Adaptive response in mouse embryos?

Abstract:

:Pre-implantation embryos of the mouse were studied for the occurrence of an adaptive response, i.e. induction of radio-resistance by a previous low dose. Various experimental designs were checked (initial doses between 3 and 10 cGy; second dose 2-6 Gy at 6-24 h after the first dose). Some of the experiments were carried out in exactly the same way that resulted in an adaptive response of human lymphocytes reported previously. However, when cell proliferation and differentiation of mouse embryos were examined, none of the conditions tested indicated the induction of an adaptive response.

journal_name

Int J Radiat Biol

authors

Müller WU,Streffer C,Niedereichholz F

doi

10.1080/09553009214551981

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

169-75

issue

2

eissn

0955-3002

issn

1362-3095

pii

JPN9PG8HDADM7MH4

journal_volume

62

pub_type

杂志文章
  • A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part III. Countermeasures under early stages of development along with 'standard of care' medicinal and procedures not requiring regulatory approv

    abstract:PURPOSE:Terrorist attacks, with their intent to maximize psychological and economic damage as well as inflicting sickness and death on given targeted populations, are an ever-growing worldwide concern in government and public sectors as they become more frequent, violent, and sensational. If given the chance, it is lik...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553002.2017.1332440

    authors: Singh VK,Hanlon BK,Santiago PT,Seed TM

    更新日期:2017-09-01 00:00:00

  • Increase in DNA single-strand break rejoining by continuous exposure of human mononuclear blood cells to radioiodine ((131)I) in vitro.

    abstract::Radioiodine ((131)I) induced a dose- and time-dependent increase in DNA single-strand breaks (DNA-ssb) in human (G0) mononuclear blood cells (MNC) in vitro. Incubation of MNC with 22MBq (131)I/ml at 4 degrees C caused a linear, time-dependent induction of DNA-ssb (increase in elution rate: 24.7 x 10(-3) h(-1) per 100 ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530097143103

    authors: Hengstler JG,Bockisch A,Fuchs J,Grimm W,Zapf AO,Lade K,Meinert R,Oesch-Bartlomowicz B,Tanner B,Oesch F

    更新日期:1997-11-01 00:00:00

  • Pulmonary immune response of dogs after exposure to 239PuO2.

    abstract::This study evaluated the cell-mediated (CMI) and humoral immune responses in four Beagle dogs five to six years after single inhalation exposures to different monodisperse 239PuO2 aerosols (0.72-1.4 microns activity median aerodynamic diameter). These exposures resulted in initial lung burdens ranging from 19 to 35 kB...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553008914550311

    authors: Galvin JB,Bice DE,Guilmette RA,Muggenburg BA,Haley PJ

    更新日期:1989-02-01 00:00:00

  • Clinical and epidemiological observations on individual radiation sensitivity and susceptibility.

    abstract::Purpose: To summarize existing knowledge and to understand individual response to radiation exposure, the MELODI Association together with CONCERT European Joint Programme has organized a workshop in March 2018 on radiation sensitivity and susceptibility.Methods: The workshop reviewed the current evidence on this matt...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553002.2019.1665209

    authors: Seibold P,Auvinen A,Averbeck D,Bourguignon M,Hartikainen JM,Hoeschen C,Laurent O,Noël G,Sabatier L,Salomaa S,Blettner M

    更新日期:2020-03-01 00:00:00

  • Evaluation and optimization of radioprotective activity of Coronopus didymus Linn. in gamma-irradiated mice.

    abstract:PURPOSE:To evaluate and optimize the radioprotective ability of the most potent fraction of an aqueous extract of Coronopus didymus in whole body gamma-irradiated Swiss albino mice and to evaluate the antioxidant status and lipid peroxidation of the livers of the surviving mice. To correlate the free radical scavenging...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000600876686

    authors: Prabhakar KR,Veerapur VP,Parihar KV,Priyadarsini KI,Rao BS,Unnikrishnan MK

    更新日期:2006-08-01 00:00:00

  • Low folate status increases chromosomal damage by X-ray irradiation.

    abstract:PURPOSE:To examine how folate status influences chromosomal damage following X-ray irradiation. MATERIAL AND METHODS:In an animal study, mice were fed either a low, basal, or high folic acid diet (0, 2, or 40 mg/kg diet, respectively) for 4 weeks, and then given total body irradiation (TBI) at 0.5 Gy. In a human study...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/09553000600721817

    authors: Endoh K,Murakami M,Araki R,Maruyama C,Umegaki K

    更新日期:2006-04-01 00:00:00

  • An image analysis technique for detection of radiation-induced DNA fragmentation after CHEF electrophoresis.

