The damage to phospholipids caused by free radical attack on glycerol and sphingosine backbone.

abstract：:The radiosensitization of two human tumour in vitro cell lines, HT-1080 and LoVo, has been compared with that of the Chinese hamster cell line V79-379A. Although the two human tumour cell lines were more radiosensitive than the V79 cell line sensitizer, enhancement ratios for misonidazole, pimonidazole and azomycin we...

journal_title：International journal of radiation biology

authors： Watts ME,Dennis MF,Roberts IJ

更新日期：1990-02-01 00:00:00

abstract：PURPOSE:Adverse effects on human health caused by electromagnetic fields (EMF) associated with the use of mobile phones, particularly among young people, are increasing all the time. The potential deleterious effects of EMF exposure resulting from mobile phones being used in close proximity to the brain require particu...

journal_title：International journal of radiation biology

authors： Erdem Koç G,Kaplan S,Altun G,Gümüş H,Gülsüm Deniz Ö,Aydin I,Emin Onger M,Altunkaynak Z

更新日期：2016-10-01 00:00:00

abstract：:The form of the hazard function for radiation-induced pneumonitis death in mice was investigated. 'Hazard' refers to the instantaneous failure rate at a specified time, conditional upon non-failure to that time. Thus, the hazard function describes the time profile for the risk of pneumonitis death among still-survivin...

journal_title：International journal of radiation biology

authors： Tucker SL,Travis EL

更新日期：1992-11-01 00:00:00

abstract：:The aim was to investigate further the relationship between radiation-induced mitotic delay and the expression of chromosome damage in V79 cells. Recently published data on the time-course of chromosome aberrations in V79 first-cycle metaphases after exposure to 10.4 MeV u(-1) Ar ions (LET = 1226 keV microm(-1)) were ...

journal_title：International journal of radiation biology

authors： Gudowska-Nowak E,Kleczkowski A,Nasonova E,Scholz M,Ritter S

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To compare experimental yields of single strand breaks (SSB) and double strand breaks (DSB) induced in plasmid DNA in aqueous solution by alpha-particles and Al(K) ultrasoft X-rays (USX) with the corresponding yields, generated via computer simulations, for a range of mean diffusion distances of the hydroxyl ra...

journal_title：International journal of radiation biology

authors： Fulford J,Nikjoo H,Goodhead DT,O'Neill P

更新日期：2001-10-01 00:00:00

abstract：:It follows from the present work that the vascularization of the normal tissue present in the treatment volume limits the temperatures achieved during heat treatment of invasive ductal breast carcinoma. The temperatures can often be increased by giving fractionated heat treatment because heat treatment may reduce the ...

journal_title：International journal of radiation biology

authors： Lyng H,Monge OR,Bøhler PJ,Rofstad EK

更新日期：1991-07-01 00:00:00

abstract：:A review is presented to the program of education and training setup within the DoReMi Network of Excellence. DoReMi was funded by Euratom under the EU 7th Framework Programme to coordinate the EU research into risks from low-dose ionizing radiation. It was seen to be necessary to form a network of expert institutions...

journal_title：International journal of radiation biology

authors： Ottolenghi A,Trott KR,Smyth V

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:To examine how folate status influences chromosomal damage following X-ray irradiation. MATERIAL AND METHODS:In an animal study, mice were fed either a low, basal, or high folic acid diet (0, 2, or 40 mg/kg diet, respectively) for 4 weeks, and then given total body irradiation (TBI) at 0.5 Gy. In a human study...

journal_title：International journal of radiation biology

authors： Endoh K,Murakami M,Araki R,Maruyama C,Umegaki K

更新日期：2006-04-01 00:00:00

abstract：:Radiation survival curves have been obtained for crypts in the small and large intestine of male BDF1 mice using the microcolony assay. Four regions of the small intestine and three regions of the large intestine were studied. One of the major objectives was to determine the optimal conditions for the microcolony assa...

journal_title：International journal of radiation biology

authors： Cai WB,Roberts SA,Bowley E,Hendry JH,Potten CS

更新日期：1997-02-01 00:00:00

abstract：PURPOSE:In radiation biology, rats are often irradiated, but the precise dose distributions are often lacking, particularly in areas that receive scatter radiation. We used a non-dedicated set of resources to calculate detailed dose distributions, including doses to peripheral organs well outside of the primary field, ...

