Whole mouse blood microRNA as biomarkers for exposure to γ-rays and (56)Fe ion.

abstract：:Lambda-prophage induction in repair-deficient and wild-type E. coli strains by heavy ions and gamma-rays has been investigated. The dose dependence of the fraction of induced cells has been measured and its initial slope (lambda-induction potency) determined. The induction by gamma-rays was found to be more efficient ...

journal_title：International journal of radiation biology

authors： Bonev MN,Kozubek S,Krasavin EA,Amirtajev KG

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:To calculate the depth distribution of radioactive decays in bone by fitting a calculated alpha-particle energy spectrum to a measured spectrum. The dose to bone surface cells is then calculated from the depth distribution. MATERIALS AND METHODS:The spectra are calculated using Monte Carlo methods and a numeri...

journal_title：International journal of radiation biology

authors： Charlton DE,Salmon PL,Utteridge TD

更新日期：1998-01-01 00:00:00

abstract：:Purpose: Projects evaluating the effects of radiation, within the National Institutes of Quantum and Radiological Science and Technology (QST), National Institute of Radiological Sciences (NIRS), have focused on risk analyses for life shortening and cancer prevalence using laboratory animals. Genetic and epigenetic al...

journal_title：International journal of radiation biology

authors： Morioka T,Blyth BJ,Imaoka T,Nishimura M,Takeshita H,Shimomura T,Ohtake J,Ishida A,Schofield P,Grosche B,Kulka U,Shimada Y,Yamada Y,Kakinuma S

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:Chronic occupational exposure to ionizing radiation (IR) induces a wide spectrum of DNA damages. The aim of this study was to assess the frequencies of micronucleus (MN), sister chromatid exchanges (SCE) and to evaluate their association with XRCC1 399 Arg/Gln and XRCC3 241 Thr/Met polymorphisms in Hospital sta...

journal_title：International journal of radiation biology

authors： Doukali H,Ben Salah G,Ben Rhouma B,Hajjaji M,Jaouadi A,Belguith-Mahfouth N,Masmoudi ML,Ammar-Keskes L,Kamoun H

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:It has been proposed previously that the ratio of complete to incomplete translocations as seen by fluorescence in situ hybridization (FISH), the S value, can be a cytogenetic fingerprint of exposure to radiation of different qualities. Results from a previous study suggested that the S value is approximately 1...

journal_title：International journal of radiation biology

authors： Nakano M,Kodama Y,Ohtaki K,Itoh M,Nakamura N

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:Solar energy has a number of short- and long-term detrimental effects on skin that can result in several skin disorders. The aim of this review is to summarise current knowledge on endogenous systems within the skin for protection from solar radiation and present research findings to date, on the exogenous opti...

journal_title：International journal of radiation biology

authors： Svobodová A,Vostálová J

更新日期：2010-12-01 00:00:00

abstract：:Chinese hamster ovary cells were exposed to various heat treatments followed by X-irradiation, and the induction and repair of DNA strand breaks was studied using the alkaline unwinding technique. Heat treatments alone were found to cause DNA strand breakage only for temperatures greater than or equal to 43 degrees C,...

journal_title：International journal of radiation biology

authors： Dikomey E,Franzke J

更新日期：1992-02-01 00:00:00

abstract：:Primary chick embryo myoblasts can be a useful tool for studying the developmental events which accompany myoblast differentiation, particularly myoblast membrane fusion. To determine whether the electrical properties and/or fusion in these systems are affected by 50 Hz magnetic fields, chick embryo myoblast cultures ...

journal_title：International journal of radiation biology

authors： Grandolfo M,Santini MT,Vecchia P,Bonincontro A,Cametti C,Indovina PL

更新日期：1991-12-01 00:00:00

abstract：PURPOSE:To investigate the hypothesis that the developmental phase at which an individual encounters radiation damage affects its long-term sensitivity to a subsequent tumourigenic insult. MATERIALS AND METHODS:Either the pregnant C57B16 mouse was exposed to 137Cs gamma-rays at 4 or 15 days post-conception (embryonic ...

journal_title：International journal of radiation biology

authors： Hoyes KP,Hendry JH,Lord BI

更新日期：2000-01-01 00:00:00

abstract：:The relationship between ionizing radiation-induced cell killing and DNA damage measured by the micronucleus and apoptosis assays was determined in three established cell lines (L929, HL-60, and Chang). Irradiation experiments revealed a dose-dependent increase of micronucleated cells until a certain dose was reached....