    abstract::CHEF-electrophoresis was used as a technique to detect radiation-induced DNA breakage with special emphasis to biological relevant X-ray doses (0-10 Gy). Fluorescence detection of DNA-fragments using a sensitive image analysis system was directly compared with conventional scintillation counting of 3H-thymidine prelab...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009314551361

    authors: Rosemann M,Kanon B,Konings AW,Kampinga HH

    更新日期:1993-08-01 00:00:00

  • Absence of the effects of 50 Hz magnetic fields on the progression of acute myeloid leukaemia in rats.

    abstract:PURPOSE:As the most recent epidemiological studies provide no definite conclusions about the effects of 50/60 Hz magnetic fields (MFs) on the incidence of leukaemia in humans, animal models in a well-controlled environment are useful for evaluating the possibility of an association between MFs and leukaemia. The presen...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000050029011

    authors: Devevey L,Patinot C,Debray M,Thierry D,Brugere H,Lambrozo J,Guillosson JJ,Nafziger J

    更新日期:2000-06-01 00:00:00

  • Association of protein phosphorylation and cell cycle progression after X-irradiation of two-cell mouse embryos.

    abstract::Studies of protein phosphorylation in the second cell cycle of mouse embryos were assessed by [32P]-incorporation and one- and two-dimensional electrophoresis. Unirradiated and X-irradiated embryos were compared. X-irradiation in the G2 phase led to a block in this cell cycle phase. The phosphorylation of proteins wit...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009114552351

    authors: Jung T,Streffer C

    更新日期:1991-09-01 00:00:00

  • DNA double-strand break repair determines the RBE of alpha-particles.

    abstract::Radiation-induced DNA double-strand breaks (dsb) were studied in Ehrlich ascites tumour cells (EATC) by sedimentation in neutral sucrose gradients at low centrifuge speed. Dsb induction was found to be linear with dose with a frequency of: ndsbmr-1D-1 = (11.7 +/- 2) x 10(-12)Gy-1 for 140 kV X-rays and ndsbmr-1D-1 = (1...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553008814552201

    authors: Blöcher D

    更新日期:1988-11-01 00:00:00

  • Radiosensitization by misonidazole, pimonidazole and azomycin and intracellular uptake in human tumour cell lines.

    abstract::The radiosensitization of two human tumour in vitro cell lines, HT-1080 and LoVo, has been compared with that of the Chinese hamster cell line V79-379A. Although the two human tumour cell lines were more radiosensitive than the V79 cell line sensitizer, enhancement ratios for misonidazole, pimonidazole and azomycin we...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009014552461

    authors: Watts ME,Dennis MF,Roberts IJ

    更新日期:1990-02-01 00:00:00

  • Protection of pig epidermis against radiation-induced damage by the infusion of BW12C.

    abstract::BW12C, which was developed as an agent for the treatment of sickle cell anaemia, increases the binding of oxygen to haemoglobin and hence reduces the availability of oxygen to tissues. Due to these changes in oxygen availability BW12C could act as a protector against radiation-induced injury to normal tissues. In this...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009114550921

    authors: van den Aardweg GJ,Hopewell JW,Adams GE,Barnes DW,Sansom JM,Stratford IJ,Nethersell AB

    更新日期:1991-04-01 00:00:00

  • 50-Hz magnetic field induces EGF-receptor clustering and activates RAS.

    abstract:PURPOSE:In a previous study, we found that exposure to a 50 Hz magnetic field (MF) could activate stress-activated protein kinase (SAPK) and P38 mitogen-activated protein (MAP) kinase (P38 MAPK) in Chinese hamster lung (CHL) fibroblast cells, and simultaneous exposure to a 'noise' MF of the same intensity inhibited the...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000801998875

    authors: Ke XQ,Sun WJ,Lu DQ,Fu YT,Chiang H

    更新日期:2008-05-01 00:00:00

  • Raman spectroscopy of tissue samples irradiated by protons.

    abstract:PURPOSE:Since the number of cancer patients treated by proton irradiation has increased in the last few years, it seems appropriate to study dose-dependent effects of proton irradiation on mammalian tissues in more detail. MATERIALS AND METHODS:Tissue samples of normal skin of mouse and swine, of a human tumour model ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000412331283515

    authors: Synytsya A,Alexa P,Besserer J,De Boer J,Froschauer S,Gerlach R,Loewe M,Moosburger M,Obstová I,Quicken P,Sosna B,Volka K,Würkner M

