Severe mental retardation after large prenatal exposures to bomb radiation. Reduction in oxygen transport to fetal brain: a possible abscopal mechanism.

abstract：PURPOSE:Gamma-irradiation leads to activation of p53 tumour suppressor gene and to p53-dependant stimulation of a large panel of cellular genes including proapoptotic genes involved in intrinsic and extrinsic pathways. Most in vivo published data referred to high (lethal) irradiation doses. The present study was perfor...

journal_title：International journal of radiation biology

authors： Alvarez S,Drané P,Meiller A,Bras M,Deguin-Chambon V,Bouvard V,May E

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:We already reported that levels of interferon (IFN)-γ have been shown to be markedly reduced in mice seven weeks after irradiation, resulting in a T helper (Th) 1/Th2 imbalance. To investigate whether the single or fractionated γ-irradiation induced an immune imbalance, we analysed the Th1-related immune respon...

journal_title：International journal of radiation biology

authors： Park HR,Jo SK,Eom HS

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:The efficacy of a boron-containing cholesteryl ester compound (BCH) as a boron neutron capture therapy (BNCT) agent for the targeted irradiation of PC-3 human prostate cancer cells was examined. MATERIALS AND METHODS:Liposome-based delivery of BCH was quantified with inductively coupled plasma-mass spectrometr...

journal_title：International journal of radiation biology

authors： Gifford I,Vreeland W,Grdanovska S,Burgett E,Kalinich J,Vergara V,Wang CK,Maimon E,Poster D,Al-Sheikhly M

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:To determine the involvement of c-Jun NH(2)-terminal kinase-1 (JNK1) and possibly of HSP27 in heat-induced apoptosis of human monoblastic leukaemia U937 cells. MATERIALS AND METHODS:Dominant negative JNK1 (APF), in which the phosphorylation sites Thr-Pro-Tyr were changed to Ala-Pro-Phe, was overexpressed in U9...

journal_title：International journal of radiation biology

authors： Enomoto A,Suzuki N,Liu C,Kang Y,Zhu J,Serizawa S,Matsumoto Y,Morita A,Ito M,Hosoi Y

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:Static magnetic field (SMF) exposure was shown experimentally to beneficially affect the healing process. The aim of this randomized, controlled trial was to evaluate the pain-inhibitory effect of local exposure to SMF on temporomandibular disorders, on alveolitis and on aphta in the oral mucosa. MATERIALS AND...

journal_title：International journal of radiation biology

authors： László JF,Farkas P,Reiczigel J,Vágó P

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:The radiation-induced bystander effect (RIBE) has important implications for the efficiency of radiotherapy but the underlying role of cellular metabolism is widely unknown. The roles of synthesis of cytochrome c oxidase 2 (SCO2), a key effector for respiratory chain, and related signaling factors in α-particle...

journal_title：International journal of radiation biology

authors： Li J,He M,Shen B,Yuan D,Shao C

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:To construct a quantitative model of the radiation-induced bystander effect based on diffusion-type spreading of bystander signal communication between the hit and non-hit cells. Cell inactivation and induced oncogenic transformation by broad- and microbeam irradiation systems are considered. MATERIALS AND MET...

journal_title：International journal of radiation biology

authors： Nikjoo H,Khvostunov IK

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Since the number of cancer patients treated by proton irradiation has increased in the last few years, it seems appropriate to study dose-dependent effects of proton irradiation on mammalian tissues in more detail. MATERIALS AND METHODS:Tissue samples of normal skin of mouse and swine, of a human tumour model ...

journal_title：International journal of radiation biology

authors： Synytsya A,Alexa P,Besserer J,De Boer J,Froschauer S,Gerlach R,Loewe M,Moosburger M,Obstová I,Quicken P,Sosna B,Volka K,Würkner M

更新日期：2004-08-01 00:00:00

abstract：:Radiation survival curves have been obtained for crypts in the small and large intestine of male BDF1 mice using the microcolony assay. Four regions of the small intestine and three regions of the large intestine were studied. One of the major objectives was to determine the optimal conditions for the microcolony assa...

journal_title：International journal of radiation biology

authors： Cai WB,Roberts SA,Bowley E,Hendry JH,Potten CS

更新日期：1997-02-01 00:00:00

abstract：:An iodinated DNA ligand, iodo Hoechst 33258, which binds in the minor groove of DNA, enhances DNA strand breakage and cell killing by UV-A irradiation. The sites of UV-induced strand breaks reflect the known sequence specificity of the ligand. ...