journal_title：International journal of radiation biology

authors： Abend M,Rhein A,Gilbertz KP,Blakely WF,Van Beuningen D

更新日期：1995-03-01 00:00:00

abstract：:Purpose: Ionizing radiation is a risk factor to the whole organism, including the heart. Cardiac damage is considered to be a late effect of radiation exposure. While the acute cardiotoxicity of high doses is well characterized, the knowledge about nature and magnitude of the cardiac risk following lower doses exposur...

journal_title：International journal of radiation biology

authors： Gramatyka M,Sokół M

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:The radiation-induced bystander effect (RIBE) has important implications for the efficiency of radiotherapy but the underlying role of cellular metabolism is widely unknown. The roles of synthesis of cytochrome c oxidase 2 (SCO2), a key effector for respiratory chain, and related signaling factors in α-particle...

journal_title：International journal of radiation biology

authors： Li J,He M,Shen B,Yuan D,Shao C

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and...

journal_title：International journal of radiation biology

authors： Dinčić M,Krstić DZ,Čolović MB,Nešović Ostojić J,Kovačević S,De Luka SR,Djordjević DM,Ćirković S,Brkić P,Todorović J

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Theoretical modelling techniques are often used to simulate the action of ionizing radiations on cells at the nanometre level. Using monoenergetic vacuum-UV (VUV) radiation to irradiate DNA either dry or humidified, the action spectra for the induction of DNA damage by low energy photons and the role of water a...

journal_title：International journal of radiation biology

authors： Folkard M,Prise KM,Vojnovic B,Brocklehurst B,Michael BD

更新日期：2000-06-01 00:00:00

abstract：:The mitogen phytohemagglutinin (PHA) works well in both human and cynomolgus monkey (Macaca fascicularis) lymphocyte cultures to stimulate T cell proliferation. T cells from rhesus monkeys (Macaca mulatta) are less responsive than human cells, producing few metaphases when thousands are required, e.g. in biological do...

journal_title：International journal of radiation biology

authors： Hill FS,Cox AB,Salmon YL,Cantu AO,Lucas JN

更新日期：1994-10-01 00:00:00

abstract：PURPOSE:Ionizing radiation (IR) produced a dose-dependent increase in apoptosis in U937/pCEP4 cells which was attenuated by the stable over expression of Bcl-2 (U937/Bcl-2). A dose of 2 Gy IR was selected for further analyses to determine if subsequent exposure to 10nM bryostatin- would overcome the resistance to IR-in...

journal_title：International journal of radiation biology

authors： Cartee L,Davis C,Lin PS,Grant S

更新日期：2000-10-01 00:00:00

abstract：:Purpose To study the effect of microwave (MW) irradiation and consistent action of microwaves and static magnetic field (MF) on the giant chromosomes endoreduplication in Drosophila melanogaster Meig. Materials and methods Experiments were carried out on inbred wild type Canton-S strain. Exposure to microwaves (freque...

journal_title：International journal of radiation biology

authors： Dyka LD,Shakina LA,Strashnyuk VY,Shckorbatov YG

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Epidemiological studies have demonstrated a possible correlation between exposure to extremely low-frequency magnetic fields (ELF-MF) and cancer. However, this correlation has yet to be definitively confirmed by epidemiological studies. The principal objective of this study was to assess the effects of 60 Hz ma...

journal_title：International journal of radiation biology

authors： Jin YB,Kang GY,Lee JS,Choi JI,Lee JW,Hong SC,Myung SH,Lee YS

更新日期：2012-04-01 00:00:00

abstract：:Cultures of JU-56 cells were irradiated in either G1 or G2 and examined either in their first post-irradiation metaphase (in diploids) or in their second post-irradiation metaphase (in colcemid-induced tetraploids). The timing of fixation, together with tritiated thymidine pulse labelling, allowed selection for scorin...

journal_title：International journal of radiation biology

authors： Moore RC,Bender MA

更新日期：1993-06-01 00:00:00

abstract：PURPOSE:To assess health, growth and reproductive success of mammals exposed for multiple generations to levels of radium-226 known to occur in environments surrounding uranium mines and mills in Canada. METHODS:The study consisted of a control group and four treatment groups each containing 40 mice (20 males and 20 f...