    更新日期:2004-08-01 00:00:00

  • The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review.

    abstract::The mechanisms of radiation damage production are used to examine the following premises: (1) the number of DNA double-strand breaks per unit dose increases with dose; (2) cell type to cell type variations in yield of DNA dsb per dose occur. Two stages of damage production are identified as possible sources of damage ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553009014551251

    authors: Ward JF

    更新日期:1990-06-01 00:00:00

  • "In situ" observation of guanine radicals induced by ultrasoft X-ray irradiation around the K-edge regions of nitrogen and oxygen.

    abstract:PURPOSE:In order to understand the molecular mechanism of nucleobase damage caused by ultrasoft X-ray irradiation, guanine radicals have been studied using an X-band EPR (electron paramagnetic resonance) spectrometer installed in a synchrotron soft X-ray beamline. MATERIALS AND METHODS:Guanine pellets were irradiated ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000400017689

    authors: Yokoya A,Akamatsu K,Fujii K,Ukai M

    更新日期:2004-11-01 00:00:00

  • Kinetics of chromosome lesion repair in synchronized quiescent and proliferating CHO cells.

    abstract::The induction of chromosome aberrations by X-rays was investigated in synchronized quiescent and proliferating CHO-K1 cells. Kinetics of chromosome lesion repair was studied using the method of fractionated irradiation. In both cell types the time-course of repair during fractionation intervals followed first-order ki...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009014552321

    authors: Volkmer B,Virsik-Peuckert RP

    更新日期:1990-12-01 00:00:00

  • A cross-sectional study on oxidative stress in workers exposed to extremely low frequency electromagnetic fields.

    abstract:PURPOSE:To investigate whether extremely low frequency electromagnetic field (ELF-EMF) exposure could induce oxidative stress in workers performing tour-inspection near transformers and distribution power lines. MATERIALS AND METHODS:Occupational short-term 'spot' measurements were performed. In total, 310 inspection ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2015.1012304

    authors: Li L,Xiong DF,Liu JW,Li ZX,Zeng GC,Li HL

    更新日期:2015-05-01 00:00:00

  • Biophysical model of the radiation-induced bystander effect.

    abstract:PURPOSE:To construct a quantitative model of the radiation-induced bystander effect based on diffusion-type spreading of bystander signal communication between the hit and non-hit cells. Cell inactivation and induced oncogenic transformation by broad- and microbeam irradiation systems are considered. MATERIALS AND MET...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:

    authors: Nikjoo H,Khvostunov IK

    更新日期:2003-01-01 00:00:00

  • Response to high LET radiation 12C (LET, 295 keV/microm) in M5 cells, a radio resistant cell strain derived from Chinese hamster V79 cells.

    abstract:PURPOSE:To study the effects of 12C-beam of 295 keV/microm (57.24 MeV) on M5 and Chinese hamster V79 cells by using cytogenetic assays like micronuclei (MN) induction, chromosomal aberrations (CA) and apoptosis. Additionally, the relative survival of these two cell lines was tested by the colony forming ability of the ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000601085964

    authors: Pathak R,Sarma A,Sengupta B,Dey SK,Khuda-Bukhsh AR

    更新日期:2007-01-01 00:00:00

  • The application of the linear quadratic model to compensate the effects of prolonged fraction delivery time on a Balb/C breast adenocarcinoma tumor: An in vivo study.

    abstract::Purpose To investigate the effect of increasing the overall treatment time as well as delivering the compensating doses on the Balb/c breast adenocarcinoma (4T1) tumor. Materials and methods A total of 72 mice were divided into two aliquots (classes A and B) based on the initial size of their induced tumor. Each class...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2016.1117677

    authors: Nikzad S,Hashemi B,Hasan ZS,Mozdarani H,Baradaran-Ghahfarokhi M,Amini P

    更新日期:2016-01-01 00:00:00

  • Differential survival of murine small and large intestinal crypts following ionizing radiation.

    abstract::Radiation survival curves have been obtained for crypts in the small and large intestine of male BDF1 mice using the microcolony assay. Four regions of the small intestine and three regions of the large intestine were studied. One of the major objectives was to determine the optimal conditions for the microcolony assa...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530097144265

    authors: Cai WB,Roberts SA,Bowley E,Hendry JH,Potten CS

    更新日期:1997-02-01 00:00:00

  • DNA strand scission and base release photosensitized by metallo-phthalocyanines.

