Ravanat JL,Pouget JP,Testard I,Cadet J

    更新日期：2006-02-01 00:00:00

  • Efficacy of delayed administration of sargramostim up to 120 hours post exposure in a nonhuman primate total body radiation model.

    abstract：BACKGROUND:High dose ionizing radiation exposure is associated with myelo-depression leading to pancytopenia and the expected clinical manifestations of acute radiation syndrome (ARS). Herein, we evaluated the efficacy of sargramostim (Leukine®, yeast-derived rhu GM-CSF), with regimens delivered at 48, 72, 96, or 120 h...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2019.1673499

    authors： Zhong Y,Pouliot M,Downey AM,Mockbee C,Roychowdhury D,Wierzbicki W,Authier S

    更新日期：2020-09-22 00:00:00

  • Collaborative exercise on the use of FISH chromosome painting for retrospective biodosimetry of Mayak nuclear-industrial personnel.

    abstract：PURPOSE:To investigate within the framework of a multilaboratory study the suitability of FISH chromosome painting to measure so-called stable translocations in peripheral lymphocytes of Mayak nuclear-industrial workers (from the Southern Urals) and their use for retrospective biodosimetry. MATERIALS AND METHODS:Chrom...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章,多中心研究

    doi：10.1080/09553000010018693

    authors： Bauchinger M,Braselmann H,Savage JR,Natarajan AT,Terzoudi GI,Pantelias GE,Darroudi F,Figgitt M,Griffin CS,Knehr S,Okladnikova ND,Santos S,Snigiryova G

    更新日期：2001-03-01 00:00:00

  • Pulmonary immune response of dogs after exposure to 239PuO2.

    abstract：:This study evaluated the cell-mediated (CMI) and humoral immune responses in four Beagle dogs five to six years after single inhalation exposures to different monodisperse 239PuO2 aerosols (0.72-1.4 microns activity median aerodynamic diameter). These exposures resulted in initial lung burdens ranging from 19 to 35 kB...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553008914550311

    authors： Galvin JB,Bice DE,Guilmette RA,Muggenburg BA,Haley PJ

    更新日期：1989-02-01 00:00:00

  • Interaction between gene repair and mobile elements-induced activity systems after low-dose irradiation.

    abstract：PURPOSE:To analyze the role of mus-genes repair in system activation P-elements in Drosophila melanogaster induced by a chronic exposure to low doses. MATERIALS AND METHODS:The materials were dysgenic individuals of Drosophila melanogaster with mutations in repair genes (mus101, mus205, mus304, mus308, mus309) and sim...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2016.1206221

    authors： Yushkova E,Zainullin V

    更新日期：2016-09-01 00:00:00

  • Anti-neoplastic and immunostimulatory effects of low-dose X-ray fractions in mice.

    abstract：PURPOSE:The exploration of immune mechanisms of the tumour-inhibitory effect of exposures to low-level fractions of X-rays. MATERIALS AND METHODS:BALB/c mice were exposed to whole-body daily irradiations with 0.01, 0.02, or 0.1 Gy X-rays per day for 5 days/week for two weeks. Then, mice were intravenously injected wit...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2010.519422

    authors： Nowosielska EM,Cheda A,Wrembel-Wargocka J,Janiak MK

    更新日期：2011-02-01 00:00:00

  • Chromatin- and temperature-dependent modulation of radiation-induced double-strand breaks.

    abstract：PURPOSE:To investigate the influence of chromatin organization and scavenging capacity in relation to irradiation temperature on the induction of double-strand breaks (DSB) in structures derived from human diploid fibroblasts. MATERIALS AND METHODS:Agarose plugs with different chromatin structures (intact cells+/-wort...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000310001610204

    authors： Elmroth K,Nygren J,Stenerlöw B,Hultborn R

    更新日期：2003-10-01 00:00:00

  • Severe mental retardation after large prenatal exposures to bomb radiation. Reduction in oxygen transport to fetal brain: a possible abscopal mechanism.

