Mobilization and detoxification of polonium-210 in rats by 2,3-dimercaptosuccinic acid and its derivatives.

abstract：PURPOSE:To analyze the role of mus-genes repair in system activation P-elements in Drosophila melanogaster induced by a chronic exposure to low doses. MATERIALS AND METHODS:The materials were dysgenic individuals of Drosophila melanogaster with mutations in repair genes (mus101, mus205, mus304, mus308, mus309) and sim...

journal_title：International journal of radiation biology

authors： Yushkova E,Zainullin V

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:The fluorescent in situ hybridization (FISH) technique, which easily detects reciprocal translocations, is currently used to estimate doses in retrospective biological dosimetry, after suspected accidental overexposure to ionizing radiation (IR). This study of 42 cases aimed to verify the appropriateness of thi...

journal_title：International journal of radiation biology

authors： Grégoire E,Roy L,Buard V,Delbos M,Durand V,Martin-Bodiot C,Voisin P,Sorokine-Durm I,Vaurijoux A,Voisin P,Baldeyron C,Barquinero JF

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:The identification of fibroblast-like cells of the marrow stroma by means of alkaline phosphatase (ALP) cytochemistry reveals delicate ALP-positive structures interspersed among haematopoietic cells and arranged in a loosely meshed network. These cells are often referred to as 'reticular' cells and the network ...

journal_title：International journal of radiation biology

authors： Almohamad K,Thiry A,Hubin F,Belaid Z,Humblet C,Boniver J,Defresne MP

更新日期：2003-04-01 00:00:00

abstract：PURPOSE:Despite proven antitumor activity of gemcitabine in chemoradiotherapy of advanced head and neck cancer, many authors refer to severe acute and late local and haematological toxicity. Fludarabine does imply nearly the same mechanisms of action as gemcitabine, inhibiting various enzymes involved in DNA replicatio...

journal_title：International journal of radiation biology

authors： Nitsche M,Christiansen H,Hermann RM,Lucke EM,Peters K,Rave-Frank M,Schmidberger H,Pradier O

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To investigate whether pre- and post-drug magnetic field (MF) exposure of 50 Hz, 0.2 mT has any significant effect on pentylenetetrazol (PTZ)-induced seizures in mice. MATERIAL AND METHODS:MF was generated by a pair of Helmholtz coils. Seizures were induced by PTZ injection intraperitoneally (i.p.) at a dose o...

journal_title：International journal of radiation biology

authors： Canseven AG,Keskil ZA,Keskil S,Seyhan N

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:Gene therapy combined with radiation has shown promising potential for the treatment of tumors. This paper aimed to clarify the synergistic effect of radiotherapy combined with the bladder cancer tissue-specific oncolytic adenovirus (Ad-PSCAE-UPII-E1A) on bladder cancer cells and to study the underlying synergy...

journal_title：International journal of radiation biology

authors： Zhang H,Wang F,Mao C,Zhang Z,Fu S,Lu J,Zhai Z,Li R,Li S,Rodriguez R,Wang Z

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:The chromosomal radiosensitivity of a selected group of familial breast cancer patients carrying a mutation in BRCA1 (n=11) or BRCA2 (n=9) and a group of healthy mutation carriers (n=12) was investigated and compared to a reference group of breast cancer patients without a BRCA1/2 mutation (n=78) and a group of...

journal_title：International journal of radiation biology

authors： Baeyens A,Thierens H,Claes K,Poppe B,de Ridder L,Vral A

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:We introduce and evaluate a high throughput biodosimetry test system (REDI-Dx) suitable for testing of thousands of potential radiation victims following a mass scale nuclear event caused by detonation of a nuclear device or a nuclear accident, as part of an overall strategy for effective medical management of ...

journal_title：International journal of radiation biology

authors： Jacobs AR,Guyon T,Headley V,Nair M,Ricketts W,Gray G,Wong JYC,Chao N,Terbrueggen R

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:To determine the relative toxicity of alpha- and beta-radiations under conditions of controlled temporal and spatial dose distribution. METHODS:Fused aluminosilicate particles were radiolabelled with either (45)Ca (a beta-emitter) or (242)Cm (an alpha-emitter). These were injected into CBA/Ca mice to give life...

journal_title：International journal of radiation biology

authors： Priest ND,Hoel DG,Brooks PN

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:The tumour suppressor protein p53 is considered to have an impact on the radiosensitivity of tumour cells. However, this concept does not easily translate to the tumour sensitivity in the clinics. The aim of the present study was to determine whether a functional or dysfunctional p53 is associated with a sensit...

