Lethal mutations attributable to misrepair of Q-lesions.

abstract：:The response to radiation of seven osteosarcoma cell lines was analysed by in vitro colony-forming assay and compared with that of eight human fibroblast strains. The values of D0, the surviving fraction after 2 Gy (S2Gy), and the mean inactivation dose (D) of osteosarcoma cells in log-phase culture were significantly...

journal_title：International journal of radiation biology

authors： Sugimoto M,Toguchida J,Kotoura Y,Yamamuro T,Utsumi H

更新日期：1992-10-01 00:00:00

abstract：PURPOSE:Immune cells accumulate in and around cancers and cooperate with each other using specific cytokines to attack the cancer cells. The heavy-ion beams for cancer therapy may stimulate immune cells and affect on the immune system. However, it is still poorly understood how the immune cells are stimulated by ion-be...

journal_title：International journal of radiation biology

authors： Mutou-Yoshihara Y,Funayama T,Yokota Y,Kobayashi Y

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:As the most recent epidemiological studies provide no definite conclusions about the effects of 50/60 Hz magnetic fields (MFs) on the incidence of leukaemia in humans, animal models in a well-controlled environment are useful for evaluating the possibility of an association between MFs and leukaemia. The presen...

journal_title：International journal of radiation biology

authors： Devevey L,Patinot C,Debray M,Thierry D,Brugere H,Lambrozo J,Guillosson JJ,Nafziger J

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:Cartilage degradation usually results as a consequence of inflammatory processes in the joints. To study this phenomenon experimentally, adjuvant-induced arthritis (AIA) was used as a model of chronic inflammation under the influence of irradiation. The potential chondroprotective effect of 13% aqueous extract ...

journal_title：International journal of radiation biology

authors： El-Ghazaly MA,El-Naby DH,Khayyal MT

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:To reduce retention and toxicity of the alpha particle emitter polonium-210 in rats by newly developed chelating agents. MATERIALS AND METHODS:Repeated subcutaneous chelation was conducted after intravenous injection of 210Po nitrate. For reduction of 210Po retention the treatment with vicinal dithiols meso-an...

journal_title：International journal of radiation biology

authors： Rencová J,Volf V,Jones MM,Singh PK

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:The aim of this research was to demonstrate the effects of 50 Hz sinusoidal extremely low frequency of magnetic fields (ELF-MF) on preincubated chicken embryo hearts at histopathological, biochemical, and ultrastructural levels. MATERIALS AND METHODS:Ninety healthy fertilized eggs were divided into six groups ...

journal_title：International journal of radiation biology

authors： Shams Lahijani M,Tehrani DM,Fereydouni N

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:Biomarkers of ionising radiation exposure are useful in a variety of scenarios, such as medical diagnostic imaging, occupational exposures, and spaceflight. This study investigates to what extent microRNA (miRNA) expression signatures in mouse peripheral blood can be used as biomarkers for exposures to radiatio...

journal_title：International journal of radiation biology

authors： Templin T,Amundson SA,Brenner DJ,Smilenov LB

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To investigate the ability of electromagnetic (EM) field pre-exposures to induce protection in chick embryos against subsequent ultraviolet (UV) light exposure. MATERIALS AND METHOD:Chick embryos in the 4th day of gestation were exposed for 20 minutes (short term) or 96 hours (long term) to 60 Hz, 8 microT mag...

journal_title：International journal of radiation biology

authors： Dicarlo AL,Hargis MT,Penafiel LM,Litovitz TA

更新日期：1999-12-01 00:00:00

abstract：PURPOSE:To examine whether a simulated mobile telephone transmission at 915 MHz has an effect on cognitive function in man. MATERIALS AND METHODS:Thirty-six subjects in two groups were each given two training sessions and then three test sessions in a randomized three-way cross-over design. About 1 W mean power at 915...

journal_title：International journal of radiation biology

authors： Preece AW,Iwi G,Davies-Smith A,Wesnes K,Butler S,Lim E,Varey A

更新日期：1999-04-01 00:00:00

abstract：:The literature suggests that the function of radiation-induced G2 arrest is to allow repair of potentially lethal damage before cell-entry into, and damage expression in, mitosis. The nature of the damage repaired is not known, but chromosome aberrations have been considered. To examine this possibility in G2 cells, t...