journal_title：International journal of radiation biology

authors： Walsh S,Satkunam M,Su B,Festarini A,Bugden M,Peery H,Mothersill C,Stuart M

更新日期：2015-07-01 00:00:00

abstract：:Pre-implantation embryos of the mouse were studied for the occurrence of an adaptive response, i.e. induction of radio-resistance by a previous low dose. Various experimental designs were checked (initial doses between 3 and 10 cGy; second dose 2-6 Gy at 6-24 h after the first dose). Some of the experiments were carri...

journal_title：International journal of radiation biology

authors： Müller WU,Streffer C,Niedereichholz F

更新日期：1992-08-01 00:00:00

abstract：:Purpose To investigate the effect of increasing the overall treatment time as well as delivering the compensating doses on the Balb/c breast adenocarcinoma (4T1) tumor. Materials and methods A total of 72 mice were divided into two aliquots (classes A and B) based on the initial size of their induced tumor. Each class...

journal_title：International journal of radiation biology

authors： Nikzad S,Hashemi B,Hasan ZS,Mozdarani H,Baradaran-Ghahfarokhi M,Amini P

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:To honour perhaps the most influential man in the radiation sciences, Henry S. Kaplan, by reviewing the field of tumour hypoxia, one of his many interests. RESULTS:It was postulated over 50 years ago by Thomlinson and Gray that human solid tumours would contain hypoxic cells and that they would exert a negativ...

journal_title：International journal of radiation biology

authors： Brown M

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:We already reported that levels of interferon (IFN)-γ have been shown to be markedly reduced in mice seven weeks after irradiation, resulting in a T helper (Th) 1/Th2 imbalance. To investigate whether the single or fractionated γ-irradiation induced an immune imbalance, we analysed the Th1-related immune respon...

journal_title：International journal of radiation biology

authors： Park HR,Jo SK,Eom HS

更新日期：2011-05-01 00:00:00

abstract：:The mechanisms of radiation damage production are used to examine the following premises: (1) the number of DNA double-strand breaks per unit dose increases with dose; (2) cell type to cell type variations in yield of DNA dsb per dose occur. Two stages of damage production are identified as possible sources of damage ...

journal_title：International journal of radiation biology

authors： Ward JF

更新日期：1990-06-01 00:00:00

abstract：PURPOSE:To illustrate the progress in normal tissue radiation biology over the last five decades and its impact on radiotherapy. MATERIALS AND METHODS:Major milestones over the last 50 years and their consequences for radiation oncology are described: The identification of clonogenic cell survival and the (target) ste...

journal_title：International journal of radiation biology

authors： Stewart FA,Dörr W

更新日期：2009-07-01 00:00:00

abstract：:Purpose Radiolabeled antibodies and peptides hold promise for molecular radiotherapy but are often limited by a low payload resulting in inadequate delivery of radioactivity to tumour tissue and, therefore, modest therapeutic effect. We developed a facile synthetic method of radiolabeling indium-111 (111In) to epiderm...

journal_title：International journal of radiation biology

authors： Song L,Falzone N,Vallis KA

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:Since the exact development of posterior subcapsular cataracts (PSCs) is poorly understood, we review various risk factors and propose a two-stage etiology for PSCs. METHODS:The biological mechanisms associated with age-related cataracts (primarily nuclear cataracts, cortical cataracts and PSCs) were reviewed ...

journal_title：International journal of radiation biology

authors： Richardson RB,Ainsbury EA,Prescott CR,Lovicu FJ

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:The molecular basis of gene regulation in cells exposed to ionising radiation is not fully understood. Gene regulation occurs at the transcriptional and post-transcriptional levels. Recent studies have suggested that micro-RNA (miRNA) plays a significant role at the post-transcriptional gene regulation. miRNA a...

journal_title：International journal of radiation biology

authors： Chaudhry MA,Kreger B,Omaruddin RA

更新日期：2010-07-01 00:00:00

abstract：:We used a cell sorter assay to evaluate the efficacy of the hypoxic cell sensitizer etanidazole over 3-4 logs of cell inactivation, with particular attention to the clinically relevant low-dose survival region. Analysis of the radiation responses in a panel of six human tumour cell lines under conditions of hypoxia an...

journal_title：International journal of radiation biology

authors： Wouters BG,Sy AM,Skarsgard LD

更新日期：1996-12-01 00:00:00