journal_title：International journal of radiation biology

authors： Kirkby C,Ghasroddashti E,Kovalchuk A,Kolb B,Kovalchuk O

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:Many studies have shown that exposure to radiofrequency radiation (RFR) could activate cellular signal transduction pathways. In the present research, we investigated the effects of exposure to a 1.8-GHz RFR at different intensities on epidermal growth factor (EGF) receptor clustering and phosphorylation in hum...

journal_title：International journal of radiation biology

authors： Sun W,Shen X,Lu D,Fu Y,Lu D,Chiang H

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:The assessment of biological effects caused by radiation exposure has been currently carried out with the linear-quadratic (LQ) model as an extension of the linear non-threshold (LNT) model. In this study, we suggest a new mathematical model named as SeaSaw (SS) model, which describes proliferation and cell dea...

journal_title：International journal of radiation biology

authors： Bando M,Tsunoyama Y,Suzuki K,Toki H

更新日期：2020-12-15 00:00:00

abstract：PURPOSE:Zearalenone is a potent estrogenic metabolite produced by some Fusarium and Gibberella species. Therefore, the aim of this study was to determine the accumulation of Technetium-[99m]-labeled zearalenone in mice organs as well as to study the protective effect of Lactobacillus plantarum. MATERIALS AND METHODS:T...

journal_title：International journal of radiation biology

authors： Sanad MH,Fouzy ASM,Sobhy HM,Hathout AS,Hussain OA

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:To describe the design and dosimetric characterization of a simple and economical small animal irradiator. MATERIALS AND METHODS:A high dose rate (HDR) (192)Ir brachytherapy source from a commercially available afterloader was used with a 1.3 cm thick tungsten collimator to provide sharp beam penumbra suitable...

journal_title：International journal of radiation biology

authors： Grams MP,Wilson ZC,Sio TT,Beltran CJ,Tryggestad EJ,Gupta SK,Blackwell CR,McCollough KP,Sarkaria JN,Furutani KM

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:It has been previously argued that the use of the one-electron oxidants (SCN)2(*-) and Br2(*-) with plasmid DNA leads to the formation of DNA guanyl radicals. These guanyl radical species are intermediates in the DNA damage produced by processes such as photo-ionization and ionizing irradiation. The present pap...

journal_title：International journal of radiation biology

authors： Milligan JR,Aguilera JA,Mares EJ,Paglinawan RA,Ward JF

更新日期：2001-11-01 00:00:00

abstract：:Radiation-induced myocardial degeneration in the rat is preceded by changes in capillary structure and function, which may be a major factor in the pathogenesis of radiation-induced heart disease. In order to investigate the mechanism of capillary damage we studied endothelial cell proliferation in untreated control r...

journal_title：International journal of radiation biology

authors： Lauk S,Trott KR

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:To investigate the radiosensitisation of gold nanoparticles (GNP) with an average diameter of 5 nm coated with the gadolinium chelating agent dithiolated diethylenetriaminepentaacetic gadolinium (Au@DTDTPA:Gd) in vitro and in mice bearing tumours (MC7-L1). MATERIALS AND METHODS:In vivo, the gadolinium chelate ...

journal_title：International journal of radiation biology

authors： Hébert EM,Debouttière PJ,Lepage M,Sanche L,Hunting DJ

更新日期：2010-08-01 00:00:00

abstract：:Radiation-induced DNA double-strand breaks (dsb) were studied in Ehrlich ascites tumour cells (EATC) by sedimentation in neutral sucrose gradients at low centrifuge speed. Dsb induction was found to be linear with dose with a frequency of: ndsbmr-1D-1 = (11.7 +/- 2) x 10(-12)Gy-1 for 140 kV X-rays and ndsbmr-1D-1 = (1...

journal_title：International journal of radiation biology

authors： Blöcher D

更新日期：1988-11-01 00:00:00

abstract：:Purpose: This review discusses recent developments in our understanding of biological and physiological mechanisms underlying radiation cataractogenesis. The areas discussed include effects of low-dose exposures to the lens including potential relevance of non-targeted effects, the development of new personal-protecti...

journal_title：International journal of radiation biology

authors： Laskowski L,Williams D,Seymour C,Mothersill C

更新日期：2020-05-26 00:00:00

abstract：:A novel 2-nitroimidazole with a theophylline side-chain, 7-(4'-(2-nitroimidazol-1-yl)-butyl)-theophylline, (NITP) was as efficient a hypoxic-cell radiosensitizer as misonidazole. However, if cells were irradiated with NITP under hypoxic conditions and then exposed to the drug under aerobic conditions, a much larger ra...