    abstract::Photoirradiation of aqueous solutions of DNA in the presence of Al- or Zn-tetrasulphonated phthalocyanines (AIPcS4 and ZnPcS4) causes formation of strand breaks and liberation of nucleobases. The effect of added D2O, which enhances singlet oxygen (1O2) lifetime, radical scavengers including alcohols and the spin-trap ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:

    authors: Gantchev TG,Gowans BJ,Hunting DJ,Wagner JR,van Lier JE

    更新日期:1994-12-01 00:00:00

  • A comparison of the chemical repair rates of free radical precursors of DNA damage and cell killing in Chinese hamster V79 cells.

    abstract::One of the important temporal stages of radiation action in cellular systems is the chemical phase, where oxygen fixation reactions compete with chemical repair reactions involving reducing agents such as GSH. Using the gas explosion technique it is possible to follow the kinetics of these fast (greater than 1 ms) rea...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009214551571

    authors: Prise KM,Davies S,Michael BD

    更新日期:1992-06-01 00:00:00

  • Daily exposure to inhomogeneous static magnetic field significantly reduces blood glucose level in diabetic mice.

    abstract:PURPOSE:The present study was designed to reveal, whether the 30 min daily full body exposure of mice to an inhomogeneous static magnetic field (SMF) has a statistically significant effect on diabetic neuropathy. MATERIALS AND METHODS:Three different doses (100, 150, or 200 mg/kg) of streptozotocin (STZ) were administ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2010.518200

    authors: László JF,Szilvási J,Fényi A,Szalai A,Gyires K,Pórszász R

    更新日期:2011-01-01 00:00:00

  • Mutagenic effects of 5-formyluracil on a plasmid vector during replication in Escherichia coli.

    abstract:PURPOSE:5-Formyluracil (5-foU) is a major derivative of thymine produced in DNA by ionizing radiation and various chemical oxidants. It has been previously shown that 5-foU in template DNA directs misincorporation of nucleotides by DNA polymerases during in vitro DNA synthesis. The present experiments were designed to ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530001453113

    authors: Miyabe I,Zhang QM,Sugiyama H,Kino K,Yonei S

    更新日期:2001-01-01 00:00:00

  • Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L. protects human fibroblasts but not human tumour cells in vitro against ionizing radiation.

    abstract:PURPOSE:Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L., has demonstrated a promising impact on chemotherapy in a variety of malignancies. The effects of the drug on cell survival, alteration of the cell cycle and induction of apoptosis were examined without and in combination with ionizing r...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000110089991

    authors: Cordes N,Plasswilm L,Bamberg M,Rodemann HP

    更新日期:2002-01-01 00:00:00

  • A 700 MHz 1H-NMR study reveals apoptosis-like behavior in human K562 erythroleukemic cells exposed to a 50 Hz sinusoidal magnetic field.

    abstract:PURPOSE:To study cell damage and possible apoptosis in K562 human erythroleukemic cells exposed for 2 h to an extremely low frequency (ELF) 50 Hz sinusoidal magnetic field with a magnetic induction of either 1 or 5 mT using high resolution proton nuclear magnetic resonance (1H-NMR) spectroscopy. MATERIALS AND METHODS:...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000500102985

    authors: Santini MT,Ferrante A,Romano R,Rainaldi G,Motta A,Donelli G,Vecchia P,Indovina PL

    更新日期:2005-02-01 00:00:00

  • X-ray-induced DNA double-strand breaks as lethal lesions in diploid human fibroblasts compared to Chinese hamster ovary cells.

    abstract::Calibration of the non-denaturing (pH 9.6) filter elution technique by 125I decays has been used to examine the relationship between X-ray-induced DNA double-strand breaks (dsb) and cellular survival of CHO cells and human fibroblasts. DNA dsb induction varies markedly between the two cell lines, reflecting the differ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009314550411

    authors: Baumstark-Khan C

    更新日期:1993-03-01 00:00:00

  • Effects on micronuclei formation of 60-Hz electromagnetic field exposure with ionizing radiation, hydrogen peroxide, or c-Myc overexpression.

    abstract:PURPOSE:Epidemiological studies have demonstrated a possible correlation between exposure to extremely low-frequency magnetic fields (ELF-MF) and cancer. However, this correlation has yet to be definitively confirmed by epidemiological studies. The principal objective of this study was to assess the effects of 60 Hz ma...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2012.652724

    authors: Jin YB,Kang GY,Lee JS,Choi JI,Lee JW,Hong SC,Myung SH,Lee YS

    更新日期:2012-04-01 00:00:00