journal_title：International journal of radiation biology

authors： Martin RF,Murray V,D'Cunha G,Pardee M,Kampouris E,Haigh A,Kelly DP,Hodgson GS

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:To clarify the experimental conditions that might influence the release of cytokines in the culture medium and give some basic input for building a model for cytokine (e.g., Interleukin-6, IL-6) regulation in the case of 'sham irradiation' and after ionising radiation exposure. MATERIALS AND METHODS:The influe...

journal_title：International journal of radiation biology

authors： Facoetti A,Mariotti L,Ballarini F,Bertolotti A,Nano R,Pasi F,Ranza E,Ottolenghi A

更新日期：2009-08-01 00:00:00

abstract：:The behaviour of polyamines (putrescine, spermidine and spermine) in the small intestine was studied in rats exposed to a single whole-body dose of 3 Gy administered at four different times of the day. Polyamine content decreased a few hours after irradiation but quickly returned to normal values. Putrescine levels re...

journal_title：International journal of radiation biology

authors： Becciolini A,Porciani S,Lanini A,Attanasio M

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:To investigate and compare the propensity of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCL) obtained from unaffected healthy individuals and ataxia telangectasia (A-T) patients to undergo apoptosis after X-ray exposure. MATERIAL AND METHODS:The LCL were exposed to 1-4 Gy X-rays at a dose-...

journal_title：International journal of radiation biology

authors： Meijer AE,Zhivotovsky B,Lewensohn R

更新日期：1999-06-01 00:00:00

abstract：:Purpose: Dose assessment plays an important role in case of radiological accidents and can be performed by scoring structural changes of chromosome morphology induced in cells by ionizing radiation. The results of such a test are biased by scorer experience, therefore, simple to learn assays are recommended to be used...

journal_title：International journal of radiation biology

authors： Gałecki M,Tartas A,Szymanek A,Sims E,Lundholm L,Sollazzo A,Cheng L,Fujishima Y,Yoshida MA,Żygierewicz J,Wojcik A,Brzozowska-Wardecka B

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:Public concern about radiation protection of the environment and non-human species is increasing. The potential impact of chronic gamma radiation on the bacterial community in a rice paddy ecosystem was investigated. MATERIALS AND METHODS:Paddy field microcosm samples were continuously exposed at a dose rate o...

journal_title：International journal of radiation biology

authors： Ishii N,Fuma S,Tagami K,Honma-Takeda S,Shikano S

更新日期：2011-07-01 00:00:00

abstract：:High doses of rHIL-1 protected C3H/HeN mice against lethal radiation damage. The optimum time of radioprotection was found when this cytokine was administered at 4 h and at 20 h before irradiation. The dose reduction factors when the IL-1 was administered at those times were about 1.30. The radioprotection at the opti...

journal_title：International journal of radiation biology

authors： Wu SG,Tuboi A,Miyamoto T

更新日期：1989-10-01 00:00:00

abstract：:This paper presents a summary of our understanding to date of the formation of DNA strand breaks induced by highly energetic particle beams (high-LET radiation). We have compared our own recent data on the formation of strand breaks induced in DNA in an aqueous solution with our previous data and those of others avail...

journal_title：International journal of radiation biology

authors： Roots R,Holley W,Chatterjee A,Irizarry M,Kraft G

更新日期：1990-07-01 00:00:00

abstract：PURPOSE:The need to determine a reliable relative biological effectiveness (RBE) value for alpha exposures has become important as reports remain controversial. Although a radiation-weighting factor of 20 has been designated for alpha particles, uncertainty exists on realistic value of the RBE of alpha radiation. The a...

journal_title：International journal of radiation biology

authors： Meenakshi C,Mohankumar MN

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:Despite proven antitumor activity of gemcitabine in chemoradiotherapy of advanced head and neck cancer, many authors refer to severe acute and late local and haematological toxicity. Fludarabine does imply nearly the same mechanisms of action as gemcitabine, inhibiting various enzymes involved in DNA replicatio...

journal_title：International journal of radiation biology

authors： Nitsche M,Christiansen H,Hermann RM,Lucke EM,Peters K,Rave-Frank M,Schmidberger H,Pradier O

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To assess intestinal radioprotection by systemic or lumenal tirilazad mesylate and to test potential tumour radioprotection. MATERIALS AND METHODS:Segments of the mid small bowel were surgically exteriorized. Tirilazad was given either intravenously or intralumenally 30 min prior to 11 Gy of X-irradiation to t...

