Abstract:
PURPOSE:To assess intestinal radioprotection by systemic or lumenal tirilazad mesylate and to test potential tumour radioprotection. MATERIALS AND METHODS:Segments of the mid small bowel were surgically exteriorized. Tirilazad was given either intravenously or intralumenally 30 min prior to 11 Gy of X-irradiation to the exteriorized intestine. Tissues were harvested 5 days later to measure crypts per circumference and mucosal height. Potential tumour protection was assessed in a mouse sarcoma model. Tumours implanted in the hind limb were allowed to grow until a standard volume was attained, then irradiated (10 Gy) 30 min after intravenous (i.v.) administration of saline or tirilazad. Tumour growth was recorded for the next 22 days to determine if pretreatment with tirilazad interfered with radiation effects. RESULTS:Systemic tirilazad provided no protection against intestinal damage and did not alter tumour growth after irradiation. Topical tirilazad yielded highly significant protection of intestinal mucosa. CONCLUSIONS:These preliminary observations showed that topical tirilazad diminished radiation enteritis. Systemic drug had no effect on the severity of damage to the intestine nor did it inhibit radiation effects on a tumour.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Felemovicius I,Bonsack ME,Griffin RJ,Delaney JPdoi
10.1080/095530098142617subject
Has Abstractpub_date
1998-02-01 00:00:00pages
219-23issue
2eissn
0955-3002issn
1362-3095journal_volume
73pub_type
杂志文章abstract:PURPOSE:Gene therapy combined with radiation has shown promising potential for the treatment of tumors. This paper aimed to clarify the synergistic effect of radiotherapy combined with the bladder cancer tissue-specific oncolytic adenovirus (Ad-PSCAE-UPII-E1A) on bladder cancer cells and to study the underlying synergy...
journal_title:International journal of radiation biology
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
abstract::During previous studies on the relationship between thermosensitivity and intracellular pH (pHi) regulation in mammalian cells, we observed that the thermoresistant TR-4 cells appeared to be resistant to manipulations of the Na+/H+ antiport, one of the two primary membrane regulators of pHi. We hypothesized that this ...
journal_title:International journal of radiation biology
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abstract:PURPOSE:Estimating the absorbed dose to tumour relative to normal tissues has often been used in the assessment of the therapeutic efficacy of radiolabelled antibodies for radioimmunotherapy. Typically, the calculations assume a uniform dose deposition and response throughout the tumour. However, the heterogeneity of t...
journal_title:International journal of radiation biology
pub_type: 杂志文章
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abstract:PURPOSE:This review will examine the role of phosphatases in cancer cell signalling and also outline emerging findings regarding the influence of phosphatases on tumor cell survival after ionising radiation. CONCLUSION:The exposure of tumour cells to clinically relevant doses of ionising radiation causes DNA damage an...
journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
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journal_title:International journal of radiation biology
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abstract::The mechanisms of radiation damage production are used to examine the following premises: (1) the number of DNA double-strand breaks per unit dose increases with dose; (2) cell type to cell type variations in yield of DNA dsb per dose occur. Two stages of damage production are identified as possible sources of damage ...
journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
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abstract:PURPOSE:To investigate the influence of chromatin organization and scavenging capacity in relation to irradiation temperature on the induction of double-strand breaks (DSB) in structures derived from human diploid fibroblasts. MATERIALS AND METHODS:Agarose plugs with different chromatin structures (intact cells+/-wort...
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abstract:PURPOSE:Public concern about radiation protection of the environment and non-human species is increasing. The potential impact of chronic gamma radiation on the bacterial community in a rice paddy ecosystem was investigated. MATERIALS AND METHODS:Paddy field microcosm samples were continuously exposed at a dose rate o...
journal_title:International journal of radiation biology
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abstract::The in vitro cell survival of a human cervix carcinoma cell line (HX156c) has been assessed using 60Co gamma-rays administered at either high (150 cGy/min) or low (3.2 cGy/min) dose rate. Recovery during low dose-rate irradiation was observed; the dose reduction factor at 10(-2) cell kill for 150 versus 3.2 cGy/min wa...
journal_title:International journal of radiation biology
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abstract:PURPOSE:To honour perhaps the most influential man in the radiation sciences, Henry S. Kaplan, by reviewing the field of tumour hypoxia, one of his many interests. RESULTS:It was postulated over 50 years ago by Thomlinson and Gray that human solid tumours would contain hypoxic cells and that they would exert a negativ...
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abstract:PURPOSE:To study the effects of 12C-beam of 295 keV/microm (57.24 MeV) on M5 and Chinese hamster V79 cells by using cytogenetic assays like micronuclei (MN) induction, chromosomal aberrations (CA) and apoptosis. Additionally, the relative survival of these two cell lines was tested by the colony forming ability of the ...
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更新日期:2007-01-01 00:00:00
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abstract:PURPOSE:To present details of the recent version of the 'Local Effect Model' (LEM), that has been developed and implemented in treatment planning for the ion beam therapy pilot project performed at GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. MATERIALS AND METHODS:The new version of the model i...
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更新日期:2012-01-01 00:00:00
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journal_title:International journal of radiation biology
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更新日期:2011-03-01 00:00:00
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journal_title:International journal of radiation biology
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更新日期:1997-01-01 00:00:00
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更新日期:2013-11-01 00:00:00
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更新日期:2011-04-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:International journal of radiation biology
pub_type: 杂志文章
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更新日期:1996-04-01 00:00:00
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更新日期:1988-07-01 00:00:00