journal_title：International journal of radiation biology

authors： Hodgkiss RJ,Kelleher E,Parrick J

更新日期：1992-06-01 00:00:00

abstract：:Swiss albino mice (7-8 weeks old) were irradiated with different doses (0-25 Gy) of gamma-radiation at a dose-rate of 0.05 Gy/s. The specific activities of glyoxalase I (GI) and glyoxalase II (GII) were determined in the spleen and liver immediately and on the 3rd and 6th day postirradiation. The results indicate that...

journal_title：International journal of radiation biology

authors： Sharma R,Kale RK

更新日期：1993-02-01 00:00:00

abstract：PURPOSE:To assess intestinal radioprotection by systemic or lumenal tirilazad mesylate and to test potential tumour radioprotection. MATERIALS AND METHODS:Segments of the mid small bowel were surgically exteriorized. Tirilazad was given either intravenously or intralumenally 30 min prior to 11 Gy of X-irradiation to t...

journal_title：International journal of radiation biology

authors： Felemovicius I,Bonsack ME,Griffin RJ,Delaney JP

更新日期：1998-02-01 00:00:00

abstract：:The effect of local stimulation on mitotic activity and radiation tolerance was studied in mouse tongue mucosa. Silver nitrate solution (0.5-20%) was used for local conditioning. The most effective protocol comprised three daily treatments (days 0-2), yielding a delayed increase in 24 h mitotic counts by about 30% on ...

journal_title：International journal of radiation biology

authors： Dörr W,Kummermehr J

更新日期：1992-03-01 00:00:00

abstract：:Most estimates of the radiation dose lethal to 50 per cent of a human population are based on historical data taken from well-known experiences reflecting inadequately known physical and biological conditions, or from medical procedures where individual patients received advantages of modern clinical care. It has been...

journal_title：International journal of radiation biology

authors： Morris MD,Jones TD

更新日期：1989-03-01 00:00:00

abstract：:Pre-implantation embryos of the mouse were studied for the occurrence of an adaptive response, i.e. induction of radio-resistance by a previous low dose. Various experimental designs were checked (initial doses between 3 and 10 cGy; second dose 2-6 Gy at 6-24 h after the first dose). Some of the experiments were carri...

journal_title：International journal of radiation biology

authors： Müller WU,Streffer C,Niedereichholz F

更新日期：1992-08-01 00:00:00

abstract：PURPOSE:To investigate the possible role of vitamin E, coenzyme Q10 and rutin in ameliorating the biochemical changes in brain and serum induced by cerebral ischemia/reperfusion (I/R) in whole body γ-irradiated rats. MATERIALS AND METHODS:Cerebral ischemia was induced in male Wistar rats (either irradiated or non-irra...

journal_title：International journal of radiation biology

authors： Abd-El-Fattah AA,El-Sawalhi MM,Rashed ER,El-Ghazaly MA

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:The nature of the transferrable factor which goes from irradiated objects to bystander objects remains undefined. Most agree that a chemical entity is the likely 'factor' although some authors have produced in vitro evidence for the involvement of a physical component or a very potent volatile capable of travel...

journal_title：International journal of radiation biology

authors： Mothersill C,Smith RW,Fazzari J,McNeill F,Prestwich W,Seymour CB

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:Recently, it was found that MK615 possessed an anti-proliferative ability on treated cancer cells as a consequence of triterpenoid compounds. It is well known that radiation affects cellular-mediated immunity in cancer patients who are treated with radiotherapy. Similarly, the ability of triterpenoid compounds ...

journal_title：International journal of radiation biology

authors： Al-Jahdari WS,Sakurai H,Yoshida Y,Mobaraki A,Suzuki Y,Nakano T

更新日期：2011-01-01 00:00:00

abstract：:Lethal mutations are induced in mammalian cells mainly, perhaps wholly, within the dose range encompassing the 'shoulder,' and may well be attributable to error-prone Q-repair. ...

journal_title：International journal of radiation biology

authors： Alper T,Mothersill C,Seymour CB

更新日期：1988-10-01 00:00:00

abstract：:Reasonable expectations, based on the normal physiology of the human fetus, cast new light on the possibilities of extrapolation from the finding of severe mental retardation (SMR) in Japanese bomb survivors after maternal exposure to 1.8-5.5 Gy T65DR Gy. After such large exposures the fetal haematopoietic tissues (DS...

journal_title：International journal of radiation biology

authors： Mole RH

更新日期：1990-10-01 00:00:00