journal_title：International journal of radiation biology

authors： Böhnke A,Westphal F,Schmidt A,El-Awady RA,Dahm-Daphi J

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:Ionizing radiation has been recognized to increase the risk of cardiovascular diseases (CVD). However, there is no consensus concerning the dose-risk relationship for low radiation doses and a mechanistic understanding of low dose effects is needed. MATERIAL AND METHODS:Previously, human umbilical vein endothe...

journal_title：International journal of radiation biology

authors： Rombouts C,Aerts A,Quintens R,Baselet B,El-Saghire H,Harms-Ringdahl M,Haghdoost S,Janssen A,Michaux A,Yentrapalli R,Benotmane MA,Van Oostveldt P,Baatout S

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:To compare experimental yields of single strand breaks (SSB) and double strand breaks (DSB) induced in plasmid DNA in aqueous solution by alpha-particles and Al(K) ultrasoft X-rays (USX) with the corresponding yields, generated via computer simulations, for a range of mean diffusion distances of the hydroxyl ra...

journal_title：International journal of radiation biology

authors： Fulford J,Nikjoo H,Goodhead DT,O'Neill P

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:Ifosfamide as a chemotherapeutic drug is used for the treatment of different cancer types. The purpose of this study is the preparation of 99mTc-ifosfamide complex to be evaluated as a potential candidate for tumor imaging. MATERIALS AND METHODS:The radiolabeling of ifosfamide with technetium-99m was carried o...

journal_title：International journal of radiation biology

authors： Motaleb MA,El-Safoury DM,Abd-Alla WH,Awad GAS,Sakr TM

更新日期：2018-12-01 00:00:00

abstract：:Radiologic accidents or terrorist acts involving radioactive material, as well as radiation exposure in medical or industrial procedures are potential sources of risk for human health. All these risks share a common element, exposure to ionizing radiation. The extent of ionizing radiation injury will depend on a numbe...

journal_title：International journal of radiation biology

authors： Soriano JL,Calpena AC,Souto EB,Clares B

更新日期：2019-05-01 00:00:00

abstract：PURPOSES:To estimate the ratio of risks for exposure to radon progeny relative to low-LET radiation based on human lung cancer data, taking account of possible time and age variations in radiation-induced lung cancer risk. MATERIALS AND METHODS:Fitting two sorts of time- and age-adjusted relative risk models to a case...

journal_title：International journal of radiation biology

authors： Little MP

更新日期：2002-03-01 00:00:00

abstract：:In mice, external X- or gamma-irradiation may induce thymic lymphomas or myeloid leukaemias, while bone-seeking alpha-emitters may induce osteosarcomas and, to a lesser extent, acute myeloid leukaemia. The present paper aims to review briefly some of the experimental data with respect to the molecular mechanisms under...

journal_title：International journal of radiation biology

authors： Janowski M,Cox R,Strauss PG

更新日期：1990-04-01 00:00:00

abstract：:The response to radiation of seven osteosarcoma cell lines was analysed by in vitro colony-forming assay and compared with that of eight human fibroblast strains. The values of D0, the surviving fraction after 2 Gy (S2Gy), and the mean inactivation dose (D) of osteosarcoma cells in log-phase culture were significantly...

journal_title：International journal of radiation biology

authors： Sugimoto M,Toguchida J,Kotoura Y,Yamamuro T,Utsumi H

更新日期：1992-10-01 00:00:00

abstract：:A comparison has been made of the in vitro light-activated drug cytotoxicities of two different porphyrin compounds, Photofrin II and TPPS4. An early passage human colon adenocarcinoma cell line, WiDr, has been exposed to either drug for 24 h, the excess drug washed from the cells and the cells irradiated with light u...

journal_title：International journal of radiation biology

authors： West CM,Moore JV

更新日期：1988-10-01 00:00:00

abstract：:The rate of recovery from radiation damage, as a function of dose per fraction, was investigated in mouse skin. Two different experimental designs were used, both incorporating the neutron top-up technique which enables the X-ray dose per fraction to be kept constant whilst changing the interfraction interval. Either ...

journal_title：International journal of radiation biology

authors： Rojas A,Joiner MC,Johns H

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:The effects of radiation +/- hypogravity on immunologic function were investigated using the Partial Weight Suspension (PWS) model ( Wagner et al. 2010 ). MATERIALS AND METHODS:Mice were exposed to 0.5, 1, or 2 Gray (Gy) dose of gamma radiation and then placed in the PWS system for 4, 24, 48 hours, or 4 days. ...