journal_title：International journal of radiation biology

authors： Felemovicius I,Bonsack ME,Griffin RJ,Delaney JP

更新日期：1998-02-01 00:00:00

abstract：:SR 2508 (etanidazole) (1 mM) or buthionine sulphoximine (BSO, 50 microM) or both drugs together did not radiosensitize oxic V79 Chinese hamster cells irradiated at either an acute dose rate (2.35 Gy/min) or at a low dose rate (0.117 Gy/min). BSO pretreatment (15 h at 37 degrees C) depleted cellular glutathione (GSH) t...

journal_title：International journal of radiation biology

authors： Wong RS,Basas RA,Ling CC

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:The tumour suppressor protein p53 is considered to have an impact on the radiosensitivity of tumour cells. However, this concept does not easily translate to the tumour sensitivity in the clinics. The aim of the present study was to determine whether a functional or dysfunctional p53 is associated with a sensit...

journal_title：International journal of radiation biology

authors： Böhnke A,Westphal F,Schmidt A,El-Awady RA,Dahm-Daphi J

更新日期：2004-01-01 00:00:00

abstract：:We have examined the timing of gamma-irradiation-induced death in relation to cell cycle progression using a panel of mouse lymphoid or myeloid cell lines. Death was found to occur immediately after irradiation ('rapid interphase' death), or after arrest in G2 phase ('delayed interphase' death). In part II of this ser...

journal_title：International journal of radiation biology

authors： Radford IR,Murphy TK

更新日期：1994-02-01 00:00:00

abstract：:The relationship between cellular radiosensitivity and normal-tissue response to radiotherapy in individual cancer patients has attracted increasing attention over the last few years. Recent work has suggested that a correlation exists between fibroblast sensitivity and normal-tissue reactions. We have examined the ra...

journal_title：International journal of radiation biology

authors： Burnet NG,Wurm R,Peacock JH

更新日期：1996-09-01 00:00:00

abstract：:Purpose: This review discusses recent developments in our understanding of biological and physiological mechanisms underlying radiation cataractogenesis. The areas discussed include effects of low-dose exposures to the lens including potential relevance of non-targeted effects, the development of new personal-protecti...

journal_title：International journal of radiation biology

authors： Laskowski L,Williams D,Seymour C,Mothersill C

更新日期：2020-05-26 00:00:00

abstract：:A radionuclide release assay for measuring the in vitro kinetics of cell death has been developed. CHO cells were labelled for 24 h with 3.0 hBq/ml of [125I] iododeoxyuridine (125IUdR) and the fate of the labelled cells and their progeny was monitored at daily intervals by measuring the rate of 125I release. Prelabell...

journal_title：International journal of radiation biology

authors： Schneiderman MH,Hofer KG,Schneiderman GS

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:This review examines the evidence for the hypothesis that epigenetics are involved in the initiation and perpetuation of radiation-induced genomic instability (RIGI). CONCLUSION:In addition to the extensively studied targeted effects of radiation, it is now apparent that non-targeted delayed effects such as RI...

journal_title：International journal of radiation biology

authors： Aypar U,Morgan WF,Baulch JE

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:To propose an improved version of RADACK, a stochastic simulation of radiolytic attack on DNA, that takes into account the reactivity of each amino acid of a specifically bound protein with hydroxyl radicals. To apply it to the natural lactose operator-repressor complex taking advantage of recently reported str...

journal_title：International journal of radiation biology

authors： Begusova M,Giliberto S,Gras J,Sy D,Charlier M,Spotheim-Maurizot M

更新日期：2003-06-01 00:00:00

abstract：:The aim was to review and summarize the results of 40 years of study concerning the response to ionizing radiation of the pair of L5178Y (LY) sublines, LY-R and LY-S, that differ in sensitivity to various DNA-damaging agents, among them X- and gamma-rays. The reviewed data indicate the key importance of DNA damage rep...

journal_title：International journal of radiation biology

authors： Szumiel I

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:To determine whether chromosomal instability is induced in human diploid fibroblasts by ionizing radiation and to investigate the effects of radiation quality by comparing X-rays, neutrons and alpha-particles. MATERIALS AND METHODS:Cells from two human diploid fibroblast lines, HF12 and HF19, were irradiated a...

journal_title：International journal of radiation biology

authors： Kadhim MA,Marsden SJ,Wright EG

更新日期：1998-02-01 00:00:00