    abstract：:Reasonable expectations, based on the normal physiology of the human fetus, cast new light on the possibilities of extrapolation from the finding of severe mental retardation (SMR) in Japanese bomb survivors after maternal exposure to 1.8-5.5 Gy T65DR Gy. After such large exposures the fetal haematopoietic tissues (DS...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009014552051

    authors： Mole RH

    更新日期：1990-10-01 00:00:00

  • Decorporating efficacy of catecholaminocarboxylate chelating agents for thorium-234 and protective effects on associated radiation injury.

    abstract：:The aim was to identify the decorporation and anti-oxidation efficacy of prompt and delayed consecutive administration of the catecholicpolyaminopolycarboxylate ligands 9501 and 7601 for radiothorium in vivo. The chelating agents 9501 or 7601 were administered intramuscularly to ICR mice 3 min or 3 days after intraper...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000500141124

    authors： Chen H,Luo M,Sun M,Hu Y,Wang Y,Jin M,Cheng W

    更新日期：2005-04-01 00:00:00

  • Precision of scoring radiation-induced chromosomal aberrations and micronuclei by unexperienced scorers.

    abstract：:Purpose: Dose assessment plays an important role in case of radiological accidents and can be performed by scoring structural changes of chromosome morphology induced in cells by ionizing radiation. The results of such a test are biased by scorer experience, therefore, simple to learn assays are recommended to be used...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2019.1625462

    authors： Gałecki M,Tartas A,Szymanek A,Sims E,Lundholm L,Sollazzo A,Cheng L,Fujishima Y,Yoshida MA,Żygierewicz J,Wojcik A,Brzozowska-Wardecka B

    更新日期：2019-09-01 00:00:00

  • Transcriptomic profiling suggests a role for IGFBP5 in premature senescence of endothelial cells after chronic low dose rate irradiation.

    abstract：PURPOSE:Ionizing radiation has been recognized to increase the risk of cardiovascular diseases (CVD). However, there is no consensus concerning the dose-risk relationship for low radiation doses and a mechanistic understanding of low dose effects is needed. MATERIAL AND METHODS:Previously, human umbilical vein endothe...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2014.905724

    authors： Rombouts C,Aerts A,Quintens R,Baselet B,El-Saghire H,Harms-Ringdahl M,Haghdoost S,Janssen A,Michaux A,Yentrapalli R,Benotmane MA,Van Oostveldt P,Baatout S

    更新日期：2014-07-01 00:00:00

  • International coordination of research: EPRI International Dose Effect Alliance.

    abstract：:Purpose: The key to increasing our understanding of low dose effects of ionizing radiation is cooperation and communication between research organizations around the world. The purpose of this article is to describe the Electric Power Research Institute (EPRI) program for such cooperation. Materials and methods: EPRI ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2019.1569770

    authors： Cool DA

    更新日期：2019-10-01 00:00:00

  • Different radiosensitivity of CD4(+)CD25(+) regulatory T cells and effector T cells to low dose gamma irradiation in vitro.

    abstract：PURPOSE:To determine the radiosensitivity difference of human Cluster of Differentiation (CD)4(+)CD25(+) regulatory T cells (Treg) and effector T cells to low dose gamma ray and elucidate the underlying mechanisms in vitro. MATERIALS AND METHODS:Blood samples were collected from five health subjects and five patients ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2010.518208

    authors： Cao M,Cabrera R,Xu Y,Liu C,Nelson D

    更新日期：2011-01-01 00:00:00

  • Effects of the K-shell X-ray absorption of phosphorus on the scission of the pentadeoxythymidylic acid.

    abstract：:The scission of pentadeoxythymidylic acid, d(pT)5, by monochromatic soft X-rays on (2153 eV) and below (2147 eV) the K-shell absorption peak of phosphorus was studied as a model of strand breakage in DNA. Samples dried on glass plates were irradiated by monochromatic soft X-rays in vacuo, and the products were analyse...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009314550201

    authors： Yamada H,Kobayashi K,Hieda K

    更新日期：1993-02-01 00:00:00