journal_title：International journal of radiation biology

authors： Sanzari JK,Wilson JM,Wagner EB,Kennedy AR

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Up to 90% of hereditary breast cancer cases are linked to germ-line mutations in one of the two copies of the BRCA1 or BRCA2 genes. Brca1 and Brca2 proteins are both involved in the cellular defence against DNA damage, although the precise function of the proteins is still not known. Some studies on a small num...

journal_title：International journal of radiation biology

authors： Nieuwenhuis B,Van Assen-Bolt AJ,Van Waarde-Verhagen MA,Sijmons RH,Van der Hout AH,Bauch T,Streffer C,Kampinga HH

更新日期：2002-04-01 00:00:00

abstract：:The effect of gamma-radiation on aqueous solutions of saturated phospholipids, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol (DPPG), 1-palmitoyl-2-lyso-sn-glycero-3-phosphocholine (lysoPC), and bovine brain sphingomyelin (SM) has been investigated. It is shown that th...

journal_title：International journal of radiation biology

authors： Edimecheva IP,Kisel MA,Shadyro OI,Vlasov AP,Yurkova IL

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:To clarify the experimental conditions that might influence the release of cytokines in the culture medium and give some basic input for building a model for cytokine (e.g., Interleukin-6, IL-6) regulation in the case of 'sham irradiation' and after ionising radiation exposure. MATERIALS AND METHODS:The influe...

journal_title：International journal of radiation biology

authors： Facoetti A,Mariotti L,Ballarini F,Bertolotti A,Nano R,Pasi F,Ranza E,Ottolenghi A

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To investigate the action of ultra-low dose beta-radiation (ULDBR) on isolated segments of blood vessels. MATERIALS AND METHODS:We used the pharmacological model of isolated rabbit carotid arteries with intact or mechanically removed endothelium. Specific vascular responses to beta-irradiation were registered ...

journal_title：International journal of radiation biology

authors： Zhirnov VV,Iakovenko IN

更新日期：2005-11-01 00:00:00

abstract：:Purpose: Radiotherapy prescription dose and dose fractionation protocols vary little between individual patients having the same tumor grade and stage. To personalize radiotherapy a predictive model is needed to simulate radiation response. Previous modeling attempts with multiple variables and parameters have been sh...

journal_title：International journal of radiation biology

authors： Sunassee ED,Tan D,Ji N,Brady R,Moros EG,Caudell JJ,Yartsev S,Enderling H

更新日期：2019-10-01 00:00:00

abstract：:Cells use substrates such as glucose and glutamine to provide energy for repair of radiation damage. Glutaminolysis and glycolysis were inhibited by aminooxyacetic acid (AOAA) and 2-deoxyglucose (2DG), respectively, to inhibit metabolism of these substrates in order to determine the effect on radiation response of CHO...

journal_title：International journal of radiation biology

authors： Hunter AJ,Blekkenhorst GH

更新日期：1998-03-01 00:00:00

abstract：:237Np nitrate was injected intravenously into 4-week-old (young) and 10-12-week-old (adult) female albino Sprague-Dawley rats. The amounts given were 52 (young), 5.2 (adult) and 26 kBq kg-1 body weight (adult). The microscopic distribution in the femur and the lumbar vertebrae was studied. Initially, neptunium was dis...

journal_title：International journal of radiation biology

authors： Sontag W

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:To assess intestinal radioprotection by systemic or lumenal tirilazad mesylate and to test potential tumour radioprotection. MATERIALS AND METHODS:Segments of the mid small bowel were surgically exteriorized. Tirilazad was given either intravenously or intralumenally 30 min prior to 11 Gy of X-irradiation to t...

journal_title：International journal of radiation biology

authors： Felemovicius I,Bonsack ME,Griffin RJ,Delaney JP

更新日期：1998-02-01 00:00:00

abstract：:Determinations of cell sensitivity in terms of survival fraction after doses employed in clinical radiation therapy, say 1-3 Gy, are of increasing interest to clinicians as they provide direct experimental data which can be employed without reference to models of cell inactivation. SF2 values are expected ultimately t...

journal_title：International journal of radiation biology

authors： Suit HD,Baumann M,Skates S,Convery K

更新日期：1989-11-01 00:00:00

abstract：:Male SAS/4 mice were injected i.v. with 6.6 kBq 239Pu-citrate. After 1 or 24 h a single i.p. injection of 15 or 30 mumol kg-1 or repeated (three or four) daily injections of 30 mumol kg-1 of tetra-THB-spermine were given, and at 4 or 7 days Pu retention was measured in liver, kidneys and femur. Besides tetra-THB-sperm...

journal_title：International journal of radiation biology

authors： Szot Z,Rochalska M,Chomiczewski K,Chimiak A,Przychodzeń W

更新日期：1989-01-01 00:00:00