journal_title：International journal of radiation biology

authors： Rowley R

更新日期：1990-09-01 00:00:00

abstract：:Radiation survival curves have been obtained for crypts in the small and large intestine of male BDF1 mice using the microcolony assay. Four regions of the small intestine and three regions of the large intestine were studied. One of the major objectives was to determine the optimal conditions for the microcolony assa...

journal_title：International journal of radiation biology

authors： Cai WB,Roberts SA,Bowley E,Hendry JH,Potten CS

更新日期：1997-02-01 00:00:00

abstract：PURPOSE:Caffeine (1,3,7-trimethyl xanthine), a dietary component, has been shown to have widely varying effects on DNA damage induced by UV and ionizing radiation, depending upon pre- or post-irradiation administration and its concentration. Caffeine administered post-UV irradiation is known to inhibit enzymatic repair...

journal_title：International journal of radiation biology

authors： Kumar SS,Devasagayam TP,Jayashree B,Kesavan PC

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:To investigate the possible role of cell cycle arrest in the radiosensitization of mouse spermatogonial stem cells due to small conditioning X-ray exposures. MATERIALS AND METHODS:A 24 h fractionation interval between conditioning (1 Gy) and challenging (8 or 9 Gy) exposures was used. Two approaches were follo...

journal_title：International journal of radiation biology

authors： Van Buul PP,Van Duyn-Goedhart A,Beumer T,Bootsma AL

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:This study is part of a general search for the anatomical bases of the severe mental retardation syndrome caused by prenatal irradiation. More specifically, it seeks reasons for the high radiosensitivity of a white matter area, the cingulum of the corpus callosum. MATERIALS AND METHODS:Pregnant primiparous Wis...

journal_title：International journal of radiation biology

authors： Reyners H,Gianfelici de Reyners E,Yan J,De Saint-Georges L,Desaintes C

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:This review will examine the role of phosphatases in cancer cell signalling and also outline emerging findings regarding the influence of phosphatases on tumor cell survival after ionising radiation. CONCLUSION:The exposure of tumour cells to clinically relevant doses of ionising radiation causes DNA damage an...

journal_title：International journal of radiation biology

authors： Hamilton J,Bernhard EJ

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To investigate the induction of chromosomal aberrations in mouse m5S cells after exposure to power-line frequency magnetic fields (extremely low frequency magnetic fields; ELFMF) at high-flux densities. MATERIAL AND METHOD:m5S cells were either untreated or pretreated during the G1 phase with mitomycin C (MMC,...

journal_title：International journal of radiation biology

authors： Yaguchi H,Yoshida M,Ding GR,Shingu K,Miyakoshi J

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:The aim of this work is to study the relative damaging effects of DNA-incorporated radionuclides by analyzing the behavior of the liquid-scintillation counting efficiency in volumes of nanometer size. METHODS:A liquid scintillation counter can detect changes in the micelle size when different percentages of an...

journal_title：International journal of radiation biology

authors： Grau Carles A

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:The linear nonthreshold (LNT) model has been used in radiation protection for over 40 years and has been hotly debated. It relies heavily on human epidemiology, with support from radiobiology. The scientific underpinnings include NCRP Report No. 136 ('Evaluation of the Linear-Nonthreshold Dose-Response Model fo...

journal_title：International journal of radiation biology

authors： Boice JD Jr

更新日期：2017-10-01 00:00:00

abstract：:A/J and C57BL/6J mice, strains which differ in susceptibility to chemical-induced lung tumours, were examined for differential sensitivity to radon-induced lung cancer. Sixty weeks after exposure to 952 WLM radon (3.34 J h1 m-3), no lung tumours were found in the control, sham- (one dust-) exposed, or radon-exposed C5...

journal_title：International journal of radiation biology

authors： Groch KM,Khan MA,Brooks AL,Saffer JD

更新日期：1997-03-01 00:00:00

abstract：PURPOSE:Exposure to ionizing radiation induces plant defenses by regulating the expression of response genes. The systemic acquired resistance deficient 1 (SARD1) is a key gene in plant defense response. In this study, the function of Oryza sativa SARD1 (OsSARD1) was investigated after exposure of seeds/plants to ioniz...

journal_title：International journal of radiation biology

authors： Jung IJ,Hwang JE,Han SM,Kim DS,Ahn JW,Choi HI,Kwon SJ,Kang SY,Kim JB

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:Although the significance of cell cycle checkpoints in overcoming low-dose hyper-radiosensitivity (HRS) has been proposed, the underlying mechanism of HRS in human hepatocellular cells remains unclear. Therefore, the aim of this study was to characterize HRS inhuman hepatocellular HepG2 cells and to explore the...

journal_title：International journal of radiation biology

authors： Xue J,Zong Y,Li PD,Wang LX,Li YQ,Niu YF

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:Zearalenone is a potent estrogenic metabolite produced by some Fusarium and Gibberella species. Therefore, the aim of this study was to determine the accumulation of Technetium-[99m]-labeled zearalenone in mice organs as well as to study the protective effect of Lactobacillus plantarum. MATERIALS AND METHODS:T...

journal_title：International journal of radiation biology

authors： Sanad MH,Fouzy ASM,Sobhy HM,Hathout AS,Hussain OA

更新日期：2018-12-01 00:00:00

abstract：:Purpose: This review discusses recent developments in our understanding of biological and physiological mechanisms underlying radiation cataractogenesis. The areas discussed include effects of low-dose exposures to the lens including potential relevance of non-targeted effects, the development of new personal-protecti...

journal_title：International journal of radiation biology

authors： Laskowski L,Williams D,Seymour C,Mothersill C

更新日期：2020-05-26 00:00:00

abstract：PURPOSE:Neutron irradiations at the McMaster Tandetron Accelerator were performed to study direct and bystander effects of neutrons in a live organism. METHODS:The neutrons were produced through (7)Li(p,n)(7)Be reaction. Although the gamma contamination of the neutron beam cannot be completely eliminated, it was desig...

journal_title：International journal of radiation biology

authors： Wang C,Smith RW,Duhig J,Prestwich WV,Byun SH,McNeill FE,Seymour CB,Mothersill CE

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:To investigate whether mobile phone radiation might affect snail nociception, employing radiofrequency (RF) electromagnetic fields (EMF) which, to our knowledge, have hitherto not been studied in a snail model. Exposure to extremely low frequency (ELF) magnetic fields has however been shown to significantly aff...

journal_title：International journal of radiation biology

authors： Nittby H,Moghadam MK,Sun W,Malmgren L,Eberhardt J,Persson BR,Salford LG

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Terrorist attacks, with their intent to maximize psychological and economic damage as well as inflicting sickness and death on given targeted populations, are an ever-growing worldwide concern in government and public sectors as they become more frequent, violent, and sensational. If given the chance, it is lik...

journal_title：International journal of radiation biology

authors： Singh VK,Hanlon BK,Santiago PT,Seed TM

更新日期：2017-09-01 00:00:00

abstract：:The role of protein kinase C in radiation-induced death of thymocytes was studied. For this purpose murine thymocytes were irradiated and incubated for 6 h at 37 degrees C and afterwards the fraction of fragmented DNA was measured. Results indicate that radiation-induced DNA fragmentation can be prevented by adding th...

journal_title：International journal of radiation biology

authors： Ojeda F,Guarda MI,Maldonado C,Folch H,Diehl H

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:The exploration of immune mechanisms of the tumour-inhibitory effect of exposures to low-level fractions of X-rays. MATERIALS AND METHODS:BALB/c mice were exposed to whole-body daily irradiations with 0.01, 0.02, or 0.1 Gy X-rays per day for 5 days/week for two weeks. Then, mice were intravenously injected wit...

journal_title：International journal of radiation biology

authors： Nowosielska EM,Cheda A,Wrembel-Wargocka J,Janiak MK

更新日期：2011-02-01 00:00:00

abstract：:Studies of early physical interactions of ionizing radiation in biological medium have evolved from water cylinders or spheres to structured volumes representing nucleosomal DNA, based on spatial co-ordinates for each individual atom. Regarding the physico-chemical and chemical stages, the models of DNA have evolved f...

journal_title：International journal of radiation biology

authors： Terrissol M

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:To describe the design and dosimetric characterization of a simple and economical small animal irradiator. MATERIALS AND METHODS:A high dose rate (HDR) (192)Ir brachytherapy source from a commercially available afterloader was used with a 1.3 cm thick tungsten collimator to provide sharp beam penumbra suitable...

journal_title：International journal of radiation biology

authors： Grams MP,Wilson ZC,Sio TT,Beltran CJ,Tryggestad EJ,Gupta SK,Blackwell CR,McCollough KP,Sarkaria JN,Furutani KM

更新日期：2014-10-